PAB1-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PAB1-binding protein , putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6H2_LEIDO

TriTrypDb:

LdBPK_101200.1 , LdCL_100019000 , LDHU3_10.1560

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6H2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034063	stress granule assembly	7	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.451
CLV_C14_Caspase3-7	478	482	PF00656	0.927
CLV_C14_Caspase3-7	68	72	PF00656	0.540
CLV_NRD_NRD_1	229	231	PF00675	0.766
CLV_NRD_NRD_1	498	500	PF00675	0.903
CLV_PCSK_KEX2_1	223	225	PF00082	0.800
CLV_PCSK_KEX2_1	498	500	PF00082	0.893
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.800
CLV_PCSK_SKI1_1	179	183	PF00082	0.544
CLV_PCSK_SKI1_1	310	314	PF00082	0.740
CLV_PCSK_SKI1_1	93	97	PF00082	0.713
DEG_Nend_Nbox_1	1	3	PF02207	0.832
DEG_SPOP_SBC_1	234	238	PF00917	0.847
DOC_CYCLIN_yClb5_NLxxxL_5	190	196	PF00134	0.544
DOC_MAPK_MEF2A_6	12	20	PF00069	0.444
DOC_PP1_RVXF_1	115	122	PF00149	0.695
DOC_PP2B_LxvP_1	279	282	PF13499	0.865
DOC_PP4_FxxP_1	305	308	PF00568	0.777
DOC_PP4_MxPP_1	423	426	PF00568	0.851
DOC_SPAK_OSR1_1	148	152	PF12202	0.585
DOC_USP7_MATH_1	219	223	PF00917	0.766
DOC_USP7_MATH_1	235	239	PF00917	0.720
DOC_USP7_MATH_1	285	289	PF00917	0.892
DOC_USP7_MATH_1	298	302	PF00917	0.710
DOC_USP7_MATH_1	308	312	PF00917	0.706
DOC_USP7_MATH_1	4	8	PF00917	0.740
DOC_USP7_MATH_1	479	483	PF00917	0.883
DOC_USP7_UBL2_3	519	523	PF12436	0.791
DOC_WW_Pin1_4	244	249	PF00397	0.812
DOC_WW_Pin1_4	294	299	PF00397	0.758
DOC_WW_Pin1_4	300	305	PF00397	0.749
DOC_WW_Pin1_4	433	438	PF00397	0.917
DOC_WW_Pin1_4	98	103	PF00397	0.809
LIG_14-3-3_CanoR_1	349	354	PF00244	0.776
LIG_BIR_III_4	218	222	PF00653	0.793
LIG_deltaCOP1_diTrp_1	332	339	PF00928	0.776
LIG_eIF4E_1	15	21	PF01652	0.444
LIG_EVH1_1	279	283	PF00568	0.903
LIG_FHA_1	159	165	PF00498	0.444
LIG_FHA_1	187	193	PF00498	0.444
LIG_FHA_1	201	207	PF00498	0.444
LIG_FHA_1	22	28	PF00498	0.585
LIG_FHA_1	301	307	PF00498	0.788
LIG_FHA_1	492	498	PF00498	0.834
LIG_FHA_2	152	158	PF00498	0.454
LIG_FHA_2	160	166	PF00498	0.431
LIG_FHA_2	178	184	PF00498	0.444
LIG_FHA_2	227	233	PF00498	0.829
LIG_FHA_2	41	47	PF00498	0.438
LIG_LIR_Apic_2	303	308	PF02991	0.784
LIG_LIR_Apic_2	324	330	PF02991	0.705
LIG_LIR_Apic_2	345	350	PF02991	0.862
LIG_LIR_Gen_1	137	145	PF02991	0.656
LIG_LIR_Gen_1	14	25	PF02991	0.469
LIG_LIR_Nem_3	137	143	PF02991	0.666
LIG_LIR_Nem_3	14	20	PF02991	0.469
LIG_PAM2_1	296	308	PF00658	0.734
LIG_RPA_C_Fungi	37	49	PF08784	0.544
LIG_SH2_CRK	327	331	PF00017	0.716
LIG_SH2_CRK	347	351	PF00017	0.874
LIG_SH2_CRK	362	366	PF00017	0.623
LIG_SH2_GRB2like	17	20	PF00017	0.444
LIG_SH2_NCK_1	327	331	PF00017	0.800
LIG_SH2_NCK_1	347	351	PF00017	0.846
LIG_SH2_SRC	84	87	PF00017	0.544
LIG_SH2_STAP1	160	164	PF00017	0.444
LIG_SH2_STAP1	340	344	PF00017	0.755
