LeishMANIAdb
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Amastin surface glycofamily protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Amastin surface glycofamily protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S5H6R5_LEIDO
TriTrypDb:
LdBPK_140500.1 * , LdCL_140010400 , LDHU3_14.0670
Length:
275

Annotations

LeishMANIAdb annotations

Structurally similar to the amastin family proteins, but with a rather divergent sequence. Also seems to be related to mammalian clarin proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3S5H6R5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6R5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 112 114 PF00675 0.585
CLV_NRD_NRD_1 214 216 PF00675 0.734
CLV_NRD_NRD_1 22 24 PF00675 0.546
CLV_NRD_NRD_1 29 31 PF00675 0.466
CLV_PCSK_KEX2_1 22 24 PF00082 0.551
CLV_PCSK_KEX2_1 29 31 PF00082 0.521
CLV_PCSK_SKI1_1 265 269 PF00082 0.434
CLV_PCSK_SKI1_1 37 41 PF00082 0.500
DEG_Nend_UBRbox_1 1 4 PF02207 0.778
DOC_MAPK_gen_1 45 52 PF00069 0.553
DOC_MAPK_MEF2A_6 45 52 PF00069 0.553
DOC_PP2B_LxvP_1 40 43 PF13499 0.622
DOC_USP7_UBL2_3 216 220 PF12436 0.424
LIG_14-3-3_CanoR_1 203 209 PF00244 0.411
LIG_14-3-3_CanoR_1 22 28 PF00244 0.815
LIG_14-3-3_CanoR_1 256 261 PF00244 0.679
LIG_BRCT_BRCA1_1 101 105 PF00533 0.399
LIG_BRCT_BRCA1_1 225 229 PF00533 0.456
LIG_FHA_1 141 147 PF00498 0.393
LIG_FHA_1 165 171 PF00498 0.442
LIG_FHA_1 174 180 PF00498 0.536
LIG_FHA_1 53 59 PF00498 0.442
LIG_FHA_1 76 82 PF00498 0.397
LIG_LIR_Gen_1 139 150 PF02991 0.411
LIG_LIR_Gen_1 156 166 PF02991 0.475
LIG_LIR_Gen_1 174 181 PF02991 0.502
LIG_LIR_Gen_1 185 195 PF02991 0.405
LIG_LIR_Gen_1 221 230 PF02991 0.399
LIG_LIR_Gen_1 244 253 PF02991 0.418
LIG_LIR_Gen_1 60 69 PF02991 0.514
LIG_LIR_Nem_3 156 161 PF02991 0.451
LIG_LIR_Nem_3 174 178 PF02991 0.502
LIG_LIR_Nem_3 185 190 PF02991 0.405
LIG_LIR_Nem_3 221 225 PF02991 0.391
LIG_LIR_Nem_3 226 232 PF02991 0.353
LIG_LIR_Nem_3 244 248 PF02991 0.387
LIG_LIR_Nem_3 60 64 PF02991 0.514
LIG_PDZ_Class_3 270 275 PF00595 0.569
LIG_Pex14_2 225 229 PF04695 0.404
LIG_Pex14_2 241 245 PF04695 0.419
LIG_PTB_Apo_2 130 137 PF02174 0.350
LIG_Rb_LxCxE_1 38 60 PF01857 0.539
LIG_SH2_CRK 158 162 PF00017 0.419
LIG_SH2_STAP1 142 146 PF00017 0.393
LIG_SH2_STAP1 201 205 PF00017 0.432
LIG_SH2_STAP1 249 253 PF00017 0.546
LIG_SH2_STAT5 126 129 PF00017 0.414
LIG_SH2_STAT5 142 145 PF00017 0.392
LIG_SH2_STAT5 222 225 PF00017 0.386
LIG_SH2_STAT5 249 252 PF00017 0.527
LIG_SH2_STAT5 41 44 PF00017 0.633
LIG_Sin3_3 61 68 PF02671 0.398
LIG_SUMO_SIM_anti_2 159 165 PF11976 0.310
LIG_SUMO_SIM_anti_2 60 66 PF11976 0.480
LIG_SUMO_SIM_par_1 187 193 PF11976 0.419
LIG_WRC_WIRS_1 58 63 PF05994 0.398
MOD_CK1_1 138 144 PF00069 0.376
MOD_CK1_1 156 162 PF00069 0.300
MOD_CK1_1 17 23 PF00069 0.762
MOD_CK1_1 204 210 PF00069 0.522
MOD_CK2_1 94 100 PF00069 0.484
MOD_Cter_Amidation 213 216 PF01082 0.737
MOD_GlcNHglycan 90 93 PF01048 0.597
MOD_GSK3_1 10 17 PF00069 0.744
MOD_GSK3_1 115 122 PF00069 0.411
MOD_GSK3_1 136 143 PF00069 0.379
MOD_GSK3_1 18 25 PF00069 0.751
MOD_GSK3_1 190 197 PF00069 0.357
MOD_GSK3_1 204 211 PF00069 0.454
MOD_GSK3_1 243 250 PF00069 0.518
MOD_N-GLC_1 208 213 PF02516 0.722
MOD_NEK2_1 105 110 PF00069 0.329
MOD_NEK2_1 18 23 PF00069 0.823
MOD_NEK2_1 208 213 PF00069 0.525
MOD_NEK2_1 225 230 PF00069 0.283
MOD_NEK2_1 231 236 PF00069 0.419
MOD_NEK2_1 241 246 PF00069 0.419
MOD_NEK2_1 52 57 PF00069 0.443
MOD_NEK2_1 94 99 PF00069 0.448
MOD_NEK2_2 116 121 PF00069 0.501
MOD_PKA_1 22 28 PF00069 0.735
MOD_PKA_1 29 35 PF00069 0.704
MOD_PKA_2 18 24 PF00069 0.752
MOD_PKA_2 29 35 PF00069 0.626
MOD_Plk_1 13 19 PF00069 0.747
MOD_Plk_1 173 179 PF00069 0.553
MOD_Plk_1 208 214 PF00069 0.527
MOD_Plk_4 105 111 PF00069 0.376
MOD_Plk_4 140 146 PF00069 0.380
MOD_Plk_4 156 162 PF00069 0.518
MOD_Plk_4 208 214 PF00069 0.499
MOD_Plk_4 256 262 PF00069 0.672
MOD_SUMO_rev_2 259 267 PF00179 0.664
TRG_ENDOCYTIC_2 142 145 PF00928 0.408
TRG_ENDOCYTIC_2 158 161 PF00928 0.419
TRG_ENDOCYTIC_2 222 225 PF00928 0.386
TRG_ENDOCYTIC_2 249 252 PF00928 0.527
TRG_ER_diArg_1 22 24 PF00400 0.822
TRG_NES_CRM1_1 86 100 PF08389 0.481
TRG_NLS_MonoExtN_4 29 34 PF00514 0.742

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2B8 Leptomonas seymouri 70% 99%
A0A3S7WSV8 Leishmania donovani 98% 100%
A4H7K8 Leishmania braziliensis 76% 100%
A4H7K9 Leishmania braziliensis 77% 100%
A4HVZ0 Leishmania infantum 98% 100%
A4HVZ1 Leishmania infantum 99% 100%
E9APP2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9APP3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QFT6 Leishmania major 92% 100%
Q4QFT7 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS