Phosphorylase family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside phosphorylase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6H0_LEIDO

TriTrypDb:

LdBPK_101090.1 , LdCL_100017800 , LDHU3_10.1440

Length:

341

Annotations

Annotations by Jardim et al.

Purine metabolism, Nucleoside phosphorylase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6H0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009116	nucleoside metabolic process	4	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901657	glycosyl compound metabolic process	4	12
GO:0006213	pyrimidine nucleoside metabolic process	5	1
GO:0006218	uridine catabolic process	8	1
GO:0009056	catabolic process	2	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009164	nucleoside catabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042454	ribonucleoside catabolic process	6	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044282	small molecule catabolic process	3	1
GO:0046108	uridine metabolic process	7	1
GO:0046131	pyrimidine ribonucleoside metabolic process	6	1
GO:0046133	pyrimidine ribonucleoside catabolic process	7	1
GO:0046135	pyrimidine nucleoside catabolic process	6	1
GO:0046700	heterocycle catabolic process	4	1
GO:0072527	pyrimidine-containing compound metabolic process	4	1
GO:0072529	pyrimidine-containing compound catabolic process	5	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901658	glycosyl compound catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	8
GO:0016757	glycosyltransferase activity	3	8
GO:0004850	uridine phosphorylase activity	5	1
GO:0016763	pentosyltransferase activity	4	2
GO:0004731	purine-nucleoside phosphorylase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.437
CLV_NRD_NRD_1	219	221	PF00675	0.470
CLV_NRD_NRD_1	309	311	PF00675	0.495
CLV_PCSK_KEX2_1	109	111	PF00082	0.447
CLV_PCSK_KEX2_1	309	311	PF00082	0.368
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.498
CLV_PCSK_SKI1_1	182	186	PF00082	0.430
CLV_PCSK_SKI1_1	329	333	PF00082	0.389
CLV_PCSK_SKI1_1	37	41	PF00082	0.374
CLV_PCSK_SKI1_1	66	70	PF00082	0.418
DEG_APCC_DBOX_1	132	140	PF00400	0.364
DOC_CKS1_1	125	130	PF01111	0.390
DOC_CKS1_1	17	22	PF01111	0.583
DOC_CKS1_1	317	322	PF01111	0.450
DOC_CYCLIN_yCln2_LP_2	125	131	PF00134	0.492
DOC_MAPK_gen_1	251	258	PF00069	0.399
DOC_PP2B_LxvP_1	256	259	PF13499	0.372
DOC_PP4_FxxP_1	317	320	PF00568	0.450
DOC_SPAK_OSR1_1	269	273	PF12202	0.481
DOC_USP7_MATH_1	222	226	PF00917	0.374
DOC_USP7_MATH_1	28	32	PF00917	0.509
DOC_USP7_MATH_1	308	312	PF00917	0.518
DOC_WW_Pin1_4	117	122	PF00397	0.511
DOC_WW_Pin1_4	124	129	PF00397	0.516
DOC_WW_Pin1_4	141	146	PF00397	0.384
DOC_WW_Pin1_4	16	21	PF00397	0.567
DOC_WW_Pin1_4	316	321	PF00397	0.450
LIG_14-3-3_CanoR_1	253	259	PF00244	0.450
LIG_14-3-3_CanoR_1	269	279	PF00244	0.428
LIG_14-3-3_CanoR_1	312	318	PF00244	0.495
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_FHA_1	176	182	PF00498	0.492
LIG_FHA_1	206	212	PF00498	0.372
LIG_FHA_1	22	28	PF00498	0.509
LIG_FHA_1	260	266	PF00498	0.502
LIG_FHA_1	300	306	PF00498	0.432
