Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6S8_LEIDO

TriTrypDb:

LdBPK_141230.1 , LdCL_140018200 , LDHU3_14.1570

Length:

350

Annotations

LeishMANIAdb annotations

Very putatively an organellar or non-TM protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.489
CLV_C14_Caspase3-7	44	48	PF00656	0.670
CLV_NRD_NRD_1	102	104	PF00675	0.579
CLV_NRD_NRD_1	16	18	PF00675	0.498
CLV_NRD_NRD_1	191	193	PF00675	0.571
CLV_NRD_NRD_1	63	65	PF00675	0.372
CLV_NRD_NRD_1	73	75	PF00675	0.341
CLV_PCSK_KEX2_1	102	104	PF00082	0.582
CLV_PCSK_KEX2_1	132	134	PF00082	0.721
CLV_PCSK_KEX2_1	16	18	PF00082	0.498
CLV_PCSK_KEX2_1	193	195	PF00082	0.576
CLV_PCSK_KEX2_1	63	65	PF00082	0.370
CLV_PCSK_KEX2_1	73	75	PF00082	0.335
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.721
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.658
CLV_PCSK_PC7_1	12	18	PF00082	0.477
CLV_PCSK_PC7_1	189	195	PF00082	0.564
CLV_PCSK_SKI1_1	193	197	PF00082	0.614
CLV_PCSK_SKI1_1	30	34	PF00082	0.540
CLV_PCSK_SKI1_1	315	319	PF00082	0.664
CLV_PCSK_SKI1_1	65	69	PF00082	0.445
DEG_SCF_FBW7_1	32	39	PF00400	0.683
DEG_SPOP_SBC_1	118	122	PF00917	0.405
DEG_SPOP_SBC_1	137	141	PF00917	0.484
DEG_SPOP_SBC_1	282	286	PF00917	0.599
DEG_SPOP_SBC_1	40	44	PF00917	0.684
DOC_CYCLIN_RxL_1	189	200	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.405
DOC_MAPK_gen_1	189	197	PF00069	0.389
DOC_MAPK_gen_1	224	234	PF00069	0.462
DOC_MAPK_gen_1	328	338	PF00069	0.403
DOC_MAPK_gen_1	63	69	PF00069	0.610
DOC_PP1_RVXF_1	191	198	PF00149	0.411
DOC_PP1_RVXF_1	63	70	PF00149	0.622
DOC_PP2B_LxvP_1	105	108	PF13499	0.367
DOC_PP2B_LxvP_1	75	78	PF13499	0.307
DOC_USP7_MATH_1	20	24	PF00917	0.770
DOC_USP7_MATH_1	243	247	PF00917	0.441
DOC_USP7_MATH_1	282	286	PF00917	0.493
DOC_USP7_MATH_1	300	304	PF00917	0.455
DOC_USP7_MATH_1	38	42	PF00917	0.767
DOC_WW_Pin1_4	139	144	PF00397	0.613
DOC_WW_Pin1_4	212	217	PF00397	0.488
DOC_WW_Pin1_4	270	275	PF00397	0.552
DOC_WW_Pin1_4	289	294	PF00397	0.424
DOC_WW_Pin1_4	301	306	PF00397	0.464
DOC_WW_Pin1_4	32	37	PF00397	0.796
LIG_14-3-3_CanoR_1	248	254	PF00244	0.357
LIG_14-3-3_CanoR_1	30	36	PF00244	0.728
LIG_Actin_WH2_2	81	99	PF00022	0.545
LIG_CSL_BTD_1	111	114	PF09270	0.454
LIG_deltaCOP1_diTrp_1	170	178	PF00928	0.456
LIG_FHA_1	282	288	PF00498	0.510
LIG_FHA_1	318	324	PF00498	0.318
LIG_FHA_2	206	212	PF00498	0.549
LIG_FHA_2	40	46	PF00498	0.708
LIG_LIR_Nem_3	66	72	PF02991	0.587
LIG_LIR_Nem_3	81	86	PF02991	0.324
LIG_LIR_Nem_3	92	98	PF02991	0.307
