GP46-like surface antigen

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6L9_LEIDO

TriTrypDb:

LdCL_120015800 , LDHU3_12.1200

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 70

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 22, no: 0
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	23
GO:0042995	cell projection	2	23
GO:0043226	organelle	2	23
GO:0043227	membrane-bounded organelle	3	23
GO:0110165	cellular anatomical entity	1	23
GO:0120025	plasma membrane bounded cell projection	3	23
GO:0005886	plasma membrane	3	5
GO:0016020	membrane	2	13

Expansion

Sequence features

A0A3S5H6L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6L9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	522	524	PF00675	0.546
CLV_NRD_NRD_1	552	554	PF00675	0.523
CLV_NRD_NRD_1	6	8	PF00675	0.558
CLV_PCSK_KEX2_1	522	524	PF00082	0.546
CLV_PCSK_KEX2_1	552	554	PF00082	0.523
CLV_PCSK_KEX2_1	6	8	PF00082	0.558
CLV_PCSK_SKI1_1	156	160	PF00082	0.315
CLV_PCSK_SKI1_1	167	171	PF00082	0.320
CLV_PCSK_SKI1_1	546	550	PF00082	0.530
CLV_PCSK_SKI1_1	7	11	PF00082	0.538
DEG_SPOP_SBC_1	299	303	PF00917	0.539
DEG_SPOP_SBC_1	311	315	PF00917	0.550
DEG_SPOP_SBC_1	319	323	PF00917	0.580
DEG_SPOP_SBC_1	327	331	PF00917	0.567
DEG_SPOP_SBC_1	335	339	PF00917	0.553
DEG_SPOP_SBC_1	343	347	PF00917	0.581
DEG_SPOP_SBC_1	351	355	PF00917	0.583
DEG_SPOP_SBC_1	359	363	PF00917	0.578
DEG_SPOP_SBC_1	367	371	PF00917	0.558
DEG_SPOP_SBC_1	375	379	PF00917	0.539
DEG_SPOP_SBC_1	383	387	PF00917	0.539
DEG_SPOP_SBC_1	391	395	PF00917	0.543
DEG_SPOP_SBC_1	399	403	PF00917	0.544
DEG_SPOP_SBC_1	407	411	PF00917	0.539
DEG_SPOP_SBC_1	415	419	PF00917	0.546
DEG_SPOP_SBC_1	423	427	PF00917	0.541
DOC_AGCK_PIF_2	69	74	PF00069	0.313
DOC_CYCLIN_RxL_1	3	13	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	548	551	PF00134	0.515
DOC_MAPK_gen_1	552	560	PF00069	0.520
DOC_MAPK_MEF2A_6	156	165	PF00069	0.239
DOC_MAPK_MEF2A_6	276	283	PF00069	0.492
DOC_MAPK_MEF2A_6	541	549	PF00069	0.539
DOC_MAPK_RevD_3	507	523	PF00069	0.527
DOC_PP1_RVXF_1	160	166	PF00149	0.246
DOC_PP2B_LxvP_1	509	512	PF13499	0.513
DOC_PP2B_LxvP_1	524	527	PF13499	0.517
DOC_PP2B_LxvP_1	547	550	PF13499	0.526
DOC_USP7_MATH_1	154	158	PF00917	0.244
DOC_USP7_MATH_1	192	196	PF00917	0.284
DOC_USP7_MATH_1	551	555	PF00917	0.516
DOC_USP7_MATH_2	174	180	PF00917	0.337
DOC_USP7_MATH_2	198	204	PF00917	0.311
DOC_WW_Pin1_4	563	568	PF00397	0.520
DOC_WW_Pin1_4	75	80	PF00397	0.313
LIG_14-3-3_CanoR_1	194	198	PF00244	0.266
LIG_14-3-3_CanoR_1	318	328	PF00244	0.550
LIG_14-3-3_CanoR_1	334	344	PF00244	0.540
LIG_14-3-3_CanoR_1	350	360	PF00244	0.556
LIG_14-3-3_CanoR_1	366	376	PF00244	0.538
LIG_14-3-3_CanoR_1	382	392	PF00244	0.539
LIG_14-3-3_CanoR_1	398	408	PF00244	0.572
LIG_14-3-3_CanoR_1	414	424	PF00244	0.548
LIG_14-3-3_CanoR_1	43	48	PF00244	0.405
LIG_14-3-3_CanoR_1	552	560	PF00244	0.520
LIG_14-3-3_CterR_2	576	579	PF00244	0.519
LIG_Actin_WH2_2	179	196	PF00022	0.305
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BRCT_BRCA1_1	135	139	PF00533	0.243
LIG_BRCT_BRCA1_1	70	74	PF00533	0.327
LIG_BRCT_BRCA1_2	70	76	PF00533	0.284
LIG_eIF4E_1	115	121	PF01652	0.306
LIG_FHA_1	168	174	PF00498	0.361
LIG_FHA_1	42	48	PF00498	0.455
LIG_FHA_2	92	98	PF00498	0.425
LIG_LIR_Gen_1	127	134	PF02991	0.311
LIG_LIR_Gen_1	151	158	PF02991	0.379
LIG_LIR_Gen_1	176	183	PF02991	0.350
LIG_LIR_Gen_1	200	209	PF02991	0.327
LIG_LIR_Gen_1	232	241	PF02991	0.357
LIG_LIR_Gen_1	248	257	PF02991	0.499
LIG_LIR_Gen_1	71	79	PF02991	0.418
LIG_LIR_Nem_3	127	131	PF02991	0.348
LIG_LIR_Nem_3	200	204	PF02991	0.311
LIG_LIR_Nem_3	215	221	PF02991	0.296
LIG_LIR_Nem_3	232	236	PF02991	0.340
LIG_LIR_Nem_3	554	560	PF02991	0.518
LIG_LIR_Nem_3	71	75	PF02991	0.440
LIG_MYND_1	507	511	PF01753	0.511
LIG_MYND_3	180	184	PF01753	0.271
LIG_PCNA_PIPBox_1	180	189	PF02747	0.253
LIG_Pex14_2	86	90	PF04695	0.309
LIG_PTB_Apo_2	227	234	PF02174	0.264
LIG_SH2_STAT5	115	118	PF00017	0.330
LIG_SH3_2	527	532	PF14604	0.528
LIG_SH3_3	429	435	PF00018	0.535
LIG_SH3_3	437	443	PF00018	0.534
LIG_SH3_3	445	451	PF00018	0.523
LIG_SH3_3	453	459	PF00018	0.514
LIG_SH3_3	461	467	PF00018	0.511
LIG_SH3_3	469	475	PF00018	0.507
LIG_SH3_3	477	483	PF00018	0.504
LIG_SH3_3	485	491	PF00018	0.504
LIG_SH3_3	493	499	PF00018	0.510
LIG_SH3_3	501	507	PF00018	0.517
LIG_SH3_3	508	514	PF00018	0.511
LIG_SH3_3	524	530	PF00018	0.519
LIG_SH3_3	93	99	PF00018	0.457
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.295
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.398
LIG_SUMO_SIM_par_1	256	261	PF11976	0.285
LIG_SUMO_SIM_par_1	279	285	PF11976	0.421
LIG_TYR_ITIM	102	107	PF00017	0.459
LIG_WW_3	431	435	PF00397	0.527
LIG_WW_3	439	443	PF00397	0.531
LIG_WW_3	447	451	PF00397	0.519
LIG_WW_3	455	459	PF00397	0.511
LIG_WW_3	463	467	PF00397	0.509
LIG_WW_3	471	475	PF00397	0.504
LIG_WW_3	479	483	PF00397	0.502
LIG_WW_3	487	491	PF00397	0.504
LIG_WW_3	503	507	PF00397	0.514
LIG_WW_3	512	516	PF00397	0.519
LIG_WW_3	526	530	PF00397	0.513
LIG_WW_3	549	553	PF00397	0.517
MOD_CDK_SPxK_1	563	569	PF00069	0.522
MOD_CK1_1	157	163	PF00069	0.350
MOD_CK1_1	202	208	PF00069	0.398
MOD_CK1_1	226	232	PF00069	0.398
MOD_CK2_1	226	232	PF00069	0.295
MOD_CK2_1	91	97	PF00069	0.442
MOD_GlcNHglycan	144	147	PF01048	0.367
MOD_GlcNHglycan	152	155	PF01048	0.297
MOD_GlcNHglycan	224	228	PF01048	0.392
MOD_GlcNHglycan	240	244	PF01048	0.366
MOD_GlcNHglycan	248	252	PF01048	0.386
MOD_GlcNHglycan	25	28	PF01048	0.570
MOD_GlcNHglycan	260	263	PF01048	0.287
MOD_GlcNHglycan	553	556	PF01048	0.519
MOD_GlcNHglycan	79	82	PF01048	0.360
MOD_GSK3_1	120	127	PF00069	0.465
MOD_GSK3_1	144	151	PF00069	0.376
MOD_GSK3_1	165	172	PF00069	0.359
MOD_GSK3_1	199	206	PF00069	0.377
MOD_GSK3_1	297	304	PF00069	0.625
MOD_GSK3_1	306	313	PF00069	0.623
MOD_GSK3_1	314	321	PF00069	0.566
MOD_GSK3_1	322	329	PF00069	0.584
MOD_GSK3_1	330	337	PF00069	0.555
MOD_GSK3_1	338	345	PF00069	0.545
MOD_GSK3_1	346	353	PF00069	0.585
MOD_GSK3_1	354	361	PF00069	0.612
MOD_GSK3_1	362	369	PF00069	0.620
MOD_GSK3_1	370	377	PF00069	0.583
MOD_GSK3_1	378	385	PF00069	0.556
MOD_GSK3_1	386	393	PF00069	0.554
MOD_GSK3_1	394	401	PF00069	0.613
MOD_GSK3_1	402	409	PF00069	0.665
MOD_GSK3_1	410	417	PF00069	0.643
MOD_GSK3_1	418	425	PF00069	0.585
MOD_GSK3_1	82	89	PF00069	0.398
MOD_N-GLC_1	62	67	PF02516	0.287
MOD_N-GLC_1	82	87	PF02516	0.292
MOD_N-GLC_2	290	292	PF02516	0.432
MOD_N-GLC_2	68	70	PF02516	0.244
MOD_NEK2_1	10	15	PF00069	0.511
MOD_NEK2_1	108	113	PF00069	0.305
MOD_NEK2_1	120	125	PF00069	0.431
MOD_NEK2_1	165	170	PF00069	0.307
MOD_NEK2_1	193	198	PF00069	0.329
MOD_NEK2_1	21	26	PF00069	0.464
MOD_NEK2_1	86	91	PF00069	0.384
MOD_PKA_2	193	199	PF00069	0.263
MOD_PKA_2	551	557	PF00069	0.517
MOD_Plk_1	175	181	PF00069	0.338
MOD_Plk_1	199	205	PF00069	0.320
MOD_Plk_1	247	253	PF00069	0.392
MOD_Plk_1	82	88	PF00069	0.300
MOD_Plk_4	133	139	PF00069	0.267
MOD_Plk_4	205	211	PF00069	0.310
MOD_Plk_4	86	92	PF00069	0.343
MOD_ProDKin_1	563	569	PF00069	0.522
MOD_ProDKin_1	75	81	PF00069	0.305
MOD_SUMO_rev_2	282	288	PF00179	0.390
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.538
TRG_ENDOCYTIC_2	104	107	PF00928	0.457
TRG_ER_diArg_1	522	524	PF00400	0.546
TRG_ER_diArg_1	531	534	PF00400	0.543
TRG_ER_diArg_1	551	553	PF00400	0.520
TRG_ER_diArg_1	6	8	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	538	543	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9A6	Leishmania donovani	57%	100%
A4HVB0	Leishmania infantum	68%	100%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AGG5	Leishmania infantum	59%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q25331	Leishmania major	57%	100%
Q4QGI0	Leishmania major	45%	100%
Q4QGI2	Leishmania major	44%	100%
Q4QGJ2	Leishmania major	43%	89%
Q4QGJ4	Leishmania major	57%	100%
Q4QGK0	Leishmania major	48%	100%
Q4QGK2	Leishmania major	43%	100%
Q4QGK4	Leishmania major	43%	87%
Q4QGK6	Leishmania major	57%	100%
Q4QGK8	Leishmania major	42%	100%
Q4QGL2	Leishmania major	42%	100%
Q4QGL4	Leishmania major	59%	100%
Q4QGL8	Leishmania major	44%	95%
Q4QGM1	Leishmania major	42%	75%