Dynein heavy chain, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein heavy chain, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6S6_LEIDO

TriTrypDb:

LdBPK_141130.1 , LdCL_140017000 , LDHU3_14.1430

Length:

4268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 57
NetGPI	no	yes: 0, no: 57

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	40
GO:0005858	axonemal dynein complex	4	14
GO:0005874	microtubule	6	56
GO:0005875	microtubule associated complex	2	58
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	4
GO:0030286	dynein complex	3	58
GO:0032991	protein-containing complex	1	58
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1

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Expansion

Sequence features

A0A3S5H6S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	14
GO:0007017	microtubule-based process	2	58
GO:0007018	microtubule-based movement	3	58
GO:0009987	cellular process	1	58
GO:0048870	cell motility	2	14
GO:0060285	cilium-dependent cell motility	4	14

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	58
GO:0003774	cytoskeletal motor activity	1	58
GO:0003777	microtubule motor activity	2	58
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	58
GO:0005515	protein binding	2	35
GO:0005524	ATP binding	5	58
GO:0008569	minus-end-directed microtubule motor activity	3	58
GO:0016462	pyrophosphatase activity	5	14
GO:0016787	hydrolase activity	2	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1392	1396	PF00656	0.438
CLV_C14_Caspase3-7	1610	1614	PF00656	0.450
CLV_C14_Caspase3-7	1676	1680	PF00656	0.383
CLV_C14_Caspase3-7	1772	1776	PF00656	0.201
CLV_C14_Caspase3-7	2590	2594	PF00656	0.531
CLV_C14_Caspase3-7	3079	3083	PF00656	0.458
CLV_C14_Caspase3-7	3199	3203	PF00656	0.459
CLV_C14_Caspase3-7	3425	3429	PF00656	0.570
CLV_C14_Caspase3-7	3465	3469	PF00656	0.433
CLV_C14_Caspase3-7	3471	3475	PF00656	0.494

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z1	Leptomonas seymouri	33%	100%
A0A0N0P8F1	Leptomonas seymouri	33%	100%
A0A0N1HVV7	Leptomonas seymouri	69%	100%
A0A0N1I4F9	Leptomonas seymouri	39%	100%
A0A0N1PBB8	Leptomonas seymouri	29%	92%
A0A0N1PCN0	Leptomonas seymouri	32%	89%
A0A0N1PCS5	Leptomonas seymouri	33%	99%
A0A0S4IM00	Bodo saltans	33%	96%
A0A0S4IWW6	Bodo saltans	33%	100%
A0A0S4IXG4	Bodo saltans	32%	92%

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