40S ribosomal protein S12

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S12, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6N5_LEIDO

TriTrypDb:

LdBPK_130460.1 , LdCL_130010000 , LDHU3_13.0630

Length:

141

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S12

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	yes	yes: 3
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005840	ribosome	5	13
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0044391	ribosomal subunit	3	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6N5

PDB structure(s): 6az1_Q

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14

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Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.305
CLV_PCSK_KEX2_1	105	107	PF00082	0.315
CLV_PCSK_SKI1_1	114	118	PF00082	0.248
CLV_PCSK_SKI1_1	75	79	PF00082	0.255
DOC_MAPK_gen_1	114	123	PF00069	0.458
LIG_14-3-3_CanoR_1	45	54	PF00244	0.468
LIG_Actin_WH2_2	101	119	PF00022	0.500
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_Clathr_ClatBox_1	88	92	PF01394	0.484
LIG_FAT_LD_1	133	141	PF03623	0.504

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9F8	Leptomonas seymouri	94%	100%
A0A0S4JTV1	Bodo saltans	66%	100%
A0A1X0NN59	Trypanosomatidae	74%	100%
A0A1X0NN85	Trypanosomatidae	69%	99%
A0A3R7KVC2	Trypanosoma rangeli	62%	99%
A0A3R7M2B9	Trypanosoma rangeli	69%	100%
A4H746	Leishmania braziliensis	94%	100%
A4HVI6	Leishmania infantum	100%	100%
D0A3U0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
D0A6S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	98%

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