ATP-binding cassette subfamily A, member 1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily A, member 10, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6J8_LEIDO

TriTrypDb:

LdBPK_290640.1 , LdCL_110018400 , LDHU3_11.1510

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H6J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6J8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005215	transporter activity	1	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0015399	primary active transmembrane transporter activity	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0022804	active transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0042626	ATPase-coupled transmembrane transporter activity	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140359	ABC-type transporter activity	3	6
GO:0140657	ATP-dependent activity	1	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	297	299	PF00675	0.294
CLV_NRD_NRD_1	466	468	PF00675	0.270
CLV_NRD_NRD_1	479	481	PF00675	0.179
CLV_NRD_NRD_1	509	511	PF00675	0.284
CLV_NRD_NRD_1	601	603	PF00675	0.292
CLV_PCSK_KEX2_1	297	299	PF00082	0.294
CLV_PCSK_KEX2_1	349	351	PF00082	0.263
CLV_PCSK_KEX2_1	479	481	PF00082	0.205
CLV_PCSK_KEX2_1	509	511	PF00082	0.284
CLV_PCSK_KEX2_1	601	603	PF00082	0.292
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.263
CLV_PCSK_SKI1_1	12	16	PF00082	0.307
CLV_PCSK_SKI1_1	359	363	PF00082	0.231
CLV_PCSK_SKI1_1	411	415	PF00082	0.209
CLV_PCSK_SKI1_1	468	472	PF00082	0.209
CLV_PCSK_SKI1_1	55	59	PF00082	0.231
DEG_APCC_DBOX_1	296	304	PF00400	0.493
DOC_ANK_TNKS_1	594	601	PF00023	0.519
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.310
DOC_MAPK_gen_1	479	488	PF00069	0.413
DOC_MAPK_MEF2A_6	25	33	PF00069	0.409
DOC_MAPK_MEF2A_6	479	488	PF00069	0.413
DOC_PP1_RVXF_1	357	364	PF00149	0.399
DOC_PP4_FxxP_1	158	161	PF00568	0.480
DOC_PP4_FxxP_1	72	75	PF00568	0.409
DOC_USP7_MATH_1	593	597	PF00917	0.505
DOC_USP7_MATH_1	76	80	PF00917	0.429
DOC_USP7_UBL2_3	556	560	PF12436	0.465
LIG_14-3-3_CanoR_1	12	20	PF00244	0.511
LIG_14-3-3_CanoR_1	467	471	PF00244	0.459
LIG_14-3-3_CanoR_1	479	485	PF00244	0.393
LIG_14-3-3_CanoR_1	572	581	PF00244	0.474
LIG_AP2alpha_1	613	617	PF02296	0.485
LIG_APCC_ABBA_1	69	74	PF00400	0.409
LIG_APCC_ABBAyCdc20_2	68	74	PF00400	0.409
LIG_BIR_III_2	308	312	PF00653	0.507
LIG_BRCT_BRCA1_1	185	189	PF00533	0.236
LIG_Clathr_ClatBox_1	249	253	PF01394	0.231
LIG_Clathr_ClatBox_1	429	433	PF01394	0.431
LIG_EH1_1	138	146	PF00400	0.217
LIG_eIF4E_1	139	145	PF01652	0.231
LIG_eIF4E_1	183	189	PF01652	0.231
LIG_FHA_1	13	19	PF00498	0.502
LIG_FHA_1	140	146	PF00498	0.326
LIG_FHA_1	165	171	PF00498	0.247
LIG_FHA_1	336	342	PF00498	0.577
LIG_FHA_1	360	366	PF00498	0.432
LIG_FHA_1	380	386	PF00498	0.442
LIG_FHA_1	424	430	PF00498	0.471
LIG_FHA_1	469	475	PF00498	0.409
LIG_FHA_1	527	533	PF00498	0.460
LIG_FHA_2	335	341	PF00498	0.503
LIG_FHA_2	429	435	PF00498	0.413
LIG_FHA_2	457	463	PF00498	0.409
