Tc40 antigen-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tc40 antigen-like

Gene product:

immunodominant antigen, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6S3_LEIDO

TriTrypDb:

LdBPK_140990.1 , LdCL_140015600 , LDHU3_14.1260

Length:

861

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	597	601	PF00656	0.685
CLV_NRD_NRD_1	495	497	PF00675	0.706
CLV_NRD_NRD_1	50	52	PF00675	0.542
CLV_NRD_NRD_1	621	623	PF00675	0.731
CLV_NRD_NRD_1	668	670	PF00675	0.672
CLV_NRD_NRD_1	850	852	PF00675	0.678
CLV_PCSK_KEX2_1	495	497	PF00082	0.706
CLV_PCSK_KEX2_1	50	52	PF00082	0.519
CLV_PCSK_KEX2_1	620	622	PF00082	0.728
CLV_PCSK_KEX2_1	850	852	PF00082	0.711
CLV_PCSK_SKI1_1	16	20	PF00082	0.671
CLV_PCSK_SKI1_1	290	294	PF00082	0.562
CLV_PCSK_SKI1_1	350	354	PF00082	0.645
CLV_PCSK_SKI1_1	385	389	PF00082	0.805
CLV_PCSK_SKI1_1	467	471	PF00082	0.677
CLV_PCSK_SKI1_1	616	620	PF00082	0.649
CLV_PCSK_SKI1_1	63	67	PF00082	0.612
CLV_PCSK_SKI1_1	733	737	PF00082	0.652
CLV_PCSK_SKI1_1	784	788	PF00082	0.605
CLV_PCSK_SKI1_1	822	826	PF00082	0.749
CLV_PCSK_SKI1_1	850	854	PF00082	0.623
CLV_Separin_Metazoa	617	621	PF03568	0.717
DEG_APCC_DBOX_1	690	698	PF00400	0.640
DEG_APCC_DBOX_1	849	857	PF00400	0.646
DEG_SCF_FBW7_2	379	386	PF00400	0.678
DEG_SPOP_SBC_1	260	264	PF00917	0.695
DEG_SPOP_SBC_1	396	400	PF00917	0.769
DEG_SPOP_SBC_1	446	450	PF00917	0.741
DOC_CKS1_1	628	633	PF01111	0.745
DOC_MAPK_gen_1	48	55	PF00069	0.510
DOC_PP1_RVXF_1	75	82	PF00149	0.596
DOC_PP2B_LxvP_1	575	578	PF13499	0.704
DOC_PP4_FxxP_1	141	144	PF00568	0.609
DOC_PP4_FxxP_1	403	406	PF00568	0.763
DOC_USP7_MATH_1	2	6	PF00917	0.646
DOC_USP7_MATH_1	209	213	PF00917	0.543
DOC_USP7_MATH_1	251	255	PF00917	0.791
DOC_USP7_MATH_1	259	263	PF00917	0.673
DOC_USP7_MATH_1	268	272	PF00917	0.465
DOC_USP7_MATH_1	374	378	PF00917	0.804
DOC_USP7_MATH_1	396	400	PF00917	0.854
DOC_USP7_MATH_1	404	408	PF00917	0.675
DOC_USP7_MATH_1	417	421	PF00917	0.784
DOC_USP7_MATH_1	429	433	PF00917	0.715
DOC_USP7_MATH_1	436	440	PF00917	0.783
DOC_USP7_MATH_1	446	450	PF00917	0.777
DOC_USP7_MATH_1	542	546	PF00917	0.722
DOC_USP7_MATH_1	558	562	PF00917	0.789
DOC_USP7_MATH_1	566	570	PF00917	0.667
DOC_USP7_MATH_1	578	582	PF00917	0.694
DOC_USP7_MATH_1	606	610	PF00917	0.683
DOC_USP7_MATH_1	659	663	PF00917	0.627
DOC_USP7_MATH_1	700	704	PF00917	0.734
DOC_USP7_MATH_1	87	91	PF00917	0.469
DOC_USP7_UBL2_3	124	128	PF12436	0.527
DOC_USP7_UBL2_3	16	20	PF12436	0.655
DOC_USP7_UBL2_3	385	389	PF12436	0.621
DOC_USP7_UBL2_3	821	825	PF12436	0.766
DOC_USP7_UBL2_3	854	858	PF12436	0.632
DOC_WW_Pin1_4	224	229	PF00397	0.565
DOC_WW_Pin1_4	375	380	PF00397	0.804
DOC_WW_Pin1_4	398	403	PF00397	0.747
DOC_WW_Pin1_4	438	443	PF00397	0.835
DOC_WW_Pin1_4	512	517	PF00397	0.661
DOC_WW_Pin1_4	627	632	PF00397	0.750
DOC_WW_Pin1_4	68	73	PF00397	0.608
DOC_WW_Pin1_4	718	723	PF00397	0.699
