Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6N4_LEIDO

TriTrypDb:

LdBPK_130400.1 , LdCL_130009400 , LDHU3_13.0560

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.709
CLV_NRD_NRD_1	175	177	PF00675	0.598
CLV_NRD_NRD_1	32	34	PF00675	0.558
CLV_NRD_NRD_1	41	43	PF00675	0.650
CLV_PCSK_KEX2_1	16	18	PF00082	0.706
CLV_PCSK_KEX2_1	175	177	PF00082	0.582
CLV_PCSK_KEX2_1	247	249	PF00082	0.818
CLV_PCSK_KEX2_1	32	34	PF00082	0.553
CLV_PCSK_KEX2_1	41	43	PF00082	0.641
CLV_PCSK_KEX2_1	75	77	PF00082	0.566
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.635
DEG_Nend_UBRbox_2	1	3	PF02207	0.703
DEG_SCF_FBW7_1	4	11	PF00400	0.754
DOC_CYCLIN_RxL_1	172	182	PF00134	0.652
DOC_MAPK_MEF2A_6	162	171	PF00069	0.703
DOC_MAPK_RevD_3	61	76	PF00069	0.700
DOC_PP1_RVXF_1	173	180	PF00149	0.682
DOC_PP2B_LxvP_1	236	239	PF13499	0.682
DOC_USP7_MATH_1	138	142	PF00917	0.443
DOC_USP7_MATH_1	243	247	PF00917	0.706
DOC_USP7_MATH_1	25	29	PF00917	0.682
DOC_USP7_MATH_1	8	12	PF00917	0.735
DOC_WW_Pin1_4	134	139	PF00397	0.684
DOC_WW_Pin1_4	4	9	PF00397	0.724
LIG_14-3-3_CanoR_1	155	164	PF00244	0.651
LIG_14-3-3_CanoR_1	175	180	PF00244	0.454
LIG_14-3-3_CanoR_1	64	72	PF00244	0.650
LIG_Actin_WH2_2	209	225	PF00022	0.655
LIG_FHA_1	105	111	PF00498	0.660
LIG_FHA_1	149	155	PF00498	0.696
LIG_FHA_1	186	192	PF00498	0.604
LIG_FHA_2	5	11	PF00498	0.731
LIG_FHA_2	98	104	PF00498	0.643
LIG_Integrin_RGD_1	121	123	PF01839	0.706
LIG_LIR_Gen_1	85	92	PF02991	0.722
LIG_LIR_Nem_3	85	90	PF02991	0.730
LIG_NRP_CendR_1	247	249	PF00754	0.830
LIG_SH2_PTP2	135	138	PF00017	0.678
LIG_SH2_STAP1	30	34	PF00017	0.544
LIG_SH2_STAT3	34	37	PF00017	0.711
LIG_SH2_STAT5	135	138	PF00017	0.640
LIG_SH2_STAT5	230	233	PF00017	0.649
LIG_SH2_STAT5	62	65	PF00017	0.691
LIG_SH3_3	218	224	PF00018	0.651
LIG_SUMO_SIM_par_1	76	81	PF11976	0.566
LIG_TRAF2_1	100	103	PF00917	0.656
LIG_TYR_ITIM	60	65	PF00017	0.485
LIG_WRC_WIRS_1	192	197	PF05994	0.631
LIG_WW_3	237	241	PF00397	0.649
MOD_CK1_1	141	147	PF00069	0.603
MOD_CK1_1	178	184	PF00069	0.707
MOD_CK1_1	194	200	PF00069	0.417
MOD_CK2_1	178	184	PF00069	0.583
MOD_CK2_1	4	10	PF00069	0.750
MOD_CK2_1	97	103	PF00069	0.663
MOD_GlcNHglycan	10	13	PF01048	0.666
MOD_GlcNHglycan	143	146	PF01048	0.646
MOD_GlcNHglycan	158	161	PF01048	0.590
MOD_GlcNHglycan	217	220	PF01048	0.704
MOD_GlcNHglycan	55	58	PF01048	0.569
MOD_GlcNHglycan	65	68	PF01048	0.514
MOD_GSK3_1	134	141	PF00069	0.607
MOD_GSK3_1	239	246	PF00069	0.553
MOD_GSK3_1	4	11	PF00069	0.690
MOD_GSK3_1	41	48	PF00069	0.672
MOD_GSK3_1	78	85	PF00069	0.562
MOD_GSK3_1	88	95	PF00069	0.560
MOD_N-GLC_1	88	93	PF02516	0.613
MOD_NEK2_1	63	68	PF00069	0.656
MOD_NEK2_2	104	109	PF00069	0.687
MOD_PIKK_1	33	39	PF00454	0.685
MOD_PKA_1	175	181	PF00069	0.594
MOD_PKA_1	32	38	PF00069	0.662
MOD_PKA_1	41	47	PF00069	0.711
MOD_PKA_2	175	181	PF00069	0.595
MOD_PKA_2	239	245	PF00069	0.675
MOD_PKA_2	32	38	PF00069	0.664
MOD_PKA_2	41	47	PF00069	0.685
MOD_PKA_2	63	69	PF00069	0.557
MOD_PKA_2	92	98	PF00069	0.698
MOD_Plk_2-3	148	154	PF00069	0.492
MOD_Plk_4	191	197	PF00069	0.712
MOD_Plk_4	25	31	PF00069	0.598
MOD_ProDKin_1	134	140	PF00069	0.687
MOD_ProDKin_1	4	10	PF00069	0.727
TRG_ENDOCYTIC_2	62	65	PF00928	0.617
TRG_ER_diArg_1	175	177	PF00400	0.687
TRG_ER_diArg_1	247	249	PF00400	0.812
TRG_ER_diArg_1	32	34	PF00400	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q3	Leptomonas seymouri	58%	85%
A0A1X0NN61	Trypanosomatidae	35%	100%
A0A422NQK2	Trypanosoma rangeli	33%	100%
A4H740	Leishmania braziliensis	80%	100%
A4HVI0	Leishmania infantum	100%	100%
D0A6T1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AP75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QGA3	Leishmania major	93%	100%
V5AVG9	Trypanosoma cruzi	35%	86%