Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6I2_LEIDO

TriTrypDb:

LdBPK_110370.1 , LdCL_110008600 , LDHU3_11.0470

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S5H6I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	513	517	PF00656	0.743
CLV_NRD_NRD_1	105	107	PF00675	0.434
CLV_NRD_NRD_1	16	18	PF00675	0.431
CLV_NRD_NRD_1	462	464	PF00675	0.485
CLV_NRD_NRD_1	511	513	PF00675	0.542
CLV_NRD_NRD_1	568	570	PF00675	0.462
CLV_NRD_NRD_1	593	595	PF00675	0.572
CLV_NRD_NRD_1	596	598	PF00675	0.443
CLV_PCSK_FUR_1	594	598	PF00082	0.530
CLV_PCSK_KEX2_1	104	106	PF00082	0.443
CLV_PCSK_KEX2_1	330	332	PF00082	0.432
CLV_PCSK_KEX2_1	367	369	PF00082	0.463
CLV_PCSK_KEX2_1	511	513	PF00082	0.542
CLV_PCSK_KEX2_1	567	569	PF00082	0.463
CLV_PCSK_KEX2_1	593	595	PF00082	0.572
CLV_PCSK_KEX2_1	596	598	PF00082	0.443
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.468
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.432
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.463
CLV_PCSK_SKI1_1	297	301	PF00082	0.452
CLV_PCSK_SKI1_1	367	371	PF00082	0.435
CLV_PCSK_SKI1_1	464	468	PF00082	0.427
CLV_PCSK_SKI1_1	597	601	PF00082	0.387
DEG_APCC_DBOX_1	22	30	PF00400	0.633
DEG_APCC_DBOX_1	87	95	PF00400	0.660
DEG_SCF_TRCP1_1	516	521	PF00400	0.674
DOC_CKS1_1	437	442	PF01111	0.661
DOC_CYCLIN_RxL_1	255	268	PF00134	0.653
DOC_CYCLIN_RxL_1	565	575	PF00134	0.687
DOC_MAPK_gen_1	17	28	PF00069	0.673
DOC_MAPK_gen_1	367	373	PF00069	0.654
DOC_MAPK_gen_1	593	603	PF00069	0.549
DOC_MAPK_gen_1	88	97	PF00069	0.663
DOC_MAPK_MEF2A_6	90	99	PF00069	0.661
DOC_MAPK_NFAT4_5	92	100	PF00069	0.656
DOC_PP2B_LxvP_1	570	573	PF13499	0.699
DOC_USP7_MATH_1	194	198	PF00917	0.735
DOC_USP7_MATH_1	206	210	PF00917	0.617
DOC_USP7_MATH_1	306	310	PF00917	0.672
DOC_USP7_MATH_1	356	360	PF00917	0.599
DOC_USP7_MATH_1	406	410	PF00917	0.823
DOC_USP7_MATH_1	415	419	PF00917	0.798
DOC_USP7_MATH_1	499	503	PF00917	0.771
DOC_WW_Pin1_4	182	187	PF00397	0.727
DOC_WW_Pin1_4	411	416	PF00397	0.769
DOC_WW_Pin1_4	436	441	PF00397	0.757
DOC_WW_Pin1_4	539	544	PF00397	0.685
LIG_14-3-3_CanoR_1	337	343	PF00244	0.667
LIG_14-3-3_CanoR_1	368	372	PF00244	0.635
LIG_14-3-3_CanoR_1	479	483	PF00244	0.608
LIG_Actin_WH2_2	255	272	PF00022	0.652
LIG_BRCT_BRCA1_1	200	204	PF00533	0.665
LIG_BRCT_BRCA1_1	358	362	PF00533	0.647
LIG_BRCT_BRCA1_1	516	520	PF00533	0.780
LIG_CaM_IQ_9	322	337	PF13499	0.584
LIG_FHA_1	164	170	PF00498	0.772
