Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H6K8_LEIDO

TriTrypDb:

LdBPK_120410.1 , LdCL_120009700 , LDHU3_12.0590

Length:

1089

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6K8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1000	1004	PF00656	0.673
CLV_C14_Caspase3-7	132	136	PF00656	0.727
CLV_C14_Caspase3-7	887	891	PF00656	0.619
CLV_C14_Caspase3-7	894	898	PF00656	0.625
CLV_C14_Caspase3-7	993	997	PF00656	0.743
CLV_NRD_NRD_1	1048	1050	PF00675	0.663
CLV_NRD_NRD_1	1087	1089	PF00675	0.706
CLV_NRD_NRD_1	208	210	PF00675	0.714
CLV_NRD_NRD_1	281	283	PF00675	0.565
CLV_NRD_NRD_1	541	543	PF00675	0.672
CLV_NRD_NRD_1	593	595	PF00675	0.458
CLV_NRD_NRD_1	737	739	PF00675	0.701
CLV_NRD_NRD_1	868	870	PF00675	0.608
CLV_NRD_NRD_1	905	907	PF00675	0.740
CLV_NRD_NRD_1	929	931	PF00675	0.694
CLV_PCSK_FUR_1	1085	1089	PF00082	0.703
CLV_PCSK_FUR_1	538	542	PF00082	0.649
CLV_PCSK_FUR_1	591	595	PF00082	0.456
CLV_PCSK_KEX2_1	1048	1050	PF00082	0.663
CLV_PCSK_KEX2_1	1084	1086	PF00082	0.752
CLV_PCSK_KEX2_1	1087	1089	PF00082	0.724
CLV_PCSK_KEX2_1	208	210	PF00082	0.714
CLV_PCSK_KEX2_1	281	283	PF00082	0.565
CLV_PCSK_KEX2_1	540	542	PF00082	0.670
CLV_PCSK_KEX2_1	593	595	PF00082	0.458
CLV_PCSK_KEX2_1	737	739	PF00082	0.701
CLV_PCSK_KEX2_1	904	906	PF00082	0.745
CLV_PCSK_PC1ET2_1	1084	1086	PF00082	0.752
CLV_PCSK_PC7_1	204	210	PF00082	0.712
CLV_PCSK_PC7_1	277	283	PF00082	0.573
CLV_PCSK_SKI1_1	1026	1030	PF00082	0.688
CLV_PCSK_SKI1_1	1040	1044	PF00082	0.519
CLV_PCSK_SKI1_1	566	570	PF00082	0.500
CLV_PCSK_SKI1_1	84	88	PF00082	0.631
CLV_PCSK_SKI1_1	870	874	PF00082	0.607
CLV_PCSK_SKI1_1	983	987	PF00082	0.692
DEG_APCC_DBOX_1	142	150	PF00400	0.605
DEG_APCC_DBOX_1	565	573	PF00400	0.493
DEG_APCC_DBOX_1	576	584	PF00400	0.375
DEG_APCC_DBOX_1	664	672	PF00400	0.601
DEG_SCF_TRCP1_1	1005	1010	PF00400	0.687
DEG_SPOP_SBC_1	16	20	PF00917	0.613
DEG_SPOP_SBC_1	233	237	PF00917	0.668
DEG_SPOP_SBC_1	506	510	PF00917	0.653
DOC_ANK_TNKS_1	281	288	PF00023	0.518
DOC_ANK_TNKS_1	523	530	PF00023	0.647
DOC_CKS1_1	561	566	PF01111	0.513
DOC_CKS1_1	859	864	PF01111	0.677
DOC_MAPK_gen_1	334	343	PF00069	0.458
DOC_MAPK_gen_1	357	366	PF00069	0.458
DOC_MAPK_gen_1	663	671	PF00069	0.549
DOC_MAPK_gen_1	869	876	PF00069	0.608
DOC_PP2B_LxvP_1	422	425	PF13499	0.631
DOC_PP4_FxxP_1	423	426	PF00568	0.627
DOC_USP7_MATH_1	1028	1032	PF00917	0.642
DOC_USP7_MATH_1	1079	1083	PF00917	0.599
DOC_USP7_MATH_1	217	221	PF00917	0.693
DOC_USP7_MATH_1	232	236	PF00917	0.570
