Integral membrane protein conserved region (DUF2404), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6M5_LEIDO

TriTrypDb:

LdBPK_120770.1 , LdCL_120019600 , LDHU3_12.1530

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S5H6M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6M5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006869	lipid transport	5	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0071702	organic substance transport	4	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	418	424	PF00089	0.379
CLV_NRD_NRD_1	194	196	PF00675	0.465
CLV_NRD_NRD_1	197	199	PF00675	0.491
CLV_NRD_NRD_1	28	30	PF00675	0.434
CLV_NRD_NRD_1	300	302	PF00675	0.391
CLV_NRD_NRD_1	39	41	PF00675	0.432
CLV_NRD_NRD_1	456	458	PF00675	0.450
CLV_NRD_NRD_1	568	570	PF00675	0.578
CLV_PCSK_FUR_1	195	199	PF00082	0.483
CLV_PCSK_FUR_1	566	570	PF00082	0.469
CLV_PCSK_KEX2_1	194	196	PF00082	0.472
CLV_PCSK_KEX2_1	197	199	PF00082	0.491
CLV_PCSK_KEX2_1	300	302	PF00082	0.391
CLV_PCSK_KEX2_1	568	570	PF00082	0.578
CLV_PCSK_SKI1_1	177	181	PF00082	0.436
CLV_PCSK_SKI1_1	338	342	PF00082	0.367
CLV_PCSK_SKI1_1	41	45	PF00082	0.325
CLV_PCSK_SKI1_1	503	507	PF00082	0.428
CLV_PCSK_SKI1_1	85	89	PF00082	0.307
DEG_SPOP_SBC_1	396	400	PF00917	0.569
DEG_SPOP_SBC_1	605	609	PF00917	0.667
DOC_CDC14_PxL_1	595	603	PF14671	0.652
DOC_CKS1_1	311	316	PF01111	0.647
DOC_CYCLIN_RxL_1	300	313	PF00134	0.627
DOC_CYCLIN_RxL_1	500	509	PF00134	0.569
DOC_MAPK_DCC_7	427	436	PF00069	0.520
DOC_MAPK_gen_1	371	380	PF00069	0.585
DOC_MAPK_gen_1	427	436	PF00069	0.520
DOC_MAPK_HePTP_8	410	422	PF00069	0.513
DOC_MAPK_HePTP_8	424	436	PF00069	0.478
DOC_MAPK_MEF2A_6	158	165	PF00069	0.654
DOC_MAPK_MEF2A_6	289	297	PF00069	0.555
DOC_MAPK_MEF2A_6	371	380	PF00069	0.540
DOC_MAPK_MEF2A_6	413	422	PF00069	0.514
DOC_MAPK_MEF2A_6	427	436	PF00069	0.482
DOC_MAPK_NFAT4_5	158	166	PF00069	0.651
DOC_MAPK_NFAT4_5	373	381	PF00069	0.534
DOC_MAPK_NFAT4_5	413	421	PF00069	0.585
DOC_PP1_RVXF_1	336	342	PF00149	0.538
DOC_PP1_RVXF_1	417	423	PF00149	0.578
DOC_PP1_RVXF_1	468	474	PF00149	0.617
DOC_PP1_RVXF_1	501	508	PF00149	0.566
DOC_PP1_RVXF_1	67	74	PF00149	0.624
DOC_PP2B_LxvP_1	259	262	PF13499	0.602
DOC_PP4_FxxP_1	518	521	PF00568	0.571
DOC_SPAK_OSR1_1	421	425	PF12202	0.550
DOC_SPAK_OSR1_1	448	452	PF12202	0.577
DOC_USP7_MATH_1	246	250	PF00917	0.692
DOC_USP7_MATH_1	262	266	PF00917	0.684
