TatD related deoxyribonuclease, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tatD related deoxyribonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6J9_LEIDO

TriTrypDb:

LdBPK_111270.1 , LdCL_110018600 , LDHU3_11.1580

Length:

336

Annotations

Annotations by Jardim et al.

Nucleases, tatD related deoxyribonuclease

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6J9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.504
CLV_C14_Caspase3-7	97	101	PF00656	0.529
CLV_NRD_NRD_1	110	112	PF00675	0.318
CLV_NRD_NRD_1	276	278	PF00675	0.237
CLV_NRD_NRD_1	307	309	PF00675	0.280
CLV_NRD_NRD_1	325	327	PF00675	0.269
CLV_PCSK_KEX2_1	154	156	PF00082	0.324
CLV_PCSK_KEX2_1	257	259	PF00082	0.283
CLV_PCSK_KEX2_1	307	309	PF00082	0.260
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.324
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.239
CLV_PCSK_SKI1_1	172	176	PF00082	0.261
CLV_PCSK_SKI1_1	230	234	PF00082	0.322
CLV_PCSK_SKI1_1	249	253	PF00082	0.144
CLV_PCSK_SKI1_1	326	330	PF00082	0.251
CLV_PCSK_SKI1_1	52	56	PF00082	0.205
DEG_SPOP_SBC_1	321	325	PF00917	0.439
DOC_CYCLIN_RxL_1	243	253	PF00134	0.461
DOC_MAPK_gen_1	111	117	PF00069	0.439
DOC_MAPK_gen_1	154	162	PF00069	0.492
DOC_MAPK_MEF2A_6	12	20	PF00069	0.400
DOC_MAPK_MEF2A_6	154	162	PF00069	0.492
DOC_MAPK_NFAT4_5	155	163	PF00069	0.524
DOC_PP1_RVXF_1	131	137	PF00149	0.405
DOC_USP7_UBL2_3	139	143	PF12436	0.504
DOC_USP7_UBL2_3	278	282	PF12436	0.534
LIG_14-3-3_CanoR_1	111	116	PF00244	0.505
LIG_14-3-3_CanoR_1	133	137	PF00244	0.465
LIG_14-3-3_CanoR_1	165	169	PF00244	0.546
LIG_14-3-3_CanoR_1	258	265	PF00244	0.516
LIG_14-3-3_CanoR_1	32	42	PF00244	0.535
LIG_14-3-3_CanoR_1	73	82	PF00244	0.519
LIG_Actin_WH2_2	202	217	PF00022	0.497
LIG_eIF4E_1	145	151	PF01652	0.504
LIG_FHA_1	323	329	PF00498	0.426
LIG_FHA_1	34	40	PF00498	0.510
LIG_FHA_2	165	171	PF00498	0.429
LIG_HCF-1_HBM_1	22	25	PF13415	0.461
LIG_Integrin_isoDGR_2	30	32	PF01839	0.324
LIG_LIR_Gen_1	130	138	PF02991	0.426
LIG_LIR_Gen_1	236	247	PF02991	0.426
LIG_LIR_Nem_3	130	134	PF02991	0.426
LIG_LIR_Nem_3	170	174	PF02991	0.431
LIG_LIR_Nem_3	22	28	PF02991	0.439
LIG_LIR_Nem_3	236	242	PF02991	0.437
LIG_PDZ_Class_1	331	336	PF00595	0.390
LIG_SH2_CRK	131	135	PF00017	0.426
LIG_SH2_CRK	25	29	PF00017	0.492
LIG_SH2_PTP2	206	209	PF00017	0.451
LIG_SH2_SRC	200	203	PF00017	0.524
LIG_SH2_STAT5	102	105	PF00017	0.478
LIG_SH2_STAT5	145	148	PF00017	0.431
LIG_SH2_STAT5	200	203	PF00017	0.467
LIG_SH2_STAT5	206	209	PF00017	0.434
LIG_SH3_3	174	180	PF00018	0.504
LIG_SH3_3	93	99	PF00018	0.524
LIG_TYR_ITIM	129	134	PF00017	0.426
LIG_WRC_WIRS_1	187	192	PF05994	0.426
MOD_CK1_1	213	219	PF00069	0.461
MOD_CK1_1	261	267	PF00069	0.507
MOD_CK2_1	190	196	PF00069	0.451
MOD_CK2_1	309	315	PF00069	0.480
MOD_CK2_1	34	40	PF00069	0.474
MOD_GlcNHglycan	333	336	PF01048	0.447
MOD_GSK3_1	186	193	PF00069	0.437
MOD_GSK3_1	257	264	PF00069	0.498
MOD_GSK3_1	34	41	PF00069	0.533
MOD_N-GLC_1	18	23	PF02516	0.237
MOD_N-GLC_2	210	212	PF02516	0.226
MOD_NEK2_1	190	195	PF00069	0.469
MOD_NEK2_1	242	247	PF00069	0.495
MOD_NEK2_1	322	327	PF00069	0.479
MOD_NEK2_1	331	336	PF00069	0.506
MOD_NEK2_1	54	59	PF00069	0.438
MOD_NEK2_1	61	66	PF00069	0.431
MOD_PIKK_1	258	264	PF00454	0.478
MOD_PK_1	111	117	PF00069	0.505
MOD_PKA_1	111	117	PF00069	0.439
MOD_PKA_1	257	263	PF00069	0.483
MOD_PKA_2	132	138	PF00069	0.489
MOD_PKA_2	164	170	PF00069	0.437
MOD_PKA_2	257	263	PF00069	0.516
MOD_Plk_1	309	315	PF00069	0.496
MOD_Plk_2-3	164	170	PF00069	0.464
MOD_Plk_2-3	310	316	PF00069	0.452
MOD_Plk_4	265	271	PF00069	0.512
MOD_Plk_4	38	44	PF00069	0.524
MOD_SUMO_rev_2	164	174	PF00179	0.461
MOD_SUMO_rev_2	236	245	PF00179	0.477
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.480
TRG_ENDOCYTIC_2	131	134	PF00928	0.426
TRG_ENDOCYTIC_2	206	209	PF00928	0.451
TRG_ENDOCYTIC_2	25	28	PF00928	0.490
TRG_ER_diArg_1	155	158	PF00400	0.524
TRG_ER_diArg_1	306	308	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.206

