Ribosome biogenesis protein BOP1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 89, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6I3_LEIDO

TriTrypDb:

LdBPK_110410.1 , LdCL_110009000 , LDHU3_11.0510

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005730	nucleolus	5	12
GO:0030684	preribosome	3	11
GO:0030687	preribosome, large subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0070545	PeBoW complex	3	1

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Expansion

Sequence features

A0A3S5H6I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6I3

Function

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Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	11
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000470	maturation of LSU-rRNA	9	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0044877	protein-containing complex binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.557
CLV_C14_Caspase3-7	549	553	PF00656	0.695
CLV_C14_Caspase3-7	575	579	PF00656	0.436
CLV_C14_Caspase3-7	86	90	PF00656	0.733
CLV_NRD_NRD_1	274	276	PF00675	0.332
CLV_NRD_NRD_1	282	284	PF00675	0.315
CLV_NRD_NRD_1	356	358	PF00675	0.333
CLV_NRD_NRD_1	631	633	PF00675	0.397
CLV_NRD_NRD_1	638	640	PF00675	0.410
CLV_NRD_NRD_1	677	679	PF00675	0.389

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I232	Leptomonas seymouri	86%	98%
A0A0S4IU17	Bodo saltans	70%	100%
A0A1X0NV50	Trypanosomatidae	76%	99%
A0A422NYV3	Trypanosoma rangeli	77%	100%
A0JMQ0	Danio rerio	34%	100%
A1CQI9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	32%	100%
A1D3F5	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	32%	100%
A2QPZ4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	34%	100%
A3LXF0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	34%	100%
A4H6F7	Leishmania braziliensis	94%	99%

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