DOC_USP7_MATH_1	362	366	PF00917	0.633
DOC_USP7_MATH_1	396	400	PF00917	0.689
DOC_USP7_MATH_1	492	496	PF00917	0.577
DOC_USP7_MATH_1	545	549	PF00917	0.770
DOC_USP7_MATH_1	694	698	PF00917	0.714
DOC_USP7_UBL2_3	356	360	PF12436	0.555
DOC_USP7_UBL2_3	41	45	PF12436	0.642
DOC_WW_Pin1_4	198	203	PF00397	0.686
DOC_WW_Pin1_4	275	280	PF00397	0.739
DOC_WW_Pin1_4	310	315	PF00397	0.642
DOC_WW_Pin1_4	637	642	PF00397	0.740
DOC_WW_Pin1_4	690	695	PF00397	0.767
LIG_14-3-3_CanoR_1	139	148	PF00244	0.633
LIG_14-3-3_CanoR_1	251	257	PF00244	0.774
LIG_14-3-3_CanoR_1	29	35	PF00244	0.622
LIG_14-3-3_CanoR_1	345	350	PF00244	0.543
LIG_14-3-3_CanoR_1	363	369	PF00244	0.556
LIG_14-3-3_CanoR_1	421	425	PF00244	0.514
LIG_14-3-3_CanoR_1	549	554	PF00244	0.699
LIG_14-3-3_CanoR_1	668	675	PF00244	0.700
LIG_Actin_WH2_2	32	47	PF00022	0.631
LIG_APCC_ABBA_1	161	166	PF00400	0.675
LIG_APCC_ABBA_1	504	509	PF00400	0.617
LIG_APCC_ABBAyCdc20_2	373	379	PF00400	0.607
LIG_APCC_ABBAyCdc20_2	503	509	PF00400	0.619
LIG_BIR_III_4	561	565	PF00653	0.720
LIG_BRCT_BRCA1_1	223	227	PF00533	0.609
LIG_BRCT_BRCA1_1	619	623	PF00533	0.658
LIG_BRCT_BRCA1_1	670	674	PF00533	0.730
LIG_CaM_NSCaTE_8	306	313	PF13499	0.632
LIG_deltaCOP1_diTrp_1	516	523	PF00928	0.619
LIG_FHA_1	16	22	PF00498	0.457
LIG_FHA_1	29	35	PF00498	0.568
LIG_FHA_1	297	303	PF00498	0.567
LIG_FHA_1	472	478	PF00498	0.631
LIG_FHA_1	90	96	PF00498	0.577
LIG_FHA_2	101	107	PF00498	0.651
LIG_FHA_2	202	208	PF00498	0.646
LIG_FHA_2	346	352	PF00498	0.622
LIG_FHA_2	398	404	PF00498	0.640
LIG_GBD_Chelix_1	497	505	PF00786	0.348
LIG_LIR_Apic_2	516	521	PF02991	0.557
LIG_LIR_Gen_1	18	28	PF02991	0.432
LIG_LIR_Gen_1	288	298	PF02991	0.569
LIG_LIR_Gen_1	304	314	PF02991	0.577
LIG_LIR_Gen_1	316	327	PF02991	0.631
LIG_LIR_Gen_1	330	340	PF02991	0.554
LIG_LIR_Gen_1	405	416	PF02991	0.536
LIG_LIR_Gen_1	48	57	PF02991	0.669
LIG_LIR_Gen_1	534	542	PF02991	0.771
LIG_LIR_Nem_3	142	148	PF02991	0.639
LIG_LIR_Nem_3	18	23	PF02991	0.393
LIG_LIR_Nem_3	288	293	PF02991	0.561
LIG_LIR_Nem_3	304	309	PF02991	0.552
LIG_LIR_Nem_3	316	322	PF02991	0.604
LIG_LIR_Nem_3	330	335	PF02991	0.560
LIG_LIR_Nem_3	405	411	PF02991	0.520
LIG_LIR_Nem_3	423	429	PF02991	0.508
LIG_LIR_Nem_3	48	52	PF02991	0.658
LIG_LIR_Nem_3	517	523	PF02991	0.684
LIG_LIR_Nem_3	534	539	PF02991	0.757
LIG_LIR_Nem_3	620	626	PF02991	0.657
LIG_LIR_Nem_3	8	14	PF02991	0.297
LIG_MYND_1	599	603	PF01753	0.735
LIG_MYND_1	641	645	PF01753	0.656
LIG_NRBOX	348	354	PF00104	0.586
LIG_PCNA_yPIPBox_3	328	338	PF02747	0.606
LIG_Pex14_2	20	24	PF04695	0.374
LIG_PTAP_UEV_1	595	600	PF05743	0.651
LIG_SH2_CRK	11	15	PF00017	0.451
LIG_SH2_CRK	145	149	PF00017	0.627
LIG_SH2_STAP1	536	540	PF00017	0.725
LIG_SH3_2	663	668	PF14604	0.726
LIG_SH3_3	390	396	PF00018	0.550
LIG_SH3_3	447	453	PF00018	0.506
LIG_SH3_3	461	467	PF00018	0.530
LIG_SH3_3	55	61	PF00018	0.671
LIG_SH3_3	593	599	PF00018	0.793
LIG_SH3_3	612	618	PF00018	0.769
LIG_SH3_3	660	666	PF00018	0.719
LIG_SH3_3	693	699	PF00018	0.799
LIG_TRAF2_1	281	284	PF00917	0.657
LIG_TYR_ITIM	424	429	PF00017	0.434
LIG_TYR_ITSM	141	148	PF00017	0.563
LIG_UBA3_1	22	30	PF00899	0.428
LIG_UBA3_1	434	439	PF00899	0.477
LIG_UBA3_1	490	496	PF00899	0.569
LIG_WRC_WIRS_1	6	11	PF05994	0.327
LIG_WRC_WIRS_1	623	628	PF05994	0.662
LIG_WW_3	662	666	PF00397	0.649
MOD_CK1_1	201	207	PF00069	0.563
MOD_CK1_1	254	260	PF00069	0.624
MOD_CK1_1	266	272	PF00069	0.538
MOD_CK1_1	288	294	PF00069	0.468
MOD_CK1_1	33	39	PF00069	0.458
MOD_CK1_1	391	397	PF00069	0.456
MOD_CK1_1	552	558	PF00069	0.727
MOD_CK1_1	572	578	PF00069	0.767
MOD_CK1_1	579	585	PF00069	0.646
MOD_CK1_1	590	596	PF00069	0.551
MOD_CK1_1	609	615	PF00069	0.796
MOD_CK1_1	622	628	PF00069	0.662
MOD_CK1_1	653	659	PF00069	0.781
MOD_CK2_1	201	207	PF00069	0.575
MOD_CK2_1	309	315	PF00069	0.548
MOD_GlcNHglycan	256	259	PF01048	0.600
MOD_GlcNHglycan	265	268	PF01048	0.576
MOD_GlcNHglycan	315	318	PF01048	0.462
MOD_GlcNHglycan	528	534	PF01048	0.710
MOD_GlcNHglycan	554	557	PF01048	0.784
MOD_GlcNHglycan	578	581	PF01048	0.737
MOD_GlcNHglycan	589	592	PF01048	0.745
MOD_GlcNHglycan	596	599	PF01048	0.722
MOD_GlcNHglycan	608	611	PF01048	0.813
MOD_GlcNHglycan	619	622	PF01048	0.710
MOD_GlcNHglycan	652	655	PF01048	0.785
MOD_GlcNHglycan	671	674	PF01048	0.476
MOD_GlcNHglycan	696	699	PF01048	0.757
MOD_GSK3_1	126	133	PF00069	0.520
MOD_GSK3_1	197	204	PF00069	0.527
MOD_GSK3_1	242	249	PF00069	0.624
MOD_GSK3_1	262	269	PF00069	0.587
MOD_GSK3_1	271	278	PF00069	0.493
MOD_GSK3_1	309	316	PF00069	0.560
MOD_GSK3_1	341	348	PF00069	0.419
MOD_GSK3_1	391	398	PF00069	0.491
MOD_GSK3_1	492	499	PF00069	0.414
MOD_GSK3_1	545	552	PF00069	0.764
MOD_GSK3_1	568	575	PF00069	0.793
MOD_GSK3_1	590	597	PF00069	0.695
MOD_GSK3_1	605	612	PF00069	0.796
MOD_GSK3_1	633	640	PF00069	0.691
MOD_GSK3_1	650	657	PF00069	0.662
MOD_GSK3_1	690	697	PF00069	0.754
MOD_N-GLC_1	139	144	PF02516	0.570
MOD_N-GLC_1	391	396	PF02516	0.439
MOD_N-GLC_1	573	578	PF02516	0.588
MOD_NEK2_1	309	314	PF00069	0.596
MOD_NEK2_1	341	346	PF00069	0.438
MOD_NEK2_1	35	40	PF00069	0.516
MOD_NEK2_1	675	680	PF00069	0.618
MOD_NEK2_1	88	93	PF00069	0.438
MOD_NEK2_2	246	251	PF00069	0.495
MOD_PIKK_1	126	132	PF00454	0.463
MOD_PIKK_1	212	218	PF00454	0.660
MOD_PIKK_1	471	477	PF00454	0.501
MOD_PK_1	30	36	PF00069	0.450
MOD_PKA_1	197	203	PF00069	0.468
MOD_PKA_1	568	574	PF00069	0.580
MOD_PKA_2	130	136	PF00069	0.548
MOD_PKA_2	197	203	PF00069	0.599
MOD_PKA_2	271	277	PF00069	0.723
MOD_PKA_2	28	34	PF00069	0.481
MOD_PKA_2	362	368	PF00069	0.497
MOD_PKA_2	420	426	PF00069	0.474
MOD_PKA_2	556	562	PF00069	0.663
MOD_PKA_2	568	574	PF00069	0.553
MOD_PKB_1	137	145	PF00069	0.563
MOD_PKB_1	195	203	PF00069	0.527
MOD_PKB_1	566	574	PF00069	0.646
MOD_Plk_4	150	156	PF00069	0.500
MOD_Plk_4	16	22	PF00069	0.369
MOD_Plk_4	30	36	PF00069	0.324
MOD_Plk_4	5	11	PF00069	0.341
MOD_ProDKin_1	198	204	PF00069	0.619
MOD_ProDKin_1	275	281	PF00069	0.692
MOD_ProDKin_1	310	316	PF00069	0.558
MOD_ProDKin_1	637	643	PF00069	0.697
MOD_ProDKin_1	690	696	PF00069	0.729
MOD_SUMO_for_1	62	65	PF00179	0.535
MOD_SUMO_rev_2	205	215	PF00179	0.546
MOD_SUMO_rev_2	351	357	PF00179	0.528
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.462
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.588
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.616
TRG_DiLeu_BaLyEn_6	686	691	PF01217	0.617
TRG_ENDOCYTIC_2	11	14	PF00928	0.337
TRG_ENDOCYTIC_2	145	148	PF00928	0.529
TRG_ENDOCYTIC_2	426	429	PF00928	0.406
TRG_ENDOCYTIC_2	536	539	PF00928	0.743
TRG_ER_diArg_1	194	196	PF00400	0.608
TRG_ER_diArg_1	300	302	PF00400	0.533
TRG_ER_diArg_1	446	449	PF00400	0.340
TRG_NLS_Bipartite_1	29	44	PF00514	0.536
TRG_NLS_MonoExtN_4	356	362	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN3	Leptomonas seymouri	66%	96%
A0A3R7MWY6	Trypanosoma rangeli	31%	100%
A4H6Z7	Leishmania braziliensis	65%	99%
C9ZI10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZI11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGI1	Leishmania infantum	99%	100%
E9AP17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4QGH2	Leishmania major	88%	100%
V5DG13	Trypanosoma cruzi	32%	100%