von_Willebrand_factor_type_A_domain_containing_pr otein_putative/Pfam:PF13768

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

von Willebrand factor type A domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6R0_LEIDO

TriTrypDb:

LdBPK_140260.1 , LdCL_140007600 , LDHU3_14.0350

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6R0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	606	610	PF00656	0.528
CLV_C14_Caspase3-7	670	674	PF00656	0.607
CLV_MEL_PAP_1	582	588	PF00089	0.485
CLV_NRD_NRD_1	706	708	PF00675	0.460
CLV_PCSK_FUR_1	704	708	PF00082	0.517
CLV_PCSK_KEX2_1	660	662	PF00082	0.547
CLV_PCSK_KEX2_1	706	708	PF00082	0.466
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.559
CLV_PCSK_SKI1_1	15	19	PF00082	0.504
CLV_PCSK_SKI1_1	413	417	PF00082	0.480
CLV_PCSK_SKI1_1	661	665	PF00082	0.514
CLV_Separin_Metazoa	267	271	PF03568	0.457
DEG_APCC_DBOX_1	179	187	PF00400	0.646
DEG_Nend_UBRbox_2	1	3	PF02207	0.754
DEG_SPOP_SBC_1	279	283	PF00917	0.565
DEG_SPOP_SBC_1	387	391	PF00917	0.402
DOC_CYCLIN_RxL_1	21	32	PF00134	0.558
DOC_MAPK_gen_1	454	463	PF00069	0.419
DOC_MAPK_MEF2A_6	248	256	PF00069	0.607
DOC_PP2B_LxvP_1	201	204	PF13499	0.562
DOC_PP4_FxxP_1	153	156	PF00568	0.509
DOC_USP7_MATH_1	118	122	PF00917	0.581
DOC_USP7_MATH_1	128	132	PF00917	0.488
DOC_USP7_MATH_1	263	267	PF00917	0.560
DOC_USP7_MATH_1	328	332	PF00917	0.451
DOC_USP7_MATH_1	335	339	PF00917	0.454
DOC_USP7_MATH_1	364	368	PF00917	0.426
DOC_USP7_MATH_1	374	378	PF00917	0.378
DOC_USP7_MATH_1	486	490	PF00917	0.637
DOC_USP7_MATH_1	505	509	PF00917	0.469
DOC_USP7_MATH_1	531	535	PF00917	0.646
DOC_USP7_MATH_1	6	10	PF00917	0.591
DOC_USP7_MATH_1	607	611	PF00917	0.585
DOC_USP7_MATH_1	94	98	PF00917	0.628
DOC_WW_Pin1_4	124	129	PF00397	0.521
DOC_WW_Pin1_4	274	279	PF00397	0.539
DOC_WW_Pin1_4	280	285	PF00397	0.760
DOC_WW_Pin1_4	396	401	PF00397	0.474
DOC_WW_Pin1_4	540	545	PF00397	0.684
DOC_WW_Pin1_4	663	668	PF00397	0.433
LIG_14-3-3_CanoR_1	206	212	PF00244	0.576
LIG_14-3-3_CanoR_1	237	243	PF00244	0.375
LIG_14-3-3_CanoR_1	270	275	PF00244	0.570
LIG_14-3-3_CanoR_1	413	423	PF00244	0.454
LIG_14-3-3_CanoR_1	93	99	PF00244	0.668
LIG_Actin_WH2_2	190	208	PF00022	0.488
LIG_BIR_III_4	550	554	PF00653	0.524
LIG_BRCT_BRCA1_1	3	7	PF00533	0.691
LIG_EVH1_1	64	68	PF00568	0.501
LIG_FHA_1	117	123	PF00498	0.543
LIG_FHA_1	146	152	PF00498	0.550
LIG_FHA_1	155	161	PF00498	0.420
LIG_FHA_1	287	293	PF00498	0.589
LIG_FHA_1	340	346	PF00498	0.419
LIG_FHA_1	414	420	PF00498	0.424
LIG_FHA_1	52	58	PF00498	0.539
LIG_FHA_1	561	567	PF00498	0.579
LIG_FHA_1	639	645	PF00498	0.574
