C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton associated protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6T3_LEIDO

TriTrypDb:

LdBPK_141540.1 , LdCL_140021300 , LDHU3_14.1920

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.494
CLV_NRD_NRD_1	325	327	PF00675	0.524
CLV_NRD_NRD_1	39	41	PF00675	0.555
CLV_NRD_NRD_1	422	424	PF00675	0.389
CLV_NRD_NRD_1	537	539	PF00675	0.677
CLV_NRD_NRD_1	540	542	PF00675	0.668
CLV_NRD_NRD_1	60	62	PF00675	0.653
CLV_NRD_NRD_1	65	67	PF00675	0.604
CLV_NRD_NRD_1	710	712	PF00675	0.622
CLV_NRD_NRD_1	734	736	PF00675	0.678
CLV_NRD_NRD_1	758	760	PF00675	0.605
CLV_NRD_NRD_1	782	784	PF00675	0.593
CLV_NRD_NRD_1	859	861	PF00675	0.723
CLV_NRD_NRD_1	91	93	PF00675	0.611
CLV_NRD_NRD_1	920	922	PF00675	0.659
CLV_NRD_NRD_1	926	928	PF00675	0.654
CLV_PCSK_FUR_1	538	542	PF00082	0.482
CLV_PCSK_FUR_1	856	860	PF00082	0.707
CLV_PCSK_KEX2_1	38	40	PF00082	0.499
CLV_PCSK_KEX2_1	422	424	PF00082	0.354
CLV_PCSK_KEX2_1	524	526	PF00082	0.551
CLV_PCSK_KEX2_1	539	541	PF00082	0.607
CLV_PCSK_KEX2_1	60	62	PF00082	0.639
CLV_PCSK_KEX2_1	65	67	PF00082	0.618
CLV_PCSK_KEX2_1	710	712	PF00082	0.622
CLV_PCSK_KEX2_1	734	736	PF00082	0.594
CLV_PCSK_KEX2_1	758	760	PF00082	0.605
CLV_PCSK_KEX2_1	782	784	PF00082	0.593
CLV_PCSK_KEX2_1	858	860	PF00082	0.719
CLV_PCSK_KEX2_1	91	93	PF00082	0.611
CLV_PCSK_KEX2_1	920	922	PF00082	0.659
CLV_PCSK_KEX2_1	926	928	PF00082	0.654
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.523
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.474
CLV_PCSK_PC7_1	61	67	PF00082	0.655
CLV_PCSK_SKI1_1	31	35	PF00082	0.547
CLV_PCSK_SKI1_1	711	715	PF00082	0.660
CLV_PCSK_SKI1_1	91	95	PF00082	0.556
DEG_APCC_DBOX_1	37	45	PF00400	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DOC_CYCLIN_yCln2_LP_2	709	715	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	733	739	PF00134	0.627
DOC_CYCLIN_yCln2_LP_2	757	763	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	781	787	PF00134	0.595
DOC_MAPK_DCC_7	94	104	PF00069	0.537
DOC_MAPK_FxFP_2	150	153	PF00069	0.382
DOC_MAPK_gen_1	135	144	PF00069	0.325
DOC_MAPK_gen_1	326	333	PF00069	0.499
DOC_MAPK_gen_1	38	46	PF00069	0.549
DOC_MAPK_gen_1	94	104	PF00069	0.481
DOC_MAPK_MEF2A_6	326	335	PF00069	0.501
DOC_MAPK_MEF2A_6	38	46	PF00069	0.549
DOC_MAPK_MEF2A_6	95	104	PF00069	0.512
DOC_MAPK_NFAT4_5	39	47	PF00069	0.559
DOC_PP2B_LxvP_1	245	248	PF13499	0.528
DOC_PP2B_LxvP_1	526	529	PF13499	0.581
DOC_PP4_FxxP_1	150	153	PF00568	0.382
DOC_USP7_MATH_1	12	16	PF00917	0.589
DOC_USP7_MATH_1	203	207	PF00917	0.471
DOC_USP7_MATH_1	296	300	PF00917	0.559
DOC_USP7_MATH_1	398	402	PF00917	0.577
DOC_USP7_MATH_1	53	57	PF00917	0.569
DOC_USP7_MATH_1	713	717	PF00917	0.644
DOC_USP7_MATH_1	723	727	PF00917	0.567
