Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | yes | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 24 |
| NetGPI | no | yes: 0, no: 24 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 23 |
| GO:0110165 | cellular anatomical entity | 1 | 23 |
Related structures:
AlphaFold database: A0A3S5H6R8
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 25 |
| GO:0006629 | lipid metabolic process | 3 | 25 |
| GO:0006631 | fatty acid metabolic process | 4 | 25 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 25 |
| GO:0008152 | metabolic process | 1 | 25 |
| GO:0008610 | lipid biosynthetic process | 4 | 25 |
| GO:0009058 | biosynthetic process | 2 | 25 |
| GO:0009987 | cellular process | 1 | 25 |
| GO:0016053 | organic acid biosynthetic process | 4 | 25 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 25 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 25 |
| GO:0043436 | oxoacid metabolic process | 4 | 25 |
| GO:0044237 | cellular metabolic process | 2 | 25 |
| GO:0044238 | primary metabolic process | 2 | 25 |
| GO:0044249 | cellular biosynthetic process | 3 | 25 |
| GO:0044255 | cellular lipid metabolic process | 3 | 25 |
| GO:0044281 | small molecule metabolic process | 2 | 25 |
| GO:0044283 | small molecule biosynthetic process | 3 | 25 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 25 |
| GO:0071704 | organic substance metabolic process | 2 | 25 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 25 |
| GO:1901576 | organic substance biosynthetic process | 3 | 25 |
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 2 |
| GO:0006643 | membrane lipid metabolic process | 4 | 2 |
| GO:0006665 | sphingolipid metabolic process | 4 | 2 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 2 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 2 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 2 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 2 |
| GO:0030497 | fatty acid elongation | 6 | 2 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 2 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 2 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 2 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 2 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 2 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 2 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 25 |
| GO:0004312 | fatty acid synthase activity | 5 | 25 |
| GO:0009922 | fatty acid elongase activity | 6 | 25 |
| GO:0016740 | transferase activity | 2 | 25 |
| GO:0016746 | acyltransferase activity | 3 | 25 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 25 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 25 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 59 | 61 | PF00675 | 0.279 |
| CLV_PCSK_KEX2_1 | 59 | 61 | PF00082 | 0.265 |
| CLV_PCSK_SKI1_1 | 203 | 207 | PF00082 | 0.331 |
| CLV_PCSK_SKI1_1 | 43 | 47 | PF00082 | 0.294 |
| CLV_PCSK_SKI1_1 | 59 | 63 | PF00082 | 0.345 |
| DOC_CDC14_PxL_1 | 131 | 139 | PF14671 | 0.222 |
| DOC_CDC14_PxL_1 | 90 | 98 | PF14671 | 0.311 |
| DOC_CYCLIN_yCln2_LP_2 | 205 | 211 | PF00134 | 0.489 |
| DOC_USP7_MATH_1 | 121 | 125 | PF00917 | 0.172 |
| DOC_USP7_MATH_1 | 290 | 294 | PF00917 | 0.661 |
| DOC_WW_Pin1_4 | 117 | 122 | PF00397 | 0.251 |
| DOC_WW_Pin1_4 | 147 | 152 | PF00397 | 0.491 |
