LeishMANIAdb
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Surface antigen protein 2, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen protein 2, putative
Gene product:
surface antigen-like protein
Species:
Leishmania donovani
UniProt:
A0A3S5H6M3_LEIDO
TriTrypDb:
LdBPK_211410.1 , LdCL_120017900 , LDHU3_12.1120 , LDHU3_12.1350
Length:
686

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 105
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 39, no: 6
NetGPI no yes: 0, no: 45
Cellular components
Term Name Level Count
GO:0005929 cilium 4 46
GO:0016020 membrane 2 26
GO:0042995 cell projection 2 46
GO:0043226 organelle 2 46
GO:0043227 membrane-bounded organelle 3 46
GO:0110165 cellular anatomical entity 1 46
GO:0120025 plasma membrane bounded cell projection 3 46
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

A0A3S5H6M3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6M3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 282 284 PF00675 0.443
CLV_NRD_NRD_1 6 8 PF00675 0.747
CLV_NRD_NRD_1 61 63 PF00675 0.434
CLV_PCSK_KEX2_1 282 284 PF00082 0.432
CLV_PCSK_KEX2_1 6 8 PF00082 0.736
CLV_PCSK_SKI1_1 154 158 PF00082 0.629
CLV_PCSK_SKI1_1 168 172 PF00082 0.579
CLV_PCSK_SKI1_1 190 194 PF00082 0.436
CLV_PCSK_SKI1_1 228 232 PF00082 0.573
CLV_PCSK_SKI1_1 300 304 PF00082 0.436
CLV_PCSK_SKI1_1 426 430 PF00082 0.443
CLV_PCSK_SKI1_1 446 450 PF00082 0.500
CLV_PCSK_SKI1_1 7 11 PF00082 0.706
DEG_APCC_DBOX_1 423 431 PF00400 0.252
DEG_SPOP_SBC_1 22 26 PF00917 0.393
DEG_SPOP_SBC_1 469 473 PF00917 0.388
DEG_SPOP_SBC_1 478 482 PF00917 0.426
DEG_SPOP_SBC_1 486 490 PF00917 0.407
DEG_SPOP_SBC_1 494 498 PF00917 0.399
DEG_SPOP_SBC_1 509 513 PF00917 0.534
DEG_SPOP_SBC_1 524 528 PF00917 0.592
DEG_SPOP_SBC_1 532 536 PF00917 0.544
DEG_SPOP_SBC_1 547 551 PF00917 0.384
DEG_SPOP_SBC_1 555 559 PF00917 0.390
DEG_SPOP_SBC_1 570 574 PF00917 0.522
DEG_SPOP_SBC_1 578 582 PF00917 0.598
DEG_SPOP_SBC_1 593 597 PF00917 0.402
DOC_AGCK_PIF_2 69 74 PF00069 0.248
DOC_CYCLIN_RxL_1 107 116 PF00134 0.238
DOC_CYCLIN_RxL_1 3 13 PF00134 0.678
DOC_CYCLIN_yCln2_LP_2 267 273 PF00134 0.232
DOC_MAPK_gen_1 228 238 PF00069 0.203
DOC_MAPK_gen_1 240 249 PF00069 0.198
DOC_MAPK_gen_1 351 358 PF00069 0.211
DOC_MAPK_MEF2A_6 231 238 PF00069 0.322
DOC_MAPK_MEF2A_6 446 453 PF00069 0.363
DOC_PP1_RVXF_1 108 115 PF00149 0.280
DOC_USP7_MATH_1 22 26 PF00917 0.516
DOC_USP7_MATH_1 373 377 PF00917 0.355
DOC_USP7_MATH_1 662 666 PF00917 0.490
DOC_USP7_MATH_2 175 181 PF00917 0.343
DOC_USP7_MATH_2 224 230 PF00917 0.257
DOC_USP7_MATH_2 320 326 PF00917 0.296
DOC_WW_Pin1_4 606 611 PF00397 0.601
LIG_14-3-3_CanoR_1 154 162 PF00244 0.381
LIG_14-3-3_CanoR_1 209 214 PF00244 0.292
LIG_14-3-3_CanoR_1 31 38 PF00244 0.633
LIG_14-3-3_CanoR_1 426 431 PF00244 0.328
