PUF nine target 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PUF nine target 1

Gene product:

PUF nine target 1

Species:

Leishmania donovani

UniProt:

A0A3S5H6I9_LEIDO

TriTrypDb:

LdBPK_110730.1 , LdCL_110012700 , LDHU3_11.0930

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	600	604	PF00656	0.717
CLV_C14_Caspase3-7	617	621	PF00656	0.720
CLV_NRD_NRD_1	298	300	PF00675	0.587
CLV_NRD_NRD_1	351	353	PF00675	0.751
CLV_NRD_NRD_1	358	360	PF00675	0.715
CLV_NRD_NRD_1	4	6	PF00675	0.534
CLV_NRD_NRD_1	515	517	PF00675	0.561
CLV_PCSK_KEX2_1	298	300	PF00082	0.627
CLV_PCSK_KEX2_1	351	353	PF00082	0.664
CLV_PCSK_KEX2_1	357	359	PF00082	0.718
CLV_PCSK_KEX2_1	4	6	PF00082	0.537
CLV_PCSK_KEX2_1	510	512	PF00082	0.628
CLV_PCSK_KEX2_1	514	516	PF00082	0.612
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.652
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.653
CLV_PCSK_PC7_1	511	517	PF00082	0.626
CLV_PCSK_SKI1_1	320	324	PF00082	0.470
CLV_PCSK_SKI1_1	35	39	PF00082	0.387
CLV_PCSK_SKI1_1	392	396	PF00082	0.644
CLV_PCSK_SKI1_1	426	430	PF00082	0.649
CLV_PCSK_SKI1_1	510	514	PF00082	0.564
CLV_PCSK_SKI1_1	515	519	PF00082	0.549
CLV_PCSK_SKI1_1	583	587	PF00082	0.540
DEG_APCC_DBOX_1	239	247	PF00400	0.589
DEG_SPOP_SBC_1	404	408	PF00917	0.547
DEG_SPOP_SBC_1	613	617	PF00917	0.668
DOC_CYCLIN_RxL_1	387	397	PF00134	0.654
DOC_CYCLIN_RxL_1	4	16	PF00134	0.484
DOC_CYCLIN_RxL_1	580	588	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.637
DOC_MAPK_gen_1	181	188	PF00069	0.350
DOC_MAPK_gen_1	298	308	PF00069	0.608
DOC_MAPK_gen_1	32	42	PF00069	0.411
DOC_MAPK_gen_1	4	12	PF00069	0.417
DOC_PP1_RVXF_1	588	594	PF00149	0.666
DOC_PP2B_LxvP_1	431	434	PF13499	0.632
DOC_PP2B_LxvP_1	610	613	PF13499	0.664
DOC_PP2B_LxvP_1	631	634	PF13499	0.629
DOC_PP4_FxxP_1	182	185	PF00568	0.314
DOC_PP4_FxxP_1	258	261	PF00568	0.683
DOC_USP7_MATH_1	247	251	PF00917	0.654
DOC_USP7_MATH_1	374	378	PF00917	0.689
DOC_USP7_MATH_1	379	383	PF00917	0.717
DOC_USP7_MATH_1	403	407	PF00917	0.688
DOC_USP7_MATH_1	44	48	PF00917	0.401
DOC_USP7_MATH_1	536	540	PF00917	0.745
DOC_USP7_MATH_1	621	625	PF00917	0.676
DOC_USP7_MATH_1	87	91	PF00917	0.378
DOC_USP7_UBL2_3	510	514	PF12436	0.654
DOC_USP7_UBL2_3	518	522	PF12436	0.639
DOC_USP7_UBL2_3	64	68	PF12436	0.548
DOC_WW_Pin1_4	281	286	PF00397	0.715
DOC_WW_Pin1_4	408	413	PF00397	0.648
DOC_WW_Pin1_4	429	434	PF00397	0.686
DOC_WW_Pin1_4	530	535	PF00397	0.769
DOC_WW_Pin1_4	576	581	PF00397	0.696
LIG_14-3-3_CanoR_1	109	113	PF00244	0.406
LIG_14-3-3_CanoR_1	231	235	PF00244	0.518
LIG_14-3-3_CanoR_1	277	282	PF00244	0.716
LIG_14-3-3_CanoR_1	35	43	PF00244	0.452
LIG_14-3-3_CanoR_1	590	594	PF00244	0.668
LIG_14-3-3_CanoR_1	636	644	PF00244	0.693
LIG_BRCT_BRCA1_1	379	383	PF00533	0.720
LIG_CtBP_PxDLS_1	447	451	PF00389	0.660
LIG_CtBP_PxDLS_1	607	611	PF00389	0.561
LIG_FHA_1	147	153	PF00498	0.326
LIG_FHA_1	208	214	PF00498	0.314
LIG_FHA_1	328	334	PF00498	0.546
LIG_FHA_1	580	586	PF00498	0.637
LIG_FHA_1	626	632	PF00498	0.745
LIG_FHA_2	162	168	PF00498	0.355
LIG_FHA_2	204	210	PF00498	0.389
LIG_FHA_2	489	495	PF00498	0.570
LIG_FHA_2	598	604	PF00498	0.669
LIG_Integrin_RGD_1	202	204	PF01839	0.406
LIG_LIR_Apic_2	180	185	PF02991	0.314
LIG_LIR_Apic_2	233	238	PF02991	0.622
LIG_LIR_Apic_2	256	261	PF02991	0.662
LIG_LIR_Gen_1	101	110	PF02991	0.496
LIG_LIR_Gen_1	123	133	PF02991	0.414
LIG_LIR_Gen_1	167	176	PF02991	0.432
LIG_LIR_Gen_1	204	213	PF02991	0.314
LIG_LIR_Gen_1	463	473	PF02991	0.387
LIG_LIR_Gen_1	494	502	PF02991	0.624
LIG_LIR_Gen_1	75	81	PF02991	0.466
LIG_LIR_Nem_3	101	105	PF02991	0.473
LIG_LIR_Nem_3	123	129	PF02991	0.428
LIG_LIR_Nem_3	167	171	PF02991	0.455
LIG_LIR_Nem_3	204	208	PF02991	0.292
LIG_LIR_Nem_3	233	237	PF02991	0.563
LIG_LIR_Nem_3	463	468	PF02991	0.394
LIG_LIR_Nem_3	75	80	PF02991	0.452
LIG_LIR_Nem_3	90	94	PF02991	0.231
LIG_PCNA_yPIPBox_3	516	530	PF02747	0.649
LIG_PCNA_yPIPBox_3	623	636	PF02747	0.660
LIG_PDZ_Class_1	648	653	PF00595	0.729
LIG_Pex14_2	131	135	PF04695	0.314
LIG_Pex14_2	80	84	PF04695	0.405
LIG_RPA_C_Fungi	354	366	PF08784	0.699
LIG_SH2_CRK	235	239	PF00017	0.620
LIG_SH2_CRK	66	70	PF00017	0.541
LIG_SH2_NCK_1	229	233	PF00017	0.497
LIG_SH2_NCK_1	235	239	PF00017	0.528
LIG_SH2_PTP2	102	105	PF00017	0.580
LIG_SH2_STAP1	481	485	PF00017	0.497
LIG_SH2_STAT3	481	484	PF00017	0.571
LIG_SH2_STAT5	102	105	PF00017	0.488
LIG_SH2_STAT5	151	154	PF00017	0.314
LIG_SH2_STAT5	196	199	PF00017	0.333
LIG_SH2_STAT5	219	222	PF00017	0.350
LIG_SH2_STAT5	328	331	PF00017	0.438
LIG_SH2_STAT5	91	94	PF00017	0.335
LIG_SH3_1	279	285	PF00018	0.703
LIG_SH3_3	279	285	PF00018	0.720
LIG_SH3_3	498	504	PF00018	0.636
