Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6T0_LEIDO

TriTrypDb:

LdBPK_141370.1 , LdCL_140019600 , LDHU3_14.1710

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.529
CLV_C14_Caspase3-7	501	505	PF00656	0.556
CLV_C14_Caspase3-7	637	641	PF00656	0.615
CLV_NRD_NRD_1	131	133	PF00675	0.543
CLV_NRD_NRD_1	148	150	PF00675	0.352
CLV_NRD_NRD_1	191	193	PF00675	0.535
CLV_NRD_NRD_1	261	263	PF00675	0.557
CLV_NRD_NRD_1	336	338	PF00675	0.536
CLV_NRD_NRD_1	36	38	PF00675	0.431
CLV_NRD_NRD_1	377	379	PF00675	0.392
CLV_NRD_NRD_1	410	412	PF00675	0.504
CLV_NRD_NRD_1	454	456	PF00675	0.654
CLV_NRD_NRD_1	475	477	PF00675	0.812
CLV_NRD_NRD_1	494	496	PF00675	0.446
CLV_NRD_NRD_1	52	54	PF00675	0.448
CLV_NRD_NRD_1	599	601	PF00675	0.736
CLV_NRD_NRD_1	61	63	PF00675	0.453
CLV_NRD_NRD_1	648	650	PF00675	0.745
CLV_NRD_NRD_1	699	701	PF00675	0.559
CLV_NRD_NRD_1	779	781	PF00675	0.606
CLV_PCSK_FUR_1	34	38	PF00082	0.440
CLV_PCSK_FUR_1	452	456	PF00082	0.644
CLV_PCSK_FUR_1	475	479	PF00082	0.671
CLV_PCSK_KEX2_1	131	133	PF00082	0.543
CLV_PCSK_KEX2_1	147	149	PF00082	0.365
CLV_PCSK_KEX2_1	191	193	PF00082	0.535
CLV_PCSK_KEX2_1	261	263	PF00082	0.557
CLV_PCSK_KEX2_1	275	277	PF00082	0.430
CLV_PCSK_KEX2_1	336	338	PF00082	0.536
CLV_PCSK_KEX2_1	36	38	PF00082	0.440
CLV_PCSK_KEX2_1	377	379	PF00082	0.392
CLV_PCSK_KEX2_1	451	453	PF00082	0.628
CLV_PCSK_KEX2_1	454	456	PF00082	0.632
CLV_PCSK_KEX2_1	475	477	PF00082	0.633
CLV_PCSK_KEX2_1	494	496	PF00082	0.520
CLV_PCSK_KEX2_1	51	53	PF00082	0.497
CLV_PCSK_KEX2_1	599	601	PF00082	0.736
CLV_PCSK_KEX2_1	61	63	PF00082	0.447
CLV_PCSK_KEX2_1	699	701	PF00082	0.562
CLV_PCSK_KEX2_1	778	780	PF00082	0.612
CLV_PCSK_KEX2_1	90	92	PF00082	0.566
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.553
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.605
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.640
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.490
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.736
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.566
CLV_PCSK_PC7_1	775	781	PF00082	0.646
CLV_PCSK_SKI1_1	112	116	PF00082	0.649
CLV_PCSK_SKI1_1	148	152	PF00082	0.608
CLV_PCSK_SKI1_1	213	217	PF00082	0.509
CLV_PCSK_SKI1_1	27	31	PF00082	0.441
CLV_PCSK_SKI1_1	276	280	PF00082	0.450
CLV_PCSK_SKI1_1	400	404	PF00082	0.473
CLV_PCSK_SKI1_1	411	415	PF00082	0.465
CLV_PCSK_SKI1_1	497	501	PF00082	0.612
DEG_APCC_DBOX_1	147	155	PF00400	0.584
DEG_APCC_DBOX_1	496	504	PF00400	0.525
DEG_SCF_FBW7_2	519	526	PF00400	0.544
DEG_SPOP_SBC_1	742	746	PF00917	0.677
DOC_ANK_TNKS_1	477	484	PF00023	0.674
DOC_ANK_TNKS_1	728	735	PF00023	0.707
DOC_CKS1_1	614	619	PF01111	0.715
