Pteridine transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6F6_LEIDO

TriTrypDb:

LdBPK_100370.1 , LdCL_100009400 , LDHU3_10.0590

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3S5H6F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	667	671	PF00656	0.777
CLV_MEL_PAP_1	438	444	PF00089	0.251
CLV_NRD_NRD_1	271	273	PF00675	0.342
CLV_NRD_NRD_1	48	50	PF00675	0.416
CLV_PCSK_KEX2_1	133	135	PF00082	0.301
CLV_PCSK_KEX2_1	299	301	PF00082	0.369
CLV_PCSK_KEX2_1	48	50	PF00082	0.441
CLV_PCSK_KEX2_1	519	521	PF00082	0.526
CLV_PCSK_KEX2_1	9	11	PF00082	0.424
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.302
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.227
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.526
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.424
CLV_PCSK_SKI1_1	116	120	PF00082	0.353
CLV_PCSK_SKI1_1	316	320	PF00082	0.396
DOC_CDC14_PxL_1	609	617	PF14671	0.336
DOC_CKS1_1	621	626	PF01111	0.425
DOC_CYCLIN_yCln2_LP_2	549	552	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	626	632	PF00134	0.384
DOC_MAPK_gen_1	133	139	PF00069	0.511
DOC_MAPK_gen_1	257	267	PF00069	0.553
DOC_MAPK_gen_1	519	527	PF00069	0.328
DOC_MAPK_gen_1	637	646	PF00069	0.593
DOC_MAPK_MEF2A_6	227	234	PF00069	0.334
DOC_MAPK_MEF2A_6	519	527	PF00069	0.361
DOC_PP1_RVXF_1	495	501	PF00149	0.524
DOC_PP2B_LxvP_1	549	552	PF13499	0.346
DOC_PP2B_LxvP_1	626	629	PF13499	0.371
DOC_PP2B_PxIxI_1	227	233	PF00149	0.289
DOC_USP7_MATH_1	196	200	PF00917	0.485
DOC_USP7_MATH_1	302	306	PF00917	0.593
DOC_USP7_MATH_1	561	565	PF00917	0.490
DOC_USP7_MATH_1	663	667	PF00917	0.771
DOC_WW_Pin1_4	298	303	PF00397	0.578
DOC_WW_Pin1_4	620	625	PF00397	0.409
LIG_14-3-3_CanoR_1	104	111	PF00244	0.490
LIG_14-3-3_CanoR_1	257	267	PF00244	0.589
LIG_14-3-3_CanoR_1	304	311	PF00244	0.548
LIG_14-3-3_CanoR_1	497	501	PF00244	0.496
LIG_APCC_ABBA_1	50	55	PF00400	0.641
LIG_APCC_ABBAyCdc20_2	49	55	PF00400	0.509
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_BIR_III_4	13	17	PF00653	0.729
LIG_Clathr_ClatBox_1	265	269	PF01394	0.448
LIG_EH1_1	499	507	PF00400	0.347
LIG_eIF4E_1	609	615	PF01652	0.232
LIG_FHA_1	117	123	PF00498	0.605
LIG_FHA_1	208	214	PF00498	0.344
LIG_FHA_1	365	371	PF00498	0.594
LIG_FHA_1	382	388	PF00498	0.357
LIG_FHA_1	397	403	PF00498	0.258
LIG_FHA_1	481	487	PF00498	0.401
LIG_FHA_1	497	503	PF00498	0.497
LIG_FHA_1	621	627	PF00498	0.423
LIG_FHA_2	269	275	PF00498	0.574
LIG_FHA_2	598	604	PF00498	0.229
LIG_GBD_Chelix_1	501	509	PF00786	0.478