LIG_FHA_1	238	244	PF00498	0.624
LIG_FHA_1	254	260	PF00498	0.637
LIG_FHA_1	368	374	PF00498	0.637
LIG_FHA_1	539	545	PF00498	0.685
LIG_FHA_1	573	579	PF00498	0.704
LIG_FHA_1	586	592	PF00498	0.751
LIG_FHA_1	7	13	PF00498	0.684
LIG_FHA_2	145	151	PF00498	0.608
LIG_FHA_2	177	183	PF00498	0.812
LIG_FHA_2	343	349	PF00498	0.643
LIG_LIR_Gen_1	147	156	PF02991	0.671
LIG_LIR_Gen_1	354	362	PF02991	0.591
LIG_LIR_Nem_3	147	152	PF02991	0.588
LIG_LIR_Nem_3	354	360	PF02991	0.588
LIG_LIR_Nem_3	615	619	PF02991	0.462
LIG_NRBOX	151	157	PF00104	0.683
LIG_PDZ_Class_2	615	620	PF00595	0.446
LIG_Pex14_1	387	391	PF04695	0.583
LIG_PTB_Apo_2	280	287	PF02174	0.609
LIG_PTB_Phospho_1	280	286	PF10480	0.607
LIG_RPA_C_Fungi	458	470	PF08784	0.613
LIG_SH2_CRK	392	396	PF00017	0.665
LIG_SH2_NCK_1	392	396	PF00017	0.672
LIG_SH2_STAP1	149	153	PF00017	0.601
LIG_SH2_STAP1	304	308	PF00017	0.589
LIG_SH3_3	434	440	PF00018	0.690
LIG_SH3_3	502	508	PF00018	0.782
LIG_TRAF2_1	247	250	PF00917	0.634
LIG_TRAF2_1	345	348	PF00917	0.513
LIG_WRC_WIRS_1	613	618	PF05994	0.573
MOD_CDC14_SPxK_1	414	417	PF00782	0.718
MOD_CDK_SPxK_1	411	417	PF00069	0.718
MOD_CK1_1	309	315	PF00069	0.601
MOD_CK1_1	363	369	PF00069	0.591
MOD_CK1_1	481	487	PF00069	0.494
MOD_CK2_1	176	182	PF00069	0.796
MOD_CK2_1	206	212	PF00069	0.742
MOD_CK2_1	342	348	PF00069	0.502
MOD_CK2_1	524	530	PF00069	0.726
MOD_Cter_Amidation	509	512	PF01082	0.724
MOD_GlcNHglycan	182	185	PF01048	0.778
MOD_GlcNHglycan	196	199	PF01048	0.727
MOD_GlcNHglycan	200	203	PF01048	0.717
MOD_GlcNHglycan	308	311	PF01048	0.595
MOD_GlcNHglycan	37	40	PF01048	0.487
MOD_GlcNHglycan	401	404	PF01048	0.716
MOD_GlcNHglycan	417	420	PF01048	0.824
MOD_GlcNHglycan	426	429	PF01048	0.733
MOD_GlcNHglycan	494	497	PF01048	0.585
MOD_GlcNHglycan	502	505	PF01048	0.637
MOD_GlcNHglycan	516	519	PF01048	0.622
MOD_GlcNHglycan	583	586	PF01048	0.659
MOD_GSK3_1	176	183	PF00069	0.711
MOD_GSK3_1	194	201	PF00069	0.561
MOD_GSK3_1	288	295	PF00069	0.547
MOD_GSK3_1	356	363	PF00069	0.498
MOD_GSK3_1	391	398	PF00069	0.574
MOD_GSK3_1	411	418	PF00069	0.466
MOD_GSK3_1	424	431	PF00069	0.656
MOD_GSK3_1	477	484	PF00069	0.588
MOD_GSK3_1	514	521	PF00069	0.678
MOD_GSK3_1	539	546	PF00069	0.655
MOD_GSK3_1	547	554	PF00069	0.602
MOD_GSK3_1	581	588	PF00069	0.689
MOD_GSK3_1	72	79	PF00069	0.628
MOD_N-GLC_1	206	211	PF02516	0.738
MOD_NEK2_1	336	341	PF00069	0.619
MOD_NEK2_1	478	483	PF00069	0.482
MOD_NEK2_1	490	495	PF00069	0.568