LIG_14-3-3_CanoR_1	120	124	PF00244	0.548
LIG_14-3-3_CanoR_1	197	207	PF00244	0.597
LIG_14-3-3_CanoR_1	223	228	PF00244	0.613
LIG_14-3-3_CanoR_1	290	295	PF00244	0.575
LIG_14-3-3_CanoR_1	339	344	PF00244	0.626
LIG_14-3-3_CanoR_1	350	355	PF00244	0.550
LIG_14-3-3_CanoR_1	397	402	PF00244	0.822
LIG_14-3-3_CanoR_1	416	426	PF00244	0.717
LIG_14-3-3_CanoR_1	562	570	PF00244	0.724
LIG_14-3-3_CanoR_1	656	662	PF00244	0.688
LIG_14-3-3_CanoR_1	739	747	PF00244	0.640
LIG_14-3-3_CanoR_1	762	768	PF00244	0.657
LIG_Actin_WH2_2	480	497	PF00022	0.762
LIG_Actin_WH2_2	683	700	PF00022	0.644
LIG_APCC_ABBA_1	23	28	PF00400	0.579
LIG_APCC_ABBA_1	307	312	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BRCT_BRCA1_1	347	351	PF00533	0.661
LIG_BRCT_BRCA1_1	38	42	PF00533	0.539
LIG_BRCT_BRCA1_1	563	567	PF00533	0.679
LIG_BRCT_BRCA1_1	805	809	PF00533	0.653
LIG_BRCT_BRCA1_1	90	94	PF00533	0.586
LIG_eIF4E_1	570	576	PF01652	0.706
LIG_FHA_1	156	162	PF00498	0.539
LIG_FHA_1	171	177	PF00498	0.475
LIG_FHA_1	351	357	PF00498	0.575
LIG_FHA_1	586	592	PF00498	0.719
LIG_FHA_1	674	680	PF00498	0.687
LIG_FHA_2	328	334	PF00498	0.566
LIG_FHA_2	595	601	PF00498	0.703
LIG_FHA_2	631	637	PF00498	0.660
LIG_FHA_2	724	730	PF00498	0.674
LIG_FHA_2	795	801	PF00498	0.636
LIG_GBD_Chelix_1	804	812	PF00786	0.583
LIG_Integrin_RGD_1	322	324	PF01839	0.630
LIG_LIR_Apic_2	400	406	PF02991	0.765
LIG_LIR_Gen_1	137	145	PF02991	0.549
LIG_LIR_Gen_1	204	214	PF02991	0.604
LIG_LIR_Gen_1	348	359	PF02991	0.569
LIG_LIR_Gen_1	745	753	PF02991	0.587
LIG_LIR_Gen_1	75	86	PF02991	0.591
LIG_LIR_Gen_1	779	789	PF02991	0.625
LIG_LIR_Gen_1	806	816	PF02991	0.664
LIG_LIR_Gen_1	92	101	PF02991	0.459
LIG_LIR_Nem_3	137	141	PF02991	0.548
LIG_LIR_Nem_3	204	210	PF02991	0.507
LIG_LIR_Nem_3	293	297	PF02991	0.565
LIG_LIR_Nem_3	348	354	PF02991	0.634
LIG_LIR_Nem_3	39	45	PF02991	0.483
LIG_LIR_Nem_3	564	570	PF02991	0.639
LIG_LIR_Nem_3	75	81	PF02991	0.503
LIG_LIR_Nem_3	779	785	PF02991	0.632
LIG_LIR_Nem_3	806	812	PF02991	0.652
LIG_LIR_Nem_3	92	98	PF02991	0.450
LIG_LYPXL_SIV_4	462	470	PF13949	0.739
LIG_NRBOX	571	577	PF00104	0.700
LIG_Pex14_1	641	645	PF04695	0.698
LIG_Pex14_1	97	101	PF04695	0.592
LIG_Pex14_2	203	207	PF04695	0.619
LIG_SH2_NCK_1	422	426	PF00017	0.757
LIG_SH2_PTP2	95	98	PF00017	0.568
LIG_SH2_STAP1	171	175	PF00017	0.619
LIG_SH2_STAT5	126	129	PF00017	0.450
LIG_SH2_STAT5	45	48	PF00017	0.503
LIG_SH2_STAT5	645	648	PF00017	0.673
LIG_SH2_STAT5	734	737	PF00017	0.558
LIG_SH2_STAT5	746	749	PF00017	0.492
LIG_SH2_STAT5	95	98	PF00017	0.573
LIG_SH3_3	280	286	PF00018	0.634
LIG_SH3_3	411	417	PF00018	0.808
LIG_SH3_3	548	554	PF00018	0.785
LIG_SH3_4	124	131	PF00018	0.581
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.423
LIG_SUMO_SIM_par_1	261	271	PF11976	0.615
LIG_SUMO_SIM_par_1	352	357	PF11976	0.567
LIG_SUMO_SIM_par_1	510	515	PF11976	0.653