LIG_FHA_2	46	52	PF00498	0.409
LIG_GBD_Chelix_1	205	213	PF00786	0.247
LIG_LIR_Apic_2	157	161	PF02991	0.409
LIG_LIR_Apic_2	70	75	PF02991	0.409
LIG_LIR_Gen_1	133	141	PF02991	0.276
LIG_LIR_Gen_1	167	176	PF02991	0.244
LIG_LIR_Gen_1	362	371	PF02991	0.508
LIG_LIR_Gen_1	48	58	PF02991	0.436
LIG_LIR_Gen_1	580	590	PF02991	0.461
LIG_LIR_Gen_1	615	622	PF02991	0.501
LIG_LIR_Gen_1	641	647	PF02991	0.436
LIG_LIR_Nem_3	123	127	PF02991	0.247
LIG_LIR_Nem_3	133	137	PF02991	0.253
LIG_LIR_Nem_3	167	171	PF02991	0.244
LIG_LIR_Nem_3	233	237	PF02991	0.237
LIG_LIR_Nem_3	362	366	PF02991	0.448
LIG_LIR_Nem_3	369	374	PF02991	0.433
LIG_LIR_Nem_3	437	442	PF02991	0.399
LIG_LIR_Nem_3	449	453	PF02991	0.399
LIG_LIR_Nem_3	48	53	PF02991	0.496
LIG_LIR_Nem_3	580	585	PF02991	0.460
LIG_LIR_Nem_3	61	67	PF02991	0.423
LIG_LIR_Nem_3	610	616	PF02991	0.504
LIG_LIR_Nem_3	641	646	PF02991	0.466
LIG_NRBOX	245	251	PF00104	0.231
LIG_PCNA_yPIPBox_3	636	645	PF02747	0.430
LIG_Pex14_1	128	132	PF04695	0.213
LIG_Pex14_1	272	276	PF04695	0.261
LIG_Pex14_2	124	128	PF04695	0.213
LIG_Pex14_2	20	24	PF04695	0.552
LIG_Pex14_2	204	208	PF04695	0.236
LIG_Pex14_2	53	57	PF04695	0.409
LIG_Pex14_2	563	567	PF04695	0.471
LIG_Pex14_2	613	617	PF04695	0.485
LIG_SH2_CRK	4	8	PF00017	0.518
LIG_SH2_CRK	439	443	PF00017	0.413
LIG_SH2_CRK	605	609	PF00017	0.503
LIG_SH2_NCK_1	404	408	PF00017	0.409
LIG_SH2_SRC	404	407	PF00017	0.409
LIG_SH2_STAP1	132	136	PF00017	0.231
LIG_SH2_STAP1	183	187	PF00017	0.288
LIG_SH2_STAP1	50	54	PF00017	0.409
LIG_SH2_STAT3	419	422	PF00017	0.413
LIG_SH2_STAT5	132	135	PF00017	0.250
LIG_SH2_STAT5	139	142	PF00017	0.213
LIG_SH2_STAT5	215	218	PF00017	0.337
LIG_SH2_STAT5	240	243	PF00017	0.310
LIG_SH2_STAT5	400	403	PF00017	0.569
LIG_SH2_STAT5	419	422	PF00017	0.358
LIG_SH2_STAT5	549	552	PF00017	0.437
LIG_SH3_3	276	282	PF00018	0.231
LIG_SH3_3	288	294	PF00018	0.256
LIG_SH3_3	308	314	PF00018	0.455
LIG_SH3_3	486	492	PF00018	0.409
LIG_SH3_3	87	93	PF00018	0.231
LIG_SH3_3	95	101	PF00018	0.200
LIG_SUMO_SIM_anti_2	426	431	PF11976	0.409
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.433
LIG_SUMO_SIM_par_1	215	220	PF11976	0.232
LIG_SUMO_SIM_par_1	248	254	PF11976	0.231
LIG_SUMO_SIM_par_1	424	431	PF11976	0.410
LIG_TRAF2_1	431	434	PF00917	0.413
LIG_TRFH_1	234	238	PF08558	0.231
LIG_TYR_ITIM	274	279	PF00017	0.231
LIG_UBA3_1	246	255	PF00899	0.231
LIG_WRC_WIRS_1	54	59	PF05994	0.409
LIG_WRC_WIRS_1	582	587	PF05994	0.462
LIG_WRC_WIRS_1	617	622	PF05994	0.472
MOD_CK1_1	194	200	PF00069	0.329
MOD_CK1_1	472	478	PF00069	0.409
MOD_CK1_1	635	641	PF00069	0.438
MOD_CK2_1	316	322	PF00069	0.502
MOD_CK2_1	428	434	PF00069	0.413
MOD_CK2_1	456	462	PF00069	0.409
MOD_CK2_1	562	568	PF00069	0.475
MOD_CK2_1	593	599	PF00069	0.508
MOD_Cter_Amidation	599	602	PF01082	0.324
MOD_GlcNHglycan	193	196	PF01048	0.506
MOD_GlcNHglycan	262	265	PF01048	0.409
MOD_GlcNHglycan	397	400	PF01048	0.216
MOD_GlcNHglycan	471	474	PF01048	0.219
MOD_GlcNHglycan	498	503	PF01048	0.213
