Putative snoRNA binding domain family protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein 56, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6F4_LEIDO

TriTrypDb:

LdBPK_100210.1 , LdCL_100007400 , LDHU3_10.0340

Length:

473

Annotations

Annotations by Jardim et al.

Nuclear proteins, nucleolar

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	12
GO:0030684	preribosome	3	12
GO:0031428	box C/D RNP complex	4	12
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1

Phosphorylation

Promastigote: 458

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0022613	ribonucleoprotein complex biogenesis	4	12
GO:0042254	ribosome biogenesis	5	12
GO:0044085	cellular component biogenesis	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0030515	snoRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	443	445	PF00675	0.490
CLV_NRD_NRD_1	447	449	PF00675	0.502
CLV_NRD_NRD_1	463	465	PF00675	0.614
CLV_PCSK_KEX2_1	279	281	PF00082	0.330
CLV_PCSK_KEX2_1	445	447	PF00082	0.501
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.323
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.516
CLV_PCSK_PC7_1	275	281	PF00082	0.323
CLV_PCSK_PC7_1	441	447	PF00082	0.550
CLV_PCSK_SKI1_1	257	261	PF00082	0.263
CLV_PCSK_SKI1_1	288	292	PF00082	0.312
CLV_PCSK_SKI1_1	298	302	PF00082	0.237
CLV_PCSK_SKI1_1	343	347	PF00082	0.263
CLV_PCSK_SKI1_1	386	390	PF00082	0.309
CLV_PCSK_SKI1_1	88	92	PF00082	0.494
DEG_APCC_DBOX_1	224	232	PF00400	0.415
DEG_APCC_KENBOX_2	372	376	PF00400	0.512
DEG_SCF_SKP2-CKS1_1	454	461	PF00560	0.595
DOC_CDC14_PxL_1	300	308	PF14671	0.463
DOC_MAPK_MEF2A_6	214	222	PF00069	0.463
DOC_PP1_RVXF_1	159	165	PF00149	0.448
DOC_PP1_RVXF_1	413	419	PF00149	0.463
DOC_PP1_RVXF_1	46	53	PF00149	0.487
DOC_PP2B_LxvP_1	113	116	PF13499	0.532
DOC_PP2B_LxvP_1	301	304	PF13499	0.474
DOC_PP4_FxxP_1	55	58	PF00568	0.474
DOC_USP7_MATH_1	258	262	PF00917	0.467
DOC_USP7_MATH_1	469	473	PF00917	0.678
DOC_USP7_UBL2_3	317	321	PF12436	0.463
DOC_USP7_UBL2_3	445	449	PF12436	0.534
DOC_USP7_UBL2_3	461	465	PF12436	0.714
DOC_USP7_UBL2_3	87	91	PF12436	0.468
DOC_WW_Pin1_4	328	333	PF00397	0.512
DOC_WW_Pin1_4	353	358	PF00397	0.459
DOC_WW_Pin1_4	41	46	PF00397	0.470
DOC_WW_Pin1_4	455	460	PF00397	0.701
DOC_WW_Pin1_4	54	59	PF00397	0.446
LIG_14-3-3_CanoR_1	225	229	PF00244	0.470
LIG_14-3-3_CanoR_1	280	285	PF00244	0.466
LIG_14-3-3_CanoR_1	3	9	PF00244	0.384
LIG_APCC_ABBA_1	130	135	PF00400	0.431
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BIR_III_2	398	402	PF00653	0.523
LIG_deltaCOP1_diTrp_1	196	202	PF00928	0.463
LIG_deltaCOP1_diTrp_1	268	277	PF00928	0.463
LIG_EH1_1	293	301	PF00400	0.463
LIG_eIF4E_1	215	221	PF01652	0.463
LIG_EVH1_2	400	404	PF00568	0.463
LIG_FHA_1	21	27	PF00498	0.543
LIG_FHA_1	333	339	PF00498	0.463
LIG_FHA_2	120	126	PF00498	0.531
LIG_FHA_2	20	26	PF00498	0.431
LIG_FHA_2	5	11	PF00498	0.388
LIG_GBD_Chelix_1	291	299	PF00786	0.323
LIG_GBD_Chelix_1	389	397	PF00786	0.263
LIG_LIR_Apic_2	7	12	PF02991	0.540
LIG_LIR_Gen_1	13	20	PF02991	0.523
LIG_LIR_Gen_1	268	278	PF02991	0.463
LIG_LIR_Gen_1	39	47	PF02991	0.463
LIG_LIR_Gen_1	437	443	PF02991	0.492
LIG_LIR_Nem_3	13	18	PF02991	0.474
LIG_LIR_Nem_3	268	274	PF02991	0.463
LIG_LIR_Nem_3	356	362	PF02991	0.463
