Ornithine decarboxylase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ornithine decarboxylase

Species:

Leishmania donovani

UniProt:

A0A3S5H6K6_LEIDO

TriTrypDb:

LdBPK_120105.1 , LdCL_120007900 , LDHU3_12.0390

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6K6

Function

Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	7
GO:0006595	polyamine metabolic process	6	7
GO:0006596	polyamine biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009308	amine metabolic process	4	7
GO:0009309	amine biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0042401	biogenic amine biosynthetic process	6	7
GO:0044237	cellular metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006591	ornithine metabolic process	5	1
GO:0009445	putrescine metabolic process	7	1
GO:0009446	putrescine biosynthetic process	8	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0033387	putrescine biosynthetic process from ornithine	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:1901605	alpha-amino acid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004586	ornithine decarboxylase activity	5	6
GO:0016829	lyase activity	2	7
GO:0016830	carbon-carbon lyase activity	3	7
GO:0016831	carboxy-lyase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.431
CLV_C14_Caspase3-7	575	579	PF00656	0.529
CLV_C14_Caspase3-7	88	92	PF00656	0.799
CLV_NRD_NRD_1	162	164	PF00675	0.388
CLV_NRD_NRD_1	191	193	PF00675	0.512
CLV_NRD_NRD_1	217	219	PF00675	0.373
CLV_NRD_NRD_1	616	618	PF00675	0.277
CLV_NRD_NRD_1	621	623	PF00675	0.295
CLV_NRD_NRD_1	677	679	PF00675	0.348
CLV_NRD_NRD_1	69	71	PF00675	0.585
CLV_PCSK_KEX2_1	162	164	PF00082	0.388
CLV_PCSK_KEX2_1	191	193	PF00082	0.512
CLV_PCSK_KEX2_1	217	219	PF00082	0.373
CLV_PCSK_KEX2_1	44	46	PF00082	0.580
CLV_PCSK_KEX2_1	615	617	PF00082	0.271
CLV_PCSK_KEX2_1	621	623	PF00082	0.283
CLV_PCSK_KEX2_1	677	679	PF00082	0.346
CLV_PCSK_KEX2_1	69	71	PF00082	0.725
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.580
CLV_PCSK_PC7_1	617	623	PF00082	0.260
CLV_PCSK_SKI1_1	226	230	PF00082	0.445
CLV_PCSK_SKI1_1	481	485	PF00082	0.275
CLV_PCSK_SKI1_1	501	505	PF00082	0.183
CLV_PCSK_SKI1_1	529	533	PF00082	0.295
CLV_PCSK_SKI1_1	69	73	PF00082	0.555
DEG_APCC_DBOX_1	274	282	PF00400	0.475
DEG_APCC_DBOX_1	480	488	PF00400	0.475
DEG_SPOP_SBC_1	115	119	PF00917	0.544
DOC_CYCLIN_RxL_1	515	526	PF00134	0.445
DOC_CYCLIN_RxL_1	63	73	PF00134	0.606
DOC_MAPK_gen_1	518	527	PF00069	0.434
DOC_PP1_RVXF_1	675	682	PF00149	0.322
DOC_PP2B_LxvP_1	655	658	PF13499	0.463
DOC_PP4_FxxP_1	331	334	PF00568	0.475
DOC_PP4_FxxP_1	391	394	PF00568	0.598
DOC_PP4_MxPP_1	48	51	PF00568	0.700
DOC_USP7_MATH_1	26	30	PF00917	0.764
DOC_USP7_MATH_1	286	290	PF00917	0.551
DOC_USP7_MATH_1	383	387	PF00917	0.452
DOC_USP7_MATH_1	428	432	PF00917	0.473
DOC_USP7_MATH_1	52	56	PF00917	0.643
DOC_USP7_MATH_1	531	535	PF00917	0.523
DOC_USP7_MATH_1	588	592	PF00917	0.484
DOC_WW_Pin1_4	146	151	PF00397	0.572
DOC_WW_Pin1_4	179	184	PF00397	0.453
DOC_WW_Pin1_4	322	327	PF00397	0.553
DOC_WW_Pin1_4	99	104	PF00397	0.753
LIG_14-3-3_CanoR_1	195	201	PF00244	0.531
LIG_14-3-3_CanoR_1	501	510	PF00244	0.492
