Proteasome subunit alpha type

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome alpha 7 subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6I0_LEIDO

TriTrypDb:

LdBPK_110240.1 , LdCL_110007300 , LDHU3_11.0300

Length:

247

Annotations

Annotations by Jardim et al.

Proteasome, Proteasome subunit alpha type

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0005737	cytoplasm	2	9
GO:0019773	proteasome core complex, alpha-subunit complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005839	proteasome core complex	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6I0

PDB structure(s): 6qm7_D , 6qm7_R , 6qm8_D , 6qm8_R

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	59	61	PF00675	0.277
CLV_PCSK_KEX2_1	241	243	PF00082	0.542
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.560
CLV_PCSK_SKI1_1	191	195	PF00082	0.277
CLV_PCSK_SKI1_1	215	219	PF00082	0.511
CLV_PCSK_SKI1_1	5	9	PF00082	0.274
DOC_ANK_TNKS_1	156	163	PF00023	0.491
DOC_CYCLIN_RxL_1	187	198	PF00134	0.477
DOC_MAPK_gen_1	27	35	PF00069	0.466
DOC_MAPK_gen_1	47	53	PF00069	0.344
DOC_MAPK_gen_1	60	71	PF00069	0.471
DOC_MAPK_MEF2A_6	64	73	PF00069	0.490
DOC_USP7_MATH_1	189	193	PF00917	0.491
DOC_USP7_UBL2_3	48	52	PF12436	0.477
DOC_WW_Pin1_4	8	13	PF00397	0.477
LIG_14-3-3_CanoR_1	215	222	PF00244	0.531
LIG_14-3-3_CanoR_1	5	10	PF00244	0.479
LIG_14-3-3_CanoR_1	93	97	PF00244	0.529
LIG_BIR_II_1	1	5	PF00653	0.338
LIG_BRCT_BRCA1_1	123	127	PF00533	0.539
LIG_Clathr_ClatBox_1	16	20	PF01394	0.477
LIG_EH1_1	187	195	PF00400	0.477
LIG_FHA_1	99	105	PF00498	0.580
LIG_FHA_2	165	171	PF00498	0.508
LIG_FHA_2	216	222	PF00498	0.523
LIG_LIR_Nem_3	154	159	PF02991	0.492
LIG_SH2_STAP1	21	25	PF00017	0.344
LIG_SH2_STAP1	3	7	PF00017	0.477
LIG_SH2_STAP1	98	102	PF00017	0.477
LIG_SH2_STAT5	110	113	PF00017	0.487
LIG_SH2_STAT5	216	219	PF00017	0.529
LIG_SH2_STAT5	70	73	PF00017	0.477
LIG_SH3_3	6	12	PF00018	0.477
LIG_SUMO_SIM_anti_2	192	199	PF11976	0.520
LIG_SUMO_SIM_anti_2	205	210	PF11976	0.422
LIG_SUMO_SIM_par_1	192	199	PF11976	0.528
LIG_SUMO_SIM_par_1	225	230	PF11976	0.500
LIG_SUMO_SIM_par_1	41	46	PF11976	0.555
LIG_SUMO_SIM_par_1	99	105	PF11976	0.432
LIG_TRAF2_1	218	221	PF00917	0.556
LIG_TRAF2_1	244	247	PF00917	0.587
LIG_UBA3_1	206	212	PF00899	0.539
MOD_CK1_1	118	124	PF00069	0.477
MOD_CK2_1	164	170	PF00069	0.529
MOD_CK2_1	178	184	PF00069	0.460
MOD_CK2_1	189	195	PF00069	0.512
MOD_CK2_1	215	221	PF00069	0.467
MOD_GlcNHglycan	120	123	PF01048	0.288
MOD_GlcNHglycan	148	152	PF01048	0.277
MOD_GlcNHglycan	153	156	PF01048	0.277
MOD_GlcNHglycan	198	201	PF01048	0.277
MOD_GlcNHglycan	48	51	PF01048	0.357
MOD_GlcNHglycan	76	79	PF01048	0.279
MOD_GSK3_1	147	154	PF00069	0.472
MOD_NEK2_1	53	58	PF00069	0.470
MOD_PIKK_1	116	122	PF00454	0.471
MOD_PKA_2	92	98	PF00069	0.531
MOD_Plk_1	164	170	PF00069	0.508
MOD_Plk_1	98	104	PF00069	0.580
MOD_Plk_4	128	134	PF00069	0.477
MOD_Plk_4	164	170	PF00069	0.508
MOD_Plk_4	189	195	PF00069	0.529
MOD_ProDKin_1	8	14	PF00069	0.477
MOD_SUMO_rev_2	138	142	PF00179	0.550
TRG_DiLeu_BaEn_3	220	226	PF01217	0.501
TRG_ENDOCYTIC_2	70	73	PF00928	0.508
TRG_NLS_MonoCore_2	238	243	PF00514	0.543
TRG_NLS_MonoExtC_3	239	245	PF00514	0.553
TRG_NLS_MonoExtN_4	239	244	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	35%	100%
A0A0N0P4E6	Leptomonas seymouri	31%	100%
A0A0N1I173	Leptomonas seymouri	39%	100%
A0A0N1I278	Leptomonas seymouri	94%	100%
A0A0N1I2E0	Leptomonas seymouri	31%	99%
A0A0N1ILS9	Leptomonas seymouri	38%	93%
A0A0N1PBJ3	Leptomonas seymouri	34%	87%
A0A0S4INC9	Bodo saltans	30%	100%
A0A0S4IQU5	Bodo saltans	30%	93%
A0A0S4IU58	Bodo saltans	41%	100%
A0A0S4IWG0	Bodo saltans	36%	92%
A0A0S4J6W0	Bodo saltans	29%	99%
A0A0S4JLA2	Bodo saltans	34%	88%
A0A1X0NHF3	Trypanosomatidae	37%	100%
A0A1X0NJ65	Trypanosomatidae	36%	100%
A0A1X0NNS5	Trypanosomatidae	31%	86%
A0A1X0NVU4	Trypanosomatidae	77%	100%