| LIG_14-3-3_CanoR_1 | 71 | 75 | PF00244 | 0.490 |
| LIG_Actin_WH2_2 | 90 | 108 | PF00022 | 0.363 |
| LIG_APCC_ABBA_1 | 1 | 6 | PF00400 | 0.378 |
| LIG_APCC_ABBA_1 | 269 | 274 | PF00400 | 0.351 |
| LIG_EH1_1 | 157 | 165 | PF00400 | 0.275 |
| LIG_FHA_1 | 138 | 144 | PF00498 | 0.274 |
| LIG_FHA_1 | 174 | 180 | PF00498 | 0.263 |
| LIG_FHA_1 | 231 | 237 | PF00498 | 0.327 |
| LIG_FHA_2 | 106 | 112 | PF00498 | 0.274 |
| LIG_GBD_Chelix_1 | 137 | 145 | PF00786 | 0.367 |
| LIG_LIR_Apic_2 | 115 | 121 | PF02991 | 0.290 |
| LIG_LIR_Gen_1 | 124 | 131 | PF02991 | 0.341 |
| LIG_LIR_Gen_1 | 189 | 199 | PF02991 | 0.356 |
| LIG_LIR_Gen_1 | 267 | 276 | PF02991 | 0.274 |
| LIG_LIR_Gen_1 | 66 | 76 | PF02991 | 0.448 |
| LIG_LIR_Nem_3 | 139 | 145 | PF02991 | 0.303 |
| LIG_LIR_Nem_3 | 189 | 195 | PF02991 | 0.288 |
| LIG_LIR_Nem_3 | 22 | 26 | PF02991 | 0.336 |
| LIG_LIR_Nem_3 | 228 | 232 | PF02991 | 0.309 |
| LIG_LIR_Nem_3 | 267 | 271 | PF02991 | 0.254 |
| LIG_LIR_Nem_3 | 66 | 72 | PF02991 | 0.443 |
| LIG_Pex14_1 | 125 | 129 | PF04695 | 0.215 |
| LIG_PTB_Apo_2 | 17 | 24 | PF02174 | 0.309 |
| LIG_PTB_Phospho_1 | 17 | 23 | PF10480 | 0.309 |
| LIG_SH2_CRK | 118 | 122 | PF00017 | 0.269 |
| LIG_SH2_GRB2like | 18 | 21 | PF00017 | 0.137 |
| LIG_SH2_GRB2like | 276 | 279 | PF00017 | 0.413 |
| LIG_SH2_GRB2like | 7 | 10 | PF00017 | 0.401 |
| LIG_SH2_NCK_1 | 18 | 22 | PF00017 | 0.172 |
| LIG_SH2_SRC | 18 | 21 | PF00017 | 0.305 |
| LIG_SH2_SRC | 276 | 279 | PF00017 | 0.225 |
| LIG_SH2_SRC | 7 | 10 | PF00017 | 0.368 |
| LIG_SH2_STAP1 | 23 | 27 | PF00017 | 0.398 |
| LIG_SH2_STAP1 | 230 | 234 | PF00017 | 0.339 |
| LIG_SH2_STAT5 | 118 | 121 | PF00017 | 0.230 |
| LIG_SH2_STAT5 | 194 | 197 | PF00017 | 0.297 |
| LIG_SH2_STAT5 | 232 | 235 | PF00017 | 0.228 |
| LIG_SH2_STAT5 | 26 | 29 | PF00017 | 0.227 |
| LIG_SH2_STAT5 | 265 | 268 | PF00017 | 0.278 |
| LIG_SH2_STAT5 | 270 | 273 | PF00017 | 0.270 |
| LIG_SH2_STAT5 | 276 | 279 | PF00017 | 0.267 |
| LIG_SH2_STAT5 | 280 | 283 | PF00017 | 0.419 |
| LIG_SH2_STAT5 | 31 | 34 | PF00017 | 0.253 |
| LIG_SH2_STAT5 | 7 | 10 | PF00017 | 0.328 |
| LIG_SH3_3 | 205 | 211 | PF00018 | 0.419 |
| LIG_SH3_3 | 88 | 94 | PF00018 | 0.289 |
| LIG_TRAF2_1 | 3 | 6 | PF00917 | 0.455 |
| LIG_TYR_ITIM | 266 | 271 | PF00017 | 0.299 |
| LIG_UBA3_1 | 128 | 133 | PF00899 | 0.318 |
| LIG_UBA3_1 | 96 | 101 | PF00899 | 0.269 |
| MOD_CDK_SPK_2 | 117 | 122 | PF00069 | 0.192 |
| MOD_CK1_1 | 82 | 88 | PF00069 | 0.233 |
| MOD_CK1_1 | 99 | 105 | PF00069 | 0.252 |
| MOD_CK2_1 | 105 | 111 | PF00069 | 0.319 |
| MOD_Cter_Amidation | 57 | 60 | PF01082 | 0.319 |
| MOD_GlcNHglycan | 255 | 258 | PF01048 | 0.470 |
| MOD_GlcNHglycan | 81 | 84 | PF01048 | 0.327 |
| MOD_GSK3_1 | 117 | 124 | PF00069 | 0.283 |
| MOD_GSK3_1 | 168 | 175 | PF00069 | 0.326 |
| MOD_GSK3_1 | 230 | 237 | PF00069 | 0.262 |
| MOD_GSK3_1 | 95 | 102 | PF00069 | 0.210 |
| MOD_N-GLC_1 | 173 | 178 | PF02516 | 0.437 |
| MOD_N-GLC_1 | 234 | 239 | PF02516 | 0.511 |
| MOD_NEK2_1 | 105 | 110 | PF00069 | 0.207 |
| MOD_NEK2_1 | 116 | 121 | PF00069 | 0.202 |
| MOD_NEK2_1 | 129 | 134 | PF00069 | 0.280 |
| MOD_NEK2_1 | 137 | 142 | PF00069 | 0.299 |
| MOD_NEK2_1 | 168 | 173 | PF00069 | 0.266 |
| MOD_NEK2_1 | 186 | 191 | PF00069 | 0.261 |
| MOD_NEK2_1 | 264 | 269 | PF00069 | 0.268 |
| MOD_NEK2_1 | 70 | 75 | PF00069 | 0.458 |