LIG_LIR_Nem_3	39	43	PF02991	0.460
LIG_LIR_Nem_3	4	9	PF02991	0.331
LIG_LIR_Nem_3	437	442	PF02991	0.457
LIG_LIR_Nem_3	44	49	PF02991	0.465
LIG_LIR_Nem_3	51	55	PF02991	0.467
LIG_PCNA_yPIPBox_3	288	300	PF02747	0.463
LIG_Pex14_2	363	367	PF04695	0.463
LIG_Pex14_2	76	80	PF04695	0.369
LIG_SH2_CRK	215	219	PF00017	0.463
LIG_SH2_CRK	359	363	PF00017	0.454
LIG_SH2_CRK	439	443	PF00017	0.460
LIG_SH2_GRB2like	215	218	PF00017	0.549
LIG_SH2_NCK_1	215	219	PF00017	0.474
LIG_SH2_NCK_1	9	13	PF00017	0.487
LIG_SH2_SRC	215	218	PF00017	0.549
LIG_SH2_STAP1	215	219	PF00017	0.463
LIG_SH2_STAP1	255	259	PF00017	0.474
LIG_SH2_STAT5	294	297	PF00017	0.463
LIG_SH2_STAT5	382	385	PF00017	0.463
LIG_SH2_STAT5	6	9	PF00017	0.457
LIG_SH3_3	206	212	PF00018	0.454
LIG_SH3_3	97	103	PF00018	0.491
LIG_TRAF2_1	22	25	PF00917	0.474
LIG_TYR_ITIM	213	218	PF00017	0.474
LIG_UBA3_1	179	185	PF00899	0.350
LIG_UBA3_1	189	195	PF00899	0.431
LIG_UBA3_1	345	353	PF00899	0.463
LIG_WRC_WIRS_1	274	279	PF05994	0.523
LIG_WRC_WIRS_1	37	42	PF05994	0.464
LIG_WRC_WIRS_1	49	54	PF05994	0.460
LIG_WRC_WIRS_1	73	78	PF05994	0.435
MOD_CDK_SPK_2	353	358	PF00069	0.463
MOD_CDK_SPK_2	455	460	PF00069	0.701
MOD_CDK_SPxK_1	455	461	PF00069	0.714
MOD_CDK_SPxxK_3	41	48	PF00069	0.474
MOD_CDK_SPxxK_3	455	462	PF00069	0.708
MOD_CK1_1	331	337	PF00069	0.513
MOD_CK1_1	39	45	PF00069	0.550
MOD_CK2_1	119	125	PF00069	0.538
MOD_CK2_1	19	25	PF00069	0.431
MOD_CK2_1	4	10	PF00069	0.388
MOD_CK2_1	467	473	PF00069	0.643
MOD_CMANNOS	197	200	PF00535	0.263
MOD_GlcNHglycan	106	109	PF01048	0.422
MOD_GlcNHglycan	176	179	PF01048	0.388
MOD_GSK3_1	317	324	PF00069	0.453
MOD_GSK3_1	328	335	PF00069	0.452
MOD_N-GLC_1	119	124	PF02516	0.475
MOD_N-GLC_1	304	309	PF02516	0.263
MOD_NEK2_1	1	6	PF00069	0.448
MOD_NEK2_1	310	315	PF00069	0.549
MOD_NEK2_1	363	368	PF00069	0.457
MOD_NEK2_1	418	423	PF00069	0.472
MOD_NEK2_1	72	77	PF00069	0.407
MOD_PIKK_1	304	310	PF00454	0.523
MOD_PKA_1	460	466	PF00069	0.656
MOD_PKA_2	20	26	PF00069	0.549
MOD_PKA_2	224	230	PF00069	0.463
MOD_PKA_2	369	375	PF00069	0.540
MOD_Plk_1	119	125	PF00069	0.472
MOD_Plk_1	304	310	PF00069	0.523
MOD_Plk_4	363	369	PF00069	0.463
MOD_Plk_4	399	405	PF00069	0.549
MOD_Plk_4	4	10	PF00069	0.342
MOD_Plk_4	72	78	PF00069	0.403
MOD_ProDKin_1	328	334	PF00069	0.512
MOD_ProDKin_1	353	359	PF00069	0.459
MOD_ProDKin_1	41	47	PF00069	0.470
MOD_ProDKin_1	455	461	PF00069	0.705
MOD_ProDKin_1	54	60	PF00069	0.446
MOD_SUMO_for_1	90	93	PF00179	0.615
MOD_SUMO_rev_2	229	238	PF00179	0.523
MOD_SUMO_rev_2	97	105	PF00179	0.406
TRG_ENDOCYTIC_2	15	18	PF00928	0.480
TRG_ENDOCYTIC_2	215	218	PF00928	0.463
TRG_ENDOCYTIC_2	359	362	PF00928	0.463
TRG_ENDOCYTIC_2	439	442	PF00928	0.450
TRG_ER_diArg_1	443	446	PF00400	0.522
TRG_NES_CRM1_1	181	196	PF08389	0.463
TRG_NLS_Bipartite_1	444	465	PF00514	0.638
TRG_NLS_MonoCore_2	349	354	PF00514	0.463
TRG_NLS_MonoExtC_3	459	464	PF00514	0.587
TRG_NLS_MonoExtN_4	347	354	PF00514	0.463
TRG_NLS_MonoExtN_4	459	465	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD49	Leptomonas seymouri	36%	100%
A0A0N1PE54	Leptomonas seymouri	91%	100%
A0A0S4IXK2	Bodo saltans	78%	100%
A0A0S4JJS5	Bodo saltans	37%	100%
A0A1X0NRL9	Trypanosomatidae	79%	97%
A0A1X0NUB3	Trypanosomatidae	38%	100%
A0A3Q8IDJ5	Leishmania donovani	23%	100%
