Cytochrome_oxidase_subunit_IV_putative/GeneDB:Lmj F.12.0670

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome oxidase subunit IV, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6L2_LEIDO

TriTrypDb:

LdBPK_120620.1 , LdCL_120011900 , LDHU3_12.0960

Length:

343

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), Cytochrome c oxidase subunit IV

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6L2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016491	oxidoreductase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.642
CLV_NRD_NRD_1	231	233	PF00675	0.453
CLV_NRD_NRD_1	25	27	PF00675	0.550
CLV_NRD_NRD_1	332	334	PF00675	0.462
CLV_NRD_NRD_1	4	6	PF00675	0.545
CLV_NRD_NRD_1	95	97	PF00675	0.525
CLV_PCSK_KEX2_1	25	27	PF00082	0.550
CLV_PCSK_KEX2_1	4	6	PF00082	0.561
CLV_PCSK_SKI1_1	154	158	PF00082	0.518
CLV_PCSK_SKI1_1	233	237	PF00082	0.463
CLV_PCSK_SKI1_1	274	278	PF00082	0.463
CLV_PCSK_SKI1_1	334	338	PF00082	0.568
CLV_PCSK_SKI1_1	68	72	PF00082	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DEG_SPOP_SBC_1	16	20	PF00917	0.586
DOC_CYCLIN_yClb5_NLxxxL_5	186	193	PF00134	0.646
DOC_MAPK_DCC_7	68	76	PF00069	0.514
DOC_MAPK_gen_1	232	238	PF00069	0.501
DOC_MAPK_MEF2A_6	68	76	PF00069	0.514
DOC_USP7_MATH_1	16	20	PF00917	0.626
DOC_USP7_MATH_1	280	284	PF00917	0.379
DOC_USP7_UBL2_3	334	338	PF12436	0.443
DOC_USP7_UBL2_3	55	59	PF12436	0.687
DOC_WW_Pin1_4	174	179	PF00397	0.518
LIG_14-3-3_CanoR_1	204	210	PF00244	0.470
LIG_14-3-3_CanoR_1	274	279	PF00244	0.483
LIG_14-3-3_CanoR_1	4	8	PF00244	0.535
LIG_APCC_ABBA_1	70	75	PF00400	0.516
LIG_CSL_BTD_1	207	210	PF09270	0.466
LIG_FHA_1	204	210	PF00498	0.466
LIG_FHA_1	271	277	PF00498	0.496
LIG_FHA_2	126	132	PF00498	0.643
LIG_FHA_2	260	266	PF00498	0.517
LIG_FHA_2	335	341	PF00498	0.483
LIG_FHA_2	58	64	PF00498	0.512
LIG_LIR_Gen_1	211	221	PF02991	0.498
LIG_LIR_Gen_1	78	87	PF02991	0.489
LIG_LIR_Nem_3	211	216	PF02991	0.496
LIG_LIR_Nem_3	219	224	PF02991	0.457
LIG_LIR_Nem_3	331	335	PF02991	0.506
LIG_LIR_Nem_3	78	83	PF02991	0.486
LIG_PDZ_Class_1	338	343	PF00595	0.519
LIG_SH2_CRK	213	217	PF00017	0.494
LIG_SH2_GRB2like	255	258	PF00017	0.373
LIG_SH2_NCK_1	310	314	PF00017	0.366
LIG_SH2_STAP1	246	250	PF00017	0.429
LIG_SH2_STAP1	255	259	PF00017	0.414
LIG_SH2_STAP1	310	314	PF00017	0.366
LIG_SH2_STAP1	80	84	PF00017	0.494
LIG_SH2_STAT5	155	158	PF00017	0.504
LIG_SH2_STAT5	217	220	PF00017	0.517
LIG_SH2_STAT5	246	249	PF00017	0.532
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.518
LIG_SUMO_SIM_par_1	234	241	PF11976	0.567
LIG_TRAF2_1	60	63	PF00917	0.525
MOD_CK1_1	177	183	PF00069	0.476
MOD_CK1_1	19	25	PF00069	0.621
MOD_CK2_1	177	183	PF00069	0.476
MOD_CK2_1	259	265	PF00069	0.448
MOD_CK2_1	334	340	PF00069	0.475
MOD_CK2_1	57	63	PF00069	0.523
MOD_CK2_1	75	81	PF00069	0.492
MOD_GlcNHglycan	7	10	PF01048	0.673
MOD_GSK3_1	15	22	PF00069	0.651
MOD_GSK3_1	270	277	PF00069	0.401
MOD_GSK3_1	334	341	PF00069	0.480
MOD_GSK3_1	49	56	PF00069	0.561
MOD_GSK3_1	57	64	PF00069	0.497
MOD_N-GLC_1	338	343	PF02516	0.519
MOD_NEK2_1	15	20	PF00069	0.627
MOD_NEK2_1	259	264	PF00069	0.541
MOD_NEK2_1	66	71	PF00069	0.498
MOD_NEK2_2	280	285	PF00069	0.387
MOD_PKA_2	203	209	PF00069	0.469
MOD_PKA_2	3	9	PF00069	0.481
MOD_Plk_1	135	141	PF00069	0.488
MOD_Plk_1	182	188	PF00069	0.494
MOD_Plk_1	61	67	PF00069	0.575
MOD_Plk_4	135	141	PF00069	0.488
MOD_Plk_4	49	55	PF00069	0.591
MOD_Plk_4	66	72	PF00069	0.530
MOD_ProDKin_1	174	180	PF00069	0.512
MOD_SUMO_for_1	58	61	PF00179	0.663
MOD_SUMO_rev_2	146	156	PF00179	0.498
MOD_SUMO_rev_2	252	262	PF00179	0.476
TRG_DiLeu_BaEn_1	321	326	PF01217	0.484
TRG_ENDOCYTIC_2	213	216	PF00928	0.493
TRG_ENDOCYTIC_2	80	83	PF00928	0.494
TRG_ER_diArg_1	25	27	PF00400	0.569
TRG_PTS1	340	343	PF00515	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRY9	Leptomonas seymouri	89%	100%
A0A0S4JH93	Bodo saltans	72%	99%
A0A1X0NMQ0	Trypanosomatidae	76%	100%
A0A3R7NBF6	Trypanosoma rangeli	78%	100%
A4H6Y0	Leishmania braziliensis	91%	100%
C9ZHY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	97%
E9AGF4	Leishmania infantum	100%	100%
E9ANZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QGM6	Leishmania major	96%	100%
V5BF65	Trypanosoma cruzi	78%	100%