Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger domain protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6J6_LEIDO

TriTrypDb:

LdBPK_111090.1 , LdCL_110016900 , LDHU3_11.1310

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S5H6J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6J6

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016409	palmitoyltransferase activity	5	17
GO:0016417	S-acyltransferase activity	5	17
GO:0016740	transferase activity	2	17
GO:0016746	acyltransferase activity	3	17
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	17
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	17
GO:0019707	protein-cysteine S-acyltransferase activity	3	17
GO:0140096	catalytic activity, acting on a protein	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.487
CLV_NRD_NRD_1	183	185	PF00675	0.252
CLV_NRD_NRD_1	81	83	PF00675	0.395
CLV_NRD_NRD_1	93	95	PF00675	0.279
CLV_PCSK_FUR_1	91	95	PF00082	0.327
CLV_PCSK_KEX2_1	182	184	PF00082	0.259
CLV_PCSK_KEX2_1	301	303	PF00082	0.328
CLV_PCSK_KEX2_1	81	83	PF00082	0.395
CLV_PCSK_KEX2_1	93	95	PF00082	0.279
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.319
CLV_PCSK_SKI1_1	94	98	PF00082	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.573
DOC_MAPK_MEF2A_6	259	267	PF00069	0.322
DOC_PP2B_LxvP_1	38	41	PF13499	0.590
DOC_PP4_FxxP_1	306	309	PF00568	0.510
DOC_PP4_FxxP_1	97	100	PF00568	0.485
DOC_USP7_MATH_1	100	104	PF00917	0.595
DOC_USP7_MATH_1	4	8	PF00917	0.659
DOC_USP7_MATH_1	58	62	PF00917	0.698
DOC_USP7_MATH_1	72	76	PF00917	0.582
DOC_USP7_UBL2_3	193	197	PF12436	0.461
LIG_14-3-3_CanoR_1	291	296	PF00244	0.449
LIG_14-3-3_CanoR_1	99	105	PF00244	0.479
LIG_Actin_WH2_2	277	293	PF00022	0.369
LIG_BIR_III_4	45	49	PF00653	0.597
LIG_BRCT_BRCA1_1	120	124	PF00533	0.351
LIG_BRCT_BRCA1_1	145	149	PF00533	0.319
LIG_BRCT_BRCA1_1	254	258	PF00533	0.287
LIG_FHA_1	303	309	PF00498	0.516
LIG_FHA_2	183	189	PF00498	0.490
LIG_LIR_Apic_2	303	309	PF02991	0.497
LIG_LIR_Gen_1	216	225	PF02991	0.514
LIG_LIR_Gen_1	228	236	PF02991	0.300
LIG_LIR_Gen_1	292	299	PF02991	0.439
LIG_LIR_Nem_3	121	127	PF02991	0.412
LIG_LIR_Nem_3	216	221	PF02991	0.482
LIG_LIR_Nem_3	228	233	PF02991	0.369
LIG_LIR_Nem_3	292	298	PF02991	0.478
LIG_MLH1_MIPbox_1	254	258	PF16413	0.287
LIG_PCNA_yPIPBox_3	135	143	PF02747	0.200
LIG_Pex14_1	120	124	PF04695	0.253
LIG_Pex14_2	145	149	PF04695	0.211
LIG_Pex14_2	161	165	PF04695	0.523
LIG_SH2_CRK	111	115	PF00017	0.366
LIG_SH2_PTP2	127	130	PF00017	0.369
LIG_SH2_SRC	104	107	PF00017	0.542
LIG_SH2_SRC	295	298	PF00017	0.516