A0A1X0P5Y6	Trypanosomatidae	32%	99%
A0A1X0P853	Trypanosomatidae	35%	93%
A0A3Q8IB07	Leishmania donovani	41%	100%
A0A3Q8IC41	Leishmania donovani	35%	100%
A0A3Q8IFZ3	Leishmania donovani	38%	100%
A0A3R7KUN3	Trypanosoma rangeli	33%	86%
A0A3R7LAV3	Trypanosoma rangeli	78%	100%
A0A3R7MIT1	Trypanosoma rangeli	35%	93%
A0A3S5H7H2	Leishmania donovani	30%	100%
A0A3S5IS75	Trypanosoma rangeli	30%	100%
A0A3S7WST4	Leishmania donovani	34%	87%
A0A422N8R3	Trypanosoma rangeli	35%	100%
A0A422N8U2	Trypanosoma rangeli	41%	100%
A0A422P146	Trypanosoma rangeli	32%	99%
A0A6L0XSJ0	Leishmania infantum	29%	100%
A0B5B1	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	25%	100%
A1RSJ8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	26%	100%
A1RWY6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	30%	100%
A2BN24	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	30%	100%
A2BN27	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	25%	100%
A2SS78	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	23%	100%
A2Y9X7	Oryza sativa subsp. indica	43%	99%
A2YVR7	Oryza sativa subsp. indica	38%	100%
A2YXU2	Oryza sativa subsp. indica	60%	99%
A2Z3I9	Oryza sativa subsp. indica	60%	99%
A3CUS9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	24%	100%
A3CW55	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	39%	100%
A3DN21	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	29%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	27%	100%
A4FYA5	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	24%	100%
A4FZT6	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	40%	95%
A4H7J0	Leishmania braziliensis	33%	100%
A4H9T4	Leishmania braziliensis	96%	100%
A4HC34	Leishmania braziliensis	39%	100%
A4HFD7	Leishmania braziliensis	31%	100%
A4HLC5	Leishmania braziliensis	35%	100%
A4HNE9	Leishmania braziliensis	29%	100%
A4HP20	Leishmania braziliensis	38%	100%
A4HUT6	Leishmania infantum	100%	100%
A4HVX3	Leishmania infantum	34%	100%
A4HZI9	Leishmania infantum	35%	100%
A4I357	Leishmania infantum	31%	100%
A4IDD0	Leishmania infantum	38%	100%
A4WMZ0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	26%	100%
A4YCU9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	43%	100%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	43%	99%
A5UM14	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	27%	100%
A6URN9	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	41%	95%
A6USJ3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	25%	100%
A6UT20	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	25%	100%
A6VIP0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	40%	95%
A6VK02	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	24%	100%
A7I841	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	23%	100%
A7I9C7	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	39%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	29%	100%
A8AB58	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	25%	100%
A9A2U7	Nitrosopumilus maritimus (strain SCM1)	23%	100%
A9A788	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	24%	100%
A9A846	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	40%	95%
B0R2T2	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	44%	98%
B1L6S7	Korarchaeum cryptofilum (strain OPF8)	24%	100%
B1L6X8	Korarchaeum cryptofilum (strain OPF8)	23%	100%
B1YA36	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	26%	100%
B1YDJ0	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	27%	100%
B6YSH9	Thermococcus onnurineus (strain NA1)	44%	95%
B6YSW2	Thermococcus onnurineus (strain NA1)	26%	100%
B8D673	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	29%	100%
B8D683	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	24%	100%
B8GEZ3	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	39%	100%
B8GG66	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	25%	100%
