C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6P0_LEIDO

TriTrypDb:

LdBPK_130770.1 , LdCL_130013100 , LDHU3_13.0980

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6P0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.664
CLV_C14_Caspase3-7	637	641	PF00656	0.684
CLV_NRD_NRD_1	219	221	PF00675	0.677
CLV_NRD_NRD_1	285	287	PF00675	0.649
CLV_NRD_NRD_1	307	309	PF00675	0.632
CLV_NRD_NRD_1	497	499	PF00675	0.587
CLV_NRD_NRD_1	81	83	PF00675	0.475
CLV_PCSK_KEX2_1	219	221	PF00082	0.677
CLV_PCSK_KEX2_1	285	287	PF00082	0.649
CLV_PCSK_KEX2_1	307	309	PF00082	0.632
CLV_PCSK_KEX2_1	486	488	PF00082	0.518
CLV_PCSK_KEX2_1	497	499	PF00082	0.528
CLV_PCSK_KEX2_1	676	678	PF00082	0.637
CLV_PCSK_KEX2_1	688	690	PF00082	0.623
CLV_PCSK_KEX2_1	81	83	PF00082	0.475
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.518
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.637
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.623
CLV_PCSK_SKI1_1	382	386	PF00082	0.448
CLV_PCSK_SKI1_1	451	455	PF00082	0.549
CLV_PCSK_SKI1_1	684	688	PF00082	0.690
DEG_SCF_FBW7_1	125	130	PF00400	0.652
DEG_SPOP_SBC_1	127	131	PF00917	0.630
DOC_AGCK_PIF_2	45	50	PF00069	0.513
DOC_CKS1_1	124	129	PF01111	0.660
DOC_CKS1_1	35	40	PF01111	0.480
DOC_MAPK_DCC_7	327	335	PF00069	0.522
DOC_MAPK_gen_1	387	394	PF00069	0.562
DOC_MAPK_MEF2A_6	387	394	PF00069	0.408
DOC_MAPK_NFAT4_5	387	395	PF00069	0.492
DOC_PP2B_LxvP_1	15	18	PF13499	0.567
DOC_USP7_MATH_1	127	131	PF00917	0.635
DOC_USP7_MATH_1	143	147	PF00917	0.493
DOC_USP7_MATH_1	522	526	PF00917	0.628
DOC_USP7_MATH_1	543	547	PF00917	0.728
DOC_USP7_MATH_1	552	556	PF00917	0.623
DOC_USP7_MATH_1	580	584	PF00917	0.717
DOC_USP7_MATH_1	586	590	PF00917	0.663
DOC_USP7_MATH_1	613	617	PF00917	0.668
DOC_USP7_MATH_1	664	668	PF00917	0.818
DOC_USP7_UBL2_3	451	455	PF12436	0.509
DOC_USP7_UBL2_3	584	588	PF12436	0.643
DOC_USP7_UBL2_3	666	670	PF12436	0.653
DOC_USP7_UBL2_3	671	675	PF12436	0.630
DOC_USP7_UBL2_3	684	688	PF12436	0.517
DOC_WW_Pin1_4	123	128	PF00397	0.711
DOC_WW_Pin1_4	20	25	PF00397	0.562
DOC_WW_Pin1_4	34	39	PF00397	0.522
DOC_WW_Pin1_4	560	565	PF00397	0.648
DOC_WW_Pin1_4	582	587	PF00397	0.646
DOC_WW_Pin1_4	66	71	PF00397	0.488
DOC_WW_Pin1_4	95	100	PF00397	0.655
LIG_14-3-3_CanoR_1	321	327	PF00244	0.624
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	41	45	PF00533	0.455
LIG_CSL_BTD_1	15	18	PF09270	0.567