LIG_SH2_STAT5	111	114	PF00017	0.348
LIG_SH2_STAT5	127	130	PF00017	0.264
LIG_SH2_STAT5	131	134	PF00017	0.338
LIG_SH2_STAT5	218	221	PF00017	0.419
LIG_SH2_STAT5	257	260	PF00017	0.248
LIG_SH2_STAT5	285	288	PF00017	0.444
LIG_SH3_3	34	40	PF00018	0.611
LIG_SUMO_SIM_par_1	50	55	PF11976	0.578
LIG_TRAF2_1	309	312	PF00917	0.500
LIG_TYR_ITSM	291	298	PF00017	0.400
LIG_WRC_WIRS_1	230	235	PF05994	0.225
MOD_CK1_1	13	19	PF00069	0.664
MOD_CK1_1	228	234	PF00069	0.308
MOD_CK2_1	64	70	PF00069	0.667
MOD_Cter_Amidation	299	302	PF01082	0.276
MOD_GlcNHglycan	10	15	PF01048	0.436
MOD_GlcNHglycan	173	176	PF01048	0.317
MOD_GlcNHglycan	225	228	PF01048	0.330
MOD_GlcNHglycan	24	28	PF01048	0.353
MOD_GlcNHglycan	254	257	PF01048	0.400
MOD_GSK3_1	182	189	PF00069	0.535
MOD_GSK3_1	225	232	PF00069	0.383
MOD_GSK3_1	83	90	PF00069	0.521
MOD_N-GLC_2	196	198	PF02516	0.249
MOD_N-GLC_2	210	212	PF02516	0.229
MOD_NEK2_1	118	123	PF00069	0.275
MOD_NEK2_1	161	166	PF00069	0.571
MOD_NEK2_1	23	28	PF00069	0.709
MOD_NEK2_1	290	295	PF00069	0.440
MOD_NEK2_2	144	149	PF00069	0.211
MOD_PIKK_1	129	135	PF00454	0.446
MOD_PKA_1	182	188	PF00069	0.503
MOD_PKA_1	316	322	PF00069	0.504
MOD_PKA_2	182	188	PF00069	0.461
MOD_PKA_2	252	258	PF00069	0.196
MOD_PKA_2	290	296	PF00069	0.471
MOD_PKA_2	87	93	PF00069	0.578
MOD_Plk_1	302	308	PF00069	0.513
MOD_Plk_4	119	125	PF00069	0.294
MOD_Plk_4	144	150	PF00069	0.362
MOD_Plk_4	225	231	PF00069	0.348
MOD_Plk_4	235	241	PF00069	0.472
TRG_ENDOCYTIC_2	111	114	PF00928	0.351
TRG_ENDOCYTIC_2	127	130	PF00928	0.224
TRG_ENDOCYTIC_2	157	160	PF00928	0.534
TRG_ENDOCYTIC_2	218	221	PF00928	0.438
TRG_ENDOCYTIC_2	285	288	PF00928	0.485
TRG_ENDOCYTIC_2	295	298	PF00928	0.417
TRG_ER_diArg_1	182	184	PF00400	0.441
TRG_ER_diArg_1	81	83	PF00400	0.576
TRG_ER_diArg_1	91	94	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	31%	79%
A0A0N1I382	Leptomonas seymouri	49%	80%
A0A1X0NUX2	Trypanosomatidae	30%	88%
A0A3R7RC91	Trypanosoma rangeli	30%	96%
A0A3S7WX91	Leishmania donovani	31%	82%
A4H6N3	Leishmania braziliensis	68%	100%
A4HCH5	Leishmania braziliensis	31%	81%
A4HV17	Leishmania infantum	100%	100%
C9ZSP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	90%
E9AH03	Leishmania infantum	31%	82%
E9ANQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	81%
Q06551	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	90%
Q4QBL2	Leishmania major	31%	82%
Q4QGX1	Leishmania major	91%	96%
Q750R7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	88%
Q8R0N9	Mus musculus	29%	67%
Q8WTX9	Homo sapiens	27%	67%
V5B8P9	Trypanosoma cruzi	31%	93%
V5BWI0	Trypanosoma cruzi	44%	94%