LIG_MYND_1	154	158	PF01753	0.418
LIG_PDZ_Class_3	345	350	PF00595	0.432
LIG_Pex14_2	109	113	PF04695	0.374
LIG_SH2_STAP1	249	253	PF00017	0.449
LIG_SH2_STAT5	98	101	PF00017	0.359
LIG_SH3_3	199	205	PF00018	0.533
LIG_SH3_3	268	274	PF00018	0.483
LIG_SH3_3	287	293	PF00018	0.561
LIG_SH3_3	299	305	PF00018	0.511
LIG_SUMO_SIM_par_1	114	123	PF11976	0.519
LIG_TRFH_1	86	90	PF08558	0.499
MOD_CK1_1	119	125	PF00069	0.420
MOD_CK1_1	139	145	PF00069	0.587
MOD_CK1_1	23	29	PF00069	0.762
MOD_CK1_1	273	279	PF00069	0.508
MOD_CK1_1	292	298	PF00069	0.454
MOD_CK1_1	31	37	PF00069	0.738
MOD_CK1_1	39	45	PF00069	0.715
MOD_CK2_1	117	123	PF00069	0.506
MOD_CK2_1	181	187	PF00069	0.466
MOD_CK2_1	205	211	PF00069	0.505
MOD_CK2_1	212	218	PF00069	0.474
MOD_CK2_1	238	244	PF00069	0.466
MOD_GlcNHglycan	22	25	PF01048	0.574
MOD_GlcNHglycan	51	54	PF01048	0.419
MOD_GlcNHglycan	6	9	PF01048	0.545
MOD_GSK3_1	119	126	PF00069	0.555
MOD_GSK3_1	133	140	PF00069	0.402
MOD_GSK3_1	160	167	PF00069	0.514
MOD_GSK3_1	205	212	PF00069	0.515
MOD_GSK3_1	26	33	PF00069	0.753
MOD_GSK3_1	313	320	PF00069	0.455
MOD_GSK3_1	34	41	PF00069	0.715
MOD_GSK3_1	4	11	PF00069	0.786
MOD_NEK2_1	317	322	PF00069	0.332
MOD_NEK2_1	4	9	PF00069	0.729
MOD_NEK2_2	78	83	PF00069	0.425
MOD_NMyristoyl	1	7	PF02799	0.613
MOD_OFUCOSY	22	27	PF10250	0.419
MOD_PIKK_1	292	298	PF00454	0.425
MOD_PKA_1	181	187	PF00069	0.470
MOD_PKA_2	4	10	PF00069	0.788
MOD_PKA_2	88	94	PF00069	0.432
MOD_Plk_1	205	211	PF00069	0.539
MOD_Plk_1	313	319	PF00069	0.443
MOD_Plk_4	160	166	PF00069	0.458
MOD_Plk_4	205	211	PF00069	0.539
MOD_ProDKin_1	139	145	PF00069	0.613
MOD_ProDKin_1	212	218	PF00069	0.485
MOD_ProDKin_1	270	276	PF00069	0.553
MOD_ProDKin_1	289	295	PF00069	0.426
MOD_ProDKin_1	301	307	PF00069	0.459
MOD_ProDKin_1	32	38	PF00069	0.797
TRG_DiLeu_BaEn_4	221	227	PF01217	0.517
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.390
TRG_ENDOCYTIC_2	83	86	PF00928	0.401
TRG_ER_diArg_1	192	195	PF00400	0.409
TRG_ER_diArg_1	62	64	PF00400	0.570
TRG_ER_diArg_1	72	74	PF00400	0.316
TRG_NLS_Bipartite_1	181	196	PF00514	0.424
TRG_NLS_MonoExtN_4	189	196	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P306	Leptomonas seymouri	46%	99%
A0A1X0NQ49	Trypanosomatidae	36%	100%
A0A3R7M3H5	Trypanosoma rangeli	32%	100%
A4H7R9	Leishmania braziliensis	66%	89%
C9ZSW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACR5	Leishmania major	91%	99%
E9AGL5	Leishmania infantum	98%	99%
E9APW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%