Methyltransferase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6M7_LEIDO

TriTrypDb:

LdBPK_120850.1 , LdCL_120020600 , LDHU3_12.1650

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6M7

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.254
CLV_NRD_NRD_1	84	86	PF00675	0.262
CLV_PCSK_KEX2_1	100	102	PF00082	0.276
CLV_PCSK_KEX2_1	200	202	PF00082	0.313
CLV_PCSK_KEX2_1	298	300	PF00082	0.437
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.304
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.414
CLV_PCSK_SKI1_1	63	67	PF00082	0.247
DOC_CKS1_1	156	161	PF01111	0.280
DOC_CKS1_1	260	265	PF01111	0.280
DOC_MAPK_gen_1	61	68	PF00069	0.243
DOC_MAPK_MEF2A_6	155	163	PF00069	0.316
DOC_MAPK_MEF2A_6	317	325	PF00069	0.302
DOC_MAPK_MEF2A_6	61	68	PF00069	0.243
DOC_PP1_RVXF_1	322	328	PF00149	0.426
DOC_PP4_FxxP_1	260	263	PF00568	0.266
DOC_PP4_MxPP_1	278	281	PF00568	0.465
DOC_USP7_UBL2_3	298	302	PF12436	0.391
DOC_WW_Pin1_4	155	160	PF00397	0.286
DOC_WW_Pin1_4	259	264	PF00397	0.306
DOC_WW_Pin1_4	273	278	PF00397	0.345
LIG_14-3-3_CanoR_1	201	205	PF00244	0.299
LIG_14-3-3_CanoR_1	285	289	PF00244	0.266
LIG_14-3-3_CanoR_1	45	53	PF00244	0.268
LIG_APCC_ABBA_1	256	261	PF00400	0.265
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_BRCT_BRCA1_1	256	260	PF00533	0.279
LIG_deltaCOP1_diTrp_1	134	139	PF00928	0.243
LIG_deltaCOP1_diTrp_1	51	60	PF00928	0.280
LIG_eIF4E_1	290	296	PF01652	0.360
LIG_FHA_1	156	162	PF00498	0.291
LIG_FHA_1	217	223	PF00498	0.336
LIG_FHA_1	240	246	PF00498	0.448
LIG_FHA_1	70	76	PF00498	0.243
LIG_FHA_2	231	237	PF00498	0.345
LIG_IRF3_LxIS_1	316	322	PF10401	0.465
LIG_LIR_Apic_2	154	159	PF02991	0.348
LIG_LIR_Apic_2	203	207	PF02991	0.291
LIG_LIR_Apic_2	257	263	PF02991	0.280
LIG_LIR_Gen_1	105	115	PF02991	0.266
LIG_LIR_Gen_1	195	204	PF02991	0.324
LIG_LIR_Nem_3	105	111	PF02991	0.258
LIG_LIR_Nem_3	133	138	PF02991	0.243
LIG_LIR_Nem_3	186	191	PF02991	0.317
LIG_LIR_Nem_3	195	199	PF02991	0.312
LIG_LIR_Nem_3	24	30	PF02991	0.388
LIG_NRP_CendR_1	341	343	PF00754	0.319
LIG_Pex14_1	135	139	PF04695	0.268
LIG_Pex14_1	54	58	PF04695	0.313
LIG_Pex14_2	239	243	PF04695	0.309
LIG_Pex14_2	260	264	PF04695	0.266
LIG_SH2_PTP2	204	207	PF00017	0.305
LIG_SH2_SRC	204	207	PF00017	0.305
LIG_SH2_STAP1	142	146	PF00017	0.314
LIG_SH2_STAP1	336	340	PF00017	0.315
LIG_SH2_STAT3	180	183	PF00017	0.453
LIG_SH2_STAT5	138	141	PF00017	0.260
LIG_SH2_STAT5	180	183	PF00017	0.350
LIG_SH2_STAT5	198	201	PF00017	0.216
LIG_SH2_STAT5	204	207	PF00017	0.290
LIG_SH2_STAT5	26	29	PF00017	0.354
LIG_SH2_STAT5	290	293	PF00017	0.268
LIG_SH3_3	274	280	PF00018	0.351
LIG_SH3_3	307	313	PF00018	0.475
LIG_SUMO_SIM_anti_2	109	116	PF11976	0.269
LIG_SUMO_SIM_anti_2	125	134	PF11976	0.184
LIG_SUMO_SIM_par_1	269	276	PF11976	0.358
LIG_UBA3_1	291	298	PF00899	0.320
LIG_WRC_WIRS_1	224	229	PF05994	0.275
MOD_CDK_SPxxK_3	155	162	PF00069	0.282
MOD_CK2_1	200	206	PF00069	0.300
MOD_CK2_1	230	236	PF00069	0.341
MOD_GlcNHglycan	166	169	PF01048	0.424
MOD_GlcNHglycan	2	5	PF01048	0.623
MOD_GSK3_1	106	113	PF00069	0.307
MOD_GSK3_1	12	19	PF00069	0.576
MOD_GSK3_1	141	148	PF00069	0.282
MOD_GSK3_1	235	242	PF00069	0.414
MOD_GSK3_1	69	76	PF00069	0.260
MOD_N-GLC_1	273	278	PF02516	0.454
MOD_NEK2_1	141	146	PF00069	0.271
MOD_NEK2_1	194	199	PF00069	0.338
MOD_NEK2_1	237	242	PF00069	0.454
MOD_NEK2_1	319	324	PF00069	0.381
MOD_NEK2_2	303	308	PF00069	0.459
MOD_NEK2_2	73	78	PF00069	0.243
MOD_PKA_1	200	206	PF00069	0.300
MOD_PKA_2	200	206	PF00069	0.300
MOD_PKA_2	284	290	PF00069	0.263
MOD_PKA_2	44	50	PF00069	0.275
MOD_Plk_1	194	200	PF00069	0.308
MOD_Plk_1	235	241	PF00069	0.361
MOD_Plk_1	303	309	PF00069	0.516
MOD_Plk_1	319	325	PF00069	0.313