LIG_FHA_2	239	245	PF00498	0.496
LIG_FHA_2	518	524	PF00498	0.492
LIG_FHA_2	644	650	PF00498	0.545
LIG_FHA_2	668	674	PF00498	0.598
LIG_LIR_Apic_2	150	156	PF02991	0.498
LIG_LIR_Apic_2	659	665	PF02991	0.433
LIG_LIR_Gen_1	249	258	PF02991	0.591
LIG_LIR_Gen_1	666	673	PF02991	0.464
LIG_LIR_Nem_3	21	26	PF02991	0.317
LIG_LIR_Nem_3	249	254	PF02991	0.602
LIG_LIR_Nem_3	4	10	PF02991	0.661
LIG_LIR_Nem_3	666	671	PF02991	0.569
LIG_NRBOX	566	572	PF00104	0.545
LIG_SH2_CRK	138	142	PF00017	0.383
LIG_SH2_CRK	23	27	PF00017	0.524
LIG_SH2_CRK	251	255	PF00017	0.538
LIG_SH2_CRK	568	572	PF00017	0.501
LIG_SH2_CRK	662	666	PF00017	0.497
LIG_SH2_CRK	668	672	PF00017	0.518
LIG_SH2_GRB2like	50	53	PF00017	0.397
LIG_SH2_STAT3	70	73	PF00017	0.558
LIG_SH2_STAT5	232	235	PF00017	0.472
LIG_SH2_STAT5	423	426	PF00017	0.355
LIG_SH2_STAT5	482	485	PF00017	0.463
LIG_SH2_STAT5	50	53	PF00017	0.428
LIG_SH2_STAT5	593	596	PF00017	0.494
LIG_SH2_STAT5	639	642	PF00017	0.459
LIG_SH2_STAT5	668	671	PF00017	0.476
LIG_SH2_STAT5	89	92	PF00017	0.552
LIG_SH3_3	255	261	PF00018	0.510
LIG_SH3_3	397	403	PF00018	0.438
LIG_SH3_3	62	68	PF00018	0.498
LIG_SH3_3	685	691	PF00018	0.586
LIG_SUMO_SIM_anti_2	646	657	PF11976	0.484
LIG_SUMO_SIM_par_1	207	212	PF11976	0.530
LIG_SUMO_SIM_par_1	315	321	PF11976	0.392
LIG_SUMO_SIM_par_1	426	432	PF11976	0.378
LIG_SUMO_SIM_par_1	44	49	PF11976	0.518
LIG_SUMO_SIM_par_1	514	520	PF11976	0.520
LIG_SUMO_SIM_par_1	654	659	PF11976	0.505
LIG_SxIP_EBH_1	153	165	PF03271	0.582
LIG_SxIP_EBH_1	412	425	PF03271	0.480
LIG_TRAF2_1	11	14	PF00917	0.603
LIG_TRAF2_1	617	620	PF00917	0.719
LIG_TYR_ITIM	566	571	PF00017	0.503
LIG_TYR_ITSM	247	254	PF00017	0.539
LIG_UBA3_1	378	383	PF00899	0.434
LIG_WW_1	67	70	PF00397	0.476
MOD_CDC14_SPxK_1	543	546	PF00782	0.633
MOD_CDK_SPxK_1	540	546	PF00069	0.669
MOD_CK1_1	282	288	PF00069	0.769
MOD_CK1_1	367	373	PF00069	0.402
MOD_CK1_1	489	495	PF00069	0.679
MOD_CK1_1	534	540	PF00069	0.729
MOD_CK1_1	573	579	PF00069	0.471
MOD_CK1_1	596	602	PF00069	0.540
MOD_CK1_1	666	672	PF00069	0.465
MOD_CK1_1	85	91	PF00069	0.529
MOD_CK1_1	9	15	PF00069	0.613
MOD_CK2_1	124	130	PF00069	0.487
MOD_CK2_1	285	291	PF00069	0.527
MOD_CK2_1	643	649	PF00069	0.571
MOD_GlcNHglycan	101	104	PF01048	0.685
MOD_GlcNHglycan	142	145	PF01048	0.491
MOD_GlcNHglycan	2	6	PF01048	0.653
MOD_GlcNHglycan	284	287	PF01048	0.641
MOD_GlcNHglycan	320	323	PF01048	0.469
MOD_GlcNHglycan	37	40	PF01048	0.476
MOD_GlcNHglycan	370	373	PF01048	0.496
MOD_GlcNHglycan	484	487	PF01048	0.570
MOD_GlcNHglycan	488	491	PF01048	0.637
MOD_GlcNHglycan	507	510	PF01048	0.419
