Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6Q6_LEIDO

TriTrypDb:

LdBPK_140080.1 , LdCL_140005700 , LDHU3_14.0100

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Q6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.416
CLV_NRD_NRD_1	100	102	PF00675	0.410
CLV_NRD_NRD_1	106	108	PF00675	0.442
CLV_NRD_NRD_1	267	269	PF00675	0.496
CLV_NRD_NRD_1	95	97	PF00675	0.406
CLV_PCSK_KEX2_1	106	108	PF00082	0.400
CLV_PCSK_KEX2_1	51	53	PF00082	0.542
CLV_PCSK_KEX2_1	95	97	PF00082	0.409
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.536
CLV_PCSK_SKI1_1	116	120	PF00082	0.266
CLV_PCSK_SKI1_1	148	152	PF00082	0.447
CLV_PCSK_SKI1_1	167	171	PF00082	0.382
CLV_PCSK_SKI1_1	91	95	PF00082	0.377
CLV_PCSK_SKI1_1	96	100	PF00082	0.367
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DOC_CKS1_1	18	23	PF01111	0.538
DOC_PP2B_PxIxI_1	242	248	PF00149	0.410
DOC_PP4_FxxP_1	5	8	PF00568	0.601
DOC_USP7_MATH_1	162	166	PF00917	0.592
DOC_WW_Pin1_4	127	132	PF00397	0.544
DOC_WW_Pin1_4	17	22	PF00397	0.543
DOC_WW_Pin1_4	77	82	PF00397	0.437
LIG_14-3-3_CanoR_1	10	19	PF00244	0.639
LIG_14-3-3_CanoR_1	67	72	PF00244	0.450
LIG_14-3-3_CanoR_1	83	88	PF00244	0.361
LIG_14-3-3_CanoR_1	95	101	PF00244	0.343
LIG_deltaCOP1_diTrp_1	60	68	PF00928	0.476
LIG_EVH1_1	18	22	PF00568	0.478
LIG_FHA_1	18	24	PF00498	0.539
LIG_FHA_2	140	146	PF00498	0.357
LIG_FHA_2	219	225	PF00498	0.488
LIG_FHA_2	37	43	PF00498	0.525
LIG_FHA_2	51	57	PF00498	0.475
LIG_LIR_Gen_1	117	125	PF02991	0.511
LIG_LIR_Gen_1	183	192	PF02991	0.370
LIG_LIR_Gen_1	198	205	PF02991	0.293
LIG_LIR_Gen_1	216	227	PF02991	0.363
LIG_LIR_Gen_1	241	250	PF02991	0.368
LIG_LIR_Nem_3	109	113	PF02991	0.511
LIG_LIR_Nem_3	117	122	PF02991	0.495
LIG_LIR_Nem_3	132	137	PF02991	0.499
LIG_LIR_Nem_3	165	169	PF02991	0.509
LIG_LIR_Nem_3	183	188	PF02991	0.350
LIG_LIR_Nem_3	198	203	PF02991	0.296
LIG_LIR_Nem_3	224	228	PF02991	0.310
LIG_LIR_Nem_3	241	247	PF02991	0.371
LIG_SH2_CRK	84	88	PF00017	0.388
LIG_SH2_NCK_1	84	88	PF00017	0.402
LIG_SH2_STAP1	178	182	PF00017	0.441
LIG_SH2_STAT3	191	194	PF00017	0.341
LIG_SH2_STAT5	84	87	PF00017	0.429
LIG_SH3_3	16	22	PF00018	0.683
LIG_SH3_3	233	239	PF00018	0.536
LIG_TYR_ITIM	82	87	PF00017	0.383
LIG_UBA3_1	149	154	PF00899	0.518
LIG_WRC_WIRS_1	182	187	PF05994	0.356
MOD_CDK_SPxK_1	77	83	PF00069	0.402
MOD_CK1_1	165	171	PF00069	0.566
MOD_CK1_1	36	42	PF00069	0.524
MOD_CK2_1	139	145	PF00069	0.370
MOD_CK2_1	173	179	PF00069	0.588
MOD_CK2_1	218	224	PF00069	0.424
MOD_CK2_1	36	42	PF00069	0.542
MOD_GSK3_1	123	130	PF00069	0.396
MOD_GSK3_1	42	49	PF00069	0.536
MOD_N-GLC_1	33	38	PF02516	0.518
MOD_NEK2_1	201	206	PF00069	0.364
MOD_NEK2_1	271	276	PF00069	0.442
MOD_NEK2_1	33	38	PF00069	0.564
MOD_PIKK_1	10	16	PF00454	0.645
MOD_PIKK_1	193	199	PF00454	0.469
MOD_PIKK_1	258	264	PF00454	0.456
MOD_PIKK_1	42	48	PF00454	0.620
MOD_PK_1	83	89	PF00069	0.412
MOD_PKA_2	138	144	PF00069	0.378
MOD_PKA_2	211	217	PF00069	0.592
MOD_PKA_2	82	88	PF00069	0.438
MOD_PKA_2	9	15	PF00069	0.698
MOD_Plk_1	33	39	PF00069	0.541
MOD_Plk_2-3	181	187	PF00069	0.470
MOD_Plk_2-3	218	224	PF00069	0.419
MOD_Plk_4	218	224	PF00069	0.478
MOD_ProDKin_1	127	133	PF00069	0.540
MOD_ProDKin_1	17	23	PF00069	0.542
MOD_ProDKin_1	77	83	PF00069	0.442
TRG_ENDOCYTIC_2	225	228	PF00928	0.338
TRG_ENDOCYTIC_2	84	87	PF00928	0.411
TRG_ER_diArg_1	106	108	PF00400	0.406
TRG_ER_diArg_1	209	212	PF00400	0.399
TRG_ER_diArg_1	94	96	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I365	Leptomonas seymouri	79%	100%
A0A0S4IUM2	Bodo saltans	57%	82%
A0A1X0NNS4	Trypanosomatidae	71%	100%
A0A3S5IS70	Trypanosoma rangeli	67%	100%
A4H7G9	Leishmania braziliensis	90%	100%
A4HVV0	Leishmania infantum	100%	100%
C9ZT77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9APK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QFX7	Leishmania major	97%	100%
V5AXQ5	Trypanosoma cruzi	71%	100%