MORN repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6F3_LEIDO

TriTrypDb:

LdBPK_100190.1 , LdCL_100007100 , LDHU3_10.0300

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S5H6F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.504
CLV_NRD_NRD_1	36	38	PF00675	0.445
CLV_PCSK_KEX2_1	36	38	PF00082	0.445
CLV_PCSK_SKI1_1	6	10	PF00082	0.651
DOC_ANK_TNKS_1	161	168	PF00023	0.425
DOC_ANK_TNKS_1	36	43	PF00023	0.493
DOC_CDC14_PxL_1	190	198	PF14671	0.578
DOC_MAPK_gen_1	4	16	PF00069	0.550
DOC_USP7_MATH_1	202	206	PF00917	0.734
DOC_USP7_MATH_1	54	58	PF00917	0.818
DOC_USP7_MATH_1	85	89	PF00917	0.594
DOC_USP7_UBL2_3	5	9	PF12436	0.582
DOC_WW_Pin1_4	200	205	PF00397	0.702
DOC_WW_Pin1_4	61	66	PF00397	0.694
DOC_WW_Pin1_4	68	73	PF00397	0.752
LIG_14-3-3_CanoR_1	58	65	PF00244	0.674
LIG_14-3-3_CanoR_1	97	103	PF00244	0.425
LIG_BIR_III_2	201	205	PF00653	0.551
LIG_BIR_III_4	45	49	PF00653	0.614
LIG_FHA_2	215	221	PF00498	0.504
LIG_LIR_Gen_1	166	176	PF02991	0.358
LIG_LIR_Nem_3	166	172	PF02991	0.358
LIG_LYPXL_S_1	192	196	PF13949	0.678
LIG_LYPXL_yS_3	193	196	PF13949	0.676
LIG_Pex14_1	177	181	PF04695	0.440
LIG_SH2_CRK	100	104	PF00017	0.412
LIG_SH2_CRK	38	42	PF00017	0.547
LIG_SH2_GRB2like	181	184	PF00017	0.457
LIG_SH2_NCK_1	100	104	PF00017	0.425
LIG_SH2_NCK_1	169	173	PF00017	0.314
LIG_SH2_NCK_1	38	42	PF00017	0.631
LIG_SH2_SRC	38	41	PF00017	0.466
LIG_SH2_STAT3	154	157	PF00017	0.349
LIG_SH2_STAT5	100	103	PF00017	0.425
LIG_SH2_STAT5	154	157	PF00017	0.350
LIG_SH2_STAT5	169	172	PF00017	0.321
LIG_SH2_STAT5	22	25	PF00017	0.482
LIG_SH3_3	201	207	PF00018	0.553
LIG_SH3_3	7	13	PF00018	0.651
MOD_CDC14_SPxK_1	64	67	PF00782	0.655
MOD_CDK_SPxK_1	61	67	PF00069	0.650
MOD_CK1_1	203	209	PF00069	0.525
MOD_CK1_1	59	65	PF00069	0.770
MOD_GlcNHglycan	118	121	PF01048	0.345
MOD_GlcNHglycan	126	129	PF01048	0.468
MOD_GlcNHglycan	140	143	PF01048	0.312
MOD_GlcNHglycan	214	217	PF01048	0.643
MOD_GlcNHglycan	74	77	PF01048	0.778
MOD_GSK3_1	138	145	PF00069	0.392
MOD_GSK3_1	208	215	PF00069	0.579
MOD_GSK3_1	54	61	PF00069	0.775
MOD_GSK3_1	68	75	PF00069	0.808
MOD_N-GLC_1	182	187	PF02516	0.430
MOD_N-GLC_1	212	217	PF02516	0.504
MOD_NEK2_1	116	121	PF00069	0.401
MOD_NEK2_1	124	129	PF00069	0.529
MOD_NEK2_1	209	214	PF00069	0.506
MOD_PKA_2	59	65	PF00069	0.629
MOD_PKB_1	58	66	PF00069	0.604
MOD_Plk_4	18	24	PF00069	0.474
MOD_ProDKin_1	200	206	PF00069	0.704
MOD_ProDKin_1	61	67	PF00069	0.698
MOD_ProDKin_1	68	74	PF00069	0.747
TRG_ENDOCYTIC_2	169	172	PF00928	0.335
TRG_ENDOCYTIC_2	193	196	PF00928	0.650
TRG_ER_diArg_1	35	37	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I749	Leptomonas seymouri	61%	86%
A0A1X0NQ66	Trypanosomatidae	42%	100%
A0A3Q8IQ71	Leishmania donovani	33%	94%
A0A3R7KKB6	Trypanosoma rangeli	46%	100%
A4HUC7	Leishmania infantum	98%	100%
C9ZVG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACU8	Leishmania major	33%	94%
E9AI39	Leishmania braziliensis	75%	97%
E9AN27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AZD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	94%
Q4QHJ9	Leishmania major	95%	100%
V5BCY8	Trypanosoma cruzi	35%	100%