LIG_CtBP_PxDLS_1	38	42	PF00389	0.465
LIG_EH1_1	259	267	PF00400	0.562
LIG_FHA_1	12	18	PF00498	0.555
LIG_FHA_1	166	172	PF00498	0.602
LIG_FHA_1	25	31	PF00498	0.544
LIG_FHA_1	364	370	PF00498	0.475
LIG_FHA_2	337	343	PF00498	0.570
LIG_FHA_2	35	41	PF00498	0.573
LIG_FHA_2	596	602	PF00498	0.633
LIG_FHA_2	67	73	PF00498	0.479
LIG_IBAR_NPY_1	258	260	PF08397	0.646
LIG_Integrin_isoDGR_2	11	13	PF01839	0.633
LIG_Integrin_RGD_1	216	218	PF01839	0.690
LIG_IRF3_LxIS_1	5	10	PF10401	0.577
LIG_LIR_Apic_2	287	293	PF02991	0.640
LIG_LIR_Apic_2	346	351	PF02991	0.443
LIG_LIR_Gen_1	397	406	PF02991	0.551
LIG_LIR_Nem_3	397	401	PF02991	0.531
LIG_LIR_Nem_3	416	421	PF02991	0.433
LIG_LIR_Nem_3	42	48	PF02991	0.486
LIG_LIR_Nem_3	79	83	PF02991	0.478
LIG_NRBOX	166	172	PF00104	0.526
LIG_SH2_CRK	348	352	PF00017	0.467
LIG_SH2_CRK	96	100	PF00017	0.657
LIG_SH2_GRB2like	348	351	PF00017	0.457
LIG_SH2_NCK_1	96	100	PF00017	0.657
LIG_SH2_PTP2	35	38	PF00017	0.486
LIG_SH2_STAP1	232	236	PF00017	0.670
LIG_SH2_STAP1	50	54	PF00017	0.564
LIG_SH2_STAT3	50	53	PF00017	0.495
LIG_SH2_STAT5	35	38	PF00017	0.486
LIG_SH2_STAT5	423	426	PF00017	0.450
LIG_SH2_STAT5	46	49	PF00017	0.523
LIG_SH2_STAT5	512	515	PF00017	0.641
LIG_SH2_STAT5	8	11	PF00017	0.522
LIG_SH3_3	243	249	PF00018	0.586
LIG_SH3_3	335	341	PF00018	0.545
LIG_SH3_4	671	678	PF00018	0.701
LIG_TRAF2_1	397	400	PF00917	0.539
LIG_TRAF2_1	641	644	PF00917	0.830
LIG_UBA3_1	461	470	PF00899	0.493
MOD_CDK_SPxK_1	582	588	PF00069	0.646
MOD_CK1_1	130	136	PF00069	0.609
MOD_CK1_1	141	147	PF00069	0.744
MOD_CK1_1	562	568	PF00069	0.579
MOD_CK1_1	609	615	PF00069	0.656
MOD_CK1_1	616	622	PF00069	0.624
MOD_CK2_1	20	26	PF00069	0.549
MOD_CK2_1	336	342	PF00069	0.576
MOD_CK2_1	34	40	PF00069	0.487
MOD_CK2_1	394	400	PF00069	0.527
MOD_CK2_1	527	533	PF00069	0.641
MOD_CK2_1	66	72	PF00069	0.489
MOD_Cter_Amidation	283	286	PF01082	0.617
MOD_Cter_Amidation	385	388	PF01082	0.514
MOD_GlcNHglycan	1	4	PF01048	0.536
MOD_GlcNHglycan	141	144	PF01048	0.693
MOD_GlcNHglycan	145	148	PF01048	0.668
MOD_GlcNHglycan	162	165	PF01048	0.457
MOD_GlcNHglycan	181	184	PF01048	0.546
MOD_GlcNHglycan	282	285	PF01048	0.632
MOD_GlcNHglycan	515	518	PF01048	0.698
MOD_GlcNHglycan	550	553	PF01048	0.720
MOD_GlcNHglycan	571	574	PF01048	0.662
MOD_GlcNHglycan	611	614	PF01048	0.663
MOD_GlcNHglycan	630	634	PF01048	0.734
MOD_GSK3_1	123	130	PF00069	0.686