DOC_USP7_MATH_1	317	321	PF00917	0.603
DOC_USP7_MATH_1	387	391	PF00917	0.658
DOC_USP7_MATH_1	430	434	PF00917	0.644
DOC_USP7_MATH_1	444	448	PF00917	0.516
DOC_USP7_MATH_1	69	73	PF00917	0.639
DOC_USP7_MATH_1	769	773	PF00917	0.573
DOC_USP7_MATH_1	79	83	PF00917	0.575
DOC_USP7_MATH_1	864	868	PF00917	0.710
DOC_USP7_MATH_1	879	883	PF00917	0.624
DOC_USP7_MATH_1	919	923	PF00917	0.747
DOC_USP7_MATH_1	98	102	PF00917	0.542
DOC_USP7_MATH_1	992	996	PF00917	0.685
DOC_WW_Pin1_4	105	110	PF00397	0.685
DOC_WW_Pin1_4	1075	1080	PF00397	0.626
DOC_WW_Pin1_4	141	146	PF00397	0.689
DOC_WW_Pin1_4	218	223	PF00397	0.641
DOC_WW_Pin1_4	285	290	PF00397	0.546
DOC_WW_Pin1_4	389	394	PF00397	0.672
DOC_WW_Pin1_4	406	411	PF00397	0.516
DOC_WW_Pin1_4	475	480	PF00397	0.661
DOC_WW_Pin1_4	492	497	PF00397	0.522
DOC_WW_Pin1_4	54	59	PF00397	0.666
DOC_WW_Pin1_4	560	565	PF00397	0.587
DOC_WW_Pin1_4	826	831	PF00397	0.723
DOC_WW_Pin1_4	858	863	PF00397	0.671
DOC_WW_Pin1_4	915	920	PF00397	0.824
LIG_14-3-3_CanoR_1	1048	1054	PF00244	0.657
LIG_14-3-3_CanoR_1	111	117	PF00244	0.740
LIG_14-3-3_CanoR_1	258	262	PF00244	0.378
LIG_14-3-3_CanoR_1	368	376	PF00244	0.495
LIG_14-3-3_CanoR_1	468	474	PF00244	0.715
LIG_14-3-3_CanoR_1	750	754	PF00244	0.735
LIG_14-3-3_CanoR_1	757	765	PF00244	0.670
LIG_14-3-3_CanoR_1	770	778	PF00244	0.531
LIG_14-3-3_CanoR_1	794	800	PF00244	0.633
LIG_14-3-3_CanoR_1	869	875	PF00244	0.719
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BRCT_BRCA1_1	771	775	PF00533	0.775
LIG_Clathr_ClatBox_1	163	167	PF01394	0.521
LIG_Clathr_ClatBox_1	847	851	PF01394	0.687
LIG_FHA_1	105	111	PF00498	0.692
LIG_FHA_1	154	160	PF00498	0.548
LIG_FHA_1	243	249	PF00498	0.599
LIG_FHA_1	368	374	PF00498	0.563
LIG_FHA_1	37	43	PF00498	0.608
LIG_FHA_1	545	551	PF00498	0.666
LIG_FHA_1	555	561	PF00498	0.617
LIG_FHA_1	869	875	PF00498	0.719
LIG_FHA_1	947	953	PF00498	0.695
LIG_FHA_2	127	133	PF00498	0.686
LIG_FHA_2	176	182	PF00498	0.496
LIG_FHA_2	268	274	PF00498	0.481
LIG_FHA_2	393	399	PF00498	0.620
LIG_FHA_2	472	478	PF00498	0.718
LIG_FHA_2	507	513	PF00498	0.654
LIG_FHA_2	850	856	PF00498	0.734
LIG_FHA_2	885	891	PF00498	0.685
LIG_FXI_DFP_1	249	253	PF00024	0.555
LIG_GBD_Chelix_1	365	373	PF00786	0.546
LIG_LIR_Apic_2	420	426	PF02991	0.632
LIG_LIR_Gen_1	384	393	PF02991	0.662
LIG_LIR_Gen_1	565	573	PF02991	0.443
LIG_LIR_Nem_3	384	388	PF02991	0.652
LIG_LIR_Nem_3	565	570	PF02991	0.453
LIG_NRBOX	778	784	PF00104	0.598
LIG_RPA_C_Fungi	864	876	PF08784	0.671