C3MQ43	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	47%	100%
C3MVG1	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	47%	100%
C3N5R0	Sulfolobus islandicus (strain M.16.27)	47%	100%
C3NEC6	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	47%	100%
C3NHC6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	47%	100%
C4KHD9	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	47%	100%
C5A2C2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	44%	95%
C5A2D5	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	25%	100%
C5A7L1	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	28%	100%
C6A2V9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	23%	100%
C6A3R1	Thermococcus sibiricus (strain DSM 12597 / MM 739)	23%	100%
C6A459	Thermococcus sibiricus (strain DSM 12597 / MM 739)	46%	95%
C7P6N4	Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)	24%	100%
C9REN7	Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)	27%	100%
C9ZKV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZT49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
C9ZYH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
D0A0Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A0Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
D0A305	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
D0A7M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D2RGT4	Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)	24%	100%
D3RX66	Ferroglobus placidus (strain DSM 10642 / AEDII12DO)	27%	100%
D3S8M7	Methanocaldococcus sp. (strain FS406-22)	25%	100%
D4GYZ1	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	25%	100%
D5EAS6	Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)	28%	100%
E9ACZ6	Leishmania major	30%	100%
E9AFW0	Leishmania major	29%	100%
E9ANH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9APM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AST1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AVG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AVH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AYS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B713	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
F4JJE5	Arabidopsis thaliana	35%	100%
O13268	Gallus gallus	56%	99%
O14250	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	91%
O14818	Homo sapiens	56%	100%
O16811	Drosophila virilis	53%	100%
O16812	Drosophila virilis	43%	100%
O17586	Caenorhabditis elegans	26%	100%
O23708	Arabidopsis thaliana	38%	100%
O23712	Arabidopsis thaliana	37%	89%
O23715	Arabidopsis thaliana	37%	99%
O24030	Solanum lycopersicum	62%	95%
O24362	Spinacia oleracea	36%	99%
O24616	Arabidopsis thaliana	60%	99%
O24733	Thermococcus sp. (strain JCM 11816 / KS-1)	45%	95%
O26782	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	42%	100%
O27270	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
O29760	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	43%	100%
O42265	Gallus gallus	34%	95%
O44156	Caenorhabditis elegans	34%	95%
O48551	Glycine max	33%	100%
O50110	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	23%	100%
O59219	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	46%	95%
O59770	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	98%
O65084	Picea mariana	24%	100%
O70435	Mus musculus	36%	97%
O73672	Carassius auratus	37%	100%
O81146	Arabidopsis thaliana	35%	100%
O81147	Arabidopsis thaliana	35%	100%
O81148	Arabidopsis thaliana	39%	99%
O81149	Arabidopsis thaliana	37%	100%
O81153	Arabidopsis thaliana	24%	100%
O82530	Petunia hybrida	39%	99%
O94517	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O94579	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
O96788	Trypanosoma brucei rhodesiense	36%	93%
P0C8Y9	Oryza sativa subsp. indica	42%	99%
P0DKK3	Oryza sativa subsp. japonica	43%	99%
P0DKK4	Oryza sativa subsp. japonica	43%	99%