LIG_GBD_Chelix_1	539	547	PF00786	0.506
LIG_HP1_1	552	556	PF01393	0.406
LIG_LIR_Apic_2	29	35	PF02991	0.618
LIG_LIR_Apic_2	348	354	PF02991	0.535
LIG_LIR_Apic_2	417	422	PF02991	0.422
LIG_LIR_Apic_2	453	457	PF02991	0.340
LIG_LIR_Apic_2	592	596	PF02991	0.307
LIG_LIR_Gen_1	124	131	PF02991	0.530
LIG_LIR_Gen_1	202	209	PF02991	0.445
LIG_LIR_Gen_1	466	475	PF02991	0.335
LIG_LIR_Gen_1	485	492	PF02991	0.375
LIG_LIR_Gen_1	566	576	PF02991	0.521
LIG_LIR_Gen_1	87	95	PF02991	0.552
LIG_LIR_Nem_3	124	129	PF02991	0.498
LIG_LIR_Nem_3	132	138	PF02991	0.497
LIG_LIR_Nem_3	202	208	PF02991	0.352
LIG_LIR_Nem_3	242	248	PF02991	0.365
LIG_LIR_Nem_3	371	377	PF02991	0.494
LIG_LIR_Nem_3	417	421	PF02991	0.392
LIG_LIR_Nem_3	464	468	PF02991	0.307
LIG_LIR_Nem_3	485	490	PF02991	0.344
LIG_Pex14_2	169	173	PF04695	0.372
LIG_Pex14_2	463	467	PF04695	0.316
LIG_Pex14_2	487	491	PF04695	0.378
LIG_PTB_Apo_2	459	466	PF02174	0.381
LIG_PTB_Apo_2	485	492	PF02174	0.445
LIG_PTB_Phospho_1	459	465	PF10480	0.415
LIG_SH2_CRK	102	106	PF00017	0.513
LIG_SH2_CRK	136	140	PF00017	0.382
LIG_SH2_CRK	151	155	PF00017	0.333
LIG_SH2_CRK	186	190	PF00017	0.520
LIG_SH2_CRK	351	355	PF00017	0.477
LIG_SH2_CRK	379	383	PF00017	0.352
LIG_SH2_CRK	454	458	PF00017	0.371
LIG_SH2_CRK	468	472	PF00017	0.304
LIG_SH2_CRK	537	541	PF00017	0.366
LIG_SH2_CRK	593	597	PF00017	0.330
LIG_SH2_CRK	609	613	PF00017	0.340
LIG_SH2_GRB2like	450	453	PF00017	0.372
LIG_SH2_GRB2like	609	612	PF00017	0.355
LIG_SH2_NCK_1	334	338	PF00017	0.438
LIG_SH2_NCK_1	468	472	PF00017	0.304
LIG_SH2_NCK_1	537	541	PF00017	0.270
LIG_SH2_PTP2	32	35	PF00017	0.612
LIG_SH2_PTP2	524	527	PF00017	0.402
LIG_SH2_SRC	32	35	PF00017	0.618
LIG_SH2_SRC	334	337	PF00017	0.441
LIG_SH2_SRC	338	341	PF00017	0.428
LIG_SH2_STAP1	131	135	PF00017	0.502
LIG_SH2_STAP1	186	190	PF00017	0.495
LIG_SH2_STAP1	334	338	PF00017	0.433
LIG_SH2_STAP1	379	383	PF00017	0.395
LIG_SH2_STAP1	569	573	PF00017	0.346
LIG_SH2_STAP1	88	92	PF00017	0.541
LIG_SH2_STAT5	131	134	PF00017	0.507
LIG_SH2_STAT5	246	249	PF00017	0.463
LIG_SH2_STAT5	32	35	PF00017	0.607
LIG_SH2_STAT5	433	436	PF00017	0.361
LIG_SH2_STAT5	450	453	PF00017	0.283
LIG_SH2_STAT5	465	468	PF00017	0.307
LIG_SH2_STAT5	524	527	PF00017	0.307
LIG_SH2_STAT5	533	536	PF00017	0.299
LIG_SH2_STAT5	537	540	PF00017	0.344
LIG_SH3_1	351	357	PF00018	0.589
LIG_SH3_3	351	357	PF00018	0.599
LIG_SH3_3	439	445	PF00018	0.375
LIG_SUMO_SIM_anti_2	631	636	PF11976	0.469
LIG_SUMO_SIM_par_1	480	485	PF11976	0.237
LIG_SUMO_SIM_par_1	551	557	PF11976	0.336
