Protein transport protein SEC31, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein transport protein SEC31, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6J7_LEIDO

TriTrypDb:

LdBPK_111140.1 , LdCL_110017400 , LDHU3_11.1380

Length:

1167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	6
GO:0030117	membrane coat	3	1
GO:0030120	vesicle coat	4	1
GO:0030127	COPII vesicle coat	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0070971	endoplasmic reticulum exit site	2	1

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Expansion

Sequence features

A0A3S5H6J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6J7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	6
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	7
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	6

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Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.495
CLV_NRD_NRD_1	1103	1105	PF00675	0.513
CLV_NRD_NRD_1	534	536	PF00675	0.499
CLV_NRD_NRD_1	739	741	PF00675	0.563
CLV_PCSK_KEX2_1	1102	1104	PF00082	0.516
CLV_PCSK_KEX2_1	491	493	PF00082	0.556
CLV_PCSK_KEX2_1	552	554	PF00082	0.542
CLV_PCSK_KEX2_1	739	741	PF00082	0.582
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.556
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.542

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K3	Leptomonas seymouri	64%	97%
A0A0S4ISW1	Bodo saltans	33%	100%
A1C6X5	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	22%	91%
A1DHK2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	92%
A4H6N8	Leishmania braziliensis	81%	99%
E9ANQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F4ICD9	Arabidopsis thaliana	25%	100%
Q3UPL0	Mus musculus	24%	95%
Q4QGW6	Leishmania major	94%	99%
Q4X0M4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	92%

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