| MOD_NEK2_1 | 79 | 84 | PF00069 | 0.275 |
| MOD_NEK2_1 | 96 | 101 | PF00069 | 0.251 |
| MOD_PKA_2 | 121 | 127 | PF00069 | 0.291 |
| MOD_PKA_2 | 70 | 76 | PF00069 | 0.490 |
| MOD_Plk_1 | 173 | 179 | PF00069 | 0.218 |
| MOD_Plk_1 | 234 | 240 | PF00069 | 0.309 |
| MOD_Plk_4 | 121 | 127 | PF00069 | 0.258 |
| MOD_Plk_4 | 137 | 143 | PF00069 | 0.232 |
| MOD_Plk_4 | 158 | 164 | PF00069 | 0.279 |
| MOD_Plk_4 | 186 | 192 | PF00069 | 0.266 |
| MOD_Plk_4 | 225 | 231 | PF00069 | 0.249 |
| MOD_Plk_4 | 264 | 270 | PF00069 | 0.248 |
| MOD_Plk_4 | 276 | 282 | PF00069 | 0.248 |
| MOD_Plk_4 | 70 | 76 | PF00069 | 0.440 |
| MOD_ProDKin_1 | 117 | 123 | PF00069 | 0.251 |
| MOD_ProDKin_1 | 147 | 153 | PF00069 | 0.491 |
| TRG_DiLeu_BaLyEn_6 | 208 | 213 | PF01217 | 0.468 |
| TRG_ENDOCYTIC_2 | 157 | 160 | PF00928 | 0.269 |
| TRG_ENDOCYTIC_2 | 18 | 21 | PF00928 | 0.245 |
| TRG_ENDOCYTIC_2 | 192 | 195 | PF00928 | 0.294 |
| TRG_ENDOCYTIC_2 | 26 | 29 | PF00928 | 0.260 |
| TRG_ENDOCYTIC_2 | 268 | 271 | PF00928 | 0.248 |
| TRG_ENDOCYTIC_2 | 31 | 34 | PF00928 | 0.258 |
| TRG_ER_diLys_1 | 291 | 294 | PF00400 | 0.625 |
| TRG_NLS_MonoExtC_3 | 146 | 151 | PF00514 | 0.535 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P5E5 | Leptomonas seymouri | 38% | 98% |
| A0A0N0P7D1 | Leptomonas seymouri | 33% | 88% |
| A0A0N0P7D6 | Leptomonas seymouri | 32% | 100% |
| A0A0N0P7R2 | Leptomonas seymouri | 40% | 96% |
| A0A0N1I9H5 | Leptomonas seymouri | 35% | 100% |
| A0A0N1IIZ8 | Leptomonas seymouri | 29% | 96% |
| A0A0N1ILQ4 | Leptomonas seymouri | 77% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 34% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 38% | 100% |
| A0A0N1PFE8 | Leptomonas seymouri | 36% | 100% |
| A0A0S4IS29 | Bodo saltans | 42% | 100% |
| A0A0S4IVJ6 | Bodo saltans | 35% | 92% |
| A0A0S4IVS6 | Bodo saltans | 41% | 100% |
| A0A0S4IW98 | Bodo saltans | 35% | 93% |
| A0A0S4J4C4 | Bodo saltans | 22% | 100% |
| A0A1X0NNK7 | Trypanosomatidae | 40% | 100% |
| A0A1X0NNL0 | Trypanosomatidae | 39% | 97% |
| A0A1X0NNM4 | Trypanosomatidae | 48% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 36% | 95% |
| A0A1X0NP89 | Trypanosomatidae | 30% | 92% |
| A0A3Q8I9U9 | Leishmania donovani | 31% | 100% |
| A0A3Q8I9X8 | Leishmania donovani | 35% | 100% |
| A0A3Q8IC05 | Leishmania donovani | 37% | 100% |
| A0A3Q8IIA9 | Leishmania donovani | 36% | 100% |
| A0A3R7KG78 | Trypanosoma rangeli | 39% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 50% | 100% |
| A0A3R7NSQ3 | Trypanosoma rangeli | 41% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 36% | 98% |
| A0A3S7WSY8 | Leishmania donovani | 36% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 34% | 98% |
| A0A3S7WT03 | Leishmania donovani | 35% | 98% |
| A0A3S7WT05 | Leishmania donovani | 26% | 96% |
| A0A3S7WT16 | Leishmania donovani | 33% | 91% |
| A0A422NNP1 | Trypanosoma rangeli | 37% | 98% |
| A0JNC4 | Bos taurus | 24% | 100% |
| A1L3X0 | Homo sapiens | 27% | 100% |
| A4H7M1 | Leishmania braziliensis | 24% | 96% |
| A4H7M2 | Leishmania braziliensis | 35% | 99% |
| A4H7M3 | Leishmania braziliensis | 36% | 97% |
| A4H7M4 | Leishmania braziliensis | 34% | 99% |
| A4H7M5 | Leishmania braziliensis | 86% | 100% |
| A4H7M6 | Leishmania braziliensis | 36% | 99% |
| A4H7M7 | Leishmania braziliensis | 34% | 100% |
