Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H6S9_LEIDO

TriTrypDb:

LdBPK_141340.1 , LdCL_140019300 , LDHU3_14.1680

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	84	86	PF00082	0.566
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.566
CLV_PCSK_SKI1_1	13	17	PF00082	0.708
CLV_PCSK_SKI1_1	58	62	PF00082	0.516
DEG_APCC_DBOX_1	93	101	PF00400	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.779
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.656
DOC_MAPK_gen_1	84	91	PF00069	0.553
DOC_MAPK_MEF2A_6	94	101	PF00069	0.542
DOC_USP7_MATH_1	37	41	PF00917	0.591
DOC_USP7_MATH_1	63	67	PF00917	0.703
DOC_WW_Pin1_4	59	64	PF00397	0.748
LIG_14-3-3_CanoR_1	137	142	PF00244	0.643
LIG_FHA_1	109	115	PF00498	0.643
LIG_FHA_1	44	50	PF00498	0.591
LIG_FHA_1	60	66	PF00498	0.542
LIG_FHA_1	88	94	PF00498	0.636
LIG_LIR_Gen_1	21	30	PF02991	0.699
LIG_LIR_Gen_1	35	45	PF02991	0.402
LIG_LIR_Gen_1	66	73	PF02991	0.593
LIG_LIR_Nem_3	111	116	PF02991	0.701
LIG_LIR_Nem_3	117	121	PF02991	0.500
LIG_LIR_Nem_3	144	150	PF02991	0.744
LIG_LIR_Nem_3	21	27	PF02991	0.642
LIG_LIR_Nem_3	35	41	PF02991	0.480
LIG_LIR_Nem_3	66	70	PF02991	0.573
LIG_SH2_CRK	38	42	PF00017	0.645
LIG_SH2_CRK	67	71	PF00017	0.587
LIG_SH2_NCK_1	34	38	PF00017	0.588
LIG_SH2_NCK_1	67	71	PF00017	0.587
LIG_SH2_STAP1	34	38	PF00017	0.588
LIG_SH2_STAP1	45	49	PF00017	0.463
LIG_SH2_STAT3	119	122	PF00017	0.572
LIG_SH2_STAT5	119	122	PF00017	0.538
LIG_SH2_STAT5	45	48	PF00017	0.604
LIG_SH3_3	132	138	PF00018	0.695
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.555
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.588
LIG_SUMO_SIM_par_1	52	57	PF11976	0.566
LIG_TYR_ITIM	116	121	PF00017	0.535
LIG_TYR_ITIM	36	41	PF00017	0.569
LIG_TYR_ITIM	65	70	PF00017	0.603
LIG_WRC_WIRS_1	88	93	PF05994	0.499
MOD_CK1_1	104	110	PF00069	0.466
MOD_CK1_1	125	131	PF00069	0.635
MOD_CK1_1	32	38	PF00069	0.512
MOD_CK1_1	52	58	PF00069	0.577
MOD_CK1_1	87	93	PF00069	0.549
MOD_CK2_1	37	43	PF00069	0.670
MOD_CK2_1	89	95	PF00069	0.507
MOD_GlcNHglycan	128	131	PF01048	0.615
MOD_GlcNHglycan	2	5	PF01048	0.709
MOD_GSK3_1	104	111	PF00069	0.721
MOD_GSK3_1	122	129	PF00069	0.371
MOD_GSK3_1	133	140	PF00069	0.568
MOD_GSK3_1	28	35	PF00069	0.613
MOD_GSK3_1	39	46	PF00069	0.544
MOD_GSK3_1	52	59	PF00069	0.496
MOD_N-GLC_1	133	138	PF02516	0.657
MOD_NEK2_1	123	128	PF00069	0.526
MOD_NEK2_1	89	94	PF00069	0.595
MOD_PK_1	137	143	PF00069	0.637
MOD_PKA_1	84	90	PF00069	0.521
MOD_PKA_2	84	90	PF00069	0.521
MOD_Plk_4	114	120	PF00069	0.517
MOD_Plk_4	142	148	PF00069	0.691
MOD_Plk_4	45	51	PF00069	0.609
MOD_Plk_4	65	71	PF00069	0.407
MOD_Plk_4	84	90	PF00069	0.368
MOD_ProDKin_1	59	65	PF00069	0.738
TRG_ENDOCYTIC_2	118	121	PF00928	0.537
TRG_ENDOCYTIC_2	12	15	PF00928	0.779
TRG_ENDOCYTIC_2	38	41	PF00928	0.646
TRG_ENDOCYTIC_2	67	70	PF00928	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA15	Leptomonas seymouri	42%	80%
A4H7U5	Leishmania braziliensis	27%	74%
A4H7U6	Leishmania braziliensis	68%	100%
A4HW72	Leishmania infantum	100%	100%
E9APX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QFK8	Leishmania major	91%	100%