Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6J0_LEIDO

TriTrypDb:

LdBPK_110750.1 , LdCL_110012900 , LDHU3_11.0950

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6J0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.416
CLV_C14_Caspase3-7	200	204	PF00656	0.657
CLV_NRD_NRD_1	207	209	PF00675	0.771
CLV_NRD_NRD_1	288	290	PF00675	0.496
CLV_NRD_NRD_1	332	334	PF00675	0.602
CLV_PCSK_KEX2_1	288	290	PF00082	0.503
CLV_PCSK_KEX2_1	326	328	PF00082	0.589
CLV_PCSK_KEX2_1	332	334	PF00082	0.581
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.673
CLV_PCSK_SKI1_1	283	287	PF00082	0.495
CLV_PCSK_SKI1_1	50	54	PF00082	0.640
CLV_PCSK_SKI1_1	63	67	PF00082	0.505
CLV_PCSK_SKI1_1	90	94	PF00082	0.548
DOC_ANK_TNKS_1	155	162	PF00023	0.480
DOC_CKS1_1	1	6	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	14	17	PF00134	0.547
DOC_PP2B_LxvP_1	14	17	PF13499	0.547
DOC_USP7_MATH_1	130	134	PF00917	0.722
DOC_USP7_MATH_1	139	143	PF00917	0.666
DOC_USP7_MATH_1	257	261	PF00917	0.546
DOC_USP7_UBL2_3	198	202	PF12436	0.532
DOC_WW_Pin1_4	215	220	PF00397	0.731
DOC_WW_Pin1_4	371	376	PF00397	0.679
LIG_14-3-3_CanoR_1	208	217	PF00244	0.524
LIG_14-3-3_CanoR_1	228	232	PF00244	0.644
LIG_14-3-3_CanoR_1	301	309	PF00244	0.735
LIG_14-3-3_CanoR_1	414	420	PF00244	0.561
LIG_Actin_WH2_2	390	407	PF00022	0.550
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BIR_III_4	7	11	PF00653	0.590
LIG_CSL_BTD_1	216	219	PF09270	0.645
LIG_CtBP_PxDLS_1	263	267	PF00389	0.715
LIG_FHA_1	339	345	PF00498	0.602
LIG_FHA_1	371	377	PF00498	0.705
LIG_FHA_1	389	395	PF00498	0.480
LIG_FHA_1	415	421	PF00498	0.582
LIG_FHA_2	1	7	PF00498	0.602
LIG_FHA_2	198	204	PF00498	0.600
LIG_FHA_2	228	234	PF00498	0.637
LIG_FHA_2	245	251	PF00498	0.659
LIG_FHA_2	27	33	PF00498	0.541
LIG_FHA_2	376	382	PF00498	0.685
LIG_FHA_2	84	90	PF00498	0.696
LIG_FHA_2	99	105	PF00498	0.617
LIG_LIR_Apic_2	150	155	PF02991	0.700
LIG_LIR_Gen_1	337	345	PF02991	0.655
LIG_LIR_Nem_3	216	220	PF02991	0.621
LIG_Pex14_1	217	221	PF04695	0.716
LIG_PTB_Apo_2	313	320	PF02174	0.631
LIG_SH2_CRK	152	156	PF00017	0.651
LIG_SH2_GRB2like	85	88	PF00017	0.490
LIG_SH2_SRC	128	131	PF00017	0.562
LIG_SH2_STAP1	31	35	PF00017	0.558
LIG_SH2_STAT5	128	131	PF00017	0.687
LIG_SH2_STAT5	244	247	PF00017	0.480
LIG_SH2_STAT5	339	342	PF00017	0.621
LIG_SH2_STAT5	85	88	PF00017	0.546
LIG_SH3_3	14	20	PF00018	0.546
LIG_SH3_3	160	166	PF00018	0.682
LIG_SH3_3	353	359	PF00018	0.540