LIG_SH2_CRK	567	571	PF00017	0.499
LIG_SH2_NCK_1	214	218	PF00017	0.628
LIG_SH2_NCK_1	567	571	PF00017	0.499
LIG_SH2_NCK_1	611	615	PF00017	0.562
LIG_SH2_SRC	611	614	PF00017	0.577
LIG_SH2_SRC	77	80	PF00017	0.627
LIG_SH2_STAT3	628	631	PF00017	0.488
LIG_SH2_STAT5	283	286	PF00017	0.575
LIG_SH2_STAT5	45	48	PF00017	0.613
LIG_SH2_STAT5	450	453	PF00017	0.631
LIG_SH2_STAT5	628	631	PF00017	0.488
LIG_SH2_STAT5	77	80	PF00017	0.627
LIG_SH2_STAT5	951	954	PF00017	0.706
LIG_SH3_1	55	61	PF00018	0.675
LIG_SH3_3	28	34	PF00018	0.691
LIG_SH3_3	422	428	PF00018	0.542
LIG_SH3_3	483	489	PF00018	0.685
LIG_SH3_3	55	61	PF00018	0.675
LIG_SH3_3	607	613	PF00018	0.588
LIG_SH3_3	647	653	PF00018	0.596
LIG_SH3_3	856	862	PF00018	0.671
LIG_SH3_CIN85_PxpxPR_1	765	770	PF14604	0.666
LIG_Sin3_3	1043	1050	PF02671	0.587
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.491
LIG_SUMO_SIM_anti_2	556	563	PF11976	0.631
LIG_SUMO_SIM_par_1	161	168	PF11976	0.531
LIG_TRAF2_1	178	181	PF00917	0.556
LIG_TRAF2_1	823	826	PF00917	0.807
LIG_TYR_ITSM	563	570	PF00017	0.471
LIG_UBA3_1	668	673	PF00899	0.612
LIG_WW_2	425	428	PF00397	0.540
MOD_CDC14_SPxK_1	108	111	PF00782	0.682
MOD_CDC14_SPxK_1	144	147	PF00782	0.682
MOD_CDK_SPxK_1	105	111	PF00069	0.688
MOD_CDK_SPxK_1	141	147	PF00069	0.693
MOD_CDK_SPxK_1	560	566	PF00069	0.573
MOD_CDK_SPxxK_3	389	396	PF00069	0.671
MOD_CK1_1	1010	1016	PF00069	0.731
MOD_CK1_1	2	8	PF00069	0.636
MOD_CK1_1	220	226	PF00069	0.741
MOD_CK1_1	288	294	PF00069	0.528
MOD_CK1_1	409	415	PF00069	0.688
MOD_CK1_1	417	423	PF00069	0.609
MOD_CK1_1	466	472	PF00069	0.701
MOD_CK1_1	475	481	PF00069	0.580
MOD_CK1_1	520	526	PF00069	0.658
MOD_CK1_1	532	538	PF00069	0.585
MOD_CK1_1	544	550	PF00069	0.611
MOD_CK1_1	72	78	PF00069	0.609
MOD_CK1_1	915	921	PF00069	0.748
MOD_CK1_1	922	928	PF00069	0.676
MOD_CK1_1	953	959	PF00069	0.666
MOD_CK2_1	126	132	PF00069	0.735
MOD_CK2_1	165	171	PF00069	0.524
MOD_CK2_1	175	181	PF00069	0.438
MOD_CK2_1	190	196	PF00069	0.404
MOD_CK2_1	267	273	PF00069	0.591
MOD_CK2_1	471	477	PF00069	0.723
MOD_CK2_1	506	512	PF00069	0.653
MOD_CK2_1	785	791	PF00069	0.598
MOD_CK2_1	802	808	PF00069	0.627
MOD_CK2_1	832	838	PF00069	0.764
MOD_CK2_1	849	855	PF00069	0.545
MOD_CK2_1	908	914	PF00069	0.746
MOD_CK2_1	953	959	PF00069	0.705
MOD_Cter_Amidation	902	905	PF01082	0.748
MOD_GlcNHglycan	1005	1008	PF01048	0.692
MOD_GlcNHglycan	1030	1033	PF01048	0.645
MOD_GlcNHglycan	1043	1046	PF01048	0.524
MOD_GlcNHglycan	210	213	PF01048	0.743
