Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6H1_LEIDO

TriTrypDb:

LdCL_100018600 , LDHU3_10.1520

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6H1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004550	nucleoside diphosphate kinase activity	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	1
GO:0019205	nucleobase-containing compound kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.603
CLV_C14_Caspase3-7	31	35	PF00656	0.314
CLV_C14_Caspase3-7	414	418	PF00656	0.523
CLV_C14_Caspase3-7	427	431	PF00656	0.486
CLV_NRD_NRD_1	293	295	PF00675	0.504
CLV_NRD_NRD_1	42	44	PF00675	0.377
CLV_NRD_NRD_1	499	501	PF00675	0.709
CLV_NRD_NRD_1	63	65	PF00675	0.400
CLV_PCSK_FUR_1	175	179	PF00082	0.533
CLV_PCSK_KEX2_1	177	179	PF00082	0.655
CLV_PCSK_KEX2_1	293	295	PF00082	0.489
CLV_PCSK_KEX2_1	42	44	PF00082	0.381
CLV_PCSK_KEX2_1	62	64	PF00082	0.302
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.655
CLV_PCSK_SKI1_1	43	47	PF00082	0.369
DEG_APCC_DBOX_1	164	172	PF00400	0.514
DEG_SPOP_SBC_1	225	229	PF00917	0.630
DEG_SPOP_SBC_1	81	85	PF00917	0.489
DOC_ANK_TNKS_1	292	299	PF00023	0.309
DOC_CKS1_1	237	242	PF01111	0.503
DOC_CKS1_1	313	318	PF01111	0.485
DOC_CKS1_1	365	370	PF01111	0.466
DOC_CKS1_1	45	50	PF01111	0.372
DOC_MAPK_gen_1	30	39	PF00069	0.329
DOC_MAPK_gen_1	484	493	PF00069	0.527
DOC_USP7_MATH_1	164	168	PF00917	0.508
DOC_USP7_MATH_1	225	229	PF00917	0.513
DOC_USP7_MATH_1	24	28	PF00917	0.313
DOC_USP7_MATH_1	241	245	PF00917	0.408
DOC_USP7_MATH_1	397	401	PF00917	0.525
DOC_USP7_MATH_1	429	433	PF00917	0.705
DOC_WW_Pin1_4	148	153	PF00397	0.554
DOC_WW_Pin1_4	211	216	PF00397	0.513
DOC_WW_Pin1_4	231	236	PF00397	0.451
DOC_WW_Pin1_4	312	317	PF00397	0.422
DOC_WW_Pin1_4	355	360	PF00397	0.536
DOC_WW_Pin1_4	361	366	PF00397	0.512
DOC_WW_Pin1_4	44	49	PF00397	0.338
DOC_WW_Pin1_4	447	452	PF00397	0.541
LIG_14-3-3_CanoR_1	165	174	PF00244	0.516
LIG_14-3-3_CanoR_1	344	348	PF00244	0.524
LIG_14-3-3_CanoR_1	387	391	PF00244	0.500
LIG_14-3-3_CanoR_1	486	493	PF00244	0.543
LIG_14-3-3_CterR_2	500	503	PF00244	0.542
LIG_BIR_III_4	428	432	PF00653	0.538
LIG_BRCT_BRCA1_1	243	247	PF00533	0.437
LIG_BRCT_BRCA1_1	84	88	PF00533	0.502
LIG_FHA_1	11	17	PF00498	0.291
LIG_FHA_1	212	218	PF00498	0.666
LIG_FHA_1	263	269	PF00498	0.397
LIG_FHA_2	1	7	PF00498	0.544
LIG_FHA_2	177	183	PF00498	0.604
LIG_FHA_2	425	431	PF00498	0.532
LIG_FHA_2	72	78	PF00498	0.446
LIG_LIR_Gen_1	370	378	PF02991	0.440
LIG_LIR_Gen_1	403	413	PF02991	0.513
LIG_LIR_Gen_1	9	19	PF02991	0.308
LIG_LIR_Nem_3	370	374	PF02991	0.442
LIG_LIR_Nem_3	389	394	PF02991	0.513
LIG_LIR_Nem_3	403	408	PF02991	0.551
LIG_LIR_Nem_3	9	15	PF02991	0.322
LIG_NRBOX	167	173	PF00104	0.517
LIG_NRBOX	266	272	PF00104	0.259
LIG_NRBOX	462	468	PF00104	0.526
LIG_Pex14_1	300	304	PF04695	0.326
LIG_SH2_CRK	391	395	PF00017	0.522
LIG_SH2_STAT5	314	317	PF00017	0.299
LIG_SH2_STAT5	391	394	PF00017	0.580
LIG_SH3_2	451	456	PF14604	0.535
LIG_SH3_3	13	19	PF00018	0.284
LIG_SH3_3	144	150	PF00018	0.545
LIG_SH3_3	283	289	PF00018	0.344
LIG_SH3_3	310	316	PF00018	0.418
LIG_SH3_3	362	368	PF00018	0.622
LIG_SH3_3	391	397	PF00018	0.502
LIG_SH3_3	42	48	PF00018	0.346
LIG_SH3_3	448	454	PF00018	0.539
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.366
LIG_TRFH_1	44	48	PF08558	0.347
LIG_UBA3_1	171	177	PF00899	0.529
LIG_WW_3	145	149	PF00397	0.499
MOD_CDC14_SPxK_1	151	154	PF00782	0.555
MOD_CDK_SPK_2	231	236	PF00069	0.524
MOD_CDK_SPxK_1	148	154	PF00069	0.557
MOD_CDK_SPxK_1	236	242	PF00069	0.507
MOD_CK1_1	186	192	PF00069	0.739
MOD_CK1_1	227	233	PF00069	0.596
MOD_CK1_1	358	364	PF00069	0.503
MOD_CK1_1	389	395	PF00069	0.474
MOD_CK1_1	400	406	PF00069	0.502
MOD_CK1_1	476	482	PF00069	0.512
MOD_CK1_1	71	77	PF00069	0.628
MOD_CK2_1	71	77	PF00069	0.443
MOD_Cter_Amidation	175	178	PF01082	0.535
MOD_DYRK1A_RPxSP_1	148	152	PF00069	0.554
MOD_GlcNHglycan	123	126	PF01048	0.701
MOD_GlcNHglycan	143	146	PF01048	0.468
MOD_GlcNHglycan	168	171	PF01048	0.662
MOD_GlcNHglycan	200	203	PF01048	0.544
MOD_GlcNHglycan	229	232	PF01048	0.517
MOD_GlcNHglycan	300	303	PF01048	0.294
MOD_GlcNHglycan	399	402	PF01048	0.736
MOD_GlcNHglycan	447	450	PF01048	0.743
MOD_GSK3_1	117	124	PF00069	0.546
MOD_GSK3_1	166	173	PF00069	0.557
MOD_GSK3_1	178	185	PF00069	0.552
MOD_GSK3_1	188	195	PF00069	0.760
MOD_GSK3_1	198	205	PF00069	0.652
MOD_GSK3_1	225	232	PF00069	0.521
MOD_GSK3_1	397	404	PF00069	0.681
MOD_GSK3_1	95	102	PF00069	0.707
MOD_NEK2_1	127	132	PF00069	0.501
MOD_NEK2_1	226	231	PF00069	0.561
MOD_NEK2_1	70	75	PF00069	0.439
MOD_NEK2_2	170	175	PF00069	0.526
MOD_PIKK_1	111	117	PF00454	0.519
MOD_PIKK_1	189	195	PF00454	0.497
MOD_PIKK_1	82	88	PF00454	0.500
MOD_PIKK_1	99	105	PF00454	0.534
MOD_PKA_1	177	183	PF00069	0.547
MOD_PKA_2	164	170	PF00069	0.505
MOD_PKA_2	177	183	PF00069	0.511
MOD_PKA_2	343	349	PF00069	0.655
MOD_PKA_2	386	392	PF00069	0.465
MOD_PKA_2	487	493	PF00069	0.636
MOD_PKB_1	484	492	PF00069	0.527
MOD_PKB_1	93	101	PF00069	0.520
MOD_Plk_4	127	133	PF00069	0.450
MOD_Plk_4	24	30	PF00069	0.450
MOD_Plk_4	256	262	PF00069	0.443
MOD_Plk_4	429	435	PF00069	0.536
MOD_ProDKin_1	148	154	PF00069	0.557
MOD_ProDKin_1	211	217	PF00069	0.512
MOD_ProDKin_1	231	237	PF00069	0.450
MOD_ProDKin_1	312	318	PF00069	0.427
MOD_ProDKin_1	355	361	PF00069	0.539
MOD_ProDKin_1	364	370	PF00069	0.475
MOD_ProDKin_1	44	50	PF00069	0.331
MOD_ProDKin_1	447	453	PF00069	0.542
MOD_SUMO_rev_2	496	502	PF00179	0.532
TRG_DiLeu_BaEn_1	462	467	PF01217	0.420
TRG_ENDOCYTIC_2	391	394	PF00928	0.535
TRG_ENDOCYTIC_2	58	61	PF00928	0.351
TRG_ER_diArg_1	293	295	PF00400	0.504
TRG_ER_diArg_1	42	44	PF00400	0.377
TRG_ER_diArg_1	482	485	PF00400	0.547
TRG_ER_diArg_1	61	64	PF00400	0.292
TRG_ER_diArg_1	93	96	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM0	Leptomonas seymouri	30%	100%
A0A422NGP5	Trypanosoma rangeli	25%	79%
A4HUM0	Leishmania infantum	99%	100%