DUF2163 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6H5_LEIDO

TriTrypDb:

LdBPK_101410.1 , LdCL_100021300 , LDHU3_10.1800

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6H5

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	53	55	PF00675	0.352
CLV_PCSK_KEX2_1	53	55	PF00082	0.375
CLV_PCSK_SKI1_1	7	11	PF00082	0.406
DEG_MDM2_SWIB_1	189	196	PF02201	0.352
DOC_CDC14_PxL_1	184	192	PF14671	0.425
DOC_PP1_RVXF_1	5	11	PF00149	0.397
DOC_USP7_MATH_1	268	272	PF00917	0.347
DOC_USP7_MATH_1	87	91	PF00917	0.385
DOC_WW_Pin1_4	258	263	PF00397	0.312
LIG_AP2alpha_2	86	88	PF02296	0.371
LIG_APCC_ABBA_1	62	67	PF00400	0.336
LIG_APCC_ABBAyCdc20_2	61	67	PF00400	0.352
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_BIR_III_4	191	195	PF00653	0.344
LIG_BIR_III_4	219	223	PF00653	0.389
LIG_BRCT_BRCA1_1	35	39	PF00533	0.352
LIG_BRCT_BRCA1_1	94	98	PF00533	0.462
LIG_eIF4E_1	33	39	PF01652	0.229
LIG_FHA_1	145	151	PF00498	0.465
LIG_FHA_1	172	178	PF00498	0.344
LIG_FHA_1	229	235	PF00498	0.356
LIG_FHA_1	79	85	PF00498	0.350
LIG_FHA_1	99	105	PF00498	0.183
LIG_FHA_2	128	134	PF00498	0.364
LIG_FHA_2	66	72	PF00498	0.352
LIG_LIR_Gen_1	111	122	PF02991	0.350
LIG_LIR_Gen_1	71	80	PF02991	0.369
LIG_LIR_Nem_3	111	117	PF02991	0.370
LIG_LIR_Nem_3	191	196	PF02991	0.346
LIG_LIR_Nem_3	23	27	PF02991	0.378
LIG_LIR_Nem_3	242	248	PF02991	0.346
LIG_LIR_Nem_3	28	33	PF02991	0.364
LIG_LIR_Nem_3	282	287	PF02991	0.343
LIG_LIR_Nem_3	298	304	PF02991	0.385
LIG_LIR_Nem_3	71	76	PF02991	0.369
LIG_MLH1_MIPbox_1	94	98	PF16413	0.459
LIG_PCNA_PIPBox_1	121	130	PF02747	0.229
LIG_PDZ_Class_2	308	313	PF00595	0.420
LIG_Pex14_2	189	193	PF04695	0.352
LIG_PTB_Apo_2	183	190	PF02174	0.220
LIG_SH2_CRK	284	288	PF00017	0.352
LIG_SH2_CRK	304	308	PF00017	0.247
LIG_SH2_CRK	73	77	PF00017	0.278
LIG_SH2_NCK_1	73	77	PF00017	0.402
LIG_SH2_STAP1	17	21	PF00017	0.361
LIG_SH2_STAT5	113	116	PF00017	0.358
LIG_SH2_STAT5	128	131	PF00017	0.341
LIG_SH2_STAT5	200	203	PF00017	0.362
LIG_SH2_STAT5	215	218	PF00017	0.321
LIG_SH2_STAT5	73	76	PF00017	0.366
LIG_SH3_2	255	260	PF14604	0.314
LIG_SH3_3	231	237	PF00018	0.352
LIG_SH3_3	252	258	PF00018	0.335
LIG_WRC_WIRS_1	21	26	PF05994	0.366
LIG_WRC_WIRS_1	230	235	PF05994	0.352
MOD_CK1_1	20	26	PF00069	0.220
MOD_CK1_1	57	63	PF00069	0.214
MOD_CK2_1	166	172	PF00069	0.390
MOD_GlcNHglycan	105	108	PF01048	0.416
MOD_GlcNHglycan	203	206	PF01048	0.344
MOD_GlcNHglycan	270	273	PF01048	0.352
MOD_GlcNHglycan	284	287	PF01048	0.352
MOD_GSK3_1	123	130	PF00069	0.311
MOD_GSK3_1	149	156	PF00069	0.359
MOD_GSK3_1	16	23	PF00069	0.334
MOD_GSK3_1	162	169	PF00069	0.335
