Chromatin_assembly_factor_1_subunit_A_putative/Pf am:PF12253

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromatin assembly factor 1 subunit A, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6G3_LEIDO

TriTrypDb:

LdBPK_100630.1 , LdCL_100013100 , LDHU3_10.0950

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S5H6G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.449
CLV_C14_Caspase3-7	156	160	PF00656	0.505
CLV_C14_Caspase3-7	414	418	PF00656	0.468
CLV_C14_Caspase3-7	422	426	PF00656	0.764
CLV_C14_Caspase3-7	436	440	PF00656	0.591
CLV_C14_Caspase3-7	759	763	PF00656	0.774
CLV_MEL_PAP_1	620	626	PF00089	0.603
CLV_NRD_NRD_1	110	112	PF00675	0.562
CLV_NRD_NRD_1	122	124	PF00675	0.483
CLV_NRD_NRD_1	138	140	PF00675	0.522
CLV_NRD_NRD_1	150	152	PF00675	0.465
CLV_NRD_NRD_1	160	162	PF00675	0.462
CLV_NRD_NRD_1	231	233	PF00675	0.676
CLV_NRD_NRD_1	258	260	PF00675	0.703
CLV_NRD_NRD_1	445	447	PF00675	0.544
CLV_NRD_NRD_1	454	456	PF00675	0.567
CLV_NRD_NRD_1	547	549	PF00675	0.535
CLV_NRD_NRD_1	596	598	PF00675	0.506
CLV_NRD_NRD_1	601	603	PF00675	0.537
CLV_PCSK_FUR_1	452	456	PF00082	0.542
CLV_PCSK_KEX2_1	110	112	PF00082	0.632
CLV_PCSK_KEX2_1	121	123	PF00082	0.657
CLV_PCSK_KEX2_1	150	152	PF00082	0.600
CLV_PCSK_KEX2_1	220	222	PF00082	0.578
CLV_PCSK_KEX2_1	231	233	PF00082	0.555
CLV_PCSK_KEX2_1	258	260	PF00082	0.703
CLV_PCSK_KEX2_1	454	456	PF00082	0.553
CLV_PCSK_KEX2_1	534	536	PF00082	0.580
CLV_PCSK_KEX2_1	547	549	PF00082	0.465
CLV_PCSK_KEX2_1	596	598	PF00082	0.511
CLV_PCSK_KEX2_1	601	603	PF00082	0.557
CLV_PCSK_KEX2_1	749	751	PF00082	0.723
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.578
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.566
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.723
CLV_PCSK_PC7_1	597	603	PF00082	0.607
CLV_PCSK_SKI1_1	122	126	PF00082	0.539
CLV_PCSK_SKI1_1	150	154	PF00082	0.529
CLV_PCSK_SKI1_1	180	184	PF00082	0.617
CLV_PCSK_SKI1_1	312	316	PF00082	0.590
CLV_PCSK_SKI1_1	548	552	PF00082	0.523
CLV_PCSK_SKI1_1	571	575	PF00082	0.579
DEG_Nend_UBRbox_2	1	3	PF02207	0.491
DEG_SCF_FBW7_1	695	701	PF00400	0.648
DEG_SPOP_SBC_1	41	45	PF00917	0.690
DEG_SPOP_SBC_1	411	415	PF00917	0.385
DOC_CKS1_1	695	700	PF01111	0.647
DOC_CYCLIN_RxL_1	601	611	PF00134	0.605
DOC_MAPK_gen_1	601	608	PF00069	0.632
DOC_MAPK_MEF2A_6	578	586	PF00069	0.583
