Nuclear transport factor 2

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear transport factor 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6G7_LEIDO

TriTrypDb:

LdBPK_100900.1 , LdCL_100015800 , LDHU3_10.1260

Length:

124

Annotations

Annotations by Jardim et al.

Transporters, nuclear transport factor 2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0044613	nuclear pore central transport channel	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6G7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006913	nucleocytoplasmic transport	5	10
GO:0009987	cellular process	1	10
GO:0046907	intracellular transport	3	10
GO:0051169	nuclear transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	21	29	PF00400	0.326
DOC_USP7_MATH_1	71	75	PF00917	0.414
LIG_14-3-3_CanoR_1	30	35	PF00244	0.310
LIG_AP2alpha_1	96	100	PF02296	0.330
LIG_BIR_II_1	1	5	PF00653	0.416
LIG_BRCT_BRCA1_1	92	96	PF00533	0.471
LIG_eIF4E_1	29	35	PF01652	0.330
LIG_LIR_Gen_1	2	11	PF02991	0.354
LIG_LIR_Gen_1	93	103	PF02991	0.429
LIG_LIR_Nem_3	2	6	PF02991	0.376
LIG_LIR_Nem_3	93	99	PF02991	0.429
LIG_Pex14_2	96	100	PF04695	0.330
LIG_PTB_Apo_2	110	117	PF02174	0.330
LIG_PTB_Apo_2	51	58	PF02174	0.386
LIG_SH2_GRB2like	14	17	PF00017	0.429
LIG_SH2_STAT5	110	113	PF00017	0.330
MOD_GlcNHglycan	73	76	PF01048	0.342
MOD_PK_1	63	69	PF00069	0.393
MOD_Plk_1	90	96	PF00069	0.354
MOD_Plk_4	30	36	PF00069	0.330
TRG_ENDOCYTIC_2	14	17	PF00928	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL30	Leptomonas seymouri	82%	100%
A0A1X0NS09	Trypanosomatidae	68%	100%
A0A3R7JTH9	Trypanosoma rangeli	65%	100%
A4H673	Leishmania braziliensis	86%	100%
A4HUJ7	Leishmania infantum	100%	100%
C9ZVM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AN95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O42242	Xenopus laevis	33%	98%
P33331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	99%
P61970	Homo sapiens	35%	98%
P61971	Mus musculus	35%	98%
P61972	Rattus norvegicus	35%	98%
P87102	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q10100	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q21735	Caenorhabditis elegans	33%	93%
Q32KP9	Bos taurus	35%	98%
Q4QHC9	Leishmania major	99%	100%
Q5R8G4	Pongo abelii	35%	98%
Q6BWC0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	33%	100%
Q6CC82	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	100%
Q6CQX4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	99%
Q6FRC6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	34%	99%
Q75AA5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	99%
Q86HW7	Dictyostelium discoideum	40%	98%
Q8NJ52	Davidiella tassiana	33%	99%
Q96VN3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	99%
Q9C7F5	Arabidopsis thaliana	39%	98%
Q9FZK4	Arabidopsis thaliana	38%	100%
Q9P926	Candida albicans	36%	100%
Q9XJ54	Oryza sativa subsp. japonica	34%	100%