MOD_GlcNHglycan	564	567	PF01048	0.261
MOD_GlcNHglycan	574	577	PF01048	0.270
MOD_GlcNHglycan	61	64	PF01048	0.209
MOD_GlcNHglycan	658	661	PF01048	0.339
MOD_GSK3_1	126	133	PF00069	0.296
MOD_GSK3_1	190	197	PF00069	0.293
MOD_GSK3_1	219	226	PF00069	0.421
MOD_GSK3_1	312	319	PF00069	0.519
MOD_GSK3_1	379	386	PF00069	0.413
MOD_GSK3_1	468	475	PF00069	0.434
MOD_GSK3_1	521	528	PF00069	0.454
MOD_GSK3_1	630	637	PF00069	0.481
MOD_N-GLC_1	12	17	PF02516	0.306
MOD_N-GLC_1	130	135	PF02516	0.529
MOD_N-GLC_1	34	39	PF02516	0.213
MOD_NEK2_1	140	145	PF00069	0.394
MOD_NEK2_1	176	181	PF00069	0.389
MOD_NEK2_1	251	256	PF00069	0.250
MOD_NEK2_1	33	38	PF00069	0.507
MOD_NEK2_1	334	339	PF00069	0.526
MOD_NEK2_1	373	378	PF00069	0.441
MOD_NEK2_1	53	58	PF00069	0.355
MOD_NEK2_1	567	572	PF00069	0.456
MOD_NEK2_1	581	586	PF00069	0.459
MOD_NEK2_2	120	125	PF00069	0.209
MOD_NEK2_2	461	466	PF00069	0.409
MOD_PIKK_1	632	638	PF00454	0.474
MOD_PIKK_1	74	80	PF00454	0.430
MOD_PK_1	480	486	PF00069	0.413
MOD_PKA_1	480	486	PF00069	0.413
MOD_PKA_2	24	30	PF00069	0.528
MOD_PKA_2	466	472	PF00069	0.431
MOD_PKA_2	59	65	PF00069	0.411
MOD_Plk_1	12	18	PF00069	0.504
MOD_Plk_1	130	136	PF00069	0.209
MOD_Plk_1	423	429	PF00069	0.409
MOD_Plk_1	461	467	PF00069	0.399
MOD_Plk_1	567	573	PF00069	0.460
MOD_Plk_1	630	636	PF00069	0.456
MOD_Plk_2-3	316	322	PF00069	0.514
MOD_Plk_2-3	428	434	PF00069	0.413
MOD_Plk_4	120	126	PF00069	0.370
MOD_Plk_4	140	146	PF00069	0.195
MOD_Plk_4	164	170	PF00069	0.242
MOD_Plk_4	183	189	PF00069	0.477
MOD_Plk_4	194	200	PF00069	0.243
MOD_Plk_4	45	51	PF00069	0.422
MOD_Plk_4	461	467	PF00069	0.401
MOD_Plk_4	521	527	PF00069	0.456
MOD_Plk_4	53	59	PF00069	0.449
MOD_Plk_4	581	587	PF00069	0.465
TRG_DiLeu_BaEn_1	449	454	PF01217	0.409
TRG_DiLeu_BaEn_1	599	604	PF01217	0.503
TRG_DiLeu_BaEn_2	368	374	PF01217	0.413
TRG_DiLeu_BaEn_4	433	439	PF01217	0.431
TRG_DiLeu_BaEn_4	533	539	PF01217	0.452
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.231
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.231
TRG_ENDOCYTIC_2	276	279	PF00928	0.310
TRG_ENDOCYTIC_2	4	7	PF00928	0.516
TRG_ENDOCYTIC_2	404	407	PF00928	0.458
TRG_ENDOCYTIC_2	439	442	PF00928	0.413
TRG_ENDOCYTIC_2	49	52	PF00928	0.401
TRG_ER_diArg_1	296	298	PF00400	0.489
TRG_ER_diArg_1	302	305	PF00400	0.499
TRG_ER_diArg_1	601	603	PF00400	0.495
TRG_NES_CRM1_1	268	280	PF08389	0.213
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KM38	Bodo saltans	47%	99%
A0A3S7WRU9	Leishmania donovani	100%	100%
A4HV30	Leishmania infantum	100%	100%
E9AYZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q1PEH6	Arabidopsis thaliana	26%	71%
Q552P3	Dictyostelium discoideum	28%	79%
Q84K47	Arabidopsis thaliana	26%	67%
Q8LPK0	Arabidopsis thaliana	25%	73%
Q8T6J0	Dictyostelium discoideum	29%	79%
Q9FLT4	Arabidopsis thaliana	28%	73%
Q9FLT8	Arabidopsis thaliana	27%	72%
Q9STT6	Arabidopsis thaliana	26%	71%
Q9STT7	Arabidopsis thaliana	27%	71%
Q9STT8	Arabidopsis thaliana	27%	71%
V5BQS2	Trypanosoma cruzi	24%	100%