MOD_NEK2_1	538	543	PF00069	0.671
MOD_NEK2_1	544	549	PF00069	0.653
MOD_NEK2_1	556	561	PF00069	0.464
MOD_NEK2_1	612	617	PF00069	0.484
MOD_PIKK_1	112	118	PF00454	0.616
MOD_PIKK_1	144	150	PF00454	0.520
MOD_PIKK_1	237	243	PF00454	0.548
MOD_PIKK_1	253	259	PF00454	0.566
MOD_PIKK_1	309	315	PF00454	0.556
MOD_PIKK_1	336	342	PF00454	0.617
MOD_PIKK_1	395	401	PF00454	0.671
MOD_PIKK_1	406	412	PF00454	0.659
MOD_PIKK_1	481	487	PF00454	0.471
MOD_PIKK_1	7	13	PF00454	0.619
MOD_PKA_1	367	373	PF00069	0.552
MOD_PKA_2	288	294	PF00069	0.586
MOD_PKA_2	336	342	PF00069	0.624
MOD_PKA_2	367	373	PF00069	0.601
MOD_PKA_2	478	484	PF00069	0.612
MOD_Plk_1	112	118	PF00069	0.572
MOD_Plk_1	253	259	PF00069	0.626
MOD_Plk_1	281	287	PF00069	0.613
MOD_Plk_1	347	353	PF00069	0.545
MOD_Plk_1	49	55	PF00069	0.505
MOD_Plk_2-3	348	354	PF00069	0.561
MOD_Plk_4	151	157	PF00069	0.567
MOD_Plk_4	271	277	PF00069	0.473
MOD_Plk_4	356	362	PF00069	0.516
MOD_Plk_4	484	490	PF00069	0.548
MOD_Plk_4	547	553	PF00069	0.564
MOD_Plk_4	599	605	PF00069	0.446
MOD_ProDKin_1	182	188	PF00069	0.680
MOD_ProDKin_1	411	417	PF00069	0.741
MOD_ProDKin_1	436	442	PF00069	0.713
MOD_ProDKin_1	539	545	PF00069	0.613
MOD_SUMO_for_1	247	250	PF00179	0.547
MOD_SUMO_rev_2	25	34	PF00179	0.476
MOD_SUMO_rev_2	266	272	PF00179	0.574
MOD_SUMO_rev_2	359	369	PF00179	0.572
MOD_SUMO_rev_2	382	389	PF00179	0.594
MOD_SUMO_rev_2	71	76	PF00179	0.586
TRG_DiLeu_BaEn_1	151	156	PF01217	0.499
TRG_DiLeu_BaEn_1	24	29	PF01217	0.606
TRG_DiLeu_BaEn_1	254	259	PF01217	0.538
TRG_DiLeu_BaEn_4	24	30	PF01217	0.581
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.703
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.339
TRG_DiLeu_LyEn_5	24	29	PF01217	0.606
TRG_ENDOCYTIC_2	149	152	PF00928	0.499
TRG_ENDOCYTIC_2	392	395	PF00928	0.568
TRG_ER_diArg_1	567	569	PF00400	0.557
TRG_ER_diArg_1	592	594	PF00400	0.698
TRG_ER_diArg_1	595	597	PF00400	0.686
TRG_NLS_MonoExtC_3	16	21	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.717
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW2	Leptomonas seymouri	57%	97%
A0A0S4ITZ6	Bodo saltans	24%	100%
A0A1X0NWL4	Trypanosomatidae	36%	100%
A0A3R7KMY4	Trypanosoma rangeli	32%	100%
A4H6F4	Leishmania braziliensis	75%	99%
A4HUU8	Leishmania infantum	98%	100%
D0A7K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ANI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QH43	Leishmania major	91%	99%
V5BB44	Trypanosoma cruzi	33%	100%