DOC_CYCLIN_RxL_1	146	157	PF00134	0.501
DOC_CYCLIN_RxL_1	21	33	PF00134	0.441
DOC_CYCLIN_RxL_1	210	217	PF00134	0.573
DOC_MAPK_gen_1	147	154	PF00069	0.500
DOC_MAPK_gen_1	336	343	PF00069	0.535
DOC_MAPK_gen_1	34	43	PF00069	0.426
DOC_MAPK_gen_1	366	373	PF00069	0.549
DOC_MAPK_gen_1	411	417	PF00069	0.506
DOC_MAPK_gen_1	51	60	PF00069	0.449
DOC_PP1_RVXF_1	147	154	PF00149	0.490
DOC_USP7_MATH_1	16	20	PF00917	0.444
DOC_USP7_MATH_1	274	278	PF00917	0.589
DOC_USP7_MATH_1	286	290	PF00917	0.442
DOC_USP7_MATH_1	312	316	PF00917	0.479
DOC_USP7_MATH_1	438	442	PF00917	0.578
DOC_USP7_MATH_1	622	626	PF00917	0.713
DOC_USP7_MATH_1	629	633	PF00917	0.623
DOC_USP7_MATH_1	718	722	PF00917	0.599
DOC_USP7_MATH_1	742	746	PF00917	0.615
DOC_USP7_MATH_1	768	772	PF00917	0.690
DOC_USP7_UBL2_3	51	55	PF12436	0.488
DOC_WW_Pin1_4	519	524	PF00397	0.608
DOC_WW_Pin1_4	549	554	PF00397	0.694
DOC_WW_Pin1_4	613	618	PF00397	0.713
DOC_WW_Pin1_4	625	630	PF00397	0.559
DOC_WW_Pin1_4	666	671	PF00397	0.632
DOC_WW_Pin1_4	724	729	PF00397	0.598
LIG_14-3-3_CanoR_1	159	164	PF00244	0.496
LIG_14-3-3_CanoR_1	170	179	PF00244	0.404
LIG_14-3-3_CanoR_1	213	219	PF00244	0.524
LIG_14-3-3_CanoR_1	256	264	PF00244	0.554
LIG_14-3-3_CanoR_1	411	416	PF00244	0.441
LIG_14-3-3_CanoR_1	467	474	PF00244	0.582
LIG_14-3-3_CanoR_1	494	503	PF00244	0.503
LIG_14-3-3_CanoR_1	564	568	PF00244	0.605
LIG_14-3-3_CanoR_1	6	12	PF00244	0.429
LIG_14-3-3_CanoR_1	605	613	PF00244	0.611
LIG_14-3-3_CanoR_1	739	747	PF00244	0.657
LIG_Actin_WH2_2	338	356	PF00022	0.532
LIG_AP2alpha_1	796	800	PF02296	0.542
LIG_APCC_ABBA_1	225	230	PF00400	0.480
LIG_BIR_II_1	1	5	PF00653	0.481
LIG_BRCT_BRCA1_1	743	747	PF00533	0.616
LIG_eIF4E_1	339	345	PF01652	0.531
LIG_FHA_1	156	162	PF00498	0.546
LIG_FHA_1	170	176	PF00498	0.401
LIG_FHA_1	329	335	PF00498	0.551
LIG_FHA_1	412	418	PF00498	0.436
LIG_FHA_1	560	566	PF00498	0.589
LIG_FHA_1	6	12	PF00498	0.451
LIG_FHA_1	629	635	PF00498	0.592
LIG_FHA_2	261	267	PF00498	0.587
LIG_FHA_2	288	294	PF00498	0.591
LIG_FHA_2	367	373	PF00498	0.501
LIG_FHA_2	656	662	PF00498	0.558
LIG_LIR_Gen_1	19	30	PF02991	0.447
LIG_LIR_Gen_1	752	761	PF02991	0.693
LIG_LIR_Gen_1	793	801	PF02991	0.545
LIG_LIR_Nem_3	19	25	PF02991	0.447
LIG_LIR_Nem_3	420	425	PF02991	0.441
LIG_LIR_Nem_3	640	646	PF02991	0.715
LIG_LIR_Nem_3	752	758	PF02991	0.692
LIG_NRBOX	139	145	PF00104	0.466
LIG_NRBOX	340	346	PF00104	0.474
LIG_Pex14_1	422	426	PF04695	0.535
LIG_Pex14_2	747	751	PF04695	0.672
LIG_Pex14_2	796	800	PF04695	0.542
LIG_RPA_C_Fungi	386	398	PF08784	0.464
LIG_RPA_C_Fungi	432	444	PF08784	0.568
LIG_SH2_CRK	426	430	PF00017	0.527
LIG_SH2_NCK_1	339	343	PF00017	0.533