LIG_TRFH_1	151	155	PF08558	0.368
LIG_TYR_ITIM	149	154	PF00017	0.388
LIG_TYR_ITSM	464	471	PF00017	0.410
LIG_UBA3_1	149	157	PF00899	0.360
LIG_UBA3_1	265	273	PF00899	0.523
LIG_UBA3_1	486	493	PF00899	0.422
LIG_UBA3_1	632	637	PF00899	0.237
LIG_Vh1_VBS_1	377	395	PF01044	0.414
MOD_CDC14_SPxK_1	301	304	PF00782	0.430
MOD_CDK_SPxK_1	298	304	PF00069	0.430
MOD_CK1_1	106	112	PF00069	0.367
MOD_CK1_1	199	205	PF00069	0.367
MOD_CK1_1	666	672	PF00069	0.611
MOD_CK2_1	268	274	PF00069	0.438
MOD_Cter_Amidation	297	300	PF01082	0.473
MOD_GlcNHglycan	158	162	PF01048	0.358
MOD_GlcNHglycan	234	237	PF01048	0.366
MOD_GlcNHglycan	442	445	PF01048	0.452
MOD_GlcNHglycan	476	479	PF01048	0.371
MOD_GSK3_1	103	110	PF00069	0.415
MOD_GSK3_1	209	216	PF00069	0.316
MOD_GSK3_1	228	235	PF00069	0.434
MOD_GSK3_1	298	305	PF00069	0.419
MOD_GSK3_1	364	371	PF00069	0.280
MOD_GSK3_1	377	384	PF00069	0.404
MOD_GSK3_1	436	443	PF00069	0.250
MOD_GSK3_1	463	470	PF00069	0.377
MOD_GSK3_1	496	503	PF00069	0.371
MOD_GSK3_1	574	581	PF00069	0.381
MOD_N-GLC_1	461	466	PF02516	0.360
MOD_N-GLC_2	620	622	PF02516	0.491
MOD_NEK2_1	111	116	PF00069	0.371
MOD_NEK2_1	129	134	PF00069	0.353
MOD_NEK2_1	137	142	PF00069	0.355
MOD_NEK2_1	169	174	PF00069	0.344
MOD_NEK2_1	209	214	PF00069	0.333
MOD_NEK2_1	268	273	PF00069	0.416
MOD_NEK2_1	377	382	PF00069	0.375
MOD_NEK2_1	396	401	PF00069	0.295
MOD_NEK2_1	463	468	PF00069	0.373
MOD_NEK2_1	500	505	PF00069	0.375
MOD_NEK2_1	578	583	PF00069	0.363
MOD_NEK2_1	68	73	PF00069	0.422
MOD_NEK2_2	228	233	PF00069	0.473
MOD_PIKK_1	179	185	PF00454	0.333
MOD_PIKK_1	597	603	PF00454	0.258
MOD_PK_1	104	110	PF00069	0.457
MOD_PK_1	436	442	PF00069	0.395
MOD_PKA_2	103	109	PF00069	0.326
MOD_PKA_2	440	446	PF00069	0.464
MOD_PKA_2	496	502	PF00069	0.356
MOD_PKA_2	561	567	PF00069	0.341
MOD_PKB_1	275	283	PF00069	0.216
MOD_Plk_1	461	467	PF00069	0.385
MOD_Plk_4	196	202	PF00069	0.353
MOD_Plk_4	209	215	PF00069	0.344
MOD_Plk_4	36	42	PF00069	0.485
MOD_Plk_4	377	383	PF00069	0.359
MOD_Plk_4	414	420	PF00069	0.401
MOD_Plk_4	463	469	PF00069	0.405
MOD_Plk_4	482	488	PF00069	0.210
MOD_Plk_4	496	502	PF00069	0.352
MOD_Plk_4	535	541	PF00069	0.353
MOD_Plk_4	563	569	PF00069	0.388
MOD_Plk_4	628	634	PF00069	0.377
MOD_ProDKin_1	298	304	PF00069	0.457
MOD_ProDKin_1	620	626	PF00069	0.409
MOD_SUMO_for_1	8	11	PF00179	0.520
MOD_SUMO_rev_2	642	651	PF00179	0.413
TRG_DiLeu_BaEn_2	261	267	PF01217	0.316
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.387
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.327