P12881	Drosophila melanogaster	37%	89%
P17220	Rattus norvegicus	38%	100%
P18053	Drosophila melanogaster	33%	94%
P18420	Rattus norvegicus	31%	94%
P18422	Rattus norvegicus	36%	97%
P21242	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	86%
P21243	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	98%
P21670	Rattus norvegicus	33%	95%
P22769	Drosophila melanogaster	52%	99%
P23638	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	96%
P23639	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	99%
P24495	Xenopus laevis	36%	100%
P25156	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	41%	100%
P25786	Homo sapiens	31%	94%
P25787	Homo sapiens	38%	100%
P25788	Homo sapiens	36%	97%
P25789	Homo sapiens	34%	95%
P28061	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	25%	100%
P28066	Homo sapiens	37%	100%
P30186	Arabidopsis thaliana	60%	99%
P32379	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	95%
P34064	Rattus norvegicus	36%	100%
P34066	Arabidopsis thaliana	37%	89%
P34119	Dictyostelium discoideum	37%	99%
P34120	Dictyostelium discoideum	55%	99%
P40301	Drosophila melanogaster	38%	100%
P40302	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P40303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	97%
P48004	Rattus norvegicus	54%	97%
P49722	Mus musculus	38%	100%
P52427	Spinacia oleracea	40%	99%
P52428	Oryza sativa subsp. japonica	38%	91%
P57697	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	44%	98%
P60900	Homo sapiens	34%	100%
P60901	Rattus norvegicus	34%	100%
P90513	Acanthamoeba castellanii	34%	98%
P92188	Trypanosoma cruzi	36%	93%
Q09583	Caenorhabditis elegans	28%	99%
Q09682	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q09841	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	93%
Q0J006	Oryza sativa subsp. japonica	60%	99%
Q0W2D6	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	26%	100%
Q10329	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	95%
Q10KF0	Oryza sativa subsp. japonica	38%	100%
Q12YV7	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	26%	100%
Q18GX3	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	25%	100%
Q18K08	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	40%	99%
Q23237	Caenorhabditis elegans	24%	100%
Q24178	Drosophila melanogaster	46%	99%
Q27488	Caenorhabditis elegans	34%	100%
Q27562	Dictyostelium discoideum	33%	100%
Q27563	Dictyostelium discoideum	35%	100%
Q27575	Drosophila melanogaster	43%	98%
Q2FQL8	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	26%	100%
Q2NI68	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	25%	100%
Q2YDE4	Bos taurus	34%	100%
Q3IPJ1	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	45%	97%
Q3T0X5	Bos taurus	31%	94%
Q3T0Y5	Bos taurus	38%	100%
Q3ZBG0	Bos taurus	56%	100%
Q3ZCK9	Bos taurus	34%	95%
Q42134	Arabidopsis thaliana	37%	100%
Q469M6	Methanosarcina barkeri (strain Fusaro / DSM 804)	40%	99%
Q46G14	Methanosarcina barkeri (strain Fusaro / DSM 804)	24%	100%
Q4JAA8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	27%	100%
Q4JB24	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	42%	100%
Q4Q1R5	Leishmania major	38%	100%
Q4QC00	Leishmania major	35%	100%
Q4QC13	Leishmania major	41%	100%
Q4QFV4	Leishmania major	35%	100%
Q4QH56	Leishmania major	99%	100%
Q4R3H2	Macaca fascicularis	31%	94%
Q4R7D9	Macaca fascicularis	56%	99%
Q4R932	Macaca fascicularis	33%	95%
Q54DM7	Dictyostelium discoideum	36%	100%
Q54XM7	Dictyostelium discoideum	32%	99%
Q55G04	Dictyostelium discoideum	35%	100%
Q58634	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q58DU5	Bos taurus	36%	97%
Q59565	Methanosarcina thermophila	41%	100%
Q5E987	Bos taurus	37%	100%
Q5JDJ9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	24%	100%
Q5JIU9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	45%	95%
Q5RDH8	Pongo abelii	55%	100%
Q5REN2	Pongo abelii	31%	94%
