PIF1-like helicase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PIF1-like helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6F8_LEIDO

TriTrypDb:

LdCL_100010200

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004386	helicase activity	2	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0140657	ATP-dependent activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.650
CLV_NRD_NRD_1	121	123	PF00675	0.619
CLV_NRD_NRD_1	230	232	PF00675	0.646
CLV_NRD_NRD_1	264	266	PF00675	0.635
CLV_NRD_NRD_1	30	32	PF00675	0.620
CLV_PCSK_KEX2_1	121	123	PF00082	0.619
CLV_PCSK_KEX2_1	230	232	PF00082	0.629
CLV_PCSK_KEX2_1	264	266	PF00082	0.635
CLV_PCSK_KEX2_1	30	32	PF00082	0.620
CLV_PCSK_SKI1_1	37	41	PF00082	0.602
DEG_Nend_UBRbox_1	1	4	PF02207	0.652
DOC_CDC14_PxL_1	190	198	PF14671	0.619
DOC_CKS1_1	210	215	PF01111	0.644
DOC_CKS1_1	69	74	PF01111	0.613
DOC_PP2B_LxvP_1	109	112	PF13499	0.604
DOC_PP2B_LxvP_1	200	203	PF13499	0.619
DOC_USP7_MATH_1	102	106	PF00917	0.638
DOC_USP7_MATH_1	125	129	PF00917	0.633
DOC_USP7_MATH_1	189	193	PF00917	0.589
DOC_USP7_MATH_1	220	224	PF00917	0.660
DOC_USP7_MATH_1	263	267	PF00917	0.630
DOC_USP7_MATH_1	52	56	PF00917	0.551
DOC_WW_Pin1_4	115	120	PF00397	0.600
DOC_WW_Pin1_4	129	134	PF00397	0.545
DOC_WW_Pin1_4	148	153	PF00397	0.598
DOC_WW_Pin1_4	209	214	PF00397	0.640
DOC_WW_Pin1_4	68	73	PF00397	0.625
LIG_14-3-3_CanoR_1	248	254	PF00244	0.599
LIG_14-3-3_CanoR_1	264	269	PF00244	0.519
LIG_Actin_WH2_2	254	271	PF00022	0.619
LIG_FHA_1	105	111	PF00498	0.590
LIG_FHA_1	235	241	PF00498	0.622
LIG_Integrin_RGD_1	224	226	PF01839	0.652
LIG_LIR_Gen_1	59	69	PF02991	0.556
LIG_LIR_LC3C_4	107	111	PF02991	0.614
LIG_LIR_Nem_3	59	64	PF02991	0.554
LIG_PAM2_1	52	64	PF00658	0.551
LIG_PDZ_Class_2	291	296	PF00595	0.577
LIG_SH3_1	63	69	PF00018	0.559
LIG_SH3_1	74	80	PF00018	0.548
LIG_SH3_2	69	74	PF14604	0.583
LIG_SH3_3	107	113	PF00018	0.608
LIG_SH3_3	183	189	PF00018	0.644
LIG_SH3_3	199	205	PF00018	0.469
LIG_SH3_3	286	292	PF00018	0.579
LIG_SH3_3	63	69	PF00018	0.592
LIG_SH3_3	74	80	PF00018	0.553
MOD_CDK_SPxK_1	115	121	PF00069	0.602
MOD_CDK_SPxK_1	68	74	PF00069	0.581
MOD_CDK_SPxxK_3	115	122	PF00069	0.604
MOD_CK1_1	104	110	PF00069	0.623
MOD_GlcNHglycan	104	107	PF01048	0.700
MOD_GlcNHglycan	191	194	PF01048	0.613
MOD_GlcNHglycan	26	29	PF01048	0.779
MOD_GlcNHglycan	261	264	PF01048	0.672
MOD_GlcNHglycan	274	277	PF01048	0.523
MOD_GlcNHglycan	44	47	PF01048	0.568
MOD_GlcNHglycan	56	59	PF01048	0.620
MOD_GSK3_1	100	107	PF00069	0.579
MOD_GSK3_1	125	132	PF00069	0.639
MOD_GSK3_1	216	223	PF00069	0.656
MOD_GSK3_1	234	241	PF00069	0.624
MOD_GSK3_1	249	256	PF00069	0.487
MOD_GSK3_1	259	266	PF00069	0.542
MOD_GSK3_1	52	59	PF00069	0.540
MOD_GSK3_1	92	99	PF00069	0.649
MOD_LATS_1	96	102	PF00433	0.646
MOD_N-GLC_1	278	283	PF02516	0.602
MOD_NEK2_1	114	119	PF00069	0.601
MOD_NEK2_1	196	201	PF00069	0.618
MOD_NEK2_1	216	221	PF00069	0.512
MOD_NEK2_1	253	258	PF00069	0.602
MOD_NEK2_1	56	61	PF00069	0.548
MOD_PKA_1	264	270	PF00069	0.638
MOD_PKA_2	263	269	PF00069	0.635
MOD_Plk_4	105	111	PF00069	0.618
MOD_Plk_4	56	62	PF00069	0.550
MOD_ProDKin_1	115	121	PF00069	0.602
MOD_ProDKin_1	129	135	PF00069	0.546
MOD_ProDKin_1	148	154	PF00069	0.595
MOD_ProDKin_1	209	215	PF00069	0.643
MOD_ProDKin_1	68	74	PF00069	0.631
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.602
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.557
TRG_ER_diArg_1	208	211	PF00400	0.640
TRG_ER_diArg_1	29	31	PF00400	0.610
TRG_ER_diArg_1	78	81	PF00400	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I7P2	Leishmania donovani	100%	100%
E9AG98	Leishmania infantum	81%	97%