MOD_GlcNHglycan	236	239	PF01048	0.674
MOD_GlcNHglycan	290	293	PF01048	0.522
MOD_GlcNHglycan	411	414	PF01048	0.689
MOD_GlcNHglycan	446	449	PF01048	0.624
MOD_GlcNHglycan	492	495	PF01048	0.660
MOD_GlcNHglycan	525	528	PF01048	0.710
MOD_GlcNHglycan	534	537	PF01048	0.634
MOD_GlcNHglycan	543	546	PF01048	0.542
MOD_GlcNHglycan	604	608	PF01048	0.571
MOD_GlcNHglycan	70	74	PF01048	0.655
MOD_GlcNHglycan	739	742	PF01048	0.700
MOD_GlcNHglycan	771	774	PF01048	0.656
MOD_GlcNHglycan	787	790	PF01048	0.503
MOD_GlcNHglycan	804	807	PF01048	0.668
MOD_GlcNHglycan	862	865	PF01048	0.684
MOD_GlcNHglycan	972	975	PF01048	0.599
MOD_GSK3_1	1	8	PF00069	0.634
MOD_GSK3_1	1049	1056	PF00069	0.670
MOD_GSK3_1	1075	1082	PF00069	0.702
MOD_GSK3_1	112	119	PF00069	0.735
MOD_GSK3_1	141	148	PF00069	0.689
MOD_GSK3_1	15	22	PF00069	0.581
MOD_GSK3_1	200	207	PF00069	0.790
MOD_GSK3_1	220	227	PF00069	0.679
MOD_GSK3_1	383	390	PF00069	0.646
MOD_GSK3_1	414	421	PF00069	0.584
MOD_GSK3_1	469	476	PF00069	0.678
MOD_GSK3_1	540	547	PF00069	0.670
MOD_GSK3_1	549	556	PF00069	0.673
MOD_GSK3_1	749	756	PF00069	0.724
MOD_GSK3_1	860	867	PF00069	0.674
MOD_GSK3_1	908	915	PF00069	0.851
MOD_GSK3_1	932	939	PF00069	0.831
MOD_GSK3_1	946	953	PF00069	0.668
MOD_GSK3_1	970	977	PF00069	0.650
MOD_GSK3_1	999	1006	PF00069	0.745
MOD_LATS_1	868	874	PF00433	0.607
MOD_N-GLC_1	20	25	PF02516	0.695
MOD_N-GLC_1	444	449	PF02516	0.607
MOD_N-GLC_1	879	884	PF02516	0.658
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	116	121	PF00069	0.719
MOD_NEK2_1	190	195	PF00069	0.556
MOD_NEK2_1	388	393	PF00069	0.652
MOD_NEK2_1	443	448	PF00069	0.602
MOD_NEK2_1	499	504	PF00069	0.671
MOD_NEK2_1	530	535	PF00069	0.673
MOD_NEK2_1	739	744	PF00069	0.782
MOD_NEK2_1	778	783	PF00069	0.594
MOD_NEK2_1	793	798	PF00069	0.600
MOD_NEK2_2	418	423	PF00069	0.643
MOD_NEK2_2	79	84	PF00069	0.620
MOD_PIKK_1	116	122	PF00454	0.717
MOD_PIKK_1	153	159	PF00454	0.560
MOD_PIKK_1	224	230	PF00454	0.688
MOD_PIKK_1	242	248	PF00454	0.449
MOD_PIKK_1	544	550	PF00454	0.596
MOD_PIKK_1	749	755	PF00454	0.690
MOD_PIKK_1	8	14	PF00454	0.693
MOD_PIKK_1	884	890	PF00454	0.685
MOD_PIKK_1	922	928	PF00454	0.675
MOD_PIKK_1	974	980	PF00454	0.736
MOD_PKA_1	208	214	PF00069	0.687
MOD_PKA_1	540	546	PF00069	0.678
MOD_PKA_1	737	743	PF00069	0.654
MOD_PKA_2	1010	1016	PF00069	0.696
MOD_PKA_2	112	118	PF00069	0.735
MOD_PKA_2	133	139	PF00069	0.704
MOD_PKA_2	208	214	PF00069	0.729
MOD_PKA_2	257	263	PF00069	0.379
MOD_PKA_2	367	373	PF00069	0.532
MOD_PKA_2	523	529	PF00069	0.710