DOC_USP7_MATH_1	737	741	PF00917	0.612
DOC_USP7_MATH_1	747	751	PF00917	0.643
DOC_USP7_MATH_1	761	765	PF00917	0.687
DOC_USP7_MATH_1	771	775	PF00917	0.559
DOC_USP7_MATH_1	834	838	PF00917	0.617
DOC_USP7_MATH_1	867	871	PF00917	0.562
DOC_USP7_MATH_1	909	913	PF00917	0.593
DOC_USP7_MATH_1	925	929	PF00917	0.706
DOC_USP7_UBL2_3	895	899	PF12436	0.575
DOC_USP7_UBL2_3	94	98	PF12436	0.540
DOC_WW_Pin1_4	298	303	PF00397	0.537
DOC_WW_Pin1_4	618	623	PF00397	0.703
DOC_WW_Pin1_4	837	842	PF00397	0.680
DOC_WW_Pin1_4	862	867	PF00397	0.615
DOC_WW_Pin1_4	921	926	PF00397	0.712
DOC_WW_Pin1_4	931	936	PF00397	0.536
LIG_14-3-3_CanoR_1	119	123	PF00244	0.382
LIG_14-3-3_CanoR_1	486	491	PF00244	0.396
LIG_14-3-3_CanoR_1	920	925	PF00244	0.812
LIG_14-3-3_CanoR_1	926	935	PF00244	0.754
LIG_Actin_WH2_2	215	231	PF00022	0.424
LIG_APCC_ABBA_1	44	49	PF00400	0.573
LIG_BIR_III_2	168	172	PF00653	0.382
LIG_BRCT_BRCA1_1	408	412	PF00533	0.325
LIG_Clathr_ClatBox_1	41	45	PF01394	0.559
LIG_deltaCOP1_diTrp_1	377	388	PF00928	0.542
LIG_FHA_1	131	137	PF00498	0.382
LIG_FHA_1	242	248	PF00498	0.551
LIG_FHA_1	250	256	PF00498	0.382
LIG_FHA_1	268	274	PF00498	0.348
LIG_FHA_1	928	934	PF00498	0.656
LIG_FHA_2	143	149	PF00498	0.309
LIG_FHA_2	712	718	PF00498	0.621
LIG_FHA_2	84	90	PF00498	0.609
LIG_G3BP_FGDF_1	821	826	PF02136	0.576
LIG_LIR_Apic_2	147	153	PF02991	0.382
LIG_LIR_Apic_2	307	313	PF02991	0.473
LIG_LIR_Apic_2	7	12	PF02991	0.595
LIG_LIR_Apic_2	862	866	PF02991	0.617
LIG_LIR_Apic_2	870	876	PF02991	0.688
LIG_LIR_Gen_1	145	154	PF02991	0.309
LIG_LIR_Gen_1	357	362	PF02991	0.494
LIG_LIR_Gen_1	409	420	PF02991	0.379
LIG_LIR_Gen_1	430	440	PF02991	0.377
LIG_LIR_Gen_1	464	472	PF02991	0.382
LIG_LIR_LC3C_4	162	166	PF02991	0.382
LIG_LIR_Nem_3	145	149	PF02991	0.357
LIG_LIR_Nem_3	151	155	PF02991	0.345
LIG_LIR_Nem_3	307	312	PF02991	0.530
LIG_LIR_Nem_3	357	361	PF02991	0.491
LIG_LIR_Nem_3	378	384	PF02991	0.546
LIG_LIR_Nem_3	408	414	PF02991	0.382
LIG_LIR_Nem_3	430	435	PF02991	0.377
LIG_LIR_Nem_3	464	470	PF02991	0.382
LIG_LIR_Nem_3	522	526	PF02991	0.513
LIG_LIR_Nem_3	822	826	PF02991	0.578
LIG_MLH1_MIPbox_1	408	412	PF16413	0.325
LIG_MYND_1	298	302	PF01753	0.526
LIG_Pex14_1	146	150	PF04695	0.382
LIG_SH2_CRK	523	527	PF00017	0.521
LIG_SH2_CRK	64	68	PF00017	0.656
LIG_SH2_GRB2like	154	157	PF00017	0.382
LIG_SH2_PTP2	432	435	PF00017	0.382
LIG_SH2_SRC	154	157	PF00017	0.325
LIG_SH2_SRC	311	314	PF00017	0.480
LIG_SH2_STAT5	154	157	PF00017	0.325
LIG_SH2_STAT5	227	230	PF00017	0.508
LIG_SH2_STAT5	269	272	PF00017	0.461
LIG_SH2_STAT5	311	314	PF00017	0.516
LIG_SH2_STAT5	432	435	PF00017	0.382
LIG_SH2_STAT5	647	650	PF00017	0.668
LIG_SH2_STAT5	9	12	PF00017	0.596
LIG_SH3_1	310	316	PF00018	0.494
LIG_SH3_1	873	879	PF00018	0.703
LIG_SH3_3	178	184	PF00018	0.302
LIG_SH3_3	197	203	PF00018	0.413
LIG_SH3_3	310	316	PF00018	0.494
LIG_SH3_3	330	336	PF00018	0.387
LIG_SH3_3	442	448	PF00018	0.382
LIG_SH3_3	696	702	PF00018	0.635
LIG_SH3_3	75	81	PF00018	0.658
LIG_SH3_3	788	794	PF00018	0.627
LIG_SH3_3	873	879	PF00018	0.703
LIG_SH3_4	291	298	PF00018	0.501
LIG_SUMO_SIM_anti_2	117	124	PF11976	0.380
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.382
LIG_SUMO_SIM_anti_2	339	352	PF11976	0.591
LIG_SUMO_SIM_anti_2	496	505	PF11976	0.382
LIG_SUMO_SIM_par_1	162	168	PF11976	0.382
LIG_SUMO_SIM_par_1	367	373	PF11976	0.537
LIG_TRAF2_1	145	148	PF00917	0.382
LIG_TRAF2_1	18	21	PF00917	0.472
LIG_TRAF2_1	213	216	PF00917	0.474
LIG_TRAF2_1	342	345	PF00917	0.604
LIG_TRAF2_1	542	545	PF00917	0.670
LIG_TRAF2_1	551	554	PF00917	0.645
LIG_TRAF2_1	607	610	PF00917	0.756
LIG_TRAF2_1	658	661	PF00917	0.643
LIG_TRAF2_1	666	669	PF00917	0.625
LIG_TRAF2_1	682	685	PF00917	0.557
LIG_TRAF2_1	695	698	PF00917	0.603
LIG_TRAF2_1	715	718	PF00917	0.629
LIG_TRAF2_1	728	731	PF00917	0.597
LIG_TRAF2_1	739	742	PF00917	0.579
LIG_TRAF2_1	752	755	PF00917	0.581
LIG_TRAF2_1	763	766	PF00917	0.580
LIG_TRAF2_1	776	779	PF00917	0.590
LIG_TRAF2_1	787	790	PF00917	0.614
LIG_TRAF2_1	794	797	PF00917	0.573
LIG_TRAF2_1	799	802	PF00917	0.555
LIG_TRAF2_2	83	88	PF00917	0.516
MOD_CDK_SPK_2	921	926	PF00069	0.712
MOD_CDK_SPxK_1	921	927	PF00069	0.689
MOD_CDK_SPxxK_3	862	869	PF00069	0.613
MOD_CK1_1	15	21	PF00069	0.580
MOD_CK1_1	206	212	PF00069	0.459
MOD_CK1_1	434	440	PF00069	0.382
MOD_CK1_1	653	659	PF00069	0.598
MOD_CK1_1	837	843	PF00069	0.707
MOD_CK1_1	862	868	PF00069	0.635
MOD_CK2_1	142	148	PF00069	0.309
MOD_CK2_1	15	21	PF00069	0.524
MOD_CK2_1	210	216	PF00069	0.465
MOD_CK2_1	338	344	PF00069	0.620
MOD_CK2_1	598	604	PF00069	0.823
MOD_CK2_1	697	703	PF00069	0.724
MOD_CK2_1	711	717	PF00069	0.584
MOD_CK2_1	789	795	PF00069	0.598
MOD_CK2_1	83	89	PF00069	0.540
MOD_CK2_1	909	915	PF00069	0.622
MOD_DYRK1A_RPxSP_1	921	925	PF00069	0.677
MOD_GlcNHglycan	112	115	PF01048	0.382
MOD_GlcNHglycan	436	439	PF01048	0.454
MOD_GlcNHglycan	55	58	PF01048	0.578
MOD_GlcNHglycan	725	728	PF01048	0.558
MOD_GlcNHglycan	749	752	PF01048	0.593
MOD_GlcNHglycan	773	776	PF01048	0.574
MOD_GlcNHglycan	836	839	PF01048	0.619
MOD_GlcNHglycan	870	873	PF01048	0.667
MOD_GlcNHglycan	879	882	PF01048	0.787
MOD_GSK3_1	206	213	PF00069	0.484
MOD_GSK3_1	218	225	PF00069	0.376
MOD_GSK3_1	406	413	PF00069	0.561
MOD_GSK3_1	713	720	PF00069	0.601
MOD_GSK3_1	737	744	PF00069	0.627
MOD_GSK3_1	761	768	PF00069	0.604
MOD_GSK3_1	915	922	PF00069	0.663
MOD_GSK3_1	927	934	PF00069	0.596
MOD_N-GLC_1	282	287	PF02516	0.595
MOD_NEK2_1	102	107	PF00069	0.382
MOD_NEK2_1	249	254	PF00069	0.431
MOD_NEK2_1	370	375	PF00069	0.560