MOD_GlcNHglycan	572	575	PF01048	0.581
MOD_GlcNHglycan	596	599	PF01048	0.655
MOD_GlcNHglycan	609	612	PF01048	0.566
MOD_GlcNHglycan	618	623	PF01048	0.705
MOD_GlcNHglycan	675	678	PF01048	0.707
MOD_GlcNHglycan	83	87	PF01048	0.552
MOD_GSK3_1	109	116	PF00069	0.596
MOD_GSK3_1	124	131	PF00069	0.516
MOD_GSK3_1	151	158	PF00069	0.526
MOD_GSK3_1	270	277	PF00069	0.584
MOD_GSK3_1	278	285	PF00069	0.670
MOD_GSK3_1	335	342	PF00069	0.479
MOD_GSK3_1	364	371	PF00069	0.480
MOD_GSK3_1	428	435	PF00069	0.379
MOD_GSK3_1	482	489	PF00069	0.578
MOD_GSK3_1	530	537	PF00069	0.583
MOD_GSK3_1	663	670	PF00069	0.507
MOD_GSK3_1	85	92	PF00069	0.585
MOD_N-GLC_1	339	344	PF02516	0.363
MOD_N-GLC_1	51	56	PF02516	0.399
MOD_NEK2_1	109	114	PF00069	0.620
MOD_NEK2_1	18	23	PF00069	0.544
MOD_NEK2_1	221	226	PF00069	0.699
MOD_NEK2_1	238	243	PF00069	0.324
MOD_NEK2_1	296	301	PF00069	0.446
MOD_NEK2_1	339	344	PF00069	0.474
MOD_NEK2_1	37	42	PF00069	0.493
MOD_NEK2_1	570	575	PF00069	0.551
MOD_NEK2_1	591	596	PF00069	0.569
MOD_NEK2_1	627	632	PF00069	0.477
MOD_PIKK_1	116	122	PF00454	0.483
MOD_PIKK_1	178	184	PF00454	0.638
MOD_PIKK_1	432	438	PF00454	0.421
MOD_PIKK_1	560	566	PF00454	0.459
MOD_PIKK_1	573	579	PF00454	0.490
MOD_PIKK_1	596	602	PF00454	0.470
MOD_PIKK_1	9	15	PF00454	0.599
MOD_PKA_2	35	41	PF00069	0.463
MOD_Plk_4	128	134	PF00069	0.434
MOD_Plk_4	155	161	PF00069	0.517
MOD_Plk_4	328	334	PF00069	0.459
MOD_Plk_4	341	347	PF00069	0.249
MOD_Plk_4	358	364	PF00069	0.453
MOD_Plk_4	374	380	PF00069	0.335
MOD_Plk_4	401	407	PF00069	0.441
MOD_ProDKin_1	124	130	PF00069	0.518
MOD_ProDKin_1	274	280	PF00069	0.553
MOD_ProDKin_1	396	402	PF00069	0.474
MOD_ProDKin_1	540	546	PF00069	0.673
MOD_ProDKin_1	663	669	PF00069	0.436
MOD_SUMO_for_1	382	385	PF00179	0.480
MOD_SUMO_rev_2	676	684	PF00179	0.737
TRG_DiLeu_BaEn_1	14	19	PF01217	0.544
TRG_DiLeu_BaEn_1	53	58	PF01217	0.527
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.562
TRG_ENDOCYTIC_2	173	176	PF00928	0.547
TRG_ENDOCYTIC_2	23	26	PF00928	0.532
TRG_ENDOCYTIC_2	251	254	PF00928	0.626
TRG_ENDOCYTIC_2	568	571	PF00928	0.500
TRG_ENDOCYTIC_2	668	671	PF00928	0.505
TRG_ER_diArg_1	703	706	PF00400	0.473
TRG_NES_CRM1_1	200	212	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B7	Leptomonas seymouri	44%	97%
A0A1X0NPD4	Trypanosomatidae	27%	86%
A0A422NXB2	Trypanosoma rangeli	28%	87%
A4H7I6	Leishmania braziliensis	77%	100%
A4HVW8	Leishmania infantum	100%	100%
C9ZT55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	86%
E9APL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QFV9	Leishmania major	94%	100%
V5AXR7	Trypanosoma cruzi	29%	86%