MOD_Plk_4	12	18	PF00069	0.627
MOD_Plk_4	141	147	PF00069	0.307
MOD_Plk_4	200	206	PF00069	0.304
MOD_Plk_4	284	290	PF00069	0.288
MOD_Plk_4	73	79	PF00069	0.293
MOD_ProDKin_1	155	161	PF00069	0.281
MOD_ProDKin_1	259	265	PF00069	0.317
MOD_ProDKin_1	273	279	PF00069	0.347
MOD_SUMO_rev_2	120	128	PF00179	0.230
MOD_SUMO_rev_2	154	164	PF00179	0.319
MOD_SUMO_rev_2	177	185	PF00179	0.403
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.304
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.365
TRG_ENDOCYTIC_2	138	141	PF00928	0.260
TRG_ENDOCYTIC_2	142	145	PF00928	0.280
TRG_ER_diArg_1	100	102	PF00400	0.282
TRG_ER_diArg_1	340	343	PF00400	0.306
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	25%	86%
A0A0N0P6T9	Leptomonas seymouri	88%	99%
A0A0N0P7Z0	Leptomonas seymouri	29%	95%
A0A0S4IRB2	Bodo saltans	26%	77%
A0A0S4JDH7	Bodo saltans	30%	98%
A0A0S4JQD8	Bodo saltans	27%	92%
A0A0S4JWH9	Bodo saltans	72%	99%
A0A1X0NKR3	Trypanosomatidae	29%	71%
A0A1X0NMC6	Trypanosomatidae	75%	100%
A0A1X0P0F1	Trypanosomatidae	30%	93%
A0A1X0PA69	Trypanosomatidae	24%	82%
A0A3R7MAM8	Trypanosoma rangeli	30%	93%
A0A3R7NHM3	Trypanosoma rangeli	26%	90%
A0A3S7WTR5	Leishmania donovani	32%	94%
A0A422NV18	Trypanosoma rangeli	70%	100%
A0A422NZF0	Trypanosoma rangeli	27%	81%
A0A451EJR0	Leishmania donovani	25%	85%
A2XYY8	Oryza sativa subsp. indica	38%	91%
A2Y953	Oryza sativa subsp. indica	34%	90%
A2Z0C0	Oryza sativa subsp. indica	48%	89%
A2Z8S0	Oryza sativa subsp. indica	37%	87%
A4H8A2	Leishmania braziliensis	27%	100%
A4H8D0	Leishmania braziliensis	31%	100%
A4HWQ2	Leishmania infantum	32%	100%
A8IEF3	Chlamydomonas reinhardtii	50%	99%
B0JYW5	Xenopus tropicalis	35%	100%
B3DLB3	Xenopus tropicalis	33%	79%
C9ZI39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	99%
C9ZPS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%
C9ZTK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	88%
D0A264	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	88%
D9IVE5	Xenopus laevis	33%	79%
E9ACK5	Leishmania major	30%	85%
E9AG49	Leishmania infantum	26%	100%
E9AGI9	Leishmania infantum	99%	100%
E9AIN9	Leishmania braziliensis	92%	100%
E9AJU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AP27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AQF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O82210	Arabidopsis thaliana	49%	94%
P38074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	99%
P55345	Homo sapiens	34%	79%
Q08A71	Arabidopsis thaliana	36%	79%
Q0J2C6	Oryza sativa subsp. japonica	48%	89%
Q28F07	Xenopus tropicalis	51%	98%
Q4QF17	Leishmania major	31%	99%
Q4QGG2	Leishmania major	96%	100%
Q54EF2	Dictyostelium discoideum	47%	100%
Q54HI0	Dictyostelium discoideum	39%	67%
Q582G4	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	25%	88%
Q5E9L5	Bos taurus	35%	91%
Q5RGQ2	Danio rerio	47%	82%
Q63009	Rattus norvegicus	50%	97%
Q68EZ3	Xenopus laevis	35%	100%
Q6NWG4	Danio rerio	41%	98%
Q6NZB1	Mus musculus	36%	91%
Q6PAK3	Mus musculus	48%	87%
Q6VRB0	Xenopus laevis	49%	98%
Q75G68	Oryza sativa subsp. japonica	37%	87%
Q7XKC0	Oryza sativa subsp. japonica	38%	88%
Q8AV13	Xenopus laevis	51%	93%
Q96LA8	Homo sapiens	35%	91%
Q99873	Homo sapiens	50%	92%
Q9JIF0	Mus musculus	50%	92%
Q9MAT5	Arabidopsis thaliana	31%	90%
Q9NR22	Homo sapiens	48%	87%
Q9R144	Mus musculus	34%	77%
Q9SNQ2	Oryza sativa subsp. japonica	34%	90%
Q9SU94	Arabidopsis thaliana	46%	88%
Q9U2X0	Caenorhabditis elegans	47%	99%
Q9URX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
V5ARC3	Trypanosoma cruzi	29%	88%
V5BF38	Trypanosoma cruzi	74%	100%
V5BT47	Trypanosoma cruzi	26%	78%
V5BXE6	Trypanosoma cruzi	26%	89%