A0A3R7NI91	Trypanosoma rangeli	38%	100%
A0A3R7NLD9	Trypanosoma rangeli	79%	98%
A0A3S5H6V9	Leishmania donovani	37%	100%
A1CL70	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	43%	80%
A1D688	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	43%	80%
A2QE38	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	41%	82%
A3LUT0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	40%	92%
A4H602	Leishmania braziliensis	94%	100%
A4H8A6	Leishmania braziliensis	37%	100%
A4HUC9	Leishmania infantum	100%	100%
A4HWM6	Leishmania infantum	37%	100%
A4I8M9	Leishmania infantum	23%	100%
A5DHW0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	39%	94%
A5E4V9	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	40%	91%
A6QYH8	Ajellomyces capsulatus (strain NAm1 / WU24)	42%	74%
A6RMY5	Botryotinia fuckeliana (strain B05.10)	43%	83%
A6ZPE5	Saccharomyces cerevisiae (strain YJM789)	40%	93%
A7F2R6	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	43%	83%
A7TIF5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	40%	92%
C9ZVG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	98%
C9ZXR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	94%
E9AN29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AQD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B3J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O00567	Homo sapiens	47%	80%
O04656	Arabidopsis thaliana	37%	100%
O04658	Arabidopsis thaliana	42%	89%
O94514	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	95%
P0CP26	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	40%	83%
P0CP27	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	40%	84%
Q0CQH1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	42%	82%
Q12460	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	94%
Q12499	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	93%
Q1E1Q5	Coccidioides immitis (strain RS)	41%	78%
Q21276	Caenorhabditis elegans	45%	97%
Q2UC04	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	82%
Q3SZ63	Bos taurus	47%	79%
Q4PBF2	Ustilago maydis (strain 521 / FGSC 9021)	40%	81%
Q4Q4L0	Leishmania major	23%	100%
Q4QF42	Leishmania major	37%	100%
Q4QHJ7	Leishmania major	99%	100%
Q4R779	Macaca fascicularis	37%	89%
Q4WYK9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	80%
Q54MT2	Dictyostelium discoideum	45%	88%
Q55FI4	Dictyostelium discoideum	41%	74%
Q59S06	Candida albicans (strain SC5314 / ATCC MYA-2876)	40%	92%
Q5B8G3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	81%
Q5RA29	Pongo abelii	47%	80%
Q6BIX6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	91%
Q6CG46	Yarrowia lipolytica (strain CLIB 122 / E 150)	40%	92%
Q6CKR8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	40%	93%
Q6DFW4	Mus musculus	37%	88%
Q6FQ21	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	92%
Q753I4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	92%
Q8X066	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	79%
Q95K50	Macaca fascicularis	47%	80%
Q9D6Z1	Mus musculus	47%	82%
Q9MAB3	Arabidopsis thaliana	41%	89%
Q9P7S7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	93%
Q9QZ86	Rattus norvegicus	37%	89%
Q9Y2X3	Homo sapiens	37%	89%
V5AU06	Trypanosoma cruzi	79%	98%
V5BK67	Trypanosoma cruzi	38%	100%