LIG_SxIP_EBH_1	406	416	PF03271	0.805
LIG_TRAF2_1	626	629	PF00917	0.683
LIG_TRAF2_1	663	666	PF00917	0.670
LIG_TRAF2_1	683	686	PF00917	0.421
LIG_UBA3_1	151	157	PF00899	0.574
LIG_UBA3_1	852	858	PF00899	0.522
LIG_WRC_WIRS_1	135	140	PF05994	0.555
LIG_WRC_WIRS_1	291	296	PF05994	0.563
LIG_WRC_WIRS_1	804	809	PF05994	0.650
MOD_CDK_SPK_2	627	632	PF00069	0.750
MOD_CDK_SPxK_1	379	385	PF00069	0.678
MOD_CDK_SPxxK_3	438	445	PF00069	0.689
MOD_CK1_1	169	175	PF00069	0.645
MOD_CK1_1	181	187	PF00069	0.547
MOD_CK1_1	195	201	PF00069	0.448
MOD_CK1_1	212	218	PF00069	0.536
MOD_CK1_1	270	276	PF00069	0.604
MOD_CK1_1	372	378	PF00069	0.790
MOD_CK1_1	398	404	PF00069	0.838
MOD_CK1_1	407	413	PF00069	0.611
MOD_CK1_1	418	424	PF00069	0.797
MOD_CK1_1	430	436	PF00069	0.813
MOD_CK1_1	449	455	PF00069	0.799
MOD_CK1_1	5	11	PF00069	0.702
MOD_CK1_1	561	567	PF00069	0.758
MOD_CK1_1	723	729	PF00069	0.643
MOD_CK1_1	88	94	PF00069	0.577
MOD_CK2_1	171	177	PF00069	0.667
MOD_CK2_1	228	234	PF00069	0.541
MOD_CK2_1	630	636	PF00069	0.704
MOD_CK2_1	659	665	PF00069	0.626
MOD_CK2_1	723	729	PF00069	0.682
MOD_CK2_1	770	776	PF00069	0.634
MOD_CK2_1	794	800	PF00069	0.611
MOD_GlcNHglycan	180	183	PF01048	0.701
MOD_GlcNHglycan	203	206	PF01048	0.550
MOD_GlcNHglycan	230	233	PF01048	0.598
MOD_GlcNHglycan	253	256	PF01048	0.800
MOD_GlcNHglycan	263	266	PF01048	0.659
MOD_GlcNHglycan	371	374	PF01048	0.731
MOD_GlcNHglycan	417	420	PF01048	0.720
MOD_GlcNHglycan	427	430	PF01048	0.798
MOD_GlcNHglycan	433	436	PF01048	0.832
MOD_GlcNHglycan	438	441	PF01048	0.790
MOD_GlcNHglycan	467	470	PF01048	0.765
MOD_GlcNHglycan	484	487	PF01048	0.724
MOD_GlcNHglycan	542	545	PF01048	0.773
MOD_GlcNHglycan	661	664	PF01048	0.673
MOD_GlcNHglycan	680	683	PF01048	0.431
MOD_GlcNHglycan	702	705	PF01048	0.709
MOD_GlcNHglycan	87	90	PF01048	0.461
MOD_GSK3_1	14	21	PF00069	0.570
MOD_GSK3_1	162	169	PF00069	0.514
MOD_GSK3_1	191	198	PF00069	0.636
MOD_GSK3_1	199	206	PF00069	0.545
MOD_GSK3_1	2	9	PF00069	0.640
MOD_GSK3_1	208	215	PF00069	0.368
MOD_GSK3_1	218	225	PF00069	0.532
MOD_GSK3_1	239	246	PF00069	0.581
MOD_GSK3_1	296	303	PF00069	0.475
MOD_GSK3_1	346	353	PF00069	0.605
MOD_GSK3_1	368	375	PF00069	0.716
MOD_GSK3_1	404	411	PF00069	0.788
MOD_GSK3_1	425	432	PF00069	0.727
MOD_GSK3_1	445	452	PF00069	0.806
MOD_GSK3_1	471	478	PF00069	0.752
MOD_GSK3_1	538	545	PF00069	0.658
MOD_GSK3_1	578	585	PF00069	0.700
MOD_GSK3_1	723	730	PF00069	0.609
MOD_GSK3_1	738	745	PF00069	0.592
MOD_GSK3_1	770	777	PF00069	0.654
MOD_GSK3_1	85	92	PF00069	0.525
MOD_N-GLC_1	223	228	PF02516	0.613
MOD_N-GLC_1	369	374	PF02516	0.674
MOD_N-GLC_1	471	476	PF02516	0.705
MOD_N-GLC_1	5	10	PF02516	0.656
MOD_N-GLC_1	607	612	PF02516	0.651
MOD_N-GLC_1	657	662	PF02516	0.630
MOD_NEK2_1	162	167	PF00069	0.482
MOD_NEK2_1	199	204	PF00069	0.569
MOD_NEK2_1	218	223	PF00069	0.597
MOD_NEK2_1	243	248	PF00069	0.605
