Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6P2_LEIDO

TriTrypDb:

LdBPK_130890.1 , LdCL_130014300 , LDHU3_13.1110

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.670
CLV_C14_Caspase3-7	311	315	PF00656	0.720
CLV_NRD_NRD_1	114	116	PF00675	0.637
CLV_NRD_NRD_1	158	160	PF00675	0.692
CLV_NRD_NRD_1	213	215	PF00675	0.535
CLV_NRD_NRD_1	273	275	PF00675	0.643
CLV_NRD_NRD_1	286	288	PF00675	0.551
CLV_NRD_NRD_1	347	349	PF00675	0.639
CLV_NRD_NRD_1	350	352	PF00675	0.599
CLV_NRD_NRD_1	366	368	PF00675	0.489
CLV_NRD_NRD_1	52	54	PF00675	0.587
CLV_PCSK_FUR_1	211	215	PF00082	0.496
CLV_PCSK_FUR_1	287	291	PF00082	0.679
CLV_PCSK_FUR_1	348	352	PF00082	0.618
CLV_PCSK_KEX2_1	114	116	PF00082	0.637
CLV_PCSK_KEX2_1	158	160	PF00082	0.692
CLV_PCSK_KEX2_1	213	215	PF00082	0.531
CLV_PCSK_KEX2_1	273	275	PF00082	0.821
CLV_PCSK_KEX2_1	289	291	PF00082	0.583
CLV_PCSK_KEX2_1	347	349	PF00082	0.639
CLV_PCSK_KEX2_1	35	37	PF00082	0.670
CLV_PCSK_KEX2_1	350	352	PF00082	0.599
CLV_PCSK_KEX2_1	366	368	PF00082	0.489
CLV_PCSK_KEX2_1	52	54	PF00082	0.644
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.648
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.613
CLV_PCSK_SKI1_1	350	354	PF00082	0.684
CLV_PCSK_SKI1_1	356	360	PF00082	0.570
CLV_PCSK_SKI1_1	409	413	PF00082	0.404
CLV_PCSK_SKI1_1	422	426	PF00082	0.387
DEG_APCC_DBOX_1	380	388	PF00400	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.673
DEG_SCF_FBW7_1	9	16	PF00400	0.606
DOC_CKS1_1	160	165	PF01111	0.707
DOC_CKS1_1	40	45	PF01111	0.583
DOC_CYCLIN_RxL_1	419	429	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.574
DOC_MAPK_MEF2A_6	231	240	PF00069	0.606
DOC_MAPK_RevD_3	200	214	PF00069	0.501
DOC_PP1_RVXF_1	407	413	PF00149	0.371
DOC_PP4_FxxP_1	440	443	PF00568	0.498
DOC_USP7_MATH_1	13	17	PF00917	0.750
DOC_USP7_MATH_1	164	168	PF00917	0.689
DOC_USP7_MATH_1	173	177	PF00917	0.615
DOC_USP7_MATH_1	24	28	PF00917	0.613
DOC_USP7_MATH_1	30	34	PF00917	0.552
DOC_USP7_MATH_1	377	381	PF00917	0.442
DOC_USP7_MATH_1	59	63	PF00917	0.709
DOC_USP7_MATH_2	189	195	PF00917	0.691
DOC_USP7_UBL2_3	180	184	PF12436	0.689
DOC_USP7_UBL2_3	60	64	PF12436	0.541
DOC_WW_Pin1_4	159	164	PF00397	0.718
DOC_WW_Pin1_4	276	281	PF00397	0.729
DOC_WW_Pin1_4	39	44	PF00397	0.615
DOC_WW_Pin1_4	9	14	PF00397	0.745
LIG_14-3-3_CanoR_1	121	126	PF00244	0.661
LIG_14-3-3_CanoR_1	330	338	PF00244	0.675
LIG_14-3-3_CanoR_1	435	439	PF00244	0.389
LIG_BRCT_BRCA1_1	436	440	PF00533	0.455
LIG_Clathr_ClatBox_1	237	241	PF01394	0.587
LIG_FHA_1	64	70	PF00498	0.675
LIG_FHA_1	97	103	PF00498	0.576
LIG_FHA_2	324	330	PF00498	0.628
LIG_FHA_2	331	337	PF00498	0.641
LIG_FHA_2	445	451	PF00498	0.476
LIG_FHA_2	70	76	PF00498	0.576
LIG_LIR_Apic_2	437	443	PF02991	0.484
LIG_LIR_Nem_3	399	404	PF02991	0.403
LIG_LIR_Nem_3	75	81	PF02991	0.507
LIG_Pex14_2	397	401	PF04695	0.414
LIG_SH2_CRK	89	93	PF00017	0.503
LIG_SH2_STAP1	404	408	PF00017	0.405
LIG_SH2_STAP1	96	100	PF00017	0.543
LIG_SH2_STAT5	217	220	PF00017	0.563
LIG_SH2_STAT5	451	454	PF00017	0.470
LIG_SH2_STAT5	89	92	PF00017	0.533
LIG_SH3_3	157	163	PF00018	0.692
LIG_SH3_3	223	229	PF00018	0.524
LIG_SH3_3	34	40	PF00018	0.653
LIG_SUMO_SIM_par_1	66	72	PF11976	0.580
LIG_SUMO_SIM_par_1	97	103	PF11976	0.576