| A4H7M8 | Leishmania braziliensis | 33% | 77% |
| A4H7M9 | Leishmania braziliensis | 33% | 72% |
| A4H7N0 | Leishmania braziliensis | 38% | 100% |
| A4HW06 | Leishmania infantum | 26% | 100% |
| A4HW07 | Leishmania infantum | 36% | 95% |
| A4HW08 | Leishmania infantum | 36% | 98% |
| A4HW09 | Leishmania infantum | 36% | 100% |
| A4HW10 | Leishmania infantum | 100% | 100% |
| A4HW12 | Leishmania infantum | 36% | 100% |
| A4HW13 | Leishmania infantum | 31% | 100% |
| A4HW14 | Leishmania infantum | 32% | 100% |
| A4HW18 | Leishmania infantum | 37% | 100% |
| C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 38% | 98% |
| C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 45% | 100% |
| C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 43% | 96% |
| D4A612 | Rattus norvegicus | 25% | 100% |
| D4ADY9 | Rattus norvegicus | 27% | 100% |
| E9AGL0 | Leishmania infantum | 34% | 98% |
| E9AGL2 | Leishmania infantum | 38% | 100% |
| E9AKM3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
| E9APQ8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 99% |
| E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 99% |
| E9APR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 96% | 100% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 96% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 96% |
| E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
| E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 100% |
| G5EEE5 | Caenorhabditis elegans | 31% | 100% |
| O35949 | Mus musculus | 32% | 100% |
| P25358 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 28% | 85% |
| P39540 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 27% | 95% |
| P40319 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 29% | 85% |
| P49191 | Caenorhabditis elegans | 31% | 92% |
| Q03574 | Caenorhabditis elegans | 31% | 100% |
| Q20300 | Caenorhabditis elegans | 33% | 100% |
| Q20303 | Caenorhabditis elegans | 34% | 100% |
| Q3S8M4 | Macaca mulatta | 27% | 94% |
| Q4QFQ9 | Leishmania major | 38% | 100% |
| Q4QFR3 | Leishmania major | 32% | 100% |
| Q4QFR4 | Leishmania major | 30% | 100% |
| Q4QFR5 | Leishmania major | 35% | 100% |
| Q4QFR6 | Leishmania major | 39% | 100% |
| Q4QFR7 | Leishmania major | 96% | 100% |
| Q4QFR8 | Leishmania major | 36% | 98% |
| Q4QFR9 | Leishmania major | 35% | 99% |
| Q4QFS0 | Leishmania major | 37% | 97% |
| Q4QFS1 | Leishmania major | 24% | 100% |
| Q5ZJR8 | Gallus gallus | 33% | 100% |
| Q6PC64 | Danio rerio | 37% | 100% |
| Q7LKX0 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 28% | 81% |
| Q920L5 | Mus musculus | 38% | 100% |
| Q95K73 | Macaca fascicularis | 27% | 94% |
| Q9BW60 | Homo sapiens | 27% | 100% |
| Q9D2Y9 | Mus musculus | 27% | 100% |
| Q9EQC4 | Mus musculus | 27% | 94% |
| Q9GZR5 | Homo sapiens | 27% | 94% |
| Q9H5J4 | Homo sapiens | 37% | 100% |
| Q9HB03 | Homo sapiens | 33% | 100% |
| Q9JLJ5 | Mus musculus | 27% | 100% |
| Q9UTF7 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 30% | 88% |
| Q9VV87 | Drosophila melanogaster | 31% | 93% |
| Q9XVQ9 | Caenorhabditis elegans | 33% | 100% |
| V5BE99 | Trypanosoma cruzi | 38% | 100% |
| V5BIX9 | Trypanosoma cruzi | 46% | 100% |
| V5BND3 | Trypanosoma cruzi | 41% | 98% |
| V5DF68 | Trypanosoma cruzi | 40% | 100% |