MOD_GSK3_1	256	263	PF00069	0.385
MOD_LATS_1	153	159	PF00433	0.214
MOD_N-GLC_1	108	113	PF02516	0.223
MOD_N-GLC_1	239	244	PF02516	0.404
MOD_N-GLC_1	33	38	PF02516	0.356
MOD_N-GLC_2	226	228	PF02516	0.338
MOD_NEK2_1	10	15	PF00069	0.418
MOD_NEK2_1	134	139	PF00069	0.254
MOD_NEK2_1	201	206	PF00069	0.385
MOD_NEK2_1	247	252	PF00069	0.496
MOD_NEK2_1	65	70	PF00069	0.357
MOD_NEK2_1	98	103	PF00069	0.349
MOD_PIKK_1	98	104	PF00454	0.352
MOD_PK_1	260	266	PF00069	0.214
MOD_PKA_2	293	299	PF00069	0.362
MOD_Plk_1	156	162	PF00069	0.444
MOD_Plk_1	17	23	PF00069	0.359
MOD_Plk_1	33	39	PF00069	0.326
MOD_Plk_1	71	77	PF00069	0.369
MOD_Plk_4	123	129	PF00069	0.360
MOD_Plk_4	17	23	PF00069	0.390
MOD_Plk_4	211	217	PF00069	0.378
MOD_Plk_4	229	235	PF00069	0.347
MOD_Plk_4	303	309	PF00069	0.427
MOD_Plk_4	33	39	PF00069	0.398
MOD_Plk_4	71	77	PF00069	0.365
MOD_Plk_4	92	98	PF00069	0.375
MOD_ProDKin_1	258	264	PF00069	0.312
MOD_SUMO_rev_2	176	184	PF00179	0.220
MOD_SUMO_rev_2	232	239	PF00179	0.331
TRG_DiLeu_BaEn_1	157	162	PF01217	0.214
TRG_ENDOCYTIC_2	118	121	PF00928	0.399
TRG_ENDOCYTIC_2	284	287	PF00928	0.352
TRG_ENDOCYTIC_2	304	307	PF00928	0.243
TRG_ENDOCYTIC_2	73	76	PF00928	0.398
TRG_ER_diArg_1	61	64	PF00400	0.381
TRG_NES_CRM1_1	133	145	PF08389	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	57%	99%
A0A0N1HYU8	Leptomonas seymouri	55%	98%
A0A0N1I429	Leptomonas seymouri	58%	96%
A0A0N1I5D6	Leptomonas seymouri	54%	99%
A0A0N1I720	Leptomonas seymouri	68%	100%
A0A0N1IL04	Leptomonas seymouri	56%	100%
A0A0N1PCE9	Leptomonas seymouri	54%	98%
A0A0R6XPC0	Leishmania donovani	53%	100%
A0A3Q8IHB3	Leishmania donovani	54%	100%
A0A3S5H6H4	Leishmania donovani	57%	100%
A0A3S7WRC9	Leishmania donovani	58%	99%
A0A3S7WRD5	Leishmania donovani	53%	99%
A0A3S7WRE8	Leishmania donovani	55%	100%
A4H6B5	Leishmania braziliensis	57%	100%
A4H6B6	Leishmania braziliensis	53%	100%
A4H6B7	Leishmania braziliensis	54%	100%
A4H6B8	Leishmania braziliensis	54%	100%
A4H6B9	Leishmania braziliensis	82%	100%
A4H6C0	Leishmania braziliensis	56%	100%
A4H6C1	Leishmania braziliensis	56%	99%
A4HUN8	Leishmania infantum	57%	100%
A4HUN9	Leishmania infantum	54%	100%
A4HUP0	Leishmania infantum	53%	100%
A4HUP1	Leishmania infantum	53%	100%
A4HUP2	Leishmania infantum	99%	100%
A4HUP3	Leishmania infantum	58%	100%
A4HUP4	Leishmania infantum	55%	99%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	99%
Q4QH83	Leishmania major	54%	99%
Q4QH84	Leishmania major	58%	100%
Q4QH85	Leishmania major	96%	100%
Q4QH86	Leishmania major	53%	100%
Q4QH87	Leishmania major	54%	100%
Q4QH88	Leishmania major	53%	100%
Q4QH89	Leishmania major	57%	100%