LIG_14-3-3_CanoR_1	521	527	PF00244	0.470
LIG_14-3-3_CanoR_1	615	620	PF00244	0.510
LIG_14-3-3_CanoR_1	625	632	PF00244	0.449
LIG_14-3-3_CterR_2	703	707	PF00244	0.518
LIG_Actin_WH2_2	507	523	PF00022	0.368
LIG_AP2alpha_2	257	259	PF02296	0.359
LIG_BRCT_BRCA1_1	387	391	PF00533	0.498
LIG_Clathr_ClatBox_1	134	138	PF01394	0.426
LIG_FHA_1	170	176	PF00498	0.401
LIG_FHA_1	460	466	PF00498	0.555
LIG_FHA_1	517	523	PF00498	0.478
LIG_FHA_1	565	571	PF00498	0.475
LIG_FHA_1	674	680	PF00498	0.334
LIG_FHA_2	156	162	PF00498	0.554
LIG_FHA_2	25	31	PF00498	0.634
LIG_FHA_2	449	455	PF00498	0.475
LIG_FHA_2	469	475	PF00498	0.511
LIG_LIR_Apic_2	328	334	PF02991	0.475
LIG_LIR_Apic_2	388	394	PF02991	0.598
LIG_LIR_Gen_1	172	181	PF02991	0.389
LIG_LIR_Gen_1	350	358	PF02991	0.475
LIG_LIR_Gen_1	435	444	PF02991	0.529
LIG_LIR_Gen_1	471	480	PF02991	0.477
LIG_LIR_Gen_1	550	561	PF02991	0.475
LIG_LIR_Gen_1	653	660	PF02991	0.475
LIG_LIR_Nem_3	149	154	PF02991	0.474
LIG_LIR_Nem_3	168	173	PF02991	0.391
LIG_LIR_Nem_3	213	219	PF02991	0.383
LIG_LIR_Nem_3	256	262	PF02991	0.360
LIG_LIR_Nem_3	350	354	PF02991	0.475
LIG_LIR_Nem_3	435	440	PF02991	0.475
LIG_LIR_Nem_3	471	476	PF02991	0.477
LIG_LIR_Nem_3	542	547	PF02991	0.519
LIG_LIR_Nem_3	550	556	PF02991	0.448
LIG_LIR_Nem_3	653	657	PF02991	0.475
LIG_PCNA_yPIPBox_3	288	299	PF02747	0.468
LIG_Pex14_2	387	391	PF04695	0.475
LIG_Pex14_2	609	613	PF04695	0.460
LIG_Pex14_2	670	674	PF04695	0.425
LIG_SH2_CRK	173	177	PF00017	0.426
LIG_SH2_GRB2like	547	550	PF00017	0.475
LIG_SH2_NCK_1	14	18	PF00017	0.519
LIG_SH2_NCK_1	173	177	PF00017	0.474
LIG_SH2_NCK_1	663	667	PF00017	0.381
LIG_SH2_PTP2	351	354	PF00017	0.475
LIG_SH2_SRC	75	78	PF00017	0.504
LIG_SH2_STAP1	663	667	PF00017	0.381
LIG_SH2_STAP1	67	71	PF00017	0.565
LIG_SH2_STAT5	223	226	PF00017	0.404
LIG_SH2_STAT5	260	263	PF00017	0.393
LIG_SH2_STAT5	284	287	PF00017	0.529
LIG_SH2_STAT5	351	354	PF00017	0.475
LIG_SH2_STAT5	429	432	PF00017	0.475
LIG_SH2_STAT5	502	505	PF00017	0.475
LIG_SH2_STAT5	547	550	PF00017	0.475
LIG_SH2_STAT5	663	666	PF00017	0.373
LIG_SH2_STAT5	695	698	PF00017	0.540
LIG_SH3_3	177	183	PF00018	0.465
LIG_SH3_3	197	203	PF00018	0.443
LIG_SH3_3	20	26	PF00018	0.569
LIG_SH3_3	245	251	PF00018	0.551
LIG_SH3_3	252	258	PF00018	0.394
LIG_SH3_3	320	326	PF00018	0.545
LIG_SH3_3	351	357	PF00018	0.495
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.475
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.475
LIG_SUMO_SIM_par_1	294	300	PF11976	0.512
LIG_SUMO_SIM_par_1	567	573	PF11976	0.475
LIG_TRAF2_1	158	161	PF00917	0.499
LIG_TRAF2_1	310	313	PF00917	0.495
LIG_TRAF2_1	59	62	PF00917	0.629
LIG_TRAF2_1	591	594	PF00917	0.478
LIG_TYR_ITIM	349	354	PF00017	0.475
LIG_UBA3_1	373	377	PF00899	0.453
LIG_WRC_WIRS_1	553	558	PF05994	0.475
MOD_CK1_1	124	130	PF00069	0.564
MOD_CK1_1	29	35	PF00069	0.641
MOD_CK1_1	386	392	PF00069	0.452
MOD_CK1_1	468	474	PF00069	0.483
MOD_CK1_1	534	540	PF00069	0.495
MOD_CK1_1	662	668	PF00069	0.377
MOD_CK2_1	155	161	PF00069	0.568
MOD_CK2_1	204	210	PF00069	0.537
MOD_CK2_1	307	313	PF00069	0.485
MOD_CK2_1	468	474	PF00069	0.495
MOD_CK2_1	520	526	PF00069	0.437
MOD_CK2_1	534	540	PF00069	0.475
