Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H6P6_LEIDO

TriTrypDb:

LdBPK_131150.1 , LdCL_130016900 , LDHU3_13.1410

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S5H6P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.727
CLV_NRD_NRD_1	67	69	PF00675	0.690
CLV_PCSK_FUR_1	26	30	PF00082	0.456
CLV_PCSK_KEX2_1	109	111	PF00082	0.698
CLV_PCSK_KEX2_1	148	150	PF00082	0.689
CLV_PCSK_KEX2_1	28	30	PF00082	0.461
CLV_PCSK_KEX2_1	67	69	PF00082	0.669
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.730
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.689
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.461
CLV_PCSK_PC7_1	63	69	PF00082	0.674
CLV_PCSK_SKI1_1	67	71	PF00082	0.698
DOC_CKS1_1	10	15	PF01111	0.676
DOC_CKS1_1	62	67	PF01111	0.465
DOC_CYCLIN_RxL_1	63	72	PF00134	0.554
DOC_WW_Pin1_4	127	132	PF00397	0.482
DOC_WW_Pin1_4	61	66	PF00397	0.456
DOC_WW_Pin1_4	9	14	PF00397	0.680
LIG_14-3-3_CanoR_1	124	131	PF00244	0.532
LIG_14-3-3_CanoR_1	26	32	PF00244	0.651
LIG_14-3-3_CanoR_1	89	94	PF00244	0.573
LIG_Clathr_ClatBox_1	39	43	PF01394	0.507
LIG_FHA_1	128	134	PF00498	0.530
LIG_FHA_1	16	22	PF00498	0.754
LIG_MYND_3	1	5	PF01753	0.605
LIG_SH2_STAT5	58	61	PF00017	0.521
LIG_SH3_3	11	17	PF00018	0.684
LIG_SH3_3	59	65	PF00018	0.551
LIG_SUMO_SIM_par_1	38	43	PF11976	0.503
LIG_TYR_ITIM	55	60	PF00017	0.311
MOD_CDK_SPxK_1	61	67	PF00069	0.462
MOD_CDK_SPxxK_3	61	68	PF00069	0.465
MOD_CK1_1	105	111	PF00069	0.515
MOD_CK1_1	123	129	PF00069	0.541
MOD_CK1_1	135	141	PF00069	0.499
MOD_CK1_1	84	90	PF00069	0.573
MOD_CK1_1	98	104	PF00069	0.434
MOD_CK2_1	126	132	PF00069	0.571
MOD_CK2_1	88	94	PF00069	0.598
MOD_Cter_Amidation	65	68	PF01082	0.681
MOD_GlcNHglycan	134	137	PF01048	0.737
MOD_GSK3_1	123	130	PF00069	0.589
MOD_GSK3_1	138	145	PF00069	0.417
MOD_GSK3_1	77	84	PF00069	0.542
MOD_GSK3_1	85	92	PF00069	0.478
MOD_GSK3_1	98	105	PF00069	0.471
MOD_LATS_1	140	146	PF00433	0.470
MOD_NEK2_1	95	100	PF00069	0.512
MOD_PK_1	89	95	PF00069	0.475
MOD_PKA_2	123	129	PF00069	0.536
MOD_PKA_2	88	94	PF00069	0.551
MOD_PKA_2	98	104	PF00069	0.460
MOD_ProDKin_1	127	133	PF00069	0.481
MOD_ProDKin_1	61	67	PF00069	0.462
MOD_ProDKin_1	9	15	PF00069	0.678
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.558
TRG_ENDOCYTIC_2	57	60	PF00928	0.429
TRG_ER_diArg_1	67	69	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.766

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P887	Leptomonas seymouri	48%	100%
A4H7A8	Leishmania braziliensis	67%	97%
A4HVQ3	Leishmania infantum	99%	100%
Q4QG29	Leishmania major	87%	100%