Adenylosuccinate synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylosuccinate synthetase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6P5_LEIDO

TriTrypDb:

LdBPK_131090.1 , LdCL_130016200 , LDHU3_13.1340

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S5H6P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6P5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006167	AMP biosynthetic process	8	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009123	nucleoside monophosphate metabolic process	5	12
GO:0009124	nucleoside monophosphate biosynthetic process	6	12
GO:0009126	purine nucleoside monophosphate metabolic process	6	12
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009152	purine ribonucleotide biosynthetic process	7	12
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	12
GO:0009161	ribonucleoside monophosphate metabolic process	6	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	12
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0044208	'de novo' AMP biosynthetic process	9	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046033	AMP metabolic process	7	12
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0072522	purine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0046040	IMP metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000287	magnesium ion binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004019	adenylosuccinate synthase activity	4	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.467
CLV_C14_Caspase3-7	356	360	PF00656	0.453
CLV_C14_Caspase3-7	58	62	PF00656	0.695
CLV_NRD_NRD_1	148	150	PF00675	0.600
CLV_NRD_NRD_1	218	220	PF00675	0.257
CLV_NRD_NRD_1	324	326	PF00675	0.342
CLV_NRD_NRD_1	4	6	PF00675	0.755
CLV_NRD_NRD_1	669	671	PF00675	0.269
CLV_PCSK_FUR_1	109	113	PF00082	0.553
CLV_PCSK_KEX2_1	111	113	PF00082	0.549
CLV_PCSK_KEX2_1	148	150	PF00082	0.600
CLV_PCSK_KEX2_1	235	237	PF00082	0.275
CLV_PCSK_KEX2_1	309	311	PF00082	0.264
CLV_PCSK_KEX2_1	326	328	PF00082	0.218
CLV_PCSK_KEX2_1	4	6	PF00082	0.755
CLV_PCSK_KEX2_1	667	669	PF00082	0.253
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.549
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.264
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.264
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.218
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.253
CLV_PCSK_SKI1_1	148	152	PF00082	0.523
CLV_PCSK_SKI1_1	220	224	PF00082	0.253
CLV_PCSK_SKI1_1	306	310	PF00082	0.358
CLV_PCSK_SKI1_1	414	418	PF00082	0.284
CLV_PCSK_SKI1_1	512	516	PF00082	0.281
DEG_SPOP_SBC_1	291	295	PF00917	0.453
DOC_CKS1_1	276	281	PF01111	0.453
DOC_CYCLIN_RxL_1	279	289	PF00134	0.456
DOC_CYCLIN_RxL_1	509	517	PF00134	0.541
DOC_MAPK_gen_1	306	314	PF00069	0.453
DOC_MAPK_gen_1	375	384	PF00069	0.528
DOC_MAPK_gen_1	456	464	PF00069	0.501
DOC_MAPK_MEF2A_6	456	464	PF00069	0.448
DOC_MAPK_MEF2A_6	543	550	PF00069	0.429
DOC_MAPK_MEF2A_6	71	79	PF00069	0.757
DOC_MAPK_RevD_3	223	236	PF00069	0.514
DOC_PP1_RVXF_1	375	381	PF00149	0.514
DOC_PP2B_LxvP_1	230	233	PF13499	0.558
DOC_PP4_FxxP_1	70	73	PF00568	0.677
DOC_USP7_MATH_1	101	105	PF00917	0.614
DOC_USP7_MATH_1	134	138	PF00917	0.579