LIG_FHA_1	330	336	PF00498	0.492
LIG_FHA_1	54	60	PF00498	0.351
LIG_FHA_1	87	93	PF00498	0.391
LIG_FHA_2	118	124	PF00498	0.491
LIG_FHA_2	125	131	PF00498	0.512
LIG_FHA_2	142	148	PF00498	0.467
LIG_FHA_2	50	56	PF00498	0.481
LIG_LIR_Apic_2	166	172	PF02991	0.299
LIG_LIR_Apic_2	316	320	PF02991	0.443
LIG_LIR_Nem_3	72	78	PF02991	0.498
LIG_NRBOX	291	297	PF00104	0.450
LIG_SH2_CRK	170	174	PF00017	0.442
LIG_SH2_CRK	75	79	PF00017	0.498
LIG_SH2_NCK_1	170	174	PF00017	0.491
LIG_SH2_SRC	170	173	PF00017	0.388
LIG_SH2_STAP1	199	203	PF00017	0.372
LIG_SH2_STAT3	105	108	PF00017	0.390
LIG_SH2_STAT3	242	245	PF00017	0.356
LIG_SH2_STAT5	231	234	PF00017	0.375
LIG_SH2_STAT5	291	294	PF00017	0.391
LIG_SH2_STAT5	53	56	PF00017	0.442
LIG_SH3_2	128	133	PF14604	0.390
LIG_SH3_3	11	17	PF00018	0.556
LIG_SH3_3	118	124	PF00018	0.445
LIG_SH3_3	125	131	PF00018	0.380
LIG_SH3_3	38	44	PF00018	0.391
LIG_SUMO_SIM_anti_2	36	43	PF11976	0.368
LIG_SUMO_SIM_anti_2	89	96	PF11976	0.396
LIG_SUMO_SIM_par_1	331	337	PF11976	0.450
LIG_SUMO_SIM_par_1	36	43	PF11976	0.383
LIG_SUMO_SIM_par_1	78	85	PF11976	0.372
MOD_CK2_1	270	276	PF00069	0.456
MOD_CK2_1	61	67	PF00069	0.450
MOD_GlcNHglycan	1	4	PF01048	0.691
MOD_GlcNHglycan	236	239	PF01048	0.381
MOD_GlcNHglycan	285	289	PF01048	0.372
MOD_GSK3_1	232	239	PF00069	0.386
MOD_GSK3_1	325	332	PF00069	0.481
MOD_GSK3_1	49	56	PF00069	0.485
MOD_GSK3_1	78	85	PF00069	0.379
MOD_N-GLC_1	175	180	PF02516	0.474
MOD_N-GLC_1	270	275	PF02516	0.416
MOD_N-GLC_1	313	318	PF02516	0.299
MOD_N-GLC_2	165	167	PF02516	0.372
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	154	159	PF00069	0.356
MOD_NEK2_1	163	168	PF00069	0.356
MOD_NEK2_1	284	289	PF00069	0.356
MOD_NEK2_1	49	54	PF00069	0.531
MOD_PIKK_1	104	110	PF00454	0.390
MOD_PIKK_1	205	211	PF00454	0.498
MOD_PKA_2	308	314	PF00069	0.525
MOD_Plk_1	284	290	PF00069	0.373
MOD_Plk_1	313	319	PF00069	0.325
MOD_Plk_4	334	340	PF00069	0.390
MOD_Plk_4	49	55	PF00069	0.481
MOD_Plk_4	78	84	PF00069	0.372
MOD_ProDKin_1	117	123	PF00069	0.511
MOD_ProDKin_1	124	130	PF00069	0.516
MOD_ProDKin_1	141	147	PF00069	0.384
MOD_ProDKin_1	16	22	PF00069	0.562
MOD_ProDKin_1	316	322	PF00069	0.450
MOD_SUMO_rev_2	62	71	PF00179	0.338
TRG_DiLeu_BaEn_4	263	269	PF01217	0.440
TRG_ENDOCYTIC_2	75	78	PF00928	0.498
TRG_ER_diArg_1	110	112	PF00400	0.415
TRG_ER_diArg_1	113	116	PF00400	0.400
TRG_ER_diArg_1	309	312	PF00400	0.431
TRG_NES_CRM1_1	90	104	PF08389	0.351
TRG_NLS_MonoExtC_3	108	113	PF00514	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N4	Leptomonas seymouri	78%	100%
A0A0S4JKY9	Bodo saltans	54%	83%
A0A1X0NEA3	Trypanosomatidae	52%	100%
A0A422NGL0	Trypanosoma rangeli	57%	99%
A4H689	Leishmania braziliensis	82%	100%
A4HUL2	Leishmania infantum	100%	100%
A4VWC2	Streptococcus suis (strain 05ZYH33)	24%	100%
A4W2M2	Streptococcus suis (strain 98HAH33)	24%	100%
C9ZVN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ANB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P50389	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
Q4QHB3	Leishmania major	96%	100%
V5BP86	Trypanosoma cruzi	57%	99%