MOD_NEK2_1	267	272	PF00069	0.572
MOD_NEK2_1	300	305	PF00069	0.633
MOD_NEK2_1	327	332	PF00069	0.560
MOD_NEK2_1	482	487	PF00069	0.736
MOD_NEK2_1	538	543	PF00069	0.673
MOD_NEK2_1	607	612	PF00069	0.698
MOD_NEK2_1	650	655	PF00069	0.661
MOD_NEK2_1	657	662	PF00069	0.681
MOD_NEK2_1	856	861	PF00069	0.713
MOD_NEK2_2	119	124	PF00069	0.620
MOD_PIKK_1	673	679	PF00454	0.713
MOD_PIKK_1	738	744	PF00454	0.668
MOD_PIKK_1	784	790	PF00454	0.684
MOD_PK_1	339	345	PF00069	0.621
MOD_PKA_2	119	125	PF00069	0.547
MOD_PKA_2	222	228	PF00069	0.658
MOD_PKA_2	338	344	PF00069	0.590
MOD_PKA_2	396	402	PF00069	0.657
MOD_PKA_2	415	421	PF00069	0.632
MOD_PKA_2	561	567	PF00069	0.728
MOD_PKA_2	591	597	PF00069	0.707
MOD_PKA_2	738	744	PF00069	0.648
MOD_PKA_2	761	767	PF00069	0.658
MOD_Plk_1	192	198	PF00069	0.664
MOD_Plk_1	327	333	PF00069	0.631
MOD_Plk_1	346	352	PF00069	0.639
MOD_Plk_1	471	477	PF00069	0.688
MOD_Plk_1	607	613	PF00069	0.650
MOD_Plk_1	657	663	PF00069	0.655
MOD_Plk_1	778	784	PF00069	0.655
MOD_Plk_2-3	761	767	PF00069	0.702
MOD_Plk_2-3	810	816	PF00069	0.568
MOD_Plk_4	14	20	PF00069	0.689
MOD_Plk_4	171	177	PF00069	0.646
MOD_Plk_4	203	209	PF00069	0.625
MOD_Plk_4	239	245	PF00069	0.596
MOD_Plk_4	296	302	PF00069	0.539
MOD_Plk_4	327	333	PF00069	0.634
MOD_Plk_4	350	356	PF00069	0.526
MOD_Plk_4	404	410	PF00069	0.779
MOD_Plk_4	723	729	PF00069	0.585
MOD_Plk_4	742	748	PF00069	0.431
MOD_Plk_4	778	784	PF00069	0.654
MOD_Plk_4	803	809	PF00069	0.657
MOD_ProDKin_1	224	230	PF00069	0.557
MOD_ProDKin_1	375	381	PF00069	0.804
MOD_ProDKin_1	398	404	PF00069	0.744
MOD_ProDKin_1	438	444	PF00069	0.836
MOD_ProDKin_1	512	518	PF00069	0.661
MOD_ProDKin_1	627	633	PF00069	0.746
MOD_ProDKin_1	68	74	PF00069	0.604
MOD_ProDKin_1	718	724	PF00069	0.691
MOD_SUMO_for_1	26	29	PF00179	0.650
MOD_SUMO_rev_2	172	181	PF00179	0.651
MOD_SUMO_rev_2	312	317	PF00179	0.482
TRG_DiLeu_BaEn_1	163	168	PF01217	0.606
TRG_DiLeu_BaEn_2	37	43	PF01217	0.582
TRG_DiLeu_BaEn_4	666	672	PF01217	0.617
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.582
TRG_ENDOCYTIC_2	126	129	PF00928	0.464
TRG_ENDOCYTIC_2	746	749	PF00928	0.577
TRG_ENDOCYTIC_2	95	98	PF00928	0.568
TRG_ER_diArg_1	494	496	PF00400	0.706
TRG_ER_diArg_1	619	622	PF00400	0.728
TRG_ER_diArg_1	849	851	PF00400	0.705
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.728
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.702
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	851	855	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P333	Leptomonas seymouri	70%	99%
A0A0S4JBI5	Bodo saltans	28%	100%
A0A3R7NEG9	Trypanosoma rangeli	32%	95%
A4H7P6	Leishmania braziliensis	85%	98%
A4HW35	Leishmania infantum	100%	100%
C9ZSY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
E9APT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QFP2	Leishmania major	95%	100%