Q5V1D4	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	40%	100%
Q5V1D5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	21%	100%
Q5V2X8	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	42%	95%
Q5VRG3	Oryza sativa subsp. japonica	42%	99%
Q60177	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	42%	95%
Q6L0W3	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	40%	100%
Q6L181	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	22%	100%
Q6LZD4	Methanococcus maripaludis (strain S2 / LL)	23%	100%
Q6M0L9	Methanococcus maripaludis (strain S2 / LL)	41%	95%
Q6YT00	Oryza sativa subsp. japonica	60%	99%
Q8L4A7	Arabidopsis thaliana	38%	100%
Q8PTU1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	40%	99%
Q8PZ04	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	24%	100%
Q8SQP9	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SRU3	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8SRU7	Encephalitozoon cuniculi (strain GB-M1)	27%	100%
Q8TAA3	Homo sapiens	54%	96%
Q8TJB5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	24%	100%
Q8TPX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	40%	100%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	28%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	43%	100%
Q8U0L6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	44%	95%
Q8U125	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	23%	100%
Q8X077	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	38%	99%
Q8ZST5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	25%	100%
Q8ZVM1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	43%	100%
Q8ZYF2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	26%	100%
Q94561	Entamoeba histolytica	36%	100%
Q95005	Caenorhabditis elegans	53%	98%
Q95008	Caenorhabditis elegans	38%	100%
Q95083	Drosophila melanogaster	36%	100%
Q975G5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	43%	100%
Q97AZ7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	25%	100%
Q97BZ8	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	44%	100%
Q9CWH6	Mus musculus	53%	99%
Q9GNZ8	Leishmania infantum	41%	100%
Q9GU37	Trypanosoma brucei brucei	27%	93%
Q9LSU0	Oryza sativa subsp. japonica	37%	99%
Q9LSU1	Oryza sativa subsp. japonica	37%	100%
Q9LSU3	Oryza sativa subsp. japonica	35%	100%
Q9M4T8	Glycine max	36%	100%
Q9N599	Caenorhabditis elegans	34%	99%
Q9NDA2	Trypanosoma brucei brucei	74%	100%
Q9P992	Methanosarcina thermophila	23%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
Q9PTW9	Carassius auratus	56%	98%
Q9PVQ1	Xenopus laevis	55%	100%
Q9PVY6	Xenopus laevis	55%	100%
Q9QUM9	Mus musculus	33%	100%
Q9R1P0	Mus musculus	33%	95%
Q9R1P4	Mus musculus	31%	94%
Q9SXU1	Cicer arietinum	59%	99%
Q9U793	Trypanosoma brucei brucei	37%	100%
Q9UAB4	Leishmania donovani	29%	99%
Q9UT97	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9UXC6	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	47%	100%
Q9V0N9	Pyrococcus abyssi (strain GE5 / Orsay)	24%	100%
Q9V122	Pyrococcus abyssi (strain GE5 / Orsay)	46%	95%
Q9V2V5	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	43%	99%
Q9V2V6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	40%	98%
Q9V5C6	Drosophila melanogaster	35%	98%
Q9VA12	Drosophila melanogaster	34%	98%
Q9XG77	Nicotiana tabacum	36%	100%
Q9XZG5	Trypanosoma brucei brucei	36%	100%
Q9XZJ4	Drosophila melanogaster	31%	100%
Q9YC01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	39%	96%
Q9YER0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	27%	100%
Q9YES4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	31%	100%
Q9Z2U0	Mus musculus	56%	100%
Q9Z2U1	Mus musculus	37%	100%
V5AWB3	Trypanosoma cruzi	30%	100%
V5AXS1	Trypanosoma cruzi	29%	100%
V5B1X4	Trypanosoma cruzi	36%	100%
V5B4E8	Trypanosoma cruzi	35%	93%
V5BLX4	Trypanosoma cruzi	40%	100%
V5BW71	Trypanosoma cruzi	78%	79%