Thioredoxin-like family protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioredoxin-like, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6Q8_LEIDO

TriTrypDb:

LdBPK_140190.1 , LdCL_140006800 , LDHU3_14.0250

Length:

199

Annotations

Annotations by Jardim et al.

Redox homeostasis, Thioredoxin-like, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 175

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.753
CLV_PCSK_KEX2_1	100	102	PF00082	0.335
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.335
CLV_PCSK_SKI1_1	70	74	PF00082	0.337
DEG_APCC_DBOX_1	160	168	PF00400	0.746
DOC_CYCLIN_RxL_1	97	107	PF00134	0.591
DOC_PP1_RVXF_1	140	146	PF00149	0.630
DOC_USP7_MATH_1	122	126	PF00917	0.539
DOC_USP7_UBL2_3	115	119	PF12436	0.487
DOC_USP7_UBL2_3	87	91	PF12436	0.483
LIG_FHA_1	150	156	PF00498	0.626
LIG_FHA_2	32	38	PF00498	0.634
LIG_FHA_2	6	12	PF00498	0.578
LIG_FHA_2	60	66	PF00498	0.534
LIG_FHA_2	76	82	PF00498	0.579
LIG_LIR_Gen_1	118	129	PF02991	0.522
LIG_LIR_Gen_1	58	68	PF02991	0.529
LIG_LIR_Nem_3	118	124	PF02991	0.522
LIG_LIR_Nem_3	38	44	PF02991	0.433
LIG_LIR_Nem_3	58	63	PF02991	0.529
LIG_PDZ_Class_1	194	199	PF00595	0.625
LIG_Pex14_1	145	149	PF04695	0.590
LIG_Pex14_2	45	49	PF04695	0.487
LIG_PTB_Apo_2	44	51	PF02174	0.487
LIG_PTB_Apo_2	54	61	PF02174	0.487
LIG_PTB_Phospho_1	44	50	PF10480	0.487
LIG_SH2_NCK_1	121	125	PF00017	0.501
LIG_SH2_SRC	111	114	PF00017	0.564
LIG_SH2_SRC	121	124	PF00017	0.385
LIG_SH2_STAP1	9	13	PF00017	0.724
LIG_SH2_STAT5	41	44	PF00017	0.489
LIG_SH2_STAT5	88	91	PF00017	0.501
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.539
LIG_TRAF2_1	169	172	PF00917	0.636
LIG_WRC_WIRS_1	46	51	PF05994	0.487
MOD_CK1_1	125	131	PF00069	0.492
MOD_CK2_1	117	123	PF00069	0.547
MOD_CK2_1	31	37	PF00069	0.614
MOD_CK2_1	59	65	PF00069	0.521
MOD_GlcNHglycan	23	26	PF01048	0.708
MOD_GSK3_1	151	158	PF00069	0.607
MOD_GSK3_1	7	14	PF00069	0.683
MOD_N-GLC_1	125	130	PF02516	0.301
MOD_N-GLC_1	155	160	PF02516	0.746
MOD_NEK2_1	149	154	PF00069	0.576
MOD_NEK2_1	45	50	PF00069	0.487
MOD_NEK2_2	194	199	PF00069	0.698
MOD_Plk_1	11	17	PF00069	0.716
MOD_Plk_1	125	131	PF00069	0.501
MOD_Plk_1	58	64	PF00069	0.494
MOD_Plk_2-3	18	24	PF00069	0.608
MOD_Plk_2-3	31	37	PF00069	0.483
MOD_Plk_2-3	5	11	PF00069	0.578
MOD_Plk_2-3	59	65	PF00069	0.521
MOD_Plk_4	125	131	PF00069	0.501
MOD_Plk_4	45	51	PF00069	0.487
MOD_SUMO_for_1	180	183	PF00179	0.791
MOD_SUMO_for_1	28	31	PF00179	0.730
MOD_SUMO_for_1	83	86	PF00179	0.533
MOD_SUMO_rev_2	107	117	PF00179	0.493
MOD_SUMO_rev_2	3	8	PF00179	0.631
MOD_SUMO_rev_2	31	40	PF00179	0.648
TRG_ENDOCYTIC_2	121	124	PF00928	0.501
TRG_ER_diArg_1	101	104	PF00400	0.535
TRG_NLS_MonoExtC_3	98	103	PF00514	0.535
TRG_NLS_MonoExtN_4	99	104	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV8	Leptomonas seymouri	82%	100%
A0A0S4J513	Bodo saltans	55%	100%
A0A1X0NP28	Trypanosomatidae	66%	100%
A0A3R7MRI8	Trypanosoma rangeli	66%	100%
A4H7H9	Leishmania braziliensis	85%	100%
A4HVW1	Leishmania infantum	100%	100%
C9ZT65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	99%
E9APL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QFW6	Leishmania major	96%	100%