LIG_SH3_3	574	580	PF00018	0.688
LIG_Sin3_3	126	133	PF02671	0.432
LIG_SUMO_SIM_par_1	286	291	PF11976	0.736
LIG_SUMO_SIM_par_1	321	327	PF11976	0.449
LIG_SUMO_SIM_par_1	602	611	PF11976	0.556
LIG_SUMO_SIM_par_1	627	632	PF11976	0.632
LIG_SxIP_EBH_1	466	476	PF03271	0.462
LIG_TRAF2_1	457	460	PF00917	0.522
LIG_UBA3_1	322	326	PF00899	0.473
LIG_WRC_WIRS_1	77	82	PF05994	0.427
LIG_WW_3	1	5	PF00397	0.524
MOD_CDK_SPK_2	530	535	PF00069	0.723
MOD_CDK_SPK_2	576	581	PF00069	0.652
MOD_CDK_SPxxK_3	576	583	PF00069	0.574
MOD_CK1_1	177	183	PF00069	0.314
MOD_CK1_1	327	333	PF00069	0.560
MOD_CK1_1	377	383	PF00069	0.696
MOD_CK1_1	449	455	PF00069	0.639
MOD_CK1_1	496	502	PF00069	0.589
MOD_CK1_1	506	512	PF00069	0.510
MOD_CK1_1	539	545	PF00069	0.599
MOD_CK1_1	579	585	PF00069	0.719
MOD_CK1_1	592	598	PF00069	0.623
MOD_CK1_1	602	608	PF00069	0.694
MOD_CK1_1	615	621	PF00069	0.666
MOD_CK1_1	625	631	PF00069	0.700
MOD_CK1_1	639	645	PF00069	0.579
MOD_CK2_1	280	286	PF00069	0.705
MOD_CK2_1	454	460	PF00069	0.509
MOD_CK2_1	488	494	PF00069	0.554
MOD_CMANNOS	23	26	PF00535	0.397
MOD_Cter_Amidation	355	358	PF01082	0.705
MOD_GlcNHglycan	176	179	PF01048	0.317
MOD_GlcNHglycan	272	275	PF01048	0.813
MOD_GlcNHglycan	290	293	PF01048	0.617
MOD_GlcNHglycan	370	373	PF01048	0.716
MOD_GlcNHglycan	377	380	PF01048	0.672
MOD_GlcNHglycan	456	459	PF01048	0.476
MOD_GlcNHglycan	494	498	PF01048	0.674
MOD_GlcNHglycan	541	544	PF01048	0.629
MOD_GlcNHglycan	562	565	PF01048	0.778
MOD_GlcNHglycan	571	574	PF01048	0.656
MOD_GlcNHglycan	610	613	PF01048	0.674
MOD_GlcNHglycan	650	653	PF01048	0.731
MOD_GSK3_1	170	177	PF00069	0.356
MOD_GSK3_1	203	210	PF00069	0.346
MOD_GSK3_1	247	254	PF00069	0.621
MOD_GSK3_1	277	284	PF00069	0.758
MOD_GSK3_1	308	315	PF00069	0.645
MOD_GSK3_1	374	381	PF00069	0.701
MOD_GSK3_1	404	411	PF00069	0.695
MOD_GSK3_1	44	51	PF00069	0.412
MOD_GSK3_1	446	453	PF00069	0.668
MOD_GSK3_1	476	483	PF00069	0.585
MOD_GSK3_1	530	537	PF00069	0.629
MOD_GSK3_1	589	596	PF00069	0.659
MOD_GSK3_1	597	604	PF00069	0.723
MOD_GSK3_1	608	615	PF00069	0.788
MOD_GSK3_1	621	628	PF00069	0.726
MOD_GSK3_1	639	646	PF00069	0.743
MOD_LATS_1	144	150	PF00433	0.350
MOD_N-GLC_1	174	179	PF02516	0.406
MOD_N-GLC_1	597	602	PF02516	0.764
MOD_N-GLC_1	622	627	PF02516	0.693
MOD_NEK2_1	13	18	PF00069	0.433
MOD_NEK2_1	288	293	PF00069	0.682