TRG_ENDOCYTIC_2	102	105	PF00928	0.346
TRG_ENDOCYTIC_2	136	139	PF00928	0.360
TRG_ENDOCYTIC_2	151	154	PF00928	0.347
TRG_ENDOCYTIC_2	186	189	PF00928	0.351
TRG_ENDOCYTIC_2	379	382	PF00928	0.351
TRG_ENDOCYTIC_2	468	471	PF00928	0.363
TRG_ENDOCYTIC_2	524	527	PF00928	0.485
TRG_ENDOCYTIC_2	537	540	PF00928	0.385
TRG_ENDOCYTIC_2	569	572	PF00928	0.347
TRG_ENDOCYTIC_2	609	612	PF00928	0.419
TRG_ENDOCYTIC_2	88	91	PF00928	0.372
TRG_ER_diArg_1	47	49	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	99%
A0A0N1HY49	Leptomonas seymouri	44%	100%
A0A0N1HZ06	Leptomonas seymouri	36%	100%
A0A0N1IHL1	Leptomonas seymouri	38%	98%
A0A0N1PAY4	Leptomonas seymouri	46%	79%
A0A0N1PB77	Leptomonas seymouri	33%	100%
A0A0N1PBZ2	Leptomonas seymouri	67%	100%
A0A0N1PCC1	Leptomonas seymouri	42%	100%
A0A381MBI0	Leishmania infantum	42%	100%
A0A3Q8I8X7	Leishmania donovani	42%	100%
A0A3Q8IAZ0	Leishmania donovani	94%	100%
A0A3Q8IH50	Leishmania donovani	59%	100%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	41%	100%
A0A3S5H5P4	Leishmania donovani	44%	100%
A0A3S5H5V2	Leishmania donovani	43%	100%
A0A3S5H763	Leishmania donovani	51%	100%
A0A3S7WR10	Leishmania donovani	42%	94%
A0A3S7WR14	Leishmania donovani	82%	100%
A0A3S7WR15	Leishmania donovani	71%	82%
A0A3S7WR24	Leishmania donovani	95%	99%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	43%	100%
A4H617	Leishmania braziliensis	81%	100%
A4H618	Leishmania braziliensis	81%	100%
A4H619	Leishmania braziliensis	81%	100%
A4H620	Leishmania braziliensis	57%	100%
A4H6C3	Leishmania braziliensis	44%	100%
A4HNH7	Leishmania braziliensis	36%	98%
A4HSS2	Leishmania infantum	44%	100%
A4HUE4	Leishmania infantum	42%	100%
A4HUE5	Leishmania infantum	75%	100%
A4HUE6	Leishmania infantum	84%	100%
A4HUE7	Leishmania infantum	94%	100%
A4HUE8	Leishmania infantum	95%	100%
A4HUF4	Leishmania infantum	98%	100%
A4HUF5	Leishmania infantum	58%	100%
A4HYA9	Leishmania infantum	52%	100%
A4IC33	Leishmania infantum	37%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AG72	Leishmania infantum	43%	100%
E9AI40	Leishmania braziliensis	77%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	98%
Q4QDC4	Leishmania major	51%	100%
Q4QH81	Leishmania major	43%	100%
Q4QHH7	Leishmania major	59%	100%
Q4QHH8	Leishmania major	92%	100%
Q4QHH9	Leishmania major	91%	100%
Q4QHI0	Leishmania major	91%	99%
Q4QHI1	Leishmania major	84%	100%
Q4QHI2	Leishmania major	79%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	43%	100%
Q7KIP2	Leishmania major	37%	100%