LIG_UBA3_1	286	293	PF00899	0.513
MOD_CK1_1	105	111	PF00069	0.507
MOD_CK1_1	201	207	PF00069	0.551
MOD_CK1_1	213	219	PF00069	0.765
MOD_CK1_1	296	302	PF00069	0.654
MOD_CK1_1	413	419	PF00069	0.654
MOD_CK2_1	318	324	PF00069	0.669
MOD_CK2_1	375	381	PF00069	0.679
MOD_GlcNHglycan	104	107	PF01048	0.622
MOD_GlcNHglycan	132	135	PF01048	0.633
MOD_GlcNHglycan	276	280	PF01048	0.675
MOD_GlcNHglycan	304	307	PF01048	0.701
MOD_GlcNHglycan	420	423	PF01048	0.438
MOD_GlcNHglycan	47	50	PF01048	0.600
MOD_GlcNHglycan	55	59	PF01048	0.556
MOD_GSK3_1	139	146	PF00069	0.546
MOD_GSK3_1	197	204	PF00069	0.581
MOD_GSK3_1	209	216	PF00069	0.622
MOD_GSK3_1	22	29	PF00069	0.630
MOD_GSK3_1	240	247	PF00069	0.692
MOD_GSK3_1	262	269	PF00069	0.589
MOD_GSK3_1	296	303	PF00069	0.757
MOD_GSK3_1	308	315	PF00069	0.701
MOD_GSK3_1	340	347	PF00069	0.560
MOD_GSK3_1	371	378	PF00069	0.734
MOD_GSK3_1	400	407	PF00069	0.498
MOD_GSK3_1	41	48	PF00069	0.693
MOD_GSK3_1	410	417	PF00069	0.600
MOD_GSK3_1	98	105	PF00069	0.497
MOD_N-GLC_1	118	123	PF02516	0.546
MOD_N-GLC_1	213	218	PF02516	0.703
MOD_N-GLC_1	388	393	PF02516	0.454
MOD_N-GLC_2	232	234	PF02516	0.637
MOD_NEK2_1	23	28	PF00069	0.594
MOD_NEK2_1	266	271	PF00069	0.596
MOD_NEK2_1	275	280	PF00069	0.528
MOD_NEK2_1	300	305	PF00069	0.771
MOD_NEK2_1	98	103	PF00069	0.473
MOD_NEK2_2	400	405	PF00069	0.550
MOD_PIKK_1	252	258	PF00454	0.539
MOD_PK_1	428	434	PF00069	0.575
MOD_PK_1	88	94	PF00069	0.651
MOD_PKA_2	227	233	PF00069	0.689
MOD_PKA_2	300	306	PF00069	0.643
MOD_PKA_2	368	374	PF00069	0.702
MOD_PKA_2	413	419	PF00069	0.595
MOD_Plk_1	213	219	PF00069	0.636
MOD_Plk_1	76	82	PF00069	0.609
MOD_Plk_1	88	94	PF00069	0.530
MOD_Plk_4	143	149	PF00069	0.706
MOD_Plk_4	201	207	PF00069	0.621
MOD_Plk_4	23	29	PF00069	0.596
MOD_Plk_4	340	346	PF00069	0.563
MOD_ProDKin_1	215	221	PF00069	0.712
MOD_ProDKin_1	371	377	PF00069	0.671
MOD_SUMO_for_1	52	55	PF00179	0.662
TRG_ENDOCYTIC_2	339	342	PF00928	0.621
TRG_ER_diArg_1	287	289	PF00400	0.608
TRG_ER_diArg_1	332	334	PF00400	0.559
TRG_ER_diArg_1	60	63	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P309	Leptomonas seymouri	57%	100%
A0A0S4JRC7	Bodo saltans	26%	100%
A0A1X0ND00	Trypanosomatidae	40%	100%
A0A422NQE0	Trypanosoma rangeli	40%	100%
A4H6J9	Leishmania braziliensis	79%	100%
A4HUY4	Leishmania infantum	99%	100%
D0A7G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QH04	Leishmania major	93%	100%
V5DT29	Trypanosoma cruzi	38%	100%