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q2	Leptomonas seymouri	67%	100%
A0A0N1IL51	Leptomonas seymouri	36%	93%
A0A0S4IY84	Bodo saltans	49%	99%
A0A0S4JNN8	Bodo saltans	34%	91%
A0A1X0NWJ2	Trypanosomatidae	60%	100%
A0A1X0P426	Trypanosomatidae	30%	86%
A0A3R7K0P4	Trypanosoma rangeli	33%	94%
A0A3R7LLG2	Trypanosoma rangeli	59%	100%
A0A3S7X0L2	Leishmania donovani	30%	89%
A4H6P9	Leishmania braziliensis	82%	100%
A4HFM3	Leishmania braziliensis	30%	100%
A4HV34	Leishmania infantum	100%	100%
A4I2Q1	Leishmania infantum	30%	100%
A4WFX9	Enterobacter sp. (strain 638)	37%	100%
A7MQN1	Cronobacter sakazakii (strain ATCC BAA-894)	31%	100%
A8ACY8	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	37%	100%
A8G8C4	Serratia proteamaculans (strain 568)	30%	100%
B1JP69	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	33%	100%
B2VG45	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	37%	100%
B5XYH5	Klebsiella pneumoniae (strain 342)	37%	100%
B7LTZ5	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	34%	100%
B7XJI2	Enterocytozoon bieneusi (strain H348)	25%	100%
C4VAS3	Nosema ceranae (strain BRL01)	30%	100%
C6C4V4	Musicola paradisiaca (strain Ech703)	31%	100%
C6DI71	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	29%	100%
C9XTA5	Cronobacter turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827 / z3032)	35%	100%
D0A5V3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	88%
D0A7B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D0KC77	Pectobacterium parmentieri (strain WPP163)	29%	100%
D0Z9R0	Edwardsiella tarda (strain EIB202)	30%	100%
D2TUZ4	Citrobacter rodentium (strain ICC168)	37%	100%
D4GGR2	Pantoea ananatis (strain LMG 20103)	32%	100%
D4ICL5	Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3)	37%	100%
D8MKW4	Erwinia billingiae (strain Eb661)	32%	100%
E0SLH6	Dickeya dadantii (strain 3937)	37%	100%
E1SKR8	Pantoea vagans (strain C9-1)	31%	100%
E3G381	Enterobacter lignolyticus (strain SCF1)	34%	100%
E6WHK1	Pantoea sp. (strain At-9b)	31%	100%
E8XYF5	Rahnella sp. (strain Y9602)	36%	100%
E9AD77	Leishmania major	29%	100%
E9ANR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AZ01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
P27859	Escherichia coli (strain K12)	33%	100%
P34220	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	80%
P39408	Escherichia coli (strain K12)	27%	100%
P73335	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q0SZ31	Shigella flexneri serotype 5b (strain 8401)	34%	100%
Q148G4	Bos taurus	43%	100%
Q3U1C6	Mus musculus	25%	100%
Q4QGV4	Leishmania major	96%	100%
Q503T5	Danio rerio	26%	100%
Q640V9	Xenopus laevis	45%	100%
Q6DAQ1	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	29%	100%
Q6GML7	Danio rerio	48%	100%
Q6P1N9	Homo sapiens	45%	100%
Q6P8M1	Mus musculus	43%	100%
Q8K9J1	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	30%	100%
Q8SW70	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q9L6M2	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	34%	100%
Q9UUF1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
V5BRW2	Trypanosoma cruzi	56%	100%