LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S5H6P8_LEIDO
TriTrypDb:
LdBPK_131210.1 , LdCL_130017600 , LDHU3_13.1490
Length:
420

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 6
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A0A3S5H6P8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6P8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.316
CLV_NRD_NRD_1 412 414 PF00675 0.443
CLV_PCSK_SKI1_1 256 260 PF00082 0.512
CLV_PCSK_SKI1_1 413 417 PF00082 0.434
DEG_Nend_UBRbox_3 1 3 PF02207 0.567
DOC_CYCLIN_yCln2_LP_2 3 9 PF00134 0.496
DOC_MAPK_gen_1 16 25 PF00069 0.533
DOC_MAPK_MEF2A_6 16 25 PF00069 0.473
DOC_PP4_FxxP_1 170 173 PF00568 0.269
DOC_PP4_FxxP_1 394 397 PF00568 0.676
DOC_PP4_FxxP_1 52 55 PF00568 0.372
DOC_USP7_MATH_1 196 200 PF00917 0.236
DOC_USP7_MATH_1 55 59 PF00917 0.396
DOC_WW_Pin1_4 108 113 PF00397 0.236
DOC_WW_Pin1_4 172 177 PF00397 0.367
DOC_WW_Pin1_4 393 398 PF00397 0.650
LIG_14-3-3_CanoR_1 143 151 PF00244 0.341
LIG_14-3-3_CanoR_1 202 207 PF00244 0.244
LIG_14-3-3_CanoR_1 334 339 PF00244 0.691
LIG_ActinCP_TwfCPI_2 52 61 PF01115 0.343
LIG_BIR_III_2 109 113 PF00653 0.236
LIG_BRCT_BRCA1_1 203 207 PF00533 0.269
LIG_BRCT_BRCA1_1 254 258 PF00533 0.369
LIG_FHA_1 119 125 PF00498 0.313
LIG_FHA_1 161 167 PF00498 0.366
LIG_FHA_1 83 89 PF00498 0.287
LIG_FHA_2 143 149 PF00498 0.307
LIG_FHA_2 219 225 PF00498 0.316
LIG_FHA_2 350 356 PF00498 0.627
LIG_GBD_Chelix_1 25 33 PF00786 0.537
LIG_IRF3_LxIS_1 151 158 PF10401 0.269
LIG_LIR_Apic_2 393 397 PF02991 0.827
LIG_LIR_Apic_2 51 55 PF02991 0.412
LIG_LIR_Gen_1 98 106 PF02991 0.293
LIG_LIR_Nem_3 132 136 PF02991 0.307
LIG_LIR_Nem_3 232 236 PF02991 0.378
LIG_LIR_Nem_3 98 104 PF02991 0.281
LIG_NRBOX 28 34 PF00104 0.425
LIG_Pex14_1 286 290 PF04695 0.360
LIG_Pex14_2 133 137 PF04695 0.269
LIG_Pex14_2 187 191 PF04695 0.308
LIG_Rb_LxCxE_1 63 80 PF01857 0.231
LIG_SH2_CRK 101 105 PF00017 0.349
LIG_SH2_STAT3 181 184 PF00017 0.287
LIG_SH2_STAT5 103 106 PF00017 0.269
LIG_SH2_STAT5 165 168 PF00017 0.259
LIG_SH2_STAT5 169 172 PF00017 0.398
LIG_SH2_STAT5 231 234 PF00017 0.353
LIG_SH2_STAT5 409 412 PF00017 0.757
LIG_SH2_STAT5 74 77 PF00017 0.345
LIG_SH3_3 148 154 PF00018 0.276
LIG_SH3_3 170 176 PF00018 0.273
LIG_SH3_3 3 9 PF00018 0.496
LIG_SUMO_SIM_anti_2 24 29 PF11976 0.554
LIG_SUMO_SIM_anti_2 292 298 PF11976 0.346
LIG_SUMO_SIM_par_1 19 24 PF11976 0.525
LIG_SUMO_SIM_par_1 28 34 PF11976 0.436
LIG_TRAF2_1 325 328 PF00917 0.688
LIG_WRC_WIRS_1 49 54 PF05994 0.333
MOD_CK1_1 220 226 PF00069 0.329
MOD_CK1_1 337 343 PF00069 0.697