DOC_PP2B_LxvP_1	183	186	PF13499	0.614
DOC_PP2B_LxvP_1	276	279	PF13499	0.666
DOC_USP7_MATH_1	261	265	PF00917	0.704
DOC_USP7_MATH_1	324	328	PF00917	0.611
DOC_USP7_MATH_1	329	333	PF00917	0.588
DOC_USP7_MATH_1	349	353	PF00917	0.511
DOC_USP7_MATH_1	35	39	PF00917	0.751
DOC_USP7_MATH_1	41	45	PF00917	0.763
DOC_USP7_MATH_1	411	415	PF00917	0.310
DOC_USP7_MATH_1	423	427	PF00917	0.668
DOC_USP7_MATH_1	48	52	PF00917	0.649
DOC_USP7_MATH_1	510	514	PF00917	0.588
DOC_USP7_MATH_1	563	567	PF00917	0.575
DOC_USP7_MATH_1	622	626	PF00917	0.686
DOC_USP7_MATH_1	682	686	PF00917	0.687
DOC_USP7_MATH_1	712	716	PF00917	0.588
DOC_USP7_MATH_1	737	741	PF00917	0.682
DOC_USP7_MATH_1	90	94	PF00917	0.674
DOC_USP7_MATH_2	737	743	PF00917	0.579
DOC_USP7_UBL2_3	180	184	PF12436	0.577
DOC_USP7_UBL2_3	567	571	PF12436	0.426
DOC_USP7_UBL2_3	734	738	PF12436	0.636
DOC_WW_Pin1_4	211	216	PF00397	0.588
DOC_WW_Pin1_4	49	54	PF00397	0.714
DOC_WW_Pin1_4	611	616	PF00397	0.626
DOC_WW_Pin1_4	629	634	PF00397	0.614
DOC_WW_Pin1_4	694	699	PF00397	0.699
DOC_WW_Pin1_4	708	713	PF00397	0.639
DOC_WW_Pin1_4	733	738	PF00397	0.659
DOC_WW_Pin1_4	96	101	PF00397	0.609
LIG_14-3-3_CanoR_1	601	607	PF00244	0.639
LIG_14-3-3_CanoR_1	623	630	PF00244	0.672
LIG_14-3-3_CanoR_1	690	695	PF00244	0.627
LIG_Actin_WH2_2	369	384	PF00022	0.362
LIG_BRCT_BRCA1_1	469	473	PF00533	0.532
LIG_BRCT_BRCA1_1	741	745	PF00533	0.566
LIG_CSL_BTD_1	612	615	PF09270	0.571
LIG_FHA_1	241	247	PF00498	0.644
LIG_FHA_1	3	9	PF00498	0.591
LIG_FHA_1	568	574	PF00498	0.583
LIG_FHA_1	636	642	PF00498	0.657
LIG_FHA_1	66	72	PF00498	0.639
LIG_FHA_1	725	731	PF00498	0.718
LIG_FHA_2	154	160	PF00498	0.559
LIG_FHA_2	420	426	PF00498	0.571
LIG_FHA_2	549	555	PF00498	0.580
LIG_FHA_2	658	664	PF00498	0.679
LIG_FHA_2	666	672	PF00498	0.691
LIG_FHA_2	695	701	PF00498	0.696
LIG_FHA_2	80	86	PF00498	0.654
LIG_LIR_Apic_2	468	472	PF02991	0.650
LIG_LIR_Gen_1	296	303	PF02991	0.541
LIG_LIR_Gen_1	327	338	PF02991	0.645
LIG_LIR_Gen_1	359	368	PF02991	0.400
LIG_LIR_Gen_1	399	408	PF02991	0.291
LIG_LIR_Nem_3	194	199	PF02991	0.668
LIG_LIR_Nem_3	327	333	PF02991	0.581
LIG_LIR_Nem_3	336	342	PF02991	0.524
LIG_LIR_Nem_3	359	363	PF02991	0.400
LIG_LIR_Nem_3	470	476	PF02991	0.536
LIG_LIR_Nem_3	490	495	PF02991	0.604
LIG_LIR_Nem_3	618	624	PF02991	0.640
LIG_LIR_Nem_3	93	97	PF02991	0.552
LIG_Pex14_2	339	343	PF04695	0.622