LIG_SH2_STAP1	84	88	PF00017	0.544
LIG_SH2_STAT5	15	18	PF00017	0.444
LIG_SH2_STAT5	160	163	PF00017	0.444
LIG_SH2_STAT5	205	208	PF00017	0.585
LIG_SH3_3	238	244	PF00018	0.887
LIG_SH3_3	264	270	PF00018	0.845
LIG_SH3_3	274	280	PF00018	0.735
LIG_SH3_3	292	298	PF00018	0.605
LIG_SH3_3	301	307	PF00018	0.788
LIG_SH3_3	363	369	PF00018	0.827
LIG_SH3_3	423	429	PF00018	0.833
LIG_SH3_3	449	455	PF00018	0.772
LIG_SUMO_SIM_par_1	23	29	PF11976	0.585
LIG_TYR_ITIM	13	18	PF00017	0.444
LIG_UBA3_1	87	93	PF00899	0.585
LIG_WRC_WIRS_1	309	314	PF05994	0.746
LIG_WW_2	270	273	PF00397	0.678
MOD_CDC14_SPxK_1	436	439	PF00782	0.917
MOD_CDK_SPxK_1	433	439	PF00069	0.915
MOD_CK1_1	134	140	PF00069	0.804
MOD_CK1_1	167	173	PF00069	0.444
MOD_CK1_1	222	228	PF00069	0.835
MOD_CK1_1	345	351	PF00069	0.726
MOD_CK1_1	447	453	PF00069	0.786
MOD_CK1_1	73	79	PF00069	0.501
MOD_CK2_1	151	157	PF00069	0.444
MOD_CK2_1	177	183	PF00069	0.544
MOD_CK2_1	226	232	PF00069	0.825
MOD_Cter_Amidation	517	520	PF01082	0.868
MOD_GlcNHglycan	185	189	PF01048	0.501
MOD_GlcNHglycan	224	227	PF01048	0.865
MOD_GlcNHglycan	237	240	PF01048	0.722
MOD_GlcNHglycan	288	291	PF01048	0.881
MOD_GlcNHglycan	300	303	PF01048	0.637
MOD_GlcNHglycan	477	480	PF01048	0.860
MOD_GlcNHglycan	481	485	PF01048	0.814
MOD_GlcNHglycan	67	70	PF01048	0.514
MOD_GSK3_1	222	229	PF00069	0.780
MOD_GSK3_1	294	301	PF00069	0.765
MOD_GSK3_1	345	352	PF00069	0.803
MOD_GSK3_1	455	462	PF00069	0.911
MOD_GSK3_1	475	482	PF00069	0.890
MOD_GSK3_1	61	68	PF00069	0.504
MOD_N-GLC_1	4	9	PF02516	0.731
MOD_NEK2_1	159	164	PF00069	0.450
MOD_NEK2_1	38	43	PF00069	0.494
MOD_PIKK_1	447	453	PF00454	0.892
MOD_PKA_2	219	225	PF00069	0.796
MOD_PKA_2	444	450	PF00069	0.853
MOD_Plk_1	342	348	PF00069	0.708
MOD_Plk_1	76	82	PF00069	0.514
MOD_Plk_2-3	115	121	PF00069	0.768
MOD_Plk_4	21	27	PF00069	0.585
MOD_Plk_4	291	297	PF00069	0.909
MOD_Plk_4	308	314	PF00069	0.557
MOD_Plk_4	315	321	PF00069	0.658
MOD_Plk_4	349	355	PF00069	0.812
MOD_ProDKin_1	244	250	PF00069	0.813
MOD_ProDKin_1	294	300	PF00069	0.756
MOD_ProDKin_1	433	439	PF00069	0.918
MOD_ProDKin_1	98	104	PF00069	0.810
MOD_SUMO_rev_2	109	119	PF00179	0.797
MOD_SUMO_rev_2	165	170	PF00179	0.544
MOD_SUMO_rev_2	85	95	PF00179	0.544
TRG_DiLeu_BaEn_2	50	56	PF01217	0.544
TRG_DiLeu_BaEn_4	274	280	PF01217	0.871
TRG_ENDOCYTIC_2	15	18	PF00928	0.444
TRG_ENDOCYTIC_2	84	87	PF00928	0.425
TRG_ER_diArg_1	497	499	PF00400	0.892
TRG_ER_diLys_1	519	523	PF00400	0.916
TRG_NLS_MonoExtC_3	494	499	PF00514	0.888
TRG_NLS_MonoExtN_4	492	499	PF00514	0.849

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I433	Leptomonas seymouri	69%	100%
A0A1X0NQC5	Trypanosomatidae	35%	95%
A0A422NGM0	Trypanosoma rangeli	38%	95%
A4H699	Leishmania braziliensis	89%	100%
A4HUM3	Leishmania infantum	100%	100%
E9ANC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QHA3	Leishmania major	98%	100%
V5DKQ2	Trypanosoma cruzi	37%	95%