MOD_PKA_2	540	546	PF00069	0.547
MOD_PKA_2	592	598	PF00069	0.527
MOD_PKA_2	737	743	PF00069	0.714
MOD_PKA_2	749	755	PF00069	0.627
MOD_PKA_2	756	762	PF00069	0.568
MOD_PKA_2	769	775	PF00069	0.545
MOD_PKA_2	793	799	PF00069	0.587
MOD_PKA_2	868	874	PF00069	0.720
MOD_PKA_2	970	976	PF00069	0.598
MOD_PKB_1	538	546	PF00069	0.704
MOD_PKB_1	906	914	PF00069	0.745
MOD_Plk_1	383	389	PF00069	0.605
MOD_Plk_1	603	609	PF00069	0.576
MOD_Plk_1	946	952	PF00069	0.736
MOD_Plk_2-3	133	139	PF00069	0.667
MOD_Plk_2-3	162	168	PF00069	0.502
MOD_Plk_2-3	267	273	PF00069	0.523
MOD_Plk_2-3	367	373	PF00069	0.507
MOD_Plk_2-3	715	721	PF00069	0.672
MOD_Plk_2-3	912	918	PF00069	0.702
MOD_Plk_2-3	999	1005	PF00069	0.697
MOD_Plk_4	165	171	PF00069	0.524
MOD_Plk_4	418	424	PF00069	0.625
MOD_Plk_4	478	484	PF00069	0.701
MOD_Plk_4	556	562	PF00069	0.634
MOD_Plk_4	778	784	PF00069	0.598
MOD_Plk_4	919	925	PF00069	0.698
MOD_Plk_4	946	952	PF00069	0.574
MOD_ProDKin_1	105	111	PF00069	0.688
MOD_ProDKin_1	1075	1081	PF00069	0.623
MOD_ProDKin_1	141	147	PF00069	0.693
MOD_ProDKin_1	218	224	PF00069	0.643
MOD_ProDKin_1	285	291	PF00069	0.546
MOD_ProDKin_1	389	395	PF00069	0.664
MOD_ProDKin_1	406	412	PF00069	0.514
MOD_ProDKin_1	475	481	PF00069	0.661
MOD_ProDKin_1	492	498	PF00069	0.523
MOD_ProDKin_1	54	60	PF00069	0.668
MOD_ProDKin_1	560	566	PF00069	0.573
MOD_ProDKin_1	826	832	PF00069	0.725
MOD_ProDKin_1	858	864	PF00069	0.673
MOD_ProDKin_1	915	921	PF00069	0.826
MOD_SUMO_rev_2	925	933	PF00179	0.671
TRG_DiLeu_BaEn_4	719	725	PF01217	0.678
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.508
TRG_ENDOCYTIC_2	567	570	PF00928	0.503
TRG_ER_diArg_1	1024	1027	PF00400	0.710
TRG_ER_diArg_1	1047	1049	PF00400	0.652
TRG_ER_diArg_1	1085	1088	PF00400	0.701
TRG_ER_diArg_1	110	113	PF00400	0.703
TRG_ER_diArg_1	208	210	PF00400	0.714
TRG_ER_diArg_1	281	283	PF00400	0.565
TRG_ER_diArg_1	358	361	PF00400	0.495
TRG_ER_diArg_1	439	442	PF00400	0.546
TRG_ER_diArg_1	538	541	PF00400	0.721
TRG_ER_diArg_1	590	593	PF00400	0.517
TRG_ER_diArg_1	737	739	PF00400	0.684
TRG_ER_diArg_1	904	906	PF00400	0.745
TRG_NES_CRM1_1	641	655	PF08389	0.503
TRG_NES_CRM1_1	959	972	PF08389	0.729
TRG_NLS_MonoExtC_3	1083	1088	PF00514	0.752
TRG_NLS_MonoExtN_4	1081	1088	PF00514	0.747
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6W0	Leishmania braziliensis	67%	99%
E9AGD3	Leishmania infantum	100%	100%
E9ANX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QGP7	Leishmania major	89%	100%