LIG_SH2_SRC	228	231	PF00017	0.487
LIG_SH2_STAP1	228	232	PF00017	0.573
LIG_SH2_STAP1	339	343	PF00017	0.533
LIG_SH2_STAP1	426	430	PF00017	0.527
LIG_SH2_STAT5	518	521	PF00017	0.550
LIG_SH3_1	583	589	PF00018	0.660
LIG_SH3_3	550	556	PF00018	0.636
LIG_SH3_3	583	589	PF00018	0.660
LIG_SH3_3	671	677	PF00018	0.689
LIG_SH3_3	771	777	PF00018	0.617
LIG_SH3_CIN85_PxpxPR_1	670	675	PF14604	0.617
LIG_SUMO_SIM_par_1	343	349	PF11976	0.469
LIG_SUMO_SIM_par_1	413	418	PF11976	0.434
LIG_TRAF2_1	238	241	PF00917	0.477
LIG_TRAF2_1	263	266	PF00917	0.599
LIG_TRAF2_1	299	302	PF00917	0.558
LIG_TRAF2_1	308	311	PF00917	0.476
LIG_TRAF2_1	524	527	PF00917	0.646
LIG_TYR_ITIM	424	429	PF00017	0.531
LIG_WRC_WIRS_1	103	108	PF05994	0.557
LIG_WW_3	472	476	PF00397	0.641
MOD_CDK_SPK_2	670	675	PF00069	0.617
MOD_CDK_SPK_2	724	729	PF00069	0.598
MOD_CDK_SPxxK_3	668	675	PF00069	0.620
MOD_CK1_1	485	491	PF00069	0.612
MOD_CK1_1	511	517	PF00069	0.650
MOD_CK1_1	557	563	PF00069	0.714
MOD_CK1_1	625	631	PF00069	0.632
MOD_CK1_1	638	644	PF00069	0.600
MOD_CK1_1	660	666	PF00069	0.655
MOD_CK1_1	741	747	PF00069	0.660
MOD_CK1_1	749	755	PF00069	0.571
MOD_CK2_1	17	23	PF00069	0.446
MOD_CK2_1	260	266	PF00069	0.622
MOD_CK2_1	287	293	PF00069	0.593
MOD_CK2_1	312	318	PF00069	0.515
MOD_CK2_1	366	372	PF00069	0.503
MOD_CK2_1	495	501	PF00069	0.499
MOD_Cter_Amidation	129	132	PF01082	0.542
MOD_Cter_Amidation	189	192	PF01082	0.490
MOD_GlcNHglycan	106	109	PF01048	0.438
MOD_GlcNHglycan	172	175	PF01048	0.454
MOD_GlcNHglycan	246	249	PF01048	0.528
MOD_GlcNHglycan	257	260	PF01048	0.582
MOD_GlcNHglycan	301	306	PF01048	0.543
MOD_GlcNHglycan	439	443	PF01048	0.609
MOD_GlcNHglycan	469	472	PF01048	0.720
MOD_GlcNHglycan	497	500	PF01048	0.535
MOD_GlcNHglycan	539	542	PF01048	0.711
MOD_GlcNHglycan	624	627	PF01048	0.707
MOD_GlcNHglycan	631	634	PF01048	0.615
MOD_GlcNHglycan	650	653	PF01048	0.503
MOD_GlcNHglycan	714	717	PF01048	0.596
MOD_GlcNHglycan	720	723	PF01048	0.589
MOD_GlcNHglycan	735	738	PF01048	0.539
MOD_GlcNHglycan	740	743	PF01048	0.606
MOD_GlcNHglycan	92	95	PF01048	0.555
MOD_GSK3_1	155	162	PF00069	0.602
MOD_GSK3_1	190	197	PF00069	0.601
MOD_GSK3_1	276	283	PF00069	0.505
MOD_GSK3_1	507	514	PF00069	0.580
MOD_GSK3_1	554	561	PF00069	0.647
MOD_GSK3_1	563	570	PF00069	0.584
MOD_GSK3_1	625	632	PF00069	0.631
MOD_GSK3_1	635	642	PF00069	0.594
MOD_GSK3_1	666	673	PF00069	0.637
MOD_GSK3_1	714	721	PF00069	0.593
MOD_GSK3_1	724	731	PF00069	0.601
MOD_GSK3_1	733	740	PF00069	0.491
MOD_GSK3_1	742	749	PF00069	0.683
MOD_LATS_1	168	174	PF00433	0.532
MOD_LATS_1	409	415	PF00433	0.504
MOD_NEK2_1	214	219	PF00069	0.507
MOD_NEK2_1	320	325	PF00069	0.576
MOD_NEK2_1	353	358	PF00069	0.550
MOD_NEK2_1	387	392	PF00069	0.502
MOD_NEK2_1	508	513	PF00069	0.578
MOD_NEK2_1	563	568	PF00069	0.593
MOD_NEK2_2	223	228	PF00069	0.512
MOD_NEK2_2	559	564	PF00069	0.714
MOD_PIKK_1	508	514	PF00454	0.573
MOD_PIKK_1	532	538	PF00454	0.682
MOD_PK_1	159	165	PF00069	0.478
MOD_PK_1	568	574	PF00069	0.693
MOD_PKA_1	131	137	PF00069	0.476
MOD_PKA_1	411	417	PF00069	0.469
MOD_PKA_1	90	96	PF00069	0.506
MOD_PKA_2	131	137	PF00069	0.530
MOD_PKA_2	169	175	PF00069	0.508
MOD_PKA_2	177	183	PF00069	0.483
MOD_PKA_2	190	196	PF00069	0.434
MOD_PKA_2	255	261	PF00069	0.574
MOD_PKA_2	353	359	PF00069	0.542
MOD_PKA_2	387	393	PF00069	0.543
MOD_PKA_2	5	11	PF00069	0.430
MOD_PKA_2	563	569	PF00069	0.616
MOD_PKA_2	604	610	PF00069	0.611
MOD_PKA_2	648	654	PF00069	0.663
MOD_PKA_2	712	718	PF00069	0.674
MOD_PKA_2	728	734	PF00069	0.545
MOD_PKA_2	738	744	PF00069	0.618
MOD_PKA_2	90	96	PF00069	0.495
MOD_Plk_1	286	292	PF00069	0.492
MOD_Plk_1	639	645	PF00069	0.622
MOD_Plk_2-3	287	293	PF00069	0.537
MOD_Plk_4	223	229	PF00069	0.506
MOD_ProDKin_1	519	525	PF00069	0.609
MOD_ProDKin_1	549	555	PF00069	0.691
MOD_ProDKin_1	613	619	PF00069	0.714
MOD_ProDKin_1	625	631	PF00069	0.558
MOD_ProDKin_1	666	672	PF00069	0.628
MOD_ProDKin_1	724	730	PF00069	0.599
MOD_SUMO_for_1	367	370	PF00179	0.497
MOD_SUMO_rev_2	268	277	PF00179	0.588
MOD_SUMO_rev_2	361	367	PF00179	0.410
MOD_SUMO_rev_2	405	414	PF00179	0.436
TRG_DiLeu_BaEn_4	241	247	PF01217	0.481
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.495
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.442
TRG_DiLeu_BaLyEn_6	779	784	PF01217	0.611
TRG_ENDOCYTIC_2	22	25	PF00928	0.449
TRG_ENDOCYTIC_2	426	429	PF00928	0.530
TRG_ER_diArg_1	131	133	PF00400	0.543
TRG_ER_diArg_1	146	149	PF00400	0.372
TRG_ER_diArg_1	260	262	PF00400	0.559
TRG_ER_diArg_1	336	338	PF00400	0.561
TRG_ER_diArg_1	34	37	PF00400	0.434
TRG_ER_diArg_1	376	378	PF00400	0.399
TRG_ER_diArg_1	43	46	PF00400	0.442
TRG_ER_diArg_1	452	455	PF00400	0.645
TRG_ER_diArg_1	474	476	PF00400	0.646
TRG_ER_diArg_1	494	497	PF00400	0.477
TRG_ER_diArg_1	60	62	PF00400	0.350
TRG_ER_diArg_1	646	649	PF00400	0.667
TRG_ER_diArg_1	698	700	PF00400	0.569
TRG_ER_diArg_1	777	780	PF00400	0.665
TRG_NLS_Bipartite_1	36	55	PF00514	0.471
TRG_NLS_MonoExtC_3	450	455	PF00514	0.608
TRG_NLS_MonoExtC_3	475	480	PF00514	0.725
TRG_NLS_MonoExtC_3	50	55	PF00514	0.486
TRG_NLS_MonoExtN_4	473	480	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P321	Leptomonas seymouri	39%	100%
A4H7U9	Leishmania braziliensis	70%	100%
A4HW75	Leishmania infantum	100%	100%
E9APX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFK5	Leishmania major	90%	100%