Pteridine transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6F6_LEIDO

TriTrypDb:

LdBPK_100370.1 , LdCL_100009400 , LDHU3_10.0590

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71

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Expansion

Sequence features

A0A3S5H6F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	667	671	PF00656	0.777
CLV_MEL_PAP_1	438	444	PF00089	0.251
CLV_NRD_NRD_1	271	273	PF00675	0.342
CLV_NRD_NRD_1	48	50	PF00675	0.416
CLV_PCSK_KEX2_1	133	135	PF00082	0.301
CLV_PCSK_KEX2_1	299	301	PF00082	0.369
CLV_PCSK_KEX2_1	48	50	PF00082	0.441
CLV_PCSK_KEX2_1	519	521	PF00082	0.526
CLV_PCSK_KEX2_1	9	11	PF00082	0.424
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.302

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	99%
A0A0N1HY49	Leptomonas seymouri	44%	100%
A0A0N1HZ06	Leptomonas seymouri	36%	100%
A0A0N1IHL1	Leptomonas seymouri	38%	98%
A0A0N1PAY4	Leptomonas seymouri	46%	79%
A0A0N1PB77	Leptomonas seymouri	33%	100%
A0A0N1PBZ2	Leptomonas seymouri	67%	100%
A0A0N1PCC1	Leptomonas seymouri	42%	100%
A0A381MBI0	Leishmania infantum	42%	100%
A0A3Q8I8X7	Leishmania donovani	42%	100%

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