LIG_TRFH_1	428	432	PF08558	0.494
LIG_UBA3_1	237	242	PF00899	0.571
MOD_CK1_1	167	173	PF00069	0.604
MOD_CK1_1	194	200	PF00069	0.668
MOD_CK1_1	276	282	PF00069	0.729
MOD_CK1_1	3	9	PF00069	0.709
MOD_CK1_1	399	405	PF00069	0.375
MOD_CK1_1	91	97	PF00069	0.464
MOD_CK2_1	323	329	PF00069	0.671
MOD_CK2_1	399	405	PF00069	0.375
MOD_CK2_1	444	450	PF00069	0.481
MOD_CK2_1	456	462	PF00069	0.544
MOD_CK2_1	69	75	PF00069	0.619
MOD_CK2_1	91	97	PF00069	0.597
MOD_Cter_Amidation	33	36	PF01082	0.620
MOD_Cter_Amidation	345	348	PF01082	0.658
MOD_DYRK1A_RPxSP_1	159	163	PF00069	0.693
MOD_GlcNHglycan	134	137	PF01048	0.635
MOD_GlcNHglycan	177	180	PF01048	0.776
MOD_GlcNHglycan	243	246	PF01048	0.796
MOD_GlcNHglycan	26	29	PF01048	0.731
MOD_GlcNHglycan	275	278	PF01048	0.753
MOD_GlcNHglycan	3	6	PF01048	0.739
MOD_GlcNHglycan	32	35	PF01048	0.668
MOD_GlcNHglycan	356	359	PF01048	0.609
MOD_GSK3_1	128	135	PF00069	0.487
MOD_GSK3_1	154	161	PF00069	0.651
MOD_GSK3_1	167	174	PF00069	0.628
MOD_GSK3_1	252	259	PF00069	0.722
MOD_GSK3_1	279	286	PF00069	0.745
MOD_GSK3_1	346	353	PF00069	0.759
MOD_GSK3_1	434	441	PF00069	0.385
MOD_GSK3_1	59	66	PF00069	0.637
MOD_GSK3_1	9	16	PF00069	0.699
MOD_LATS_1	328	334	PF00433	0.672
MOD_LATS_1	45	51	PF00433	0.613
MOD_N-GLC_1	24	29	PF02516	0.728
MOD_N-GLC_1	456	461	PF02516	0.530
MOD_NEK2_1	1	6	PF00069	0.828
MOD_NEK2_1	151	156	PF00069	0.654
MOD_NEK2_1	352	357	PF00069	0.666
MOD_NEK2_1	434	439	PF00069	0.409
MOD_NEK2_1	444	449	PF00069	0.319
MOD_NEK2_2	136	141	PF00069	0.465
MOD_NEK2_2	88	93	PF00069	0.451
MOD_PIKK_1	451	457	PF00454	0.426
MOD_PKA_1	158	164	PF00069	0.647
MOD_PKA_1	273	279	PF00069	0.644
MOD_PKA_1	350	356	PF00069	0.653
MOD_PKA_2	158	164	PF00069	0.647
MOD_PKA_2	273	279	PF00069	0.644
MOD_PKA_2	346	352	PF00069	0.765
MOD_PKA_2	434	440	PF00069	0.383
MOD_PKB_1	128	136	PF00069	0.479
MOD_PKB_1	348	356	PF00069	0.633
MOD_Plk_1	136	142	PF00069	0.467
MOD_Plk_1	194	200	PF00069	0.625
MOD_Plk_1	456	462	PF00069	0.544
MOD_Plk_1	96	102	PF00069	0.548
MOD_Plk_2-3	456	462	PF00069	0.544
MOD_Plk_4	356	362	PF00069	0.618
MOD_Plk_4	414	420	PF00069	0.374
MOD_Plk_4	434	440	PF00069	0.379
MOD_Plk_4	65	71	PF00069	0.593
MOD_ProDKin_1	159	165	PF00069	0.719
MOD_ProDKin_1	276	282	PF00069	0.731
MOD_ProDKin_1	39	45	PF00069	0.618
MOD_ProDKin_1	9	15	PF00069	0.747
MOD_SUMO_for_1	257	260	PF00179	0.711
MOD_SUMO_for_1	308	311	PF00179	0.721
MOD_SUMO_rev_2	161	170	PF00179	0.665
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.564
TRG_ENDOCYTIC_2	89	92	PF00928	0.493
TRG_ER_diArg_1	114	116	PF00400	0.656
TRG_ER_diArg_1	127	130	PF00400	0.416
TRG_ER_diArg_1	158	160	PF00400	0.689
TRG_ER_diArg_1	210	213	PF00400	0.508
TRG_ER_diArg_1	290	293	PF00400	0.720
TRG_ER_diArg_1	347	350	PF00400	0.616
TRG_ER_diArg_1	365	367	PF00400	0.527
TRG_ER_diArg_1	387	390	PF00400	0.395
TRG_NLS_Bipartite_1	273	293	PF00514	0.585
TRG_NLS_MonoCore_2	286	291	PF00514	0.594
TRG_NLS_MonoExtC_3	287	292	PF00514	0.593
TRG_NLS_MonoExtN_4	284	291	PF00514	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7S2	Leptomonas seymouri	49%	100%
A4H788	Leishmania braziliensis	72%	100%
A4HVM8	Leishmania infantum	100%	100%
E9APC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QG54	Leishmania major	89%	100%