Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H6G6_LEIDO

TriTrypDb:

LdBPK_100820.1 , LdCL_100015000 , LDHU3_10.1180

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.453
CLV_NRD_NRD_1	233	235	PF00675	0.666
CLV_NRD_NRD_1	278	280	PF00675	0.571
CLV_NRD_NRD_1	315	317	PF00675	0.594
CLV_NRD_NRD_1	446	448	PF00675	0.591
CLV_NRD_NRD_1	490	492	PF00675	0.610
CLV_NRD_NRD_1	75	77	PF00675	0.569
CLV_PCSK_FUR_1	446	450	PF00082	0.569
CLV_PCSK_KEX2_1	232	234	PF00082	0.692
CLV_PCSK_KEX2_1	242	244	PF00082	0.605
CLV_PCSK_KEX2_1	278	280	PF00082	0.571
CLV_PCSK_KEX2_1	315	317	PF00082	0.594
CLV_PCSK_KEX2_1	446	448	PF00082	0.561
CLV_PCSK_KEX2_1	490	492	PF00082	0.610
CLV_PCSK_KEX2_1	75	77	PF00082	0.461
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.640
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.605
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.579
CLV_PCSK_SKI1_1	303	307	PF00082	0.499
CLV_PCSK_SKI1_1	340	344	PF00082	0.483
CLV_PCSK_SKI1_1	75	79	PF00082	0.486
DEG_APCC_DBOX_1	518	526	PF00400	0.447
DEG_Kelch_actinfilin_1	328	332	PF01344	0.398
DOC_CYCLIN_RxL_1	202	212	PF00134	0.355
DOC_CYCLIN_RxL_1	297	310	PF00134	0.449
DOC_MAPK_DCC_7	81	90	PF00069	0.516
DOC_MAPK_HePTP_8	78	90	PF00069	0.489
DOC_MAPK_MEF2A_6	152	160	PF00069	0.431
DOC_MAPK_MEF2A_6	16	23	PF00069	0.453
DOC_MAPK_MEF2A_6	252	261	PF00069	0.495
DOC_MAPK_MEF2A_6	81	90	PF00069	0.644
DOC_PP1_RVXF_1	203	210	PF00149	0.426
DOC_USP7_MATH_1	188	192	PF00917	0.739
DOC_USP7_MATH_1	34	38	PF00917	0.680
DOC_WW_Pin1_4	111	116	PF00397	0.684
DOC_WW_Pin1_4	305	310	PF00397	0.490
DOC_WW_Pin1_4	385	390	PF00397	0.650
DOC_WW_Pin1_4	42	47	PF00397	0.764
DOC_WW_Pin1_4	54	59	PF00397	0.503
DOC_WW_Pin1_4	81	86	PF00397	0.588
DOC_WW_Pin1_4	93	98	PF00397	0.703
LIG_14-3-3_CanoR_1	152	160	PF00244	0.431
LIG_14-3-3_CanoR_1	16	22	PF00244	0.502
LIG_14-3-3_CanoR_1	203	208	PF00244	0.432
LIG_14-3-3_CanoR_1	278	287	PF00244	0.561
LIG_14-3-3_CanoR_1	38	43	PF00244	0.693
LIG_14-3-3_CanoR_1	496	502	PF00244	0.454
LIG_14-3-3_CanoR_1	89	97	PF00244	0.747
LIG_APCC_ABBA_1	523	528	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_BRCT_BRCA1_1	205	209	PF00533	0.481
LIG_BRCT_BRCA1_1	318	322	PF00533	0.555
LIG_DLG_GKlike_1	203	210	PF00625	0.426
LIG_FHA_1	18	24	PF00498	0.511
LIG_FHA_1	187	193	PF00498	0.645
LIG_FHA_1	223	229	PF00498	0.501
LIG_FHA_1	331	337	PF00498	0.448
LIG_FHA_1	341	347	PF00498	0.417
LIG_FHA_1	412	418	PF00498	0.418
LIG_FHA_1	469	475	PF00498	0.532
LIG_FHA_1	503	509	PF00498	0.450
LIG_FHA_1	64	70	PF00498	0.491
LIG_FHA_2	123	129	PF00498	0.523
LIG_FHA_2	133	139	PF00498	0.517
LIG_FHA_2	336	342	PF00498	0.351
LIG_Integrin_RGD_1	81	83	PF01839	0.539
LIG_LIR_Gen_1	410	420	PF02991	0.438
LIG_LIR_Nem_3	282	287	PF02991	0.469
LIG_LIR_Nem_3	341	345	PF02991	0.438
LIG_LIR_Nem_3	410	416	PF02991	0.436
LIG_LIR_Nem_3	435	440	PF02991	0.467
LIG_Pex14_2	11	15	PF04695	0.483
LIG_Pex14_2	209	213	PF04695	0.461
LIG_SH2_CRK	413	417	PF00017	0.439
LIG_SH2_SRC	287	290	PF00017	0.361
LIG_SH2_STAP1	180	184	PF00017	0.523
LIG_SH2_STAP1	413	417	PF00017	0.430
LIG_SH2_STAP1	429	433	PF00017	0.300
LIG_SH2_STAT3	541	544	PF00017	0.453
LIG_SH2_STAT5	345	348	PF00017	0.438
LIG_SH2_STAT5	413	416	PF00017	0.388
LIG_SH3_3	256	262	PF00018	0.454
LIG_SH3_3	393	399	PF00018	0.520
LIG_SH3_3	40	46	PF00018	0.602
LIG_SH3_3	94	100	PF00018	0.716
LIG_SUMO_SIM_anti_2	388	394	PF11976	0.557
LIG_SUMO_SIM_anti_2	503	511	PF11976	0.509
LIG_SUMO_SIM_par_1	19	26	PF11976	0.525
LIG_SUMO_SIM_par_1	328	333	PF11976	0.396
LIG_SUMO_SIM_par_1	470	477	PF11976	0.587
LIG_TYR_ITIM	411	416	PF00017	0.436
LIG_UBA3_1	407	415	PF00899	0.439
LIG_UBA3_1	522	529	PF00899	0.467
MOD_CK1_1	191	197	PF00069	0.710
MOD_CK1_1	30	36	PF00069	0.638
MOD_CK1_1	468	474	PF00069	0.578
MOD_CK1_1	93	99	PF00069	0.686
MOD_CK2_1	122	128	PF00069	0.490
MOD_CK2_1	151	157	PF00069	0.526
MOD_CK2_1	30	36	PF00069	0.667
MOD_CK2_1	305	311	PF00069	0.497
MOD_CK2_1	335	341	PF00069	0.448
MOD_CK2_1	42	48	PF00069	0.707
MOD_CK2_1	458	464	PF00069	0.449
MOD_Cter_Amidation	73	76	PF01082	0.435
MOD_GlcNHglycan	101	104	PF01048	0.751
MOD_GlcNHglycan	153	156	PF01048	0.615
MOD_GlcNHglycan	176	179	PF01048	0.648
MOD_GlcNHglycan	180	183	PF01048	0.659
MOD_GlcNHglycan	243	246	PF01048	0.571
MOD_GlcNHglycan	29	32	PF01048	0.621
MOD_GlcNHglycan	418	421	PF01048	0.452
MOD_GlcNHglycan	467	470	PF01048	0.743
MOD_GlcNHglycan	498	501	PF01048	0.576
MOD_GlcNHglycan	547	550	PF01048	0.518
MOD_GSK3_1	169	176	PF00069	0.595
MOD_GSK3_1	191	198	PF00069	0.707
MOD_GSK3_1	23	30	PF00069	0.629
MOD_GSK3_1	237	244	PF00069	0.587
MOD_GSK3_1	330	337	PF00069	0.545
MOD_GSK3_1	34	41	PF00069	0.781
MOD_GSK3_1	407	414	PF00069	0.441
MOD_GSK3_1	428	435	PF00069	0.528
MOD_GSK3_1	454	461	PF00069	0.638
MOD_GSK3_1	468	475	PF00069	0.568
MOD_GSK3_1	496	503	PF00069	0.562
MOD_LATS_1	314	320	PF00433	0.565
MOD_N-GLC_1	23	28	PF02516	0.532
MOD_N-GLC_1	465	470	PF02516	0.569
MOD_NEK2_1	1	6	PF00069	0.603
MOD_NEK2_1	169	174	PF00069	0.438
MOD_NEK2_1	267	272	PF00069	0.430
MOD_NEK2_1	280	285	PF00069	0.397
MOD_NEK2_1	335	340	PF00069	0.415
MOD_NEK2_1	407	412	PF00069	0.426
MOD_NEK2_1	458	463	PF00069	0.448
MOD_NEK2_2	318	323	PF00069	0.496
MOD_PIKK_1	1	7	PF00454	0.569
MOD_PIKK_1	330	336	PF00454	0.454
MOD_PKA_2	151	157	PF00069	0.583
MOD_PKA_2	495	501	PF00069	0.408
MOD_Plk_1	169	175	PF00069	0.636
MOD_Plk_1	195	201	PF00069	0.714
MOD_Plk_1	23	29	PF00069	0.542
MOD_Plk_1	454	460	PF00069	0.560
MOD_Plk_4	188	194	PF00069	0.744
MOD_Plk_4	454	460	PF00069	0.560
MOD_ProDKin_1	111	117	PF00069	0.684
MOD_ProDKin_1	305	311	PF00069	0.497
MOD_ProDKin_1	385	391	PF00069	0.637
MOD_ProDKin_1	42	48	PF00069	0.762
MOD_ProDKin_1	54	60	PF00069	0.493
MOD_ProDKin_1	81	87	PF00069	0.601
MOD_ProDKin_1	93	99	PF00069	0.700
TRG_DiLeu_BaEn_1	504	509	PF01217	0.434
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.425
TRG_ENDOCYTIC_2	413	416	PF00928	0.438
TRG_ER_diArg_1	277	279	PF00400	0.569
TRG_ER_diArg_1	315	317	PF00400	0.595
TRG_ER_diArg_1	445	447	PF00400	0.557
TRG_ER_diArg_1	489	491	PF00400	0.423
TRG_ER_diArg_1	75	77	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	37%	80%
A0A0N1PDV8	Leptomonas seymouri	30%	95%
A0A3S7WR70	Leishmania donovani	31%	86%
A4H664	Leishmania braziliensis	31%	100%
A4HUI8	Leishmania infantum	30%	100%
A4HUI9	Leishmania infantum	99%	100%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QHD7	Leishmania major	88%	100%
Q4QHD8	Leishmania major	32%	87%