LeishMANIAdb
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Lipoprotein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Lipoprotein
Gene product:
Protein of unknown function (DUF962), putative
Species:
Leishmania donovani
UniProt:
A0A3S5H6L3_LEIDO
TriTrypDb:
LdBPK_120660.1 , LdCL_120012300 , LDHU3_12.1000
Length:
108

Annotations

LeishMANIAdb annotations

This small protein is closely similar to a large group of poorly-studied prokaryotic proteins (annotated as DUF962 domain proteins). Some members are also found in plants and slime molds.. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A0A3S5H6L3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6L3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 32 34 PF00675 0.293
CLV_PCSK_KEX2_1 32 34 PF00082 0.293
DOC_ANK_TNKS_1 51 58 PF00023 0.313
DOC_PP4_FxxP_1 84 87 PF00568 0.524
DOC_USP7_MATH_1 24 28 PF00917 0.557
DOC_USP7_MATH_1 46 50 PF00917 0.323
DOC_USP7_MATH_1 58 62 PF00917 0.356
LIG_BRCT_BRCA1_1 4 8 PF00533 0.644
LIG_FHA_2 72 78 PF00498 0.445
LIG_GBD_Chelix_1 98 106 PF00786 0.345
LIG_LIR_Apic_2 82 87 PF02991 0.514
LIG_LIR_Nem_3 17 22 PF02991 0.504
LIG_LIR_Nem_3 93 98 PF02991 0.513
LIG_SH2_STAT5 19 22 PF00017 0.481
MOD_CK1_1 90 96 PF00069 0.584
MOD_CK2_1 71 77 PF00069 0.433
MOD_GlcNHglycan 10 13 PF01048 0.356
MOD_GlcNHglycan 4 7 PF01048 0.443
MOD_GlcNHglycan 48 51 PF01048 0.435
MOD_GSK3_1 24 31 PF00069 0.513
MOD_GSK3_1 76 83 PF00069 0.513
MOD_LATS_1 26 32 PF00433 0.522
MOD_N-GLC_1 2 7 PF02516 0.428
MOD_NEK2_1 36 41 PF00069 0.363
MOD_NEK2_1 8 13 PF00069 0.696
MOD_NEK2_1 97 102 PF00069 0.513
MOD_PIKK_1 76 82 PF00454 0.513
MOD_Plk_4 71 77 PF00069 0.298
MOD_Plk_4 97 103 PF00069 0.513
TRG_ER_diArg_1 32 34 PF00400 0.499

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2C1 Leptomonas seymouri 70% 100%
A0A0N1HYH1 Leptomonas seymouri 36% 100%
A0A0S4IVD1 Bodo saltans 33% 96%
A0A1X0NMC7 Trypanosomatidae 47% 99%
A0A3Q8IHQ7 Leishmania donovani 39% 100%
A0A3R7N4G9 Trypanosoma rangeli 43% 99%
A4H6Y4 Leishmania braziliensis 85% 100%
A4H6Y5 Leishmania braziliensis 39% 100%
E9AGF8 Leishmania infantum 100% 100%
E9AGF9 Leishmania infantum 38% 100%
E9ANZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QGM2 Leishmania major 99% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS