DNA repair metallo-beta-lactamase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6Q1_LEIDO

TriTrypDb:

LdBPK_131540.1 , LdCL_130019500 , LDHU3_13.1710

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Q1

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031848	protection from non-homologous end joining at telomere	6	1
GO:0032200	telomere organization	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0036297	interstrand cross-link repair	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043247	telomere maintenance in response to DNA damage	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0035312	5'-3' DNA exonuclease activity	7	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	525	529	PF00656	0.681
CLV_C14_Caspase3-7	580	584	PF00656	0.759
CLV_C14_Caspase3-7	703	707	PF00656	0.716
CLV_C14_Caspase3-7	765	769	PF00656	0.700
CLV_C14_Caspase3-7	93	97	PF00656	0.717
CLV_NRD_NRD_1	19	21	PF00675	0.629
CLV_NRD_NRD_1	221	223	PF00675	0.478
CLV_NRD_NRD_1	590	592	PF00675	0.712
CLV_PCSK_KEX2_1	19	21	PF00082	0.677
CLV_PCSK_KEX2_1	221	223	PF00082	0.462
CLV_PCSK_KEX2_1	400	402	PF00082	0.581
CLV_PCSK_KEX2_1	590	592	PF00082	0.716
CLV_PCSK_KEX2_1	701	703	PF00082	0.762
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.581
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.775
CLV_PCSK_SKI1_1	151	155	PF00082	0.514
CLV_PCSK_SKI1_1	281	285	PF00082	0.437
CLV_PCSK_SKI1_1	305	309	PF00082	0.477
CLV_PCSK_SKI1_1	59	63	PF00082	0.458
CLV_PCSK_SKI1_1	734	738	PF00082	0.734
DEG_APCC_DBOX_1	556	564	PF00400	0.519
DEG_Nend_UBRbox_1	1	4	PF02207	0.514
DEG_SCF_FBW7_1	249	254	PF00400	0.691
DEG_SPOP_SBC_1	251	255	PF00917	0.729
DEG_SPOP_SBC_1	639	643	PF00917	0.702
DOC_ANK_TNKS_1	667	674	PF00023	0.690
DOC_CKS1_1	124	129	PF01111	0.504
DOC_CYCLIN_RxL_1	56	67	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	478	484	PF00134	0.441
DOC_MAPK_DCC_7	400	410	PF00069	0.627
DOC_MAPK_gen_1	70	78	PF00069	0.417
DOC_MAPK_HePTP_8	497	509	PF00069	0.622
DOC_MAPK_MEF2A_6	2	10	PF00069	0.573
DOC_MAPK_MEF2A_6	266	275	PF00069	0.503
DOC_MAPK_MEF2A_6	401	410	PF00069	0.627
DOC_MAPK_MEF2A_6	500	509	PF00069	0.624
DOC_MAPK_MEF2A_6	70	78	PF00069	0.472
DOC_MAPK_MEF2A_6	744	751	PF00069	0.653
DOC_MAPK_RevD_3	6	20	PF00069	0.443
DOC_PP2B_LxvP_1	505	508	PF13499	0.646
DOC_PP2B_LxvP_1	74	77	PF13499	0.531
DOC_PP2B_PxIxI_1	405	411	PF00149	0.520
DOC_PP4_FxxP_1	114	117	PF00568	0.395
DOC_PP4_FxxP_1	634	637	PF00568	0.795
DOC_PP4_MxPP_1	600	603	PF00568	0.573
DOC_USP7_MATH_1	251	255	PF00917	0.759
DOC_USP7_MATH_1	260	264	PF00917	0.622
DOC_USP7_MATH_1	391	395	PF00917	0.727
DOC_USP7_MATH_1	452	456	PF00917	0.658
DOC_USP7_MATH_1	611	615	PF00917	0.689
DOC_USP7_MATH_1	90	94	PF00917	0.683
DOC_WW_Pin1_4	123	128	PF00397	0.482
DOC_WW_Pin1_4	145	150	PF00397	0.435
DOC_WW_Pin1_4	182	187	PF00397	0.773
DOC_WW_Pin1_4	247	252	PF00397	0.720
DOC_WW_Pin1_4	324	329	PF00397	0.675
DOC_WW_Pin1_4	429	434	PF00397	0.552
DOC_WW_Pin1_4	465	470	PF00397	0.453
DOC_WW_Pin1_4	482	487	PF00397	0.457
DOC_WW_Pin1_4	635	640	PF00397	0.709
LIG_14-3-3_CanoR_1	19	27	PF00244	0.486
LIG_14-3-3_CanoR_1	2	7	PF00244	0.578
LIG_14-3-3_CanoR_1	305	310	PF00244	0.434
LIG_14-3-3_CanoR_1	444	452	PF00244	0.659
LIG_14-3-3_CanoR_1	480	485	PF00244	0.451
LIG_14-3-3_CanoR_1	675	680	PF00244	0.679
LIG_14-3-3_CanoR_1	721	729	PF00244	0.771
LIG_14-3-3_CanoR_1	81	85	PF00244	0.440
LIG_BIR_III_4	241	245	PF00653	0.573
LIG_eIF4E_1	542	548	PF01652	0.520
LIG_FHA_1	292	298	PF00498	0.494
LIG_FHA_1	52	58	PF00498	0.397
LIG_FHA_1	525	531	PF00498	0.677
LIG_FHA_1	560	566	PF00498	0.603
LIG_FHA_1	624	630	PF00498	0.706
LIG_FHA_1	640	646	PF00498	0.747
LIG_FHA_1	724	730	PF00498	0.682
LIG_FHA_1	755	761	PF00498	0.786
LIG_FHA_1	80	86	PF00498	0.444
LIG_FHA_1	98	104	PF00498	0.601
LIG_FHA_2	306	312	PF00498	0.454
LIG_FHA_2	466	472	PF00498	0.498
LIG_FHA_2	523	529	PF00498	0.706
LIG_HCF-1_HBM_1	160	163	PF13415	0.410
LIG_Integrin_isoDGR_2	381	383	PF01839	0.518
LIG_KLC1_Yacidic_2	160	165	PF13176	0.406
LIG_LIR_Gen_1	165	176	PF02991	0.482
LIG_LIR_Gen_1	300	310	PF02991	0.440
LIG_LIR_Gen_1	474	482	PF02991	0.474
LIG_LIR_Nem_3	11	16	PF02991	0.467
LIG_LIR_Nem_3	165	171	PF02991	0.425
LIG_LIR_Nem_3	300	306	PF02991	0.441
LIG_LIR_Nem_3	432	438	PF02991	0.432
LIG_LIR_Nem_3	440	445	PF02991	0.510
LIG_LIR_Nem_3	474	478	PF02991	0.475
LIG_LIR_Nem_3	682	686	PF02991	0.469
LIG_NRBOX	202	208	PF00104	0.565
LIG_NRBOX	564	570	PF00104	0.464
LIG_PCNA_PIPBox_1	147	156	PF02747	0.477
LIG_PDZ_Class_2	767	772	PF00595	0.773
LIG_Pex14_1	47	51	PF04695	0.354
LIG_Pex14_2	31	35	PF04695	0.537
LIG_SH2_CRK	303	307	PF00017	0.494
LIG_SH2_CRK	435	439	PF00017	0.426
LIG_SH2_PTP2	107	110	PF00017	0.434
LIG_SH2_SRC	542	545	PF00017	0.481
LIG_SH2_STAP1	140	144	PF00017	0.514
LIG_SH2_STAP1	303	307	PF00017	0.494
LIG_SH2_STAT3	225	228	PF00017	0.536
LIG_SH2_STAT5	107	110	PF00017	0.351
LIG_SH2_STAT5	123	126	PF00017	0.433
LIG_SH2_STAT5	132	135	PF00017	0.401
LIG_SH2_STAT5	140	143	PF00017	0.423
LIG_SH2_STAT5	163	166	PF00017	0.405
LIG_SH2_STAT5	274	277	PF00017	0.480
LIG_SH2_STAT5	504	507	PF00017	0.541
LIG_SH2_STAT5	542	545	PF00017	0.598
LIG_SH2_STAT5	546	549	PF00017	0.545
LIG_SH2_STAT5	633	636	PF00017	0.724
LIG_SH2_STAT5	686	689	PF00017	0.642
LIG_SH3_1	538	544	PF00018	0.580
LIG_SH3_3	385	391	PF00018	0.713
LIG_SH3_3	538	544	PF00018	0.582
LIG_SUMO_SIM_anti_2	474	480	PF11976	0.476
LIG_SUMO_SIM_anti_2	562	567	PF11976	0.487
LIG_SUMO_SIM_par_1	305	311	PF11976	0.535
LIG_SUMO_SIM_par_1	4	12	PF11976	0.558
LIG_SUMO_SIM_par_1	406	413	PF11976	0.495
LIG_SUMO_SIM_par_1	480	485	PF11976	0.485
LIG_TRAF2_1	312	315	PF00917	0.508
LIG_TRAF2_1	339	342	PF00917	0.541
LIG_TRAF2_1	468	471	PF00917	0.511
LIG_TRAF2_1	584	587	PF00917	0.706
LIG_TYR_ITIM	105	110	PF00017	0.440
LIG_TYR_ITSM	430	437	PF00017	0.576
LIG_WRC_WIRS_1	150	155	PF05994	0.507
LIG_WRC_WIRS_1	362	367	PF05994	0.473
MOD_CDC14_SPxK_1	148	151	PF00782	0.467
MOD_CDC14_SPxK_1	327	330	PF00782	0.628
MOD_CDK_SPK_2	635	640	PF00069	0.583
MOD_CDK_SPxK_1	145	151	PF00069	0.487
MOD_CDK_SPxK_1	324	330	PF00069	0.606
MOD_CK1_1	128	134	PF00069	0.474
MOD_CK1_1	252	258	PF00069	0.731
MOD_CK1_1	413	419	PF00069	0.597
MOD_CK1_1	45	51	PF00069	0.505
MOD_CK1_1	55	61	PF00069	0.455
MOD_CK1_1	638	644	PF00069	0.758
MOD_CK1_1	664	670	PF00069	0.815
MOD_CK1_1	691	697	PF00069	0.680
MOD_CK1_1	752	758	PF00069	0.737
MOD_CK1_1	83	89	PF00069	0.464
MOD_CK1_1	97	103	PF00069	0.600
MOD_CK2_1	22	28	PF00069	0.591
MOD_CK2_1	305	311	PF00069	0.454
MOD_CK2_1	336	342	PF00069	0.577
MOD_CK2_1	345	351	PF00069	0.516
MOD_CK2_1	465	471	PF00069	0.478
MOD_CK2_1	489	495	PF00069	0.570
MOD_CK2_1	611	617	PF00069	0.723
MOD_Cter_Amidation	17	20	PF01082	0.565
MOD_Cter_Amidation	219	222	PF01082	0.453
MOD_Cter_Amidation	699	702	PF01082	0.828
MOD_GlcNHglycan	118	121	PF01048	0.415
MOD_GlcNHglycan	127	130	PF01048	0.442
MOD_GlcNHglycan	197	200	PF01048	0.659
MOD_GlcNHglycan	22	25	PF01048	0.632
MOD_GlcNHglycan	256	259	PF01048	0.793
MOD_GlcNHglycan	338	341	PF01048	0.614
MOD_GlcNHglycan	347	350	PF01048	0.496
MOD_GlcNHglycan	393	396	PF01048	0.680
MOD_GlcNHglycan	425	428	PF01048	0.591
MOD_GlcNHglycan	439	442	PF01048	0.366
MOD_GlcNHglycan	454	457	PF01048	0.584
MOD_GlcNHglycan	557	560	PF01048	0.722
MOD_GlcNHglycan	613	616	PF01048	0.721
MOD_GlcNHglycan	697	700	PF01048	0.729
MOD_GlcNHglycan	730	733	PF01048	0.790
MOD_GlcNHglycan	754	757	PF01048	0.749
MOD_GlcNHglycan	85	88	PF01048	0.541
MOD_GSK3_1	128	135	PF00069	0.452
MOD_GSK3_1	145	152	PF00069	0.387
MOD_GSK3_1	18	25	PF00069	0.653
MOD_GSK3_1	247	254	PF00069	0.754
MOD_GSK3_1	256	263	PF00069	0.676
MOD_GSK3_1	30	37	PF00069	0.404
MOD_GSK3_1	391	398	PF00069	0.724
MOD_GSK3_1	409	416	PF00069	0.366
MOD_GSK3_1	41	48	PF00069	0.460
MOD_GSK3_1	460	467	PF00069	0.460
MOD_GSK3_1	51	58	PF00069	0.453
MOD_GSK3_1	517	524	PF00069	0.736
MOD_GSK3_1	551	558	PF00069	0.649
MOD_GSK3_1	623	630	PF00069	0.702
MOD_GSK3_1	635	642	PF00069	0.728
MOD_GSK3_1	660	667	PF00069	0.828
MOD_GSK3_1	675	682	PF00069	0.553
MOD_GSK3_1	688	695	PF00069	0.632
MOD_GSK3_1	750	757	PF00069	0.725
MOD_GSK3_1	79	86	PF00069	0.466
MOD_GSK3_1	90	97	PF00069	0.630
MOD_LATS_1	39	45	PF00433	0.568
MOD_N-GLC_1	242	247	PF02516	0.766
MOD_NEK2_1	1	6	PF00069	0.485
MOD_NEK2_1	153	158	PF00069	0.492
MOD_NEK2_1	164	169	PF00069	0.334
MOD_NEK2_1	30	35	PF00069	0.456
MOD_NEK2_1	43	48	PF00069	0.288
MOD_NEK2_1	51	56	PF00069	0.392
MOD_NEK2_1	674	679	PF00069	0.698
MOD_NEK2_1	688	693	PF00069	0.551
MOD_NEK2_1	750	755	PF00069	0.749
MOD_NEK2_2	149	154	PF00069	0.469
MOD_NEK2_2	395	400	PF00069	0.632
MOD_NEK2_2	723	728	PF00069	0.594
MOD_OFUCOSY	687	692	PF10250	0.507
MOD_PIKK_1	235	241	PF00454	0.601
MOD_PIKK_1	363	369	PF00454	0.507
MOD_PIKK_1	444	450	PF00454	0.729
MOD_PIKK_1	546	552	PF00454	0.586
MOD_PIKK_1	686	692	PF00454	0.716
MOD_PK_1	480	486	PF00069	0.427
MOD_PKA_2	1	7	PF00069	0.450
MOD_PKA_2	18	24	PF00069	0.698
MOD_PKA_2	345	351	PF00069	0.516
MOD_PKA_2	413	419	PF00069	0.620
MOD_PKA_2	489	495	PF00069	0.576
MOD_PKA_2	674	680	PF00069	0.696
MOD_PKA_2	80	86	PF00069	0.405
MOD_Plk_1	164	170	PF00069	0.418
MOD_Plk_1	395	401	PF00069	0.706
MOD_Plk_1	661	667	PF00069	0.702
MOD_Plk_4	106	112	PF00069	0.431
MOD_Plk_4	128	134	PF00069	0.466
MOD_Plk_4	164	170	PF00069	0.401
MOD_Plk_4	305	311	PF00069	0.564
MOD_Plk_4	561	567	PF00069	0.649
MOD_Plk_4	675	681	PF00069	0.723
MOD_Plk_4	80	86	PF00069	0.334
MOD_ProDKin_1	123	129	PF00069	0.487
MOD_ProDKin_1	145	151	PF00069	0.439
MOD_ProDKin_1	182	188	PF00069	0.773
MOD_ProDKin_1	247	253	PF00069	0.721
MOD_ProDKin_1	324	330	PF00069	0.681
MOD_ProDKin_1	429	435	PF00069	0.548
MOD_ProDKin_1	465	471	PF00069	0.451
MOD_ProDKin_1	482	488	PF00069	0.462
MOD_ProDKin_1	635	641	PF00069	0.709
MOD_SUMO_for_1	727	730	PF00179	0.669
MOD_SUMO_rev_2	314	323	PF00179	0.406
MOD_SUMO_rev_2	580	589	PF00179	0.734
TRG_DiLeu_BaEn_2	470	476	PF01217	0.566
TRG_DiLeu_BaEn_4	315	321	PF01217	0.534
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.488
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.547
TRG_ENDOCYTIC_2	107	110	PF00928	0.434
TRG_ENDOCYTIC_2	303	306	PF00928	0.435
TRG_ENDOCYTIC_2	434	437	PF00928	0.429
TRG_ENDOCYTIC_2	504	507	PF00928	0.613
TRG_ER_diArg_1	221	223	PF00400	0.478
TRG_ER_diArg_1	292	295	PF00400	0.493
TRG_ER_diArg_1	589	591	PF00400	0.787
TRG_ER_diArg_1	593	596	PF00400	0.784
TRG_ER_diArg_1	69	72	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAX7	Leptomonas seymouri	49%	100%
A0A422P493	Trypanosoma rangeli	37%	100%
A4H7D0	Leishmania braziliensis	74%	100%
A4HVS7	Leishmania infantum	100%	100%
E9APH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QG05	Leishmania major	89%	100%