MOD_NEK2_1	410	415	PF00069	0.382
MOD_NEK2_1	567	572	PF00069	0.665
MOD_NEK2_1	73	78	PF00069	0.608
MOD_NEK2_1	891	896	PF00069	0.657
MOD_PIKK_1	314	320	PF00454	0.581
MOD_PIKK_1	447	453	PF00454	0.256
MOD_PIKK_1	624	630	PF00454	0.647
MOD_PIKK_1	653	659	PF00454	0.623
MOD_PIKK_1	789	795	PF00454	0.610
MOD_PK_1	486	492	PF00069	0.325
MOD_PK_1	598	604	PF00069	0.633
MOD_PKA_1	859	865	PF00069	0.712
MOD_PKA_1	920	926	PF00069	0.678
MOD_PKA_2	118	124	PF00069	0.382
MOD_PKA_2	277	283	PF00069	0.590
MOD_PKA_2	859	865	PF00069	0.700
MOD_PKA_2	919	925	PF00069	0.759
MOD_PKA_2	926	932	PF00069	0.690
MOD_Plk_1	203	209	PF00069	0.436
MOD_Plk_1	915	921	PF00069	0.638
MOD_Plk_2-3	340	346	PF00069	0.627
MOD_Plk_2-3	441	447	PF00069	0.382
MOD_Plk_2-3	604	610	PF00069	0.665
MOD_Plk_2-3	650	656	PF00069	0.671
MOD_Plk_2-3	697	703	PF00069	0.636
MOD_Plk_4	218	224	PF00069	0.448
MOD_Plk_4	249	255	PF00069	0.484
MOD_Plk_4	284	290	PF00069	0.579
MOD_Plk_4	406	412	PF00069	0.465
MOD_Plk_4	859	865	PF00069	0.647
MOD_ProDKin_1	298	304	PF00069	0.531
MOD_ProDKin_1	618	624	PF00069	0.707
MOD_ProDKin_1	837	843	PF00069	0.679
MOD_ProDKin_1	862	868	PF00069	0.614
MOD_ProDKin_1	921	927	PF00069	0.717
MOD_ProDKin_1	931	937	PF00069	0.534
MOD_SUMO_for_1	336	339	PF00179	0.532
MOD_SUMO_for_1	658	661	PF00179	0.631
MOD_SUMO_rev_2	29	36	PF00179	0.547
MOD_SUMO_rev_2	604	613	PF00179	0.623
TRG_DiLeu_BaEn_1	22	27	PF01217	0.569
TRG_DiLeu_BaEn_1	344	349	PF01217	0.603
TRG_DiLeu_BaEn_1	37	42	PF01217	0.413
TRG_DiLeu_BaEn_1	483	488	PF01217	0.382
TRG_DiLeu_BaEn_3	498	504	PF01217	0.256
TRG_DiLeu_LyEn_5	22	27	PF01217	0.569
TRG_ENDOCYTIC_2	2	5	PF00928	0.608
TRG_ENDOCYTIC_2	309	312	PF00928	0.525
TRG_ENDOCYTIC_2	432	435	PF00928	0.382
TRG_ENDOCYTIC_2	523	526	PF00928	0.512
TRG_ENDOCYTIC_2	64	67	PF00928	0.656
TRG_ER_diArg_1	38	40	PF00400	0.542
TRG_ER_diArg_1	421	423	PF00400	0.354
TRG_ER_diArg_1	50	53	PF00400	0.491
TRG_ER_diArg_1	537	540	PF00400	0.652
TRG_ER_diArg_1	59	61	PF00400	0.566
TRG_ER_diArg_1	64	66	PF00400	0.538
TRG_ER_diArg_1	709	711	PF00400	0.640
TRG_ER_diArg_1	733	735	PF00400	0.604
TRG_ER_diArg_1	757	759	PF00400	0.608
TRG_ER_diArg_1	781	783	PF00400	0.597
TRG_ER_diArg_1	856	859	PF00400	0.703
TRG_ER_diArg_1	90	92	PF00400	0.619
TRG_ER_diArg_1	919	921	PF00400	0.650
TRG_ER_diArg_1	925	927	PF00400	0.658
TRG_NES_CRM1_1	346	359	PF08389	0.532
TRG_NES_CRM1_1	408	424	PF08389	0.354
TRG_NLS_Bipartite_1	524	543	PF00514	0.541
TRG_NLS_MonoCore_2	537	542	PF00514	0.483
TRG_NLS_MonoExtC_3	538	544	PF00514	0.483
TRG_NLS_MonoExtN_4	538	543	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7W4	Leishmania braziliensis	67%	100%
A4HW91	Leishmania infantum	98%	93%
E9APZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4QFI9	Leishmania major	90%	100%