LIG_14-3-3_CanoR_1 43 48 PF00244 0.417
LIG_BIR_II_1 1 5 PF00653 0.660
LIG_deltaCOP1_diTrp_1 177 185 PF00928 0.328
LIG_DLG_GKlike_1 209 216 PF00625 0.202
LIG_FHA_1 104 110 PF00498 0.250
LIG_FHA_1 169 175 PF00498 0.319
LIG_FHA_1 208 214 PF00498 0.312
LIG_FHA_1 290 296 PF00498 0.364
LIG_FHA_1 377 383 PF00498 0.323
LIG_FHA_1 42 48 PF00498 0.435
LIG_FHA_1 650 656 PF00498 0.451
LIG_FHA_2 254 260 PF00498 0.387
LIG_FHA_2 301 307 PF00498 0.222
LIG_FHA_2 594 600 PF00498 0.566
LIG_FHA_2 618 624 PF00498 0.569
LIG_FHA_2 63 69 PF00498 0.408
LIG_FHA_2 92 98 PF00498 0.394
LIG_LIR_Gen_1 103 112 PF02991 0.349
LIG_LIR_Gen_1 113 121 PF02991 0.354
LIG_LIR_Gen_1 128 136 PF02991 0.297
LIG_LIR_Gen_1 177 186 PF02991 0.303
LIG_LIR_Gen_1 232 243 PF02991 0.255
LIG_LIR_Gen_1 322 330 PF02991 0.254
LIG_LIR_Gen_1 370 378 PF02991 0.275
LIG_LIR_Gen_1 418 427 PF02991 0.354
LIG_LIR_Nem_3 103 107 PF02991 0.373
LIG_LIR_Nem_3 113 117 PF02991 0.361
LIG_LIR_Nem_3 128 132 PF02991 0.407
LIG_LIR_Nem_3 152 156 PF02991 0.267
LIG_LIR_Nem_3 232 238 PF02991 0.285
LIG_LIR_Nem_3 297 302 PF02991 0.400
LIG_LIR_Nem_3 370 374 PF02991 0.273
LIG_NRBOX 352 358 PF00104 0.341
LIG_PCNA_PIPBox_1 326 335 PF02747 0.245
LIG_PDZ_Class_2 681 686 PF00595 0.236
LIG_PTAP_UEV_1 589 594 PF05743 0.373
LIG_SH2_CRK 104 108 PF00017 0.239
LIG_SH2_SRC 235 238 PF00017 0.205
LIG_SH2_STAP1 104 108 PF00017 0.223
LIG_SH2_STAT5 104 107 PF00017 0.348
LIG_SH2_STAT5 186 189 PF00017 0.187
LIG_SH2_STAT5 235 238 PF00017 0.345
LIG_SH2_STAT5 285 288 PF00017 0.248
LIG_SH2_STAT5 645 648 PF00017 0.413
LIG_SH2_STAT5 656 659 PF00017 0.362
LIG_SH2_STAT5 74 77 PF00017 0.212
LIG_SH3_3 267 273 PF00018 0.227
LIG_SH3_3 587 593 PF00018 0.574
LIG_SH3_3 598 604 PF00018 0.594
LIG_SH3_3 93 99 PF00018 0.429
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.405
LIG_SUMO_SIM_par_1 209 215 PF11976 0.403
LIG_SUMO_SIM_par_1 449 455 PF11976 0.280
LIG_TYR_ITIM 102 107 PF00017 0.411
LIG_TYR_ITIM 184 189 PF00017 0.227
LIG_TYR_ITIM 233 238 PF00017 0.321
MOD_CK1_1 179 185 PF00069 0.276
MOD_CK1_1 203 209 PF00069 0.323
MOD_CK1_1 217 223 PF00069 0.275
MOD_CK1_1 229 235 PF00069 0.290
MOD_CK1_1 241 247 PF00069 0.261
MOD_CK1_1 265 271 PF00069 0.307
MOD_CK1_1 277 283 PF00069 0.293
MOD_CK1_1 325 331 PF00069 0.273
MOD_CK1_1 376 382 PF00069 0.341
MOD_CK1_1 385 391 PF00069 0.357
MOD_CK1_1 396 402 PF00069 0.352
MOD_CK1_1 602 608 PF00069 0.516
MOD_CK1_1 649 655 PF00069 0.405
MOD_CK2_1 253 259 PF00069 0.356
MOD_CK2_1 334 340 PF00069 0.201
MOD_CK2_1 593 599 PF00069 0.515
MOD_CK2_1 617 623 PF00069 0.556
MOD_CK2_1 91 97 PF00069 0.412
MOD_Cter_Amidation 60 63 PF01082 0.418
MOD_GlcNHglycan 121 124 PF01048 0.573
MOD_GlcNHglycan 140 143 PF01048 0.535
MOD_GlcNHglycan 145 148 PF01048 0.529
MOD_GlcNHglycan 181 184 PF01048 0.494
MOD_GlcNHglycan 194 197 PF01048 0.555
MOD_GlcNHglycan 218 222 PF01048 0.487
MOD_GlcNHglycan 243 246 PF01048 0.549
MOD_GlcNHglycan 25 28 PF01048 0.729
MOD_GlcNHglycan 267 270 PF01048 0.531
MOD_GlcNHglycan 315 318 PF01048 0.615
MOD_GlcNHglycan 363 366 PF01048 0.539
MOD_GlcNHglycan 370 374 PF01048 0.538
MOD_GlcNHglycan 382 385 PF01048 0.578
MOD_GlcNHglycan 387 390 PF01048 0.614
MOD_GlcNHglycan 395 398 PF01048 0.602
MOD_GlcNHglycan 410 414 PF01048 0.605
MOD_GlcNHglycan 418 422 PF01048 0.629
MOD_GlcNHglycan 633 636 PF01048 0.693
MOD_GlcNHglycan 665 668 PF01048 0.439
MOD_GlcNHglycan 84 87 PF01048 0.542
MOD_GSK3_1 121 128 PF00069 0.374
MOD_GSK3_1 134 141 PF00069 0.247
MOD_GSK3_1 145 152 PF00069 0.310
MOD_GSK3_1 200 207 PF00069 0.342
MOD_GSK3_1 258 265 PF00069 0.303
MOD_GSK3_1 273 280 PF00069 0.308
MOD_GSK3_1 291 298 PF00069 0.272
MOD_GSK3_1 32 39 PF00069 0.601
MOD_GSK3_1 369 376 PF00069 0.320
MOD_GSK3_1 467 474 PF00069 0.489
MOD_GSK3_1 477 484 PF00069 0.497
MOD_GSK3_1 485 492 PF00069 0.450
MOD_GSK3_1 493 500 PF00069 0.437
MOD_GSK3_1 504 511 PF00069 0.439
MOD_GSK3_1 512 519 PF00069 0.460
MOD_GSK3_1 523 530 PF00069 0.442
MOD_GSK3_1 531 538 PF00069 0.448
MOD_GSK3_1 542 549 PF00069 0.444
MOD_GSK3_1 550 557 PF00069 0.488
MOD_GSK3_1 558 565 PF00069 0.484
MOD_GSK3_1 569 576 PF00069 0.435
MOD_GSK3_1 577 584 PF00069 0.454
MOD_GSK3_1 588 595 PF00069 0.480
MOD_GSK3_1 599 606 PF00069 0.517
MOD_GSK3_1 645 652 PF00069 0.408
MOD_GSK3_1 68 75 PF00069 0.277
MOD_GSK3_1 87 94 PF00069 0.341
MOD_N-GLC_1 77 82 PF02516 0.466
MOD_N-GLC_2 460 462 PF02516 0.526
MOD_NEK2_1 10 15 PF00069 0.616
MOD_NEK2_1 119 124 PF00069 0.327
MOD_NEK2_1 138 143 PF00069 0.321
MOD_NEK2_1 170 175 PF00069 0.262
MOD_NEK2_1 192 197 PF00069 0.308
MOD_NEK2_1 236 241 PF00069 0.262
MOD_NEK2_1 262 267 PF00069 0.338
MOD_NEK2_1 286 291 PF00069 0.340
MOD_NEK2_1 310 315 PF00069 0.405
MOD_NEK2_1 332 337 PF00069 0.285
MOD_NEK2_1 358 363 PF00069 0.299
MOD_NEK2_1 380 385 PF00069 0.330
MOD_NEK2_1 411 416 PF00069 0.382
MOD_PIKK_1 154 160 PF00454 0.262
MOD_PIKK_1 396 402 PF00454 0.216
MOD_PIKK_1 584 590 PF00454 0.417
MOD_PKA_1 62 68 PF00069 0.282
MOD_PKA_2 241 247 PF00069 0.294
MOD_PKA_2 262 268 PF00069 0.279
MOD_PKA_2 289 295 PF00069 0.301
MOD_PKA_2 30 36 PF00069 0.551
MOD_PKB_1 166 174 PF00069 0.223
MOD_PKB_1 424 432 PF00069 0.314
MOD_Plk_1 102 108 PF00069 0.248
MOD_Plk_1 176 182 PF00069 0.314
MOD_Plk_1 258 264 PF00069 0.248
MOD_Plk_1 369 375 PF00069 0.355
MOD_Plk_1 417 423 PF00069 0.295
MOD_Plk_1 649 655 PF00069 0.471
MOD_Plk_2-3 253 259 PF00069 0.230
MOD_Plk_2-3 68 74 PF00069 0.314
MOD_Plk_4 103 109 PF00069 0.245
MOD_Plk_4 229 235 PF00069 0.274
MOD_Plk_4 334 340 PF00069 0.221
MOD_Plk_4 358 364 PF00069 0.268
MOD_Plk_4 373 379 PF00069 0.275
MOD_ProDKin_1 606 612 PF00069 0.602
MOD_SUMO_rev_2 220 230 PF00179 0.204
MOD_SUMO_rev_2 306 316 PF00179 0.209
MOD_SUMO_rev_2 452 458 PF00179 0.267
TRG_DiLeu_BaEn_1 650 655 PF01217 0.325
TRG_DiLeu_BaLyEn_6 151 156 PF01217 0.349
TRG_ENDOCYTIC_2 104 107 PF00928 0.409
TRG_ENDOCYTIC_2 186 189 PF00928 0.197
TRG_ENDOCYTIC_2 235 238 PF00928 0.328
TRG_ER_diArg_1 166 169 PF00400 0.232
TRG_ER_diArg_1 281 283 PF00400 0.240
TRG_ER_diArg_1 423 426 PF00400 0.375
TRG_ER_diArg_1 6 8 PF00400 0.708
TRG_NES_CRM1_1 301 312 PF08389 0.203
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.420
TRG_Pf-PMV_PEXEL_1 214 218 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0R0HPY5 Glycine max 25% 70%
A0A0S4ILX2 Bodo saltans 26% 70%
A0A0S4IRQ2 Bodo saltans 33% 80%
A0A0S4IXY3 Bodo saltans 23% 68%
A0A0S4J014 Bodo saltans 26% 96%
A0A0S4J100 Bodo saltans 26% 82%
A0A0S4J1D6 Bodo saltans 25% 70%
A0A0S4J206 Bodo saltans 35% 100%
A0A0S4J2H8 Bodo saltans 26% 100%
A0A0S4J954 Bodo saltans 24% 93%
A0A0S4J985 Bodo saltans 30% 69%
A0A0S4JB95 Bodo saltans 24% 100%
A0A0S4JJG7 Bodo saltans 25% 66%
A0A0S4JNU2 Bodo saltans 34% 84%
A0A0S4JQZ4 Bodo saltans 32% 68%
A0A0S4JTQ7 Bodo saltans 35% 100%
A0A0S4KIR5 Bodo saltans 22% 82%
A0A1X0ND37 Trypanosomatidae 25% 72%
A0A3Q8IC27 Leishmania donovani 35% 100%
A0A3S5H6M4 Leishmania donovani 65% 100%
A0A3S7WS66 Leishmania donovani 65% 100%
A4H6Y8 Leishmania braziliensis 46% 75%
A4HBX3 Leishmania braziliensis 36% 100%
A4HM88 Leishmania braziliensis 26% 79%
A4HZ93 Leishmania infantum 35% 100%
C0LGT6 Arabidopsis thaliana 22% 67%
D1GJ51 Leishmania infantum 59% 100%
E9AGG2 Leishmania infantum 91% 100%
E9AGG7 Leishmania infantum 59% 100%
E9AGG9 Leishmania infantum 54% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 97%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 98%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
F4I9S3 Arabidopsis thaliana 23% 74%
F4K4T3 Arabidopsis thaliana 22% 72%
Q4QC79 Leishmania major 36% 100%
Q4QGI0 Leishmania major 58% 100%
Q4QGI2 Leishmania major 54% 100%
Q4QGI4 Leishmania major 52% 100%
Q4QGI6 Leishmania major 55% 100%
Q4QGI8 Leishmania major 52% 90%
Q4QGJ0 Leishmania major 80% 100%
Q4QGJ2 Leishmania major 59% 100%
Q4QGJ9 Leishmania major 61% 100%
Q4QGK0 Leishmania major 58% 100%
Q4QGK1 Leishmania major 79% 97%
Q4QGK2 Leishmania major 53% 100%
Q4QGK4 Leishmania major 59% 100%
Q4QGK8 Leishmania major 54% 100%
Q4QGL2 Leishmania major 54% 100%
Q4QGL8 Leishmania major 54% 100%
Q4QGM1 Leishmania major 52% 88%
Q69SP5 Oryza sativa subsp. japonica 23% 70%
Q8LPB4 Daucus carota 22% 67%
Q9FN37 Arabidopsis thaliana 22% 66%
Q9LY03 Arabidopsis thaliana 25% 71%
Q9M0G7 Arabidopsis thaliana 25% 68%
Q9SVM3 Arabidopsis thaliana 21% 81%
Q9SVN2 Arabidopsis thaliana 23% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS