40S ribosomal protein S12

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S12, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6N5_LEIDO

TriTrypDb:

LdBPK_130460.1 , LdCL_130010000 , LDHU3_13.0630

Length:

141

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S12

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	yes	yes: 3
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005737	cytoplasm	2	1
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6N5

PDB structure(s): 6az1_Q

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.305
CLV_PCSK_KEX2_1	105	107	PF00082	0.315
CLV_PCSK_SKI1_1	114	118	PF00082	0.248
CLV_PCSK_SKI1_1	75	79	PF00082	0.255
DOC_MAPK_gen_1	114	123	PF00069	0.458
LIG_14-3-3_CanoR_1	45	54	PF00244	0.468
LIG_Actin_WH2_2	101	119	PF00022	0.500
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_Clathr_ClatBox_1	88	92	PF01394	0.484
LIG_FAT_LD_1	133	141	PF03623	0.504
LIG_FHA_1	111	117	PF00498	0.519
LIG_FHA_1	128	134	PF00498	0.415
LIG_FHA_1	3	9	PF00498	0.617
LIG_LIR_Nem_3	70	76	PF02991	0.459
LIG_NRBOX	132	138	PF00104	0.483
LIG_SH2_CRK	73	77	PF00017	0.460
LIG_SH2_STAT5	135	138	PF00017	0.540
LIG_SH3_3	5	11	PF00018	0.599
LIG_TRAF2_1	12	15	PF00917	0.713
MOD_GSK3_1	112	119	PF00069	0.452
MOD_NEK2_1	116	121	PF00069	0.465
MOD_NEK2_2	2	7	PF00069	0.644
MOD_PIKK_1	135	141	PF00454	0.574
MOD_PK_1	117	123	PF00069	0.528
MOD_Plk_1	2	8	PF00069	0.656
MOD_SUMO_rev_2	49	59	PF00179	0.533
MOD_SUMO_rev_2	66	76	PF00179	0.370
TRG_DiLeu_BaEn_1	39	44	PF01217	0.455
TRG_DiLeu_BaEn_1	72	77	PF01217	0.463
TRG_DiLeu_BaEn_4	92	98	PF01217	0.511
TRG_ENDOCYTIC_2	73	76	PF00928	0.460
TRG_ER_diArg_1	104	106	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9F8	Leptomonas seymouri	94%	100%
A0A0S4JTV1	Bodo saltans	66%	100%
A0A1X0NN59	Trypanosomatidae	74%	100%
A0A1X0NN85	Trypanosomatidae	69%	99%
A0A3R7KVC2	Trypanosoma rangeli	62%	99%
A0A3R7M2B9	Trypanosoma rangeli	69%	100%
A4H746	Leishmania braziliensis	94%	100%
A4HVI6	Leishmania infantum	100%	100%
D0A3U0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
D0A6S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	98%
E9AP81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O13019	Oreochromis niloticus	39%	100%
O14062	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	97%
O59936	Blumeria hordei	38%	100%
O74322	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	95%
O97249	Plasmodium falciparum (isolate 3D7)	39%	100%
P25398	Homo sapiens	40%	100%
P46405	Sus scrofa	40%	100%
P47840	Xenopus laevis	40%	100%
P48589	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	99%
P49196	Caenorhabditis elegans	35%	100%
P63323	Mus musculus	40%	100%
P63324	Rattus norvegicus	40%	100%
P80455	Drosophila melanogaster	41%	100%
P84175	Gallus gallus	40%	100%
Q03253	Trypanosoma brucei brucei	69%	98%
Q4QG97	Leishmania major	99%	100%
Q54PX9	Dictyostelium discoideum	37%	100%
Q5ADQ6	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	99%
Q76I81	Bos taurus	40%	100%
Q9S9P1	Arabidopsis thaliana	37%	98%
Q9SKZ3	Arabidopsis thaliana	38%	98%
Q9SMI3	Cyanophora paradoxa	37%	100%
Q9XHS0	Hordeum vulgare	36%	99%