MOD_CK2_1	579	585	PF00069	0.458
MOD_CK2_1	588	594	PF00069	0.476
MOD_GlcNHglycan	109	112	PF01048	0.579
MOD_GlcNHglycan	206	209	PF01048	0.488
MOD_GlcNHglycan	232	235	PF01048	0.544
MOD_GlcNHglycan	299	302	PF01048	0.340
MOD_GlcNHglycan	368	371	PF01048	0.296
MOD_GlcNHglycan	40	43	PF01048	0.606
MOD_GlcNHglycan	420	423	PF01048	0.268
MOD_GlcNHglycan	424	429	PF01048	0.273
MOD_GlcNHglycan	430	433	PF01048	0.288
MOD_GlcNHglycan	466	470	PF01048	0.277
MOD_GlcNHglycan	52	55	PF01048	0.709
MOD_GlcNHglycan	581	584	PF01048	0.342
MOD_GlcNHglycan	599	602	PF01048	0.278
MOD_GlcNHglycan	610	613	PF01048	0.199
MOD_GlcNHglycan	91	94	PF01048	0.667
MOD_GSK3_1	121	128	PF00069	0.677
MOD_GSK3_1	204	211	PF00069	0.566
MOD_GSK3_1	217	224	PF00069	0.403
MOD_GSK3_1	29	36	PF00069	0.651
MOD_GSK3_1	424	431	PF00069	0.498
MOD_GSK3_1	465	472	PF00069	0.473
MOD_GSK3_1	516	523	PF00069	0.383
MOD_GSK3_1	85	92	PF00069	0.680
MOD_N-GLC_1	204	209	PF02516	0.552
MOD_N-GLC_1	378	383	PF02516	0.329
MOD_N-GLC_1	408	413	PF02516	0.252
MOD_N-GLC_1	469	474	PF02516	0.295
MOD_NEK2_1	137	142	PF00069	0.538
MOD_NEK2_1	408	413	PF00069	0.434
MOD_NEK2_1	448	453	PF00069	0.489
MOD_NEK2_1	552	557	PF00069	0.475
MOD_NEK2_1	608	613	PF00069	0.441
MOD_NEK2_1	624	629	PF00069	0.516
MOD_NEK2_2	33	38	PF00069	0.643
MOD_NEK2_2	413	418	PF00069	0.473
MOD_NEK2_2	516	521	PF00069	0.381
MOD_PIKK_1	125	131	PF00454	0.471
MOD_PIKK_1	137	143	PF00454	0.483
MOD_PIKK_1	221	227	PF00454	0.343
MOD_PKA_1	191	197	PF00069	0.544
MOD_PKA_1	217	223	PF00069	0.377
MOD_PKA_1	615	621	PF00069	0.495
MOD_PKA_2	191	197	PF00069	0.568
MOD_PKA_2	217	223	PF00069	0.377
MOD_PKA_2	520	526	PF00069	0.437
MOD_PKA_2	615	621	PF00069	0.505
MOD_PKA_2	624	630	PF00069	0.452
MOD_Plk_1	204	210	PF00069	0.573
MOD_Plk_1	408	414	PF00069	0.550
MOD_Plk_1	424	430	PF00069	0.427
MOD_Plk_1	469	475	PF00069	0.475
MOD_Plk_1	491	497	PF00069	0.475
MOD_Plk_1	595	601	PF00069	0.577
MOD_Plk_4	196	202	PF00069	0.601
MOD_Plk_4	347	353	PF00069	0.475
MOD_Plk_4	448	454	PF00069	0.493
MOD_Plk_4	491	497	PF00069	0.475
MOD_Plk_4	531	537	PF00069	0.598
MOD_Plk_4	564	570	PF00069	0.475
MOD_Plk_4	625	631	PF00069	0.475
MOD_ProDKin_1	146	152	PF00069	0.575
MOD_ProDKin_1	179	185	PF00069	0.459
MOD_ProDKin_1	322	328	PF00069	0.553
MOD_ProDKin_1	99	105	PF00069	0.753
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.559
TRG_ENDOCYTIC_2	173	176	PF00928	0.457
TRG_ENDOCYTIC_2	19	22	PF00928	0.623
TRG_ENDOCYTIC_2	284	287	PF00928	0.529
TRG_ENDOCYTIC_2	351	354	PF00928	0.475
TRG_ENDOCYTIC_2	437	440	PF00928	0.475
TRG_ENDOCYTIC_2	553	556	PF00928	0.498
TRG_ER_diArg_1	191	193	PF00400	0.475
TRG_ER_diArg_1	216	218	PF00400	0.373
TRG_ER_diArg_1	45	48	PF00400	0.670
TRG_ER_diArg_1	615	617	PF00400	0.472
TRG_ER_diArg_1	621	623	PF00400	0.479
TRG_ER_diArg_1	677	679	PF00400	0.346
TRG_ER_diArg_1	69	71	PF00400	0.718
TRG_ER_diArg_1	690	693	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I681	Leptomonas seymouri	63%	98%
A4H6U3	Leishmania braziliensis	70%	96%
E9AGB5	Leishmania infantum	99%	100%
E9ANV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
P27116	Leishmania donovani	99%	100%
Q4QGR5	Leishmania major	91%	100%