MOD_GSK3_1	138	145	PF00069	0.514
MOD_GSK3_1	175	182	PF00069	0.660
MOD_GSK3_1	18	25	PF00069	0.508
MOD_GSK3_1	226	233	PF00069	0.578
MOD_GSK3_1	280	287	PF00069	0.663
MOD_GSK3_1	309	316	PF00069	0.702
MOD_GSK3_1	513	520	PF00069	0.622
MOD_GSK3_1	548	555	PF00069	0.717
MOD_GSK3_1	576	583	PF00069	0.680
MOD_GSK3_1	607	614	PF00069	0.642
MOD_GSK3_1	615	622	PF00069	0.634
MOD_GSK3_1	7	14	PF00069	0.595
MOD_N-GLC_1	184	189	PF02516	0.690
MOD_NEK2_1	138	143	PF00069	0.657
MOD_NEK2_1	230	235	PF00069	0.669
MOD_NEK2_1	303	308	PF00069	0.623
MOD_NEK2_1	322	327	PF00069	0.469
MOD_NEK2_1	39	44	PF00069	0.458
MOD_NEK2_1	511	516	PF00069	0.671
MOD_NEK2_1	559	564	PF00069	0.603
MOD_NEK2_1	7	12	PF00069	0.527
MOD_PIKK_1	130	136	PF00454	0.636
MOD_PIKK_1	165	171	PF00454	0.602
MOD_PIKK_1	230	236	PF00454	0.670
MOD_PIKK_1	311	317	PF00454	0.704
MOD_PIKK_1	503	509	PF00454	0.747
MOD_PIKK_1	517	523	PF00454	0.524
MOD_PIKK_1	536	542	PF00454	0.655
MOD_PIKK_1	543	549	PF00454	0.640
MOD_PIKK_1	562	568	PF00454	0.529
MOD_PKA_1	684	690	PF00069	0.702
MOD_PKA_2	18	24	PF00069	0.594
MOD_PKA_2	284	290	PF00069	0.699
MOD_Plk_2-3	336	342	PF00069	0.524
MOD_Plk_2-3	527	533	PF00069	0.641
MOD_Plk_4	343	349	PF00069	0.439
MOD_Plk_4	363	369	PF00069	0.478
MOD_Plk_4	552	558	PF00069	0.749
MOD_ProDKin_1	123	129	PF00069	0.711
MOD_ProDKin_1	20	26	PF00069	0.556
MOD_ProDKin_1	34	40	PF00069	0.514
MOD_ProDKin_1	560	566	PF00069	0.649
MOD_ProDKin_1	582	588	PF00069	0.647
MOD_ProDKin_1	66	72	PF00069	0.489
MOD_ProDKin_1	95	101	PF00069	0.659
MOD_SUMO_rev_2	23	30	PF00179	0.625
MOD_SUMO_rev_2	342	347	PF00179	0.503
MOD_SUMO_rev_2	377	384	PF00179	0.476
MOD_SUMO_rev_2	397	404	PF00179	0.485
MOD_SUMO_rev_2	481	488	PF00179	0.602
MOD_SUMO_rev_2	655	664	PF00179	0.649
TRG_DiLeu_BaEn_2	85	91	PF01217	0.512
TRG_ENDOCYTIC_2	254	257	PF00928	0.735
TRG_ER_diArg_1	219	221	PF00400	0.702
TRG_ER_diArg_1	80	82	PF00400	0.473
TRG_NLS_Bipartite_1	665	680	PF00514	0.693
TRG_NLS_MonoExtC_3	674	679	PF00514	0.632
TRG_NLS_MonoExtC_3	687	692	PF00514	0.621
TRG_NLS_MonoExtN_4	663	669	PF00514	0.645
TRG_NLS_MonoExtN_4	672	679	PF00514	0.618
TRG_NLS_MonoExtN_4	685	692	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX4	Leptomonas seymouri	54%	100%
A4H776	Leishmania braziliensis	86%	99%
A4HVL6	Leishmania infantum	99%	100%
E9APB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QG66	Leishmania major	95%	100%