DOC_USP7_MATH_1	15	19	PF00917	0.785
DOC_USP7_MATH_1	154	158	PF00917	0.209
DOC_USP7_MATH_1	290	294	PF00917	0.456
DOC_USP7_MATH_1	36	40	PF00917	0.765
DOC_USP7_MATH_1	468	472	PF00917	0.451
DOC_USP7_MATH_1	477	481	PF00917	0.453
DOC_USP7_MATH_1	551	555	PF00917	0.478
DOC_USP7_MATH_1	638	642	PF00917	0.480
DOC_USP7_MATH_1	87	91	PF00917	0.764
DOC_USP7_UBL2_3	216	220	PF12436	0.539
DOC_USP7_UBL2_3	326	330	PF12436	0.558
DOC_WW_Pin1_4	11	16	PF00397	0.768
DOC_WW_Pin1_4	19	24	PF00397	0.740
DOC_WW_Pin1_4	275	280	PF00397	0.453
DOC_WW_Pin1_4	29	34	PF00397	0.695
LIG_14-3-3_CanoR_1	112	122	PF00244	0.630
LIG_14-3-3_CanoR_1	127	132	PF00244	0.485
LIG_14-3-3_CanoR_1	9	15	PF00244	0.748
LIG_AP2alpha_1	515	519	PF02296	0.558
LIG_APCC_ABBA_1	382	387	PF00400	0.464
LIG_EH1_1	648	656	PF00400	0.464
LIG_FHA_1	400	406	PF00498	0.554
LIG_FHA_2	128	134	PF00498	0.507
LIG_FHA_2	210	216	PF00498	0.453
LIG_FHA_2	42	48	PF00498	0.771
LIG_FHA_2	435	441	PF00498	0.453
LIG_FHA_2	493	499	PF00498	0.464
LIG_Integrin_RGD_1	597	599	PF01839	0.253
LIG_IRF3_LxIS_1	588	593	PF10401	0.453
LIG_LIR_Gen_1	130	140	PF02991	0.522
LIG_LIR_Gen_1	278	287	PF02991	0.453
LIG_LIR_Gen_1	599	609	PF02991	0.453
LIG_LIR_Nem_3	118	123	PF02991	0.624
LIG_LIR_Nem_3	130	135	PF02991	0.408
LIG_LIR_Nem_3	160	166	PF02991	0.382
LIG_LIR_Nem_3	278	283	PF02991	0.453
LIG_LIR_Nem_3	333	338	PF02991	0.464
LIG_LIR_Nem_3	599	604	PF02991	0.453
LIG_LIR_Nem_3	607	613	PF02991	0.453
LIG_MAD2	692	700	PF02301	0.514
LIG_NRBOX	282	288	PF00104	0.464
LIG_Pex14_2	515	519	PF04695	0.478
LIG_PTB_Apo_2	389	396	PF02174	0.539
LIG_SH2_CRK	280	284	PF00017	0.453
LIG_SH2_CRK	601	605	PF00017	0.478
LIG_SH2_GRB2like	123	126	PF00017	0.572
LIG_SH2_GRB2like	55	58	PF00017	0.608
LIG_SH2_GRB2like	612	615	PF00017	0.463
LIG_SH2_NCK_1	214	218	PF00017	0.514
LIG_SH2_NCK_1	601	605	PF00017	0.478
LIG_SH2_PTP2	238	241	PF00017	0.478
LIG_SH2_SRC	367	370	PF00017	0.558
LIG_SH2_STAP1	403	407	PF00017	0.565
LIG_SH2_STAT3	707	710	PF00017	0.400
LIG_SH2_STAT5	120	123	PF00017	0.478
LIG_SH2_STAT5	238	241	PF00017	0.476
LIG_SH2_STAT5	335	338	PF00017	0.470
LIG_SH2_STAT5	367	370	PF00017	0.467
LIG_SH2_STAT5	487	490	PF00017	0.466
LIG_SH2_STAT5	55	58	PF00017	0.666
LIG_SH2_STAT5	589	592	PF00017	0.453
LIG_SH2_STAT5	610	613	PF00017	0.453
LIG_SH2_STAT5	687	690	PF00017	0.539
LIG_SH2_STAT5	707	710	PF00017	0.217
LIG_SH2_STAT5	99	102	PF00017	0.571
LIG_SH3_1	390	396	PF00018	0.539
LIG_SH3_2	393	398	PF14604	0.539
LIG_SH3_3	241	247	PF00018	0.453
LIG_SH3_3	27	33	PF00018	0.694
LIG_SH3_3	359	365	PF00018	0.531
LIG_SH3_3	390	396	PF00018	0.539
LIG_SH3_3	637	643	PF00018	0.475
LIG_TRFH_1	223	227	PF08558	0.453
MOD_CDK_SPxxK_3	275	282	PF00069	0.453
MOD_CK1_1	103	109	PF00069	0.718
MOD_CK1_1	118	124	PF00069	0.545
MOD_CK1_1	22	28	PF00069	0.692
MOD_CK1_1	435	441	PF00069	0.453
MOD_CK1_1	538	544	PF00069	0.516
MOD_CK2_1	127	133	PF00069	0.527
MOD_CK2_1	246	252	PF00069	0.453
MOD_CK2_1	680	686	PF00069	0.514
MOD_Cter_Amidation	217	220	PF01082	0.262
MOD_Cter_Amidation	233	236	PF01082	0.221
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.553
MOD_GlcNHglycan	117	120	PF01048	0.555
MOD_GlcNHglycan	204	207	PF01048	0.253
MOD_GlcNHglycan	227	230	PF01048	0.264