MOD_NEK2_1	308	313	PF00069	0.636
MOD_NEK2_1	436	441	PF00069	0.736
MOD_NEK2_1	450	455	PF00069	0.660
MOD_NEK2_1	488	493	PF00069	0.539
MOD_NEK2_1	545	550	PF00069	0.653
MOD_NEK2_1	591	596	PF00069	0.716
MOD_NEK2_1	608	613	PF00069	0.772
MOD_NEK2_1	614	619	PF00069	0.671
MOD_NEK2_1	76	81	PF00069	0.419
MOD_NEK2_2	622	627	PF00069	0.636
MOD_PIKK_1	253	259	PF00454	0.612
MOD_PIKK_1	480	486	PF00454	0.557
MOD_PK_1	476	482	PF00069	0.587
MOD_PKA_2	108	114	PF00069	0.406
MOD_PKA_2	230	236	PF00069	0.512
MOD_PKA_2	294	300	PF00069	0.577
MOD_PKA_2	589	595	PF00069	0.700
MOD_PKB_1	357	365	PF00069	0.714
MOD_Plk_1	174	180	PF00069	0.380
MOD_Plk_1	18	24	PF00069	0.468
MOD_Plk_1	203	209	PF00069	0.330
MOD_Plk_1	247	253	PF00069	0.636
MOD_Plk_1	308	314	PF00069	0.625
MOD_Plk_1	426	432	PF00069	0.663
MOD_Plk_1	493	499	PF00069	0.603
MOD_Plk_1	602	608	PF00069	0.722
MOD_Plk_1	622	628	PF00069	0.651
MOD_Plk_2-3	48	54	PF00069	0.487
MOD_Plk_4	230	236	PF00069	0.512
MOD_Plk_4	308	314	PF00069	0.625
MOD_Plk_4	324	330	PF00069	0.463
MOD_Plk_4	476	482	PF00069	0.588
MOD_Plk_4	625	631	PF00069	0.703
MOD_Plk_4	76	82	PF00069	0.426
MOD_ProDKin_1	281	287	PF00069	0.716
MOD_ProDKin_1	408	414	PF00069	0.647
MOD_ProDKin_1	429	435	PF00069	0.687
MOD_ProDKin_1	530	536	PF00069	0.767
MOD_ProDKin_1	576	582	PF00069	0.696
MOD_SUMO_rev_2	315	322	PF00179	0.533
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.634
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.378
TRG_ENDOCYTIC_2	102	105	PF00928	0.488
TRG_ENDOCYTIC_2	168	171	PF00928	0.432
TRG_ENDOCYTIC_2	495	498	PF00928	0.627
TRG_ENDOCYTIC_2	66	69	PF00928	0.447
TRG_ER_diArg_1	298	301	PF00400	0.743
TRG_ER_diArg_1	3	5	PF00400	0.505
TRG_ER_diArg_1	351	353	PF00400	0.679
TRG_ER_diArg_1	357	359	PF00400	0.718
TRG_ER_diArg_1	580	583	PF00400	0.593
TRG_NLS_MonoExtC_3	513	518	PF00514	0.645
TRG_NLS_MonoExtN_4	511	518	PF00514	0.647
TRG_Pf-PMV_PEXEL_1	358	363	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	583	588	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q1	Leptomonas seymouri	74%	100%
A0A422NQF9	Trypanosoma rangeli	46%	100%
A4H6J7	Leishmania braziliensis	80%	98%
A4HUY2	Leishmania infantum	100%	100%
D0A7G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ANL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QH06	Leishmania major	92%	100%