LIG_PTB_Apo_2	387	394	PF02174	0.291
LIG_PTB_Phospho_1	387	393	PF10480	0.291
LIG_RPA_C_Fungi	597	609	PF08784	0.623
LIG_SH2_CRK	469	473	PF00017	0.625
LIG_SH2_STAT3	499	502	PF00017	0.445
LIG_SH2_STAT5	281	284	PF00017	0.612
LIG_SH2_STAT5	356	359	PF00017	0.313
LIG_SH2_STAT5	499	502	PF00017	0.535
LIG_SH3_1	609	615	PF00018	0.573
LIG_SH3_3	29	35	PF00018	0.647
LIG_SH3_3	323	329	PF00018	0.602
LIG_SH3_3	471	477	PF00018	0.587
LIG_SH3_3	609	615	PF00018	0.595
LIG_SH3_3	627	633	PF00018	0.652
LIG_SH3_3	692	698	PF00018	0.658
LIG_SUMO_SIM_anti_2	17	25	PF11976	0.583
LIG_TRAF2_1	527	530	PF00917	0.562
LIG_TRAF2_1	701	704	PF00917	0.715
LIG_TRAF2_1	751	754	PF00917	0.629
LIG_TRAF2_1	82	85	PF00917	0.592
LIG_UBA3_1	195	204	PF00899	0.633
LIG_UBA3_1	22	27	PF00899	0.702
LIG_WRC_WIRS_1	330	335	PF05994	0.612
LIG_WRC_WIRS_1	91	96	PF05994	0.512
LIG_WW_1	278	281	PF00397	0.605
MOD_CDC14_SPxK_1	99	102	PF00782	0.484
MOD_CDK_SPK_2	733	738	PF00069	0.599
MOD_CDK_SPxK_1	96	102	PF00069	0.506
MOD_CDK_SPxxK_3	96	103	PF00069	0.589
MOD_CK1_1	25	31	PF00069	0.775
MOD_CK1_1	413	419	PF00069	0.310
MOD_CK1_1	426	432	PF00069	0.599
MOD_CK1_1	43	49	PF00069	0.554
MOD_CK1_1	566	572	PF00069	0.557
MOD_CK1_1	711	717	PF00069	0.711
MOD_CK1_1	763	769	PF00069	0.655
MOD_CK2_1	235	241	PF00069	0.646
MOD_CK2_1	41	47	PF00069	0.737
MOD_CK2_1	427	433	PF00069	0.724
MOD_CK2_1	48	54	PF00069	0.730
MOD_CK2_1	518	524	PF00069	0.643
MOD_CK2_1	548	554	PF00069	0.588
MOD_CK2_1	665	671	PF00069	0.575
MOD_CK2_1	694	700	PF00069	0.758
MOD_CK2_1	71	77	PF00069	0.610
MOD_CK2_1	711	717	PF00069	0.721
MOD_CK2_1	733	739	PF00069	0.671
MOD_CK2_1	79	85	PF00069	0.630
MOD_GlcNHglycan	396	399	PF01048	0.309
MOD_GlcNHglycan	469	472	PF01048	0.536
MOD_GlcNHglycan	512	515	PF01048	0.595
MOD_GlcNHglycan	526	529	PF01048	0.663
MOD_GlcNHglycan	692	695	PF01048	0.675
MOD_GlcNHglycan	714	717	PF01048	0.710
MOD_GlcNHglycan	739	742	PF01048	0.712
MOD_GlcNHglycan	762	765	PF01048	0.652
MOD_GlcNHglycan	79	82	PF01048	0.612
MOD_GSK3_1	411	418	PF00069	0.305
MOD_GSK3_1	419	426	PF00069	0.612
MOD_GSK3_1	437	444	PF00069	0.543
MOD_GSK3_1	557	564	PF00069	0.563
MOD_GSK3_1	635	642	PF00069	0.720
MOD_GSK3_1	65	72	PF00069	0.706
MOD_GSK3_1	690	697	PF00069	0.678
MOD_GSK3_1	708	715	PF00069	0.682
MOD_GSK3_1	724	731	PF00069	0.482
MOD_GSK3_1	733	740	PF00069	0.645
MOD_GSK3_1	762	769	PF00069	0.651
MOD_N-GLC_1	246	251	PF02516	0.712
MOD_N-GLC_1	460	465	PF02516	0.559
MOD_N-GLC_1	760	765	PF02516	0.603
MOD_NEK2_1	198	203	PF00069	0.600
MOD_NEK2_1	22	27	PF00069	0.605
MOD_NEK2_1	71	76	PF00069	0.615
MOD_NEK2_1	724	729	PF00069	0.544
MOD_PIKK_1	441	447	PF00454	0.544
MOD_PIKK_1	498	504	PF00454	0.402
MOD_PIKK_1	725	731	PF00454	0.542
MOD_PKA_2	386	392	PF00069	0.414
MOD_PKA_2	622	628	PF00069	0.645
MOD_PKA_2	647	653	PF00069	0.654
MOD_PKB_1	458	466	PF00069	0.549
MOD_Plk_1	240	246	PF00069	0.716
MOD_Plk_1	270	276	PF00069	0.578
MOD_Plk_1	591	597	PF00069	0.542
MOD_Plk_1	666	672	PF00069	0.673
MOD_Plk_2-3	437	443	PF00069	0.542
MOD_Plk_2-3	657	663	PF00069	0.675
MOD_Plk_4	191	197	PF00069	0.682
MOD_Plk_4	241	247	PF00069	0.685
MOD_Plk_4	271	277	PF00069	0.575
MOD_Plk_4	557	563	PF00069	0.588
MOD_Plk_4	719	725	PF00069	0.615
MOD_ProDKin_1	211	217	PF00069	0.588
MOD_ProDKin_1	49	55	PF00069	0.713
MOD_ProDKin_1	611	617	PF00069	0.617
MOD_ProDKin_1	629	635	PF00069	0.617
MOD_ProDKin_1	694	700	PF00069	0.702
MOD_ProDKin_1	708	714	PF00069	0.640
MOD_ProDKin_1	733	739	PF00069	0.659
MOD_ProDKin_1	96	102	PF00069	0.605
MOD_SUMO_for_1	124	127	PF00179	0.491
MOD_SUMO_for_1	132	135	PF00179	0.409
MOD_SUMO_for_1	203	206	PF00179	0.637
MOD_SUMO_for_1	718	721	PF00179	0.717
MOD_SUMO_rev_2	144	149	PF00179	0.568
MOD_SUMO_rev_2	549	558	PF00179	0.598
MOD_SUMO_rev_2	711	720	PF00179	0.699
TRG_DiLeu_BaEn_1	127	132	PF01217	0.519
TRG_DiLeu_BaEn_1	18	23	PF01217	0.557
TRG_DiLeu_BaEn_1	271	276	PF01217	0.587
TRG_DiLeu_BaEn_4	271	277	PF01217	0.647
TRG_ENDOCYTIC_2	330	333	PF00928	0.644
TRG_ENDOCYTIC_2	360	363	PF00928	0.396
TRG_ER_diArg_1	121	123	PF00400	0.543
TRG_ER_diArg_1	150	152	PF00400	0.526
TRG_ER_diArg_1	230	232	PF00400	0.668
TRG_ER_diArg_1	452	455	PF00400	0.548
TRG_ER_diArg_1	595	597	PF00400	0.553
TRG_ER_diArg_1	601	604	PF00400	0.605
TRG_NLS_MonoCore_2	627	632	PF00514	0.627
TRG_NLS_MonoExtC_3	102	107	PF00514	0.668
TRG_NLS_MonoExtN_4	100	107	PF00514	0.457
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	312	317	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G0	Leptomonas seymouri	55%	98%
A0A1X0NRX9	Trypanosomatidae	40%	94%
A4H650	Leishmania braziliensis	78%	100%
A4HUH0	Leishmania infantum	100%	100%
E9AN68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHF7	Leishmania major	93%	100%
V5D2A3	Trypanosoma cruzi	37%	100%