Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6K4_LEIDO

TriTrypDb:

LdBPK_120160.1 , LdCL_120006900 , LDHU3_12.0260

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.568
CLV_C14_Caspase3-7	602	606	PF00656	0.421
CLV_C14_Caspase3-7	616	620	PF00656	0.393
CLV_MEL_PAP_1	11	17	PF00089	0.579
CLV_NRD_NRD_1	181	183	PF00675	0.606
CLV_NRD_NRD_1	219	221	PF00675	0.415
CLV_NRD_NRD_1	245	247	PF00675	0.570
CLV_NRD_NRD_1	253	255	PF00675	0.362
CLV_NRD_NRD_1	288	290	PF00675	0.608
CLV_NRD_NRD_1	291	293	PF00675	0.558
CLV_NRD_NRD_1	383	385	PF00675	0.800
CLV_NRD_NRD_1	501	503	PF00675	0.559
CLV_NRD_NRD_1	525	527	PF00675	0.442
CLV_NRD_NRD_1	653	655	PF00675	0.469
CLV_NRD_NRD_1	724	726	PF00675	0.740
CLV_NRD_NRD_1	731	733	PF00675	0.688
CLV_NRD_NRD_1	747	749	PF00675	0.544
CLV_PCSK_FUR_1	289	293	PF00082	0.637
CLV_PCSK_FUR_1	651	655	PF00082	0.445
CLV_PCSK_KEX2_1	183	185	PF00082	0.595
CLV_PCSK_KEX2_1	219	221	PF00082	0.415
CLV_PCSK_KEX2_1	245	247	PF00082	0.572
CLV_PCSK_KEX2_1	253	255	PF00082	0.364
CLV_PCSK_KEX2_1	288	290	PF00082	0.608
CLV_PCSK_KEX2_1	291	293	PF00082	0.558
CLV_PCSK_KEX2_1	501	503	PF00082	0.559
CLV_PCSK_KEX2_1	525	527	PF00082	0.442
CLV_PCSK_KEX2_1	653	655	PF00082	0.424
CLV_PCSK_KEX2_1	731	733	PF00082	0.695
CLV_PCSK_KEX2_1	747	749	PF00082	0.518
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.644
CLV_PCSK_SKI1_1	101	105	PF00082	0.423
CLV_PCSK_SKI1_1	228	232	PF00082	0.451
CLV_PCSK_SKI1_1	253	257	PF00082	0.338
CLV_PCSK_SKI1_1	266	270	PF00082	0.505
CLV_PCSK_SKI1_1	660	664	PF00082	0.401
CLV_PCSK_SKI1_1	702	706	PF00082	0.494
CLV_PCSK_SKI1_1	901	905	PF00082	0.517
DEG_APCC_DBOX_1	252	260	PF00400	0.383
DEG_APCC_DBOX_1	545	553	PF00400	0.392
DEG_ODPH_VHL_1	751	763	PF01847	0.558
DEG_SPOP_SBC_1	142	146	PF00917	0.662
DEG_SPOP_SBC_1	50	54	PF00917	0.654
DEG_SPOP_SBC_1	564	568	PF00917	0.580
DOC_ANK_TNKS_1	236	243	PF00023	0.544
DOC_CDC14_PxL_1	749	757	PF14671	0.568
DOC_CYCLIN_RxL_1	654	667	PF00134	0.409
DOC_CYCLIN_RxL_1	839	848	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	530	536	PF00134	0.510
DOC_MAPK_gen_1	253	259	PF00069	0.415
DOC_MAPK_gen_1	288	299	PF00069	0.515
DOC_MAPK_gen_1	525	531	PF00069	0.467
DOC_MAPK_gen_1	651	661	PF00069	0.447
DOC_MAPK_JIP1_4	323	329	PF00069	0.448
DOC_MAPK_MEF2A_6	292	301	PF00069	0.452
DOC_MAPK_MEF2A_6	351	358	PF00069	0.483
DOC_MAPK_MEF2A_6	546	554	PF00069	0.409
DOC_MAPK_MEF2A_6	654	663	PF00069	0.455
DOC_MAPK_MEF2A_6	78	87	PF00069	0.478
DOC_MAPK_MEF2A_6	860	869	PF00069	0.477
DOC_PP1_RVXF_1	264	270	PF00149	0.550
DOC_PP2B_LxvP_1	134	137	PF13499	0.619
DOC_PP2B_LxvP_1	327	330	PF13499	0.364
DOC_PP2B_LxvP_1	436	439	PF13499	0.620
DOC_PP2B_LxvP_1	852	855	PF13499	0.539
DOC_PP4_FxxP_1	508	511	PF00568	0.531
DOC_PP4_FxxP_1	832	835	PF00568	0.455
DOC_USP7_MATH_1	142	146	PF00917	0.627
DOC_USP7_MATH_1	189	193	PF00917	0.624
DOC_USP7_MATH_1	279	283	PF00917	0.750
DOC_USP7_MATH_1	42	46	PF00917	0.607
DOC_USP7_MATH_1	441	445	PF00917	0.681
DOC_USP7_MATH_1	461	465	PF00917	0.434
DOC_USP7_MATH_1	50	54	PF00917	0.612
DOC_USP7_MATH_1	545	549	PF00917	0.504
DOC_USP7_MATH_1	580	584	PF00917	0.710
DOC_USP7_MATH_1	673	677	PF00917	0.520
DOC_USP7_MATH_1	721	725	PF00917	0.507
DOC_USP7_MATH_1	738	742	PF00917	0.540
DOC_USP7_MATH_1	805	809	PF00917	0.824
DOC_USP7_MATH_1	819	823	PF00917	0.561
DOC_USP7_MATH_1	95	99	PF00917	0.475
DOC_WW_Pin1_4	168	173	PF00397	0.649
DOC_WW_Pin1_4	418	423	PF00397	0.612
DOC_WW_Pin1_4	459	464	PF00397	0.564
DOC_WW_Pin1_4	474	479	PF00397	0.500
DOC_WW_Pin1_4	578	583	PF00397	0.593
DOC_WW_Pin1_4	58	63	PF00397	0.655
LIG_14-3-3_CanoR_1	14	20	PF00244	0.591
LIG_14-3-3_CanoR_1	246	252	PF00244	0.478
LIG_14-3-3_CanoR_1	260	269	PF00244	0.438
LIG_14-3-3_CanoR_1	314	324	PF00244	0.357
LIG_14-3-3_CanoR_1	390	394	PF00244	0.588
LIG_14-3-3_CanoR_1	455	459	PF00244	0.653
LIG_14-3-3_CanoR_1	501	511	PF00244	0.537
LIG_14-3-3_CanoR_1	546	550	PF00244	0.458
LIG_14-3-3_CanoR_1	66	71	PF00244	0.660
LIG_14-3-3_CanoR_1	688	697	PF00244	0.458
LIG_14-3-3_CanoR_1	747	752	PF00244	0.591
LIG_Actin_WH2_2	637	655	PF00022	0.423
LIG_APCC_ABBA_1	637	642	PF00400	0.350
LIG_APCC_ABBA_1	710	715	PF00400	0.552
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BRCT_BRCA1_1	109	113	PF00533	0.473
LIG_BRCT_BRCA1_1	15	19	PF00533	0.593
LIG_BRCT_BRCA1_1	504	508	PF00533	0.516
LIG_deltaCOP1_diTrp_1	160	166	PF00928	0.572
LIG_EH1_1	698	706	PF00400	0.483
LIG_eIF4E_1	251	257	PF01652	0.305
LIG_FHA_1	116	122	PF00498	0.422
LIG_FHA_1	316	322	PF00498	0.403
LIG_FHA_1	486	492	PF00498	0.575
LIG_FHA_1	598	604	PF00498	0.435
LIG_FHA_1	633	639	PF00498	0.376
LIG_FHA_1	88	94	PF00498	0.519
LIG_FHA_2	20	26	PF00498	0.542
LIG_FHA_2	203	209	PF00498	0.541
LIG_FHA_2	307	313	PF00498	0.462
LIG_FHA_2	419	425	PF00498	0.553
LIG_FHA_2	440	446	PF00498	0.561
LIG_FHA_2	690	696	PF00498	0.525
LIG_FHA_2	813	819	PF00498	0.709
LIG_FHA_2	900	906	PF00498	0.592
LIG_Integrin_RGD_1	32	34	PF01839	0.479
LIG_LIR_Apic_2	505	511	PF02991	0.516
LIG_LIR_Apic_2	830	835	PF02991	0.492
LIG_LIR_Gen_1	110	121	PF02991	0.471
LIG_LIR_Gen_1	295	306	PF02991	0.435
LIG_LIR_Gen_1	635	645	PF02991	0.382
LIG_LIR_Nem_3	110	116	PF02991	0.467
LIG_LIR_Nem_3	295	301	PF02991	0.443
LIG_LIR_Nem_3	635	640	PF02991	0.400
LIG_LIR_Nem_3	77	82	PF02991	0.525
LIG_LIR_Nem_3	830	836	PF02991	0.623
LIG_MLH1_MIPbox_1	504	508	PF16413	0.516
LIG_NRBOX	251	257	PF00104	0.455
LIG_NRBOX	603	609	PF00104	0.446
LIG_PCNA_PIPBox_1	1	10	PF02747	0.547
LIG_PCNA_PIPBox_1	24	33	PF02747	0.491
LIG_PCNA_PIPBox_1	826	835	PF02747	0.423
LIG_PDZ_Class_3	902	907	PF00595	0.568
LIG_Pex14_1	166	170	PF04695	0.523
LIG_Pex14_1	353	357	PF04695	0.498
LIG_REV1ctd_RIR_1	505	510	PF16727	0.458
LIG_SH2_CRK	833	837	PF00017	0.592
LIG_SH2_GRB2like	7	10	PF00017	0.572
LIG_SH2_NCK_1	456	460	PF00017	0.515
LIG_SH2_NCK_1	714	718	PF00017	0.513
LIG_SH2_SRC	7	10	PF00017	0.543
LIG_SH2_STAP1	311	315	PF00017	0.470
LIG_SH2_STAP1	641	645	PF00017	0.365
LIG_SH2_STAP1	714	718	PF00017	0.513
LIG_SH2_STAT5	251	254	PF00017	0.330
LIG_SH2_STAT5	298	301	PF00017	0.432
LIG_SH2_STAT5	7	10	PF00017	0.543
LIG_SH2_STAT5	845	848	PF00017	0.593
LIG_SH3_1	586	592	PF00018	0.499
LIG_SH3_3	318	324	PF00018	0.317
LIG_SH3_3	576	582	PF00018	0.644
LIG_SH3_3	586	592	PF00018	0.721
LIG_SH3_3	67	73	PF00018	0.673
LIG_SH3_3	703	709	PF00018	0.612
LIG_SH3_3	832	838	PF00018	0.445
LIG_SUMO_SIM_anti_2	118	125	PF11976	0.537
LIG_SUMO_SIM_anti_2	599	605	PF11976	0.329
LIG_SUMO_SIM_anti_2	758	765	PF11976	0.623
LIG_SUMO_SIM_anti_2	874	882	PF11976	0.490
LIG_SUMO_SIM_par_1	114	120	PF11976	0.300
LIG_SUMO_SIM_par_1	191	198	PF11976	0.533
LIG_SUMO_SIM_par_1	325	334	PF11976	0.403
LIG_SUMO_SIM_par_1	599	605	PF11976	0.316
LIG_SUMO_SIM_par_1	622	628	PF11976	0.492
LIG_SUMO_SIM_par_1	878	884	PF11976	0.483
LIG_TRFH_1	507	511	PF08558	0.497
LIG_TYR_ITIM	639	644	PF00017	0.366
LIG_TYR_ITIM	712	717	PF00017	0.502
LIG_UBA3_1	878	883	PF00899	0.476
LIG_WRC_WIRS_1	27	32	PF05994	0.476
MOD_CDK_SPxxK_3	418	425	PF00069	0.603
MOD_CK1_1	168	174	PF00069	0.639
MOD_CK1_1	198	204	PF00069	0.672
MOD_CK1_1	284	290	PF00069	0.652
MOD_CK1_1	398	404	PF00069	0.623
MOD_CK1_1	457	463	PF00069	0.647
MOD_CK1_1	474	480	PF00069	0.500
MOD_CK1_1	541	547	PF00069	0.504
MOD_CK1_1	566	572	PF00069	0.659
MOD_CK1_1	822	828	PF00069	0.526
MOD_CK1_1	899	905	PF00069	0.516
MOD_CK1_1	94	100	PF00069	0.497
MOD_CK2_1	202	208	PF00069	0.556
MOD_CK2_1	306	312	PF00069	0.454
MOD_CK2_1	418	424	PF00069	0.565
MOD_CK2_1	439	445	PF00069	0.728
MOD_CK2_1	469	475	PF00069	0.608
MOD_CK2_1	689	695	PF00069	0.489
MOD_CK2_1	727	733	PF00069	0.642
MOD_CK2_1	766	772	PF00069	0.502
MOD_GlcNHglycan	145	148	PF01048	0.642
MOD_GlcNHglycan	15	18	PF01048	0.528
MOD_GlcNHglycan	172	175	PF01048	0.756
MOD_GlcNHglycan	191	194	PF01048	0.461
MOD_GlcNHglycan	283	286	PF01048	0.621
MOD_GlcNHglycan	364	367	PF01048	0.693
MOD_GlcNHglycan	397	400	PF01048	0.667
MOD_GlcNHglycan	42	45	PF01048	0.666
MOD_GlcNHglycan	459	462	PF01048	0.728
MOD_GlcNHglycan	471	474	PF01048	0.524
MOD_GlcNHglycan	491	494	PF01048	0.549
MOD_GlcNHglycan	568	571	PF01048	0.553
MOD_GlcNHglycan	670	673	PF01048	0.525
MOD_GlcNHglycan	808	811	PF01048	0.622
MOD_GlcNHglycan	821	824	PF01048	0.512
MOD_GlcNHglycan	898	901	PF01048	0.518
MOD_GlcNHglycan	93	96	PF01048	0.481
MOD_GlcNHglycan	97	100	PF01048	0.479
MOD_GSK3_1	117	124	PF00069	0.538
MOD_GSK3_1	15	22	PF00069	0.583
MOD_GSK3_1	161	168	PF00069	0.562
MOD_GSK3_1	184	191	PF00069	0.486
MOD_GSK3_1	198	205	PF00069	0.466
MOD_GSK3_1	279	286	PF00069	0.760
MOD_GSK3_1	331	338	PF00069	0.664
MOD_GSK3_1	357	364	PF00069	0.532
MOD_GSK3_1	394	401	PF00069	0.707
MOD_GSK3_1	42	49	PF00069	0.616
MOD_GSK3_1	457	464	PF00069	0.607
MOD_GSK3_1	485	492	PF00069	0.807
MOD_GSK3_1	51	58	PF00069	0.664
MOD_GSK3_1	541	548	PF00069	0.530
MOD_GSK3_1	566	573	PF00069	0.601
MOD_GSK3_1	87	94	PF00069	0.428
MOD_GSK3_1	890	897	PF00069	0.546
MOD_GSK3_1	899	906	PF00069	0.555
MOD_NEK2_1	107	112	PF00069	0.518
MOD_NEK2_1	117	122	PF00069	0.478
MOD_NEK2_1	161	166	PF00069	0.594
MOD_NEK2_1	283	288	PF00069	0.533
MOD_NEK2_1	315	320	PF00069	0.441
MOD_NEK2_1	454	459	PF00069	0.776
MOD_NEK2_1	563	568	PF00069	0.535
MOD_NEK2_1	74	79	PF00069	0.547
MOD_NEK2_1	755	760	PF00069	0.495
MOD_NEK2_1	766	771	PF00069	0.484
MOD_NEK2_1	890	895	PF00069	0.521
MOD_NEK2_2	306	311	PF00069	0.452
MOD_PIKK_1	161	167	PF00454	0.596
MOD_PIKK_1	822	828	PF00454	0.569
MOD_PKA_1	747	753	PF00069	0.611
MOD_PKA_2	13	19	PF00069	0.591
MOD_PKA_2	389	395	PF00069	0.576
MOD_PKA_2	454	460	PF00069	0.652
MOD_PKA_2	489	495	PF00069	0.713
MOD_PKA_2	509	515	PF00069	0.410
MOD_PKA_2	545	551	PF00069	0.499
MOD_PKA_2	65	71	PF00069	0.583
MOD_PKA_2	747	753	PF00069	0.574
MOD_PKA_2	812	818	PF00069	0.618
MOD_PKB_1	182	190	PF00069	0.762
MOD_Plk_1	195	201	PF00069	0.523
MOD_Plk_1	331	337	PF00069	0.509
MOD_Plk_4	117	123	PF00069	0.521
MOD_Plk_4	15	21	PF00069	0.581
MOD_Plk_4	247	253	PF00069	0.403
MOD_Plk_4	26	32	PF00069	0.437
MOD_Plk_4	306	312	PF00069	0.422
MOD_Plk_4	335	341	PF00069	0.508
MOD_Plk_4	389	395	PF00069	0.741
MOD_Plk_4	406	412	PF00069	0.738
MOD_Plk_4	545	551	PF00069	0.523
MOD_Plk_4	580	586	PF00069	0.562
MOD_Plk_4	592	598	PF00069	0.408
MOD_Plk_4	632	638	PF00069	0.377
MOD_Plk_4	756	762	PF00069	0.592
MOD_Plk_4	88	94	PF00069	0.456
MOD_ProDKin_1	168	174	PF00069	0.648
MOD_ProDKin_1	418	424	PF00069	0.608
MOD_ProDKin_1	459	465	PF00069	0.567
MOD_ProDKin_1	474	480	PF00069	0.502
MOD_ProDKin_1	578	584	PF00069	0.593
MOD_ProDKin_1	58	64	PF00069	0.653
TRG_DiLeu_BaEn_1	226	231	PF01217	0.478
TRG_DiLeu_BaEn_1	876	881	PF01217	0.487
TRG_DiLeu_BaEn_4	226	232	PF01217	0.485
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.460
TRG_ENDOCYTIC_2	298	301	PF00928	0.432
TRG_ENDOCYTIC_2	641	644	PF00928	0.358
TRG_ENDOCYTIC_2	714	717	PF00928	0.512
TRG_ENDOCYTIC_2	833	836	PF00928	0.606
TRG_ER_diArg_1	181	184	PF00400	0.607
TRG_ER_diArg_1	219	221	PF00400	0.415
TRG_ER_diArg_1	252	254	PF00400	0.451
TRG_ER_diArg_1	288	291	PF00400	0.565
TRG_ER_diArg_1	411	414	PF00400	0.659
TRG_ER_diArg_1	500	502	PF00400	0.543
TRG_ER_diArg_1	524	526	PF00400	0.458
TRG_ER_diArg_1	651	654	PF00400	0.471
TRG_ER_diArg_1	746	748	PF00400	0.636
TRG_NES_CRM1_1	602	617	PF08389	0.458
TRG_NLS_MonoExtC_3	181	186	PF00514	0.647
TRG_NLS_MonoExtN_4	182	187	PF00514	0.643
TRG_NLS_MonoExtN_4	245	250	PF00514	0.463
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	901	905	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE7	Leptomonas seymouri	51%	100%
A0A3R7MWG9	Trypanosoma rangeli	29%	100%
A4H6T3	Leishmania braziliensis	75%	100%
C9ZQC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AGA7	Leishmania infantum	99%	100%
E9ANU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGS5	Leishmania major	91%	100%