Plus-3_domain/Zinc_finger_C3HC4_type_(RING_finger )_containing_protein_putative/Pfam:PF03126/Pfam:PF13920

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ornithine decarboxylase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6K3_LEIDO

TriTrypDb:

LdBPK_120100.1 , LdCL_120006100 , LDHU3_12.0150

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6K3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003677	DNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.418
CLV_NRD_NRD_1	151	153	PF00675	0.580
CLV_NRD_NRD_1	172	174	PF00675	0.591
CLV_NRD_NRD_1	188	190	PF00675	0.627
CLV_NRD_NRD_1	43	45	PF00675	0.357
CLV_PCSK_KEX2_1	151	153	PF00082	0.571
CLV_PCSK_KEX2_1	172	174	PF00082	0.600
CLV_PCSK_KEX2_1	188	190	PF00082	0.293
CLV_PCSK_KEX2_1	43	45	PF00082	0.357
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.604
CLV_PCSK_SKI1_1	174	178	PF00082	0.560
CLV_PCSK_SKI1_1	206	210	PF00082	0.441
CLV_PCSK_SKI1_1	224	228	PF00082	0.418
CLV_PCSK_SKI1_1	31	35	PF00082	0.325
DEG_APCC_DBOX_1	205	213	PF00400	0.455
DEG_Nend_Nbox_1	1	3	PF02207	0.274
DOC_CDC14_PxL_1	125	133	PF14671	0.554
DOC_CYCLIN_RxL_1	188	200	PF00134	0.581
DOC_CYCLIN_RxL_1	26	38	PF00134	0.326
DOC_PP1_RVXF_1	119	126	PF00149	0.627
DOC_USP7_UBL2_3	247	251	PF12436	0.451
DOC_WW_Pin1_4	100	105	PF00397	0.343
DOC_WW_Pin1_4	261	266	PF00397	0.482
DOC_WW_Pin1_4	43	48	PF00397	0.425
LIG_14-3-3_CanoR_1	173	181	PF00244	0.626
LIG_14-3-3_CanoR_1	231	239	PF00244	0.357
LIG_14-3-3_CanoR_1	87	95	PF00244	0.343
LIG_14-3-3_CanoR_1	9	13	PF00244	0.371
LIG_deltaCOP1_diTrp_1	17	21	PF00928	0.353
LIG_FHA_1	118	124	PF00498	0.623
LIG_FHA_1	175	181	PF00498	0.561
LIG_LIR_Gen_1	48	58	PF02991	0.431
LIG_LIR_Gen_1	73	84	PF02991	0.332
LIG_LIR_Nem_3	122	128	PF02991	0.600
LIG_LIR_Nem_3	17	21	PF02991	0.336
LIG_LIR_Nem_3	269	273	PF02991	0.438
LIG_LIR_Nem_3	48	54	PF02991	0.414
LIG_LIR_Nem_3	73	79	PF02991	0.339
LIG_PTB_Apo_2	99	106	PF02174	0.343
LIG_SH2_GRB2like	110	113	PF00017	0.451
LIG_SH2_PTP2	29	32	PF00017	0.371
LIG_SH2_PTP2	51	54	PF00017	0.451
LIG_SH2_STAP1	268	272	PF00017	0.548
LIG_SH2_STAT5	268	271	PF00017	0.550
LIG_SH2_STAT5	29	32	PF00017	0.371
LIG_SH2_STAT5	51	54	PF00017	0.316
LIG_SH3_3	123	129	PF00018	0.602
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.562
LIG_SUMO_SIM_par_1	207	213	PF11976	0.544
LIG_TRAF2_1	38	41	PF00917	0.449
MOD_CDC14_SPxK_1	103	106	PF00782	0.358
MOD_CDK_SPxK_1	100	106	PF00069	0.358
MOD_CK1_1	124	130	PF00069	0.575
MOD_CK1_1	65	71	PF00069	0.345
MOD_CK2_1	215	221	PF00069	0.430
MOD_CK2_1	35	41	PF00069	0.449
MOD_GlcNHglycan	64	67	PF01048	0.358
MOD_GSK3_1	117	124	PF00069	0.600
MOD_GSK3_1	96	103	PF00069	0.324
MOD_LATS_1	229	235	PF00433	0.376
MOD_N-GLC_1	117	122	PF02516	0.600
MOD_N-GLC_1	19	24	PF02516	0.456
MOD_NEK2_1	7	12	PF00069	0.343
MOD_NEK2_1	86	91	PF00069	0.343
MOD_NEK2_2	249	254	PF00069	0.420
MOD_PIKK_1	86	92	PF00454	0.346
MOD_PKA_1	174	180	PF00069	0.544
MOD_PKA_2	174	180	PF00069	0.544
MOD_PKA_2	215	221	PF00069	0.437
MOD_PKA_2	36	42	PF00069	0.454
MOD_PKA_2	8	14	PF00069	0.371
MOD_PKA_2	86	92	PF00069	0.332
MOD_Plk_1	121	127	PF00069	0.610
MOD_Plk_4	8	14	PF00069	0.356
MOD_ProDKin_1	100	106	PF00069	0.343
MOD_ProDKin_1	261	267	PF00069	0.482
MOD_ProDKin_1	43	49	PF00069	0.425
TRG_DiLeu_BaEn_1	207	212	PF01217	0.563
TRG_ENDOCYTIC_2	29	32	PF00928	0.353
TRG_ENDOCYTIC_2	51	54	PF00928	0.382
TRG_ENDOCYTIC_2	64	67	PF00928	0.215
TRG_ER_diArg_1	150	152	PF00400	0.588
TRG_ER_diArg_1	173	176	PF00400	0.602
TRG_ER_diArg_1	187	189	PF00400	0.622
TRG_ER_diArg_1	253	256	PF00400	0.352
TRG_NES_CRM1_1	207	221	PF08389	0.466
TRG_NLS_MonoExtC_3	172	178	PF00514	0.593
TRG_NLS_MonoExtN_4	172	177	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T3	Leptomonas seymouri	89%	94%
A0A0S4JCN1	Bodo saltans	26%	85%
A0A0S4JLV2	Bodo saltans	53%	95%
A0A1X0NMT4	Trypanosomatidae	68%	94%
A0A3R7KK47	Trypanosoma rangeli	67%	94%
A4H6S6	Leishmania braziliensis	93%	100%
A4HV54	Leishmania infantum	100%	100%
C9ZQD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	94%
D0A9C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	68%
E9ANT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QGT3	Leishmania major	98%	100%
V5BHW6	Trypanosoma cruzi	66%	94%