MOD_GlcNHglycan	288	291	PF01048	0.253
MOD_GlcNHglycan	437	440	PF01048	0.253
MOD_GlcNHglycan	488	491	PF01048	0.258
MOD_GlcNHglycan	553	556	PF01048	0.291
MOD_GlcNHglycan	592	595	PF01048	0.253
MOD_GSK3_1	11	18	PF00069	0.780
MOD_GSK3_1	154	161	PF00069	0.476
MOD_GSK3_1	19	26	PF00069	0.752
MOD_GSK3_1	286	293	PF00069	0.451
MOD_GSK3_1	36	43	PF00069	0.746
MOD_GSK3_1	419	426	PF00069	0.453
MOD_GSK3_1	434	441	PF00069	0.453
MOD_GSK3_1	97	104	PF00069	0.733
MOD_N-GLC_1	10	15	PF02516	0.746
MOD_N-GLC_1	101	106	PF02516	0.752
MOD_N-GLC_1	291	296	PF02516	0.264
MOD_N-GLC_1	342	347	PF02516	0.339
MOD_N-GLC_2	273	275	PF02516	0.339
MOD_NEK2_1	158	163	PF00069	0.462
MOD_NEK2_1	286	291	PF00069	0.461
MOD_NEK2_1	41	46	PF00069	0.605
MOD_NEK2_1	432	437	PF00069	0.453
MOD_NEK2_1	447	452	PF00069	0.453
MOD_NEK2_1	590	595	PF00069	0.458
MOD_NEK2_2	134	139	PF00069	0.579
MOD_NEK2_2	154	159	PF00069	0.215
MOD_NEK2_2	209	214	PF00069	0.453
MOD_PIKK_1	447	453	PF00454	0.522
MOD_PIKK_1	87	93	PF00454	0.714
MOD_PK_1	456	462	PF00069	0.501
MOD_PK_1	692	698	PF00069	0.453
MOD_PK_1	71	77	PF00069	0.755
MOD_PK_1	92	98	PF00069	0.804
MOD_Plk_1	154	160	PF00069	0.435
MOD_Plk_1	291	297	PF00069	0.464
MOD_Plk_1	320	326	PF00069	0.537
MOD_Plk_1	399	405	PF00069	0.503
MOD_Plk_2-3	246	252	PF00069	0.453
MOD_Plk_4	118	124	PF00069	0.628
MOD_Plk_4	127	133	PF00069	0.409
MOD_Plk_4	158	164	PF00069	0.445
MOD_Plk_4	209	215	PF00069	0.447
MOD_Plk_4	246	252	PF00069	0.558
MOD_Plk_4	331	337	PF00069	0.465
MOD_Plk_4	419	425	PF00069	0.449
MOD_Plk_4	456	462	PF00069	0.490
MOD_Plk_4	478	484	PF00069	0.478
MOD_ProDKin_1	11	17	PF00069	0.769
MOD_ProDKin_1	19	25	PF00069	0.740
MOD_ProDKin_1	275	281	PF00069	0.453
MOD_ProDKin_1	29	35	PF00069	0.692
TRG_DiLeu_BaEn_1	254	259	PF01217	0.464
TRG_ENDOCYTIC_2	132	135	PF00928	0.398
TRG_ENDOCYTIC_2	163	166	PF00928	0.366
TRG_ENDOCYTIC_2	280	283	PF00928	0.453
TRG_ENDOCYTIC_2	335	338	PF00928	0.453
TRG_ENDOCYTIC_2	589	592	PF00928	0.453
TRG_ENDOCYTIC_2	601	604	PF00928	0.453
TRG_ER_diArg_1	147	149	PF00400	0.591
TRG_ER_diArg_1	3	5	PF00400	0.754
TRG_ER_diArg_1	324	327	PF00400	0.464
TRG_ER_diArg_1	668	670	PF00400	0.539
TRG_NLS_MonoCore_2	565	570	PF00514	0.464
TRG_NLS_MonoCore_2	666	671	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY9	Leptomonas seymouri	75%	100%
A0A0S4JP31	Bodo saltans	66%	100%
A0A1X0NMZ2	Trypanosomatidae	70%	100%
A0A422NLD0	Trypanosoma rangeli	67%	100%
A2XD35	Oryza sativa subsp. indica	24%	100%
A4H7A3	Leishmania braziliensis	87%	100%
A4HVP7	Leishmania infantum	99%	100%
A7LBL2	Leishmania donovani	99%	100%
A9TIK2	Physcomitrium patens	23%	100%
C5WVW2	Sorghum bicolor	24%	100%
D0A6J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9APE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O24578	Zea mays	24%	100%
Q017T9	Ostreococcus tauri	23%	100%
Q10R17	Oryza sativa subsp. japonica	24%	100%
Q386E7	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	68%	100%
Q4CWX1	Trypanosoma cruzi (strain CL Brener)	71%	100%
Q4DLT6	Trypanosoma cruzi (strain CL Brener)	71%	100%
Q4QG35	Leishmania major	95%	100%
Q851S8	Oryza sativa subsp. japonica	23%	100%
Q96529	Arabidopsis thaliana	24%	100%
V5BBP4	Trypanosoma cruzi	71%	100%