MOD_CK1_1 349 355 PF00069 0.811
MOD_CK1_1 393 399 PF00069 0.693
MOD_CK1_1 407 413 PF00069 0.646
MOD_GlcNHglycan 126 129 PF01048 0.492
MOD_GlcNHglycan 184 187 PF01048 0.410
MOD_GlcNHglycan 227 230 PF01048 0.635
MOD_GlcNHglycan 352 355 PF01048 0.504
MOD_GlcNHglycan 379 382 PF01048 0.618
MOD_GlcNHglycan 56 60 PF01048 0.535
MOD_GSK3_1 104 111 PF00069 0.352
MOD_GSK3_1 182 189 PF00069 0.311
MOD_GSK3_1 216 223 PF00069 0.329
MOD_GSK3_1 225 232 PF00069 0.374
MOD_GSK3_1 248 255 PF00069 0.375
MOD_GSK3_1 262 269 PF00069 0.326
MOD_GSK3_1 326 333 PF00069 0.759
MOD_GSK3_1 334 341 PF00069 0.699
MOD_GSK3_1 346 353 PF00069 0.745
MOD_N-GLC_1 191 196 PF02516 0.469
MOD_N-GLC_1 242 247 PF02516 0.646
MOD_N-GLC_1 276 281 PF02516 0.664
MOD_N-GLC_1 377 382 PF02516 0.556
MOD_NEK2_1 1 6 PF00069 0.510
MOD_NEK2_1 155 160 PF00069 0.269
MOD_NEK2_1 191 196 PF00069 0.247
MOD_NEK2_1 236 241 PF00069 0.382
MOD_NEK2_1 275 280 PF00069 0.556
MOD_NEK2_1 302 307 PF00069 0.275
MOD_NEK2_1 338 343 PF00069 0.702
MOD_NEK2_1 360 365 PF00069 0.627
MOD_NEK2_2 404 409 PF00069 0.641
MOD_PIKK_1 196 202 PF00454 0.258
MOD_PIKK_1 248 254 PF00454 0.370
MOD_PIKK_1 262 268 PF00454 0.456
MOD_PIKK_1 346 352 PF00454 0.762
MOD_PKA_1 413 419 PF00069 0.661
MOD_PKA_2 142 148 PF00069 0.341
MOD_PKA_2 201 207 PF00069 0.266
MOD_PKA_2 252 258 PF00069 0.328
MOD_PKA_2 350 356 PF00069 0.741
MOD_Plk_1 217 223 PF00069 0.308
MOD_Plk_2-3 218 224 PF00069 0.269
MOD_Plk_4 160 166 PF00069 0.287
MOD_Plk_4 186 192 PF00069 0.255
MOD_Plk_4 202 208 PF00069 0.265
MOD_Plk_4 237 243 PF00069 0.422
MOD_Plk_4 334 340 PF00069 0.700
MOD_Plk_4 370 376 PF00069 0.704
MOD_Plk_4 404 410 PF00069 0.640
MOD_ProDKin_1 108 114 PF00069 0.236
MOD_ProDKin_1 172 178 PF00069 0.367
MOD_ProDKin_1 393 399 PF00069 0.650
MOD_SUMO_rev_2 218 228 PF00179 0.258
MOD_SUMO_rev_2 407 416 PF00179 0.629
TRG_ENDOCYTIC_2 101 104 PF00928 0.322
TRG_ENDOCYTIC_2 233 236 PF00928 0.406
TRG_NES_CRM1_1 359 371 PF08389 0.618

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY91 Leptomonas seymouri 36% 100%
A0A0N1PG18 Leptomonas seymouri 49% 94%
A0A1X0NVE8 Trypanosomatidae 23% 100%
A0A3S5H587 Leishmania donovani 35% 100%
A4H3U3 Leishmania braziliensis 35% 100%
A4H7B4 Leishmania braziliensis 69% 100%
A4HS17 Leishmania infantum 35% 100%
A4HVQ9 Leishmania infantum 100% 100%
E9AK04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9APF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%
Q4QG23 Leishmania major 87% 100%
Q9XZY2 Leishmania major 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS