LeishMANIAdb
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Amino acid permease 24, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amino acid permease 24, putative
Gene product:
amino acid permease 24
Species:
Leishmania donovani
UniProt:
A0A3S5H6G5_LEIDO
TriTrypDb:
LdBPK_100770.1 , LdCL_100014500 , LDHU3_10.1110
Length:
488

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0005774 vacuolar membrane 5 2
GO:0031090 organelle membrane 3 2
GO:0098588 bounding membrane of organelle 4 2

Expansion

Sequence features

A0A3S5H6G5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6G5

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 2
GO:0006810 transport 3 2
GO:0006865 amino acid transport 5 2
GO:0009987 cellular process 1 2
GO:0015849 organic acid transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1905039 carboxylic acid transmembrane transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0015171 amino acid transmembrane transporter activity 5 2
GO:0015179 L-amino acid transmembrane transporter activity 6 2
GO:0022857 transmembrane transporter activity 2 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 437 441 PF00656 0.620
CLV_C14_Caspase3-7 7 11 PF00656 0.680
CLV_NRD_NRD_1 24 26 PF00675 0.481
CLV_PCSK_KEX2_1 296 298 PF00082 0.344
CLV_PCSK_KEX2_1 462 464 PF00082 0.356
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.344
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.411
CLV_PCSK_SKI1_1 301 305 PF00082 0.288
CLV_PCSK_SKI1_1 347 351 PF00082 0.295
CLV_PCSK_SKI1_1 450 454 PF00082 0.335
CLV_PCSK_SKI1_1 88 92 PF00082 0.224
DEG_APCC_KENBOX_2 80 84 PF00400 0.602
DOC_MAPK_FxFP_2 356 359 PF00069 0.317
DOC_MAPK_gen_1 196 205 PF00069 0.263
DOC_MAPK_gen_1 374 383 PF00069 0.453
DOC_MAPK_gen_1 462 472 PF00069 0.461
DOC_MAPK_HePTP_8 373 385 PF00069 0.497
DOC_MAPK_MEF2A_6 133 142 PF00069 0.340
DOC_MAPK_MEF2A_6 196 205 PF00069 0.305
DOC_MAPK_MEF2A_6 347 356 PF00069 0.316
DOC_MAPK_MEF2A_6 376 385 PF00069 0.445
DOC_MAPK_MEF2A_6 386 393 PF00069 0.241
DOC_MAPK_MEF2A_6 463 472 PF00069 0.463
DOC_MAPK_NFAT4_5 386 394 PF00069 0.317
DOC_PP1_RVXF_1 345 351 PF00149 0.323
DOC_PP4_FxxP_1 103 106 PF00568 0.275
DOC_PP4_FxxP_1 356 359 PF00568 0.317
DOC_USP7_MATH_1 224 228 PF00917 0.294
DOC_USP7_MATH_1 230 234 PF00917 0.294
DOC_USP7_MATH_1 414 418 PF00917 0.373
DOC_WW_Pin1_4 337 342 PF00397 0.310
LIG_14-3-3_CanoR_1 23 29 PF00244 0.703
LIG_14-3-3_CanoR_1 3 13 PF00244 0.770
LIG_14-3-3_CanoR_1 443 447 PF00244 0.521
LIG_BIR_II_1 1 5 PF00653 0.732
LIG_BRCT_BRCA1_1 203 207 PF00533 0.454
LIG_EH1_1 113 121 PF00400 0.303
LIG_FHA_1 130 136 PF00498 0.379
LIG_FHA_1 229 235 PF00498 0.324
LIG_FHA_1 302 308 PF00498 0.468
LIG_FHA_1 318 324 PF00498 0.233
LIG_FHA_1 328 334 PF00498 0.229
LIG_FHA_1 355 361 PF00498 0.324
LIG_FHA_1 400 406 PF00498 0.301
LIG_FHA_1 479 485 PF00498 0.308
LIG_FHA_2 15 21 PF00498 0.580
LIG_FHA_2 186 192 PF00498 0.324
LIG_FHA_2 25 31 PF00498 0.704
LIG_FHA_2 5 11 PF00498 0.772
LIG_GBD_Chelix_1 115 123 PF00786 0.368
LIG_GBD_Chelix_1 311 319 PF00786 0.422
LIG_LIR_Apic_2 100 106 PF02991 0.294
LIG_LIR_Gen_1 148 157 PF02991 0.476
LIG_LIR_Gen_1 198 208 PF02991 0.289
LIG_LIR_Gen_1 233 244 PF02991 0.351
LIG_LIR_Gen_1 30 38 PF02991 0.676
LIG_LIR_Gen_1 60 68 PF02991 0.737
LIG_LIR_Gen_1 89 98 PF02991 0.355
LIG_LIR_Nem_3 148 153 PF02991 0.438
LIG_LIR_Nem_3 198 203 PF02991 0.297
LIG_LIR_Nem_3 233 239 PF02991 0.366
LIG_LIR_Nem_3 30 35 PF02991 0.704
LIG_LIR_Nem_3 320 325 PF02991 0.346
LIG_LIR_Nem_3 379 383 PF02991 0.471
LIG_LIR_Nem_3 460 464 PF02991 0.525
LIG_LIR_Nem_3 89 94 PF02991 0.355
LIG_PALB2_WD40_1 265 273 PF16756 0.297
LIG_PDZ_Class_3 483 488 PF00595 0.375
LIG_Pex14_1 313 317 PF04695 0.342
LIG_Pex14_1 449 453 PF04695 0.574
LIG_Pex14_2 207 211 PF04695 0.346
LIG_SH2_CRK 150 154 PF00017 0.467
LIG_SH2_CRK 181 185 PF00017 0.364
LIG_SH2_CRK 236 240 PF00017 0.396
LIG_SH2_NCK_1 482 486 PF00017 0.376
LIG_SH2_PTP2 467 470 PF00017 0.426
LIG_SH2_STAP1 181 185 PF00017 0.324
LIG_SH2_STAT3 358 361 PF00017 0.294
LIG_SH2_STAT5 114 117 PF00017 0.325
LIG_SH2_STAT5 156 159 PF00017 0.468
LIG_SH2_STAT5 181 184 PF00017 0.249
LIG_SH2_STAT5 200 203 PF00017 0.317
LIG_SH2_STAT5 314 317 PF00017 0.292
LIG_SH2_STAT5 322 325 PF00017 0.310
LIG_SH2_STAT5 467 470 PF00017 0.284
LIG_SH2_STAT5 61 64 PF00017 0.741
LIG_SH3_3 433 439 PF00018 0.509
LIG_SH3_3 451 457 PF00018 0.614
LIG_SUMO_SIM_anti_2 217 224 PF11976 0.486
LIG_SUMO_SIM_anti_2 281 287 PF11976 0.342
LIG_SUMO_SIM_par_1 221 227 PF11976 0.483
LIG_SUMO_SIM_par_1 303 308 PF11976 0.386
LIG_TYR_ITIM 179 184 PF00017 0.323
LIG_TYR_ITIM 234 239 PF00017 0.396
LIG_TYR_ITSM 146 153 PF00017 0.517
LIG_UBA3_1 427 433 PF00899 0.226
LIG_WRC_WIRS_1 105 110 PF05994 0.323
MOD_CK1_1 145 151 PF00069 0.474
MOD_CK1_1 328 334 PF00069 0.311
MOD_CK1_1 6 12 PF00069 0.726
MOD_CK2_1 14 20 PF00069 0.599
MOD_CK2_1 185 191 PF00069 0.325
MOD_CK2_1 24 30 PF00069 0.704
MOD_CK2_1 31 37 PF00069 0.677
MOD_CK2_1 480 486 PF00069 0.296
MOD_CK2_1 6 12 PF00069 0.738
MOD_GlcNHglycan 363 366 PF01048 0.336
MOD_GlcNHglycan 402 405 PF01048 0.498
MOD_GlcNHglycan 88 91 PF01048 0.287
MOD_GSK3_1 142 149 PF00069 0.542
MOD_GSK3_1 214 221 PF00069 0.336
MOD_GSK3_1 224 231 PF00069 0.288
MOD_GSK3_1 301 308 PF00069 0.492
MOD_GSK3_1 325 332 PF00069 0.302
MOD_GSK3_1 337 344 PF00069 0.234
MOD_GSK3_1 400 407 PF00069 0.368
MOD_GSK3_1 480 487 PF00069 0.318
MOD_N-GLC_1 142 147 PF02516 0.263
MOD_N-GLC_1 218 223 PF02516 0.256
MOD_NEK2_1 179 184 PF00069 0.324
MOD_NEK2_1 185 190 PF00069 0.296
MOD_NEK2_1 195 200 PF00069 0.217
MOD_NEK2_1 201 206 PF00069 0.295
MOD_NEK2_1 242 247 PF00069 0.340
MOD_NEK2_1 305 310 PF00069 0.386
MOD_NEK2_1 317 322 PF00069 0.260
MOD_NEK2_1 329 334 PF00069 0.201
MOD_NEK2_1 354 359 PF00069 0.317
MOD_NEK2_2 230 235 PF00069 0.429
MOD_NEK2_2 342 347 PF00069 0.301
MOD_NEK2_2 457 462 PF00069 0.620
MOD_OFUCOSY 210 215 PF10250 0.318
MOD_PIKK_1 14 20 PF00454 0.655
MOD_PIKK_1 148 154 PF00454 0.497
MOD_PIKK_1 179 185 PF00454 0.320
MOD_PIKK_1 247 253 PF00454 0.321
MOD_PIKK_1 291 297 PF00454 0.505
MOD_PKA_2 24 30 PF00069 0.679
MOD_PKA_2 442 448 PF00069 0.515
MOD_Plk_1 129 135 PF00069 0.321
MOD_Plk_1 145 151 PF00069 0.500
MOD_Plk_1 218 224 PF00069 0.456
MOD_Plk_1 369 375 PF00069 0.512
MOD_Plk_1 68 74 PF00069 0.634
MOD_Plk_4 104 110 PF00069 0.314
MOD_Plk_4 114 120 PF00069 0.313
MOD_Plk_4 185 191 PF00069 0.216
MOD_Plk_4 201 207 PF00069 0.340
MOD_Plk_4 218 224 PF00069 0.450
MOD_Plk_4 230 236 PF00069 0.253
MOD_Plk_4 24 30 PF00069 0.696
MOD_Plk_4 242 248 PF00069 0.247
MOD_Plk_4 301 307 PF00069 0.460
MOD_Plk_4 329 335 PF00069 0.233
MOD_Plk_4 404 410 PF00069 0.257
MOD_Plk_4 423 429 PF00069 0.175
MOD_Plk_4 68 74 PF00069 0.672
MOD_ProDKin_1 337 343 PF00069 0.310
MOD_SUMO_rev_2 50 58 PF00179 0.775
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.345
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.393
TRG_ENDOCYTIC_2 150 153 PF00928 0.431
TRG_ENDOCYTIC_2 181 184 PF00928 0.333
TRG_ENDOCYTIC_2 200 203 PF00928 0.179
TRG_ENDOCYTIC_2 236 239 PF00928 0.350
TRG_ENDOCYTIC_2 314 317 PF00928 0.295
TRG_ENDOCYTIC_2 467 470 PF00928 0.305
TRG_ENDOCYTIC_2 61 64 PF00928 0.741
TRG_NLS_Bipartite_1 450 466 PF00514 0.565
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.422
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.487

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6H0 Leptomonas seymouri 71% 100%
A0A0N0P8T9 Leptomonas seymouri 21% 98%
A0A0N1PCP5 Leptomonas seymouri 69% 100%
A0A1X0NHS6 Trypanosomatidae 45% 100%
A0A1X0NKS5 Trypanosomatidae 21% 100%
A0A1X0NKV2 Trypanosomatidae 23% 98%
A0A1X0NRL3 Trypanosomatidae 24% 100%
A0A1X0NYI3 Trypanosomatidae 22% 98%
A0A1X0NZK6 Trypanosomatidae 49% 100%
A0A1X0P7Z8 Trypanosomatidae 31% 78%
A0A381MBS1 Leishmania infantum 99% 100%
A0A3Q8IB21 Leishmania donovani 100% 100%
A0A3Q8IFZ0 Leishmania donovani 23% 95%
A0A3S5H6T4 Leishmania donovani 23% 96%
A0A3S5ISG3 Trypanosoma rangeli 25% 99%
A0A3S7WQ39 Leishmania donovani 21% 100%
A0A422MW74 Trypanosoma rangeli 21% 95%
A0A422MZQ8 Trypanosoma rangeli 34% 82%
A4H565 Leishmania braziliensis 21% 100%
A4H662 Leishmania braziliensis 80% 100%
A4HJ07 Leishmania braziliensis 22% 98%
A4HKQ7 Leishmania braziliensis 23% 100%
A4HNZ6 Leishmania braziliensis 30% 100%
A4HTE2 Leishmania infantum 22% 100%
A4HUI4 Leishmania infantum 98% 100%
A4I6K0 Leishmania infantum 23% 95%
C9ZW15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A2X2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 85%
E9AN82 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AYW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
F4ILY9 Arabidopsis thaliana 24% 100%
O22719 Arabidopsis thaliana 20% 100%
P36062 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 71%
Q10074 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 74%
Q495M3 Homo sapiens 20% 100%
Q495N2 Homo sapiens 23% 100%
Q4KL91 Xenopus laevis 21% 93%
Q4Q6M8 Leishmania major 24% 95%
Q4QHE2 Leishmania major 94% 100%
Q4QHE4 Leishmania major 94% 100%
Q4QIH0 Leishmania major 22% 100%
Q4V8B1 Rattus norvegicus 24% 100%
Q6YBV0 Homo sapiens 21% 97%
Q7Z2H8 Homo sapiens 22% 100%
Q811P0 Mus musculus 23% 100%
Q8CH36 Mus musculus 22% 98%
Q8K415 Rattus norvegicus 22% 100%
Q8K4D3 Mus musculus 23% 100%
Q924A5 Rattus norvegicus 22% 100%
Q9SF09 Arabidopsis thaliana 21% 100%
Q9SS86 Arabidopsis thaliana 21% 100%
Q9SVG0 Arabidopsis thaliana 23% 100%
Q9VT04 Drosophila melanogaster 20% 100%
Q9W056 Drosophila melanogaster 26% 100%
V5BHF0 Trypanosoma cruzi 